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公开(公告)号：US07439498B2
公开(公告)日：2008-10-21
申请号：US11260663
申请日：2005-10-28
申请人： Albert Edward Litherland , Jonathan P. Doupe , William Edward Kieser , Xiao-Lei Zhao , Gholamreza Javahery , Lisa Cousins , Ilia Tomski , Charles Jolliffe
发明人： Albert Edward Litherland , Jonathan P. Doupe , William Edward Kieser , Xiao-Lei Zhao , Gholamreza Javahery , Lisa Cousins , Ilia Tomski , Charles Jolliffe
CPC分类号： H01J49/0086 , B01D59/44 , H01J49/0077 , H01J49/06
摘要： This invention relates to a method and apparatus for separation of rare stable or radioactive isotopes from their atomic or molecular isobars in mass spectrometry (MS). In the present invention, the approach taken to removing atomic isobars utilizes a high transmission device for decelerating ions in combination with low energy reactions, such as ion-molecule reactions or near resonant electron transfer, in RF ion guides. The isobar is selectively depleted by electron transfer or other reactions between negative ions and gaseous targets in pressurized RF ion guides at low energies. The energy is controlled in such a way as to prevent reaction of the ion of interest while inducing reactions with the undesired isobar interference. The technique is of particular relevance to accelerator mass spectrometry (AMS) for which it allows substantial reductions in the necessary terminal voltage. The effect is to allow reductions in the size and cost of AMS installations.
摘要翻译： 本发明涉及在质谱（MS）中从其原子或分子等值线分离稀有稳定或放射性同位素的方法和装置。 在本发明中，用于除去原子等压线的方法利用高传输装置，用于在RF离子导向器中结合低能量反应（例如离子分子反应或接近谐振电子转移）来减速离子。 在低能量下，加压RF离子导向器中的等离子体被电子转移或负离子与气态靶之间的其它反应选择性地耗尽。 控制能量以防止感兴趣的离子的反应，同时诱导与不期望的等压线干涉的反应。 该技术与加速器质谱（AMS）特别相关，其能够显着降低必需的终端电压。 其效果是可以减少AMS安装的尺寸和成本。
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公开(公告)号：US07932488B2
公开(公告)日：2011-04-26
申请号：US12437203
申请日：2009-05-07
CPC分类号： H01J49/066
摘要： An ion guide includes multiple stages. An electric field within each stage guides ions along a guide axis. Within each stage, amplitude and frequency, and resolving potential of the electric field may be independently varied. The geometry of the rods maintains a similarly shaped field from stage to stage, allowing efficient guidance of the ions along the axis. In particular, each rod segment of the ith of stage has a cross sectional radius ri, and a central axis located a distance Ri+ri from the guide axis. The ratio ri/Ri and is substantially constant along the guide axis, thereby preserving the shape of the field.
摘要翻译： 离子导向器包括多个阶段。 每个阶段内的电场沿引导轴引导离子。 在每个阶段内，可以独立地改变振幅和频率以及电场的分辨能力。 杆的几何形状保持了从阶段到阶段的类似形状的场，允许离子沿轴线的有效引导。 特别地，平台的第i个的每个杆段具有横截面半径ri，并且中心轴线位于与引导轴线的距离Ri + ri。 比率ri / Ri并且沿引导轴线基本上恒定，从而保持场的形状。
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公开(公告)号：US07569811B2
公开(公告)日：2009-08-04
申请号：US11331153
申请日：2006-01-13
CPC分类号： H01J49/066
摘要： An ion guide includes multiple stages. An electric field within each stage guides ions along a guide axis. Within each stage, amplitude and frequency, and resolving potential of the electric field may be independently varied. The geometry of the rods maintains a similarly shaped field from stage to stage, allowing efficient guidance of the ions along the axis. In particular, each rod segment of the ith of stage has a cross sectional radius ri, and a central axis located a distance Ri+ri from the guide axis. The ratio ri/Ri and is substantially constant along the guide axis, thereby preserving the shape of the field.
摘要翻译： 离子导向器包括多个阶段。 每个阶段内的电场沿引导轴引导离子。 在每个阶段内，可以独立地改变振幅和频率以及电场的分辨能力。 杆的几何形状保持了从阶段到阶段的类似形状的场，允许离子沿轴线的有效引导。 特别地，平台的第i个的每个杆段具有横截面半径ri，并且中心轴线与引导轴线定位距离Ri + ri。 比率ri / Ri并且沿引导轴线基本上恒定，从而保持场的形状。
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公开(公告)号：US20060113464A1
公开(公告)日：2006-06-01
申请号：US11260663
申请日：2005-10-28
申请人： Albert Litherland , Jonathan Doupe , William Kieser , Xiao-Lei Zhao , Gholamreza Javahery , Lisa Cousins , Ilia Tomski , Charles Jolliffe
发明人： Albert Litherland , Jonathan Doupe , William Kieser , Xiao-Lei Zhao , Gholamreza Javahery , Lisa Cousins , Ilia Tomski , Charles Jolliffe
IPC分类号： H01J49/00
CPC分类号： H01J49/0086 , B01D59/44 , H01J49/0077 , H01J49/06
摘要： This invention relates to a method and apparatus for separation of rare stable or radioactive isotopes from their atomic or molecular isobars in mass spectrometry (MS). In the present invention, the approach taken to removing atomic isobars utilizes a high transmission device for decelerating ions in combination with low energy reactions, such as ion-molecule reactions or near resonant electron transfer, in RF ion guides. The isobar is selectively depleted by electron transfer or other reactions between negative ions and gaseous targets in pressurized RF ion guides at low energies. The energy is controlled in such a way as to prevent reaction of the ion of interest while inducing reactions with the undesired isobar interference. The technique is of particular relevance to accelerator mass spectrometry (AMS) for which it allows substantial reductions in the necessary terminal voltage. The effect is to allow reductions in the size and cost of AMS installations.
摘要翻译： 本发明涉及在质谱（MS）中从其原子或分子等值线分离稀有稳定或放射性同位素的方法和装置。 在本发明中，用于除去原子等压线的方法利用高传输装置，用于在RF离子导向器中结合低能量反应（例如离子分子反应或接近谐振电子转移）来减速离子。 在低能量下，加压RF离子导向器中的等离子体被电子转移或负离子与气态靶之间的其它反应选择性地耗尽。 控制能量以防止感兴趣的离子的反应，同时诱导与不期望的等压线干涉的反应。 该技术与加速器质谱（AMS）特别相关，其能够显着降低必需的终端电压。 其效果是可以减少AMS安装的尺寸和成本。
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公开(公告)号：US08008619B2
公开(公告)日：2011-08-30
申请号：US12656701
申请日：2010-02-12
CPC分类号： G01N30/7233 , H01J49/04 , H01J49/067 , H01J49/107
摘要： An interface for mass spectrometers. The interface uses non coaxial sampling pathways of the analyte ion beam prior to entering the entrance of a mass spectrometer for decreasing chemical background, and can be done in such a way as to permit multiple sprayers, increasing sample throughput and sensitivity for LC/MS (liquid chromatography/MS). The interface includes an ion source having an exit from which a beam of analyte ions are emitted, a curtain plate and an aperture in the curtain plate member, an orifice plate having an orifice therein. The orifice plate is being spaced from the curtain plate member defining a flow passageway therebetween, and the aperture in the orifice plate is aligned with a sample entrance to a first vacuum stage of a mass spectrometer maintained substantially lower than atmospheric pressure. The aperture in the curtain plate member is non coaxially aligned with the orifice in the orifice plate and the interface includes a gas flow mechanism for directing a counter flow gas into the flow passageway.
摘要翻译： 质谱仪界面。 在进入质谱仪入口以减少化学背景之前，界面使用分析物离子束的非同轴取样路径，并且可以以允许多个喷雾器，增加LC / MS的样品通量和灵敏度的方式进行 液相色谱/质谱）。 该界面包括离子源，其具有从其分离的离子束射出的出口，帘板和帘板构件中的孔，其中具有孔口的孔板。 孔板与限定其间的流动通道的帘板构件间隔开，并且孔板中的孔与进入维持在基本上低于大气压的质谱仪的第一真空级的样品入口对准。 帘板构件中的孔与孔板中的孔不同轴地对准，并且界面包括用于将逆流气体引导到流动通道中的气流机构。
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公开(公告)号：US20110133079A1
公开(公告)日：2011-06-09
申请号：US12958797
申请日：2010-12-02
申请人： Lisa Cousins , Gholamreza Javahery , Ilia Tomski
发明人： Lisa Cousins , Gholamreza Javahery , Ilia Tomski
CPC分类号： H01J49/063
摘要： An ion guide includes a plurality of rods, arranged about an axis that extends lengthwise from one end to the other of the guide. The rods guide ions in a guide region along and about the axis. A conductive casing surrounds the rods. The casing and the rods are geometrically arranged to produce an axial electric field along the axis. Specifically, the geometry is such that a first constant applied DC voltage (UDC), applied to the rods, and a second constant applied DC voltage (UCASE) applied to the casing, produce a voltage gradient between said casing and said axis that has a different magnitude at different positions along said axis.
摘要翻译： 离子导向器包括多个杆，其围绕从引导件的一端到另一端纵向延伸的轴线布置。 杆沿引导区域沿轴线引导离子。 导电套管围绕着棒。 壳体和杆几何地布置成沿轴线产生轴向电场。 具体地，几何形状使得施加到杆的第一恒定施加的DC电压（UDC）和施加到壳体的第二恒定施加的DC电压（UCASE）在所述壳体和所述轴线之间产生电压梯度，所述电压梯度具有 沿着所述轴的不同位置处的不同大小。
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公开(公告)号：US20080265154A1
公开(公告)日：2008-10-30
申请号：US11742203
申请日：2007-04-30
申请人： Lisa Cousins , Gholamreza Javahery , Ilia Tomski
发明人： Lisa Cousins , Gholamreza Javahery , Ilia Tomski
IPC分类号： H01J49/04
CPC分类号： H01J49/063
摘要： An ion guide includes a plurality of rods, arranged about an axis that extends lengthwise from one end to the other of the guide. The rods guide ions in a guide region along and about the axis. A conductive casing surrounds the rods. The casing and the rods are geometrically arranged to produce an axial electric field along the axis. Specifically, the geometry is such that a first constant applied DC voltage (UDC), applied to the rods, and a second constant applied DC voltage (UCASE) applied to the casing, produce a voltage gradient between said casing and said axis that has a different magnitude at different positions along said axis.
摘要翻译： 离子导向器包括多个杆，其围绕从引导件的一端到另一端纵向延伸的轴线布置。 杆沿引导区域沿轴线引导离子。 导电套管围绕着棒。 壳体和杆几何地布置成沿轴线产生轴向电场。 特别地，几何形状使得施加到杆上的第一恒定施加的DC电压（U SUB DC）和施加到杆的第二恒定施加的DC电压（U> CASE ）施加到 所述壳体在所述壳体和所述轴线之间产生在所述轴线的不同位置处具有不同大小的电压梯度。
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公开(公告)号：US20070164213A1
公开(公告)日：2007-07-19
申请号：US11331153
申请日：2006-01-13
IPC分类号： H01J49/42
CPC分类号： H01J49/066
摘要： An ion guide includes multiple stages. An electric field within each stage guides ions along a guide axis. Within each stage, amplitude and frequency, and resolving potential of the electric field may be independently varied. The geometry of the rods maintains a similarly shaped field from stage to stage, allowing efficient guidance of the ions along the axis. In particular, each rod segment of the ith of stage has a cross sectional radius ri, and a central axis located a distance Ri+ri from the guide axis. The ratio ri/Ri and is substantially constant along the guide axis, thereby preserving the shape of the field.
摘要翻译： 离子导向器包括多个阶段。 每个阶段内的电场沿引导轴引导离子。 在每个阶段内，可以独立地改变振幅和频率以及电场的分辨能力。 杆的几何形状保持了从阶段到阶段的类似形状的场，允许离子沿轴线的有效引导。 特别地，台阶i的每个棒段具有横截面半径r 1，并且中心轴位于距离R i + r 从引导轴。 比率r＆lt; i＆gt; / i＆lt; i＆gt;并且沿着引导轴线基本上是恒定的，从而保持场的形状。
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公开(公告)号：US07868289B2
公开(公告)日：2011-01-11
申请号：US11742203
申请日：2007-04-30
申请人： Lisa Cousins , Gholamreza Javahery , Ilia Tomski
发明人： Lisa Cousins , Gholamreza Javahery , Ilia Tomski
IPC分类号： H01J49/42
CPC分类号： H01J49/063
摘要： An ion guide includes a plurality of rods, arranged about an axis that extends lengthwise from one end to the other of the guide. The rods guide ions in a guide region along and about the axis. A conductive casing surrounds the rods. The casing and the rods are geometrically arranged to produce an axial electric field along the axis. Specifically, the geometry is such that a first constant applied DC voltage (UDC), applied to the rods, and a second constant applied DC voltage (UCASE) applied to the casing, produce a voltage gradient between said casing and said axis that has a different magnitude at different positions along said axis.
摘要翻译： 离子导向器包括多个杆，其围绕从引导件的一端到另一端纵向延伸的轴线布置。 杆沿引导区域沿轴线引导离子。 导电套管围绕着棒。 壳体和杆几何地布置成沿轴线产生轴向电场。 具体地，几何形状使得施加到杆的第一恒定施加的DC电压（UDC）和施加到壳体的第二恒定施加的DC电压（UCASE）在所述壳体和所述轴线之间产生电压梯度，所述电压梯度具有 沿着所述轴的不同位置处的不同大小。
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公开(公告)号：US20100148059A1
公开(公告)日：2010-06-17
申请号：US12656701
申请日：2010-02-12
IPC分类号： H01J49/26
CPC分类号： G01N30/7233 , H01J49/04 , H01J49/067 , H01J49/107
摘要： An interface for mass spectrometers. The interface uses non coaxial sampling pathways of the analyte ion beam prior to entering the entrance of a mass spectrometer for decreasing chemical background, and can be done in such a way as to permit multiple sprayers, increasing sample throughput and sensitivity for LC/MS (liquid chromatography/MS). The interface includes an ion source having an exit from which a beam of analyte ions are emitted, a curtain plate and an aperture in the curtain plate member, an orifice plate having an orifice therein. The orifice plate is being spaced from the curtain plate member defining a flow passageway therebetween, and the aperture in the orifice plate is aligned with a sample entrance to a first vacuum stage of a mass spectrometer maintained substantially lower than atmospheric pressure. The aperture in the curtain plate member is non coaxially aligned with the orifice in the orifice plate and the interface includes a gas flow mechanism for directing a counter flow gas into the flow passageway.
摘要翻译： 质谱仪界面。 在进入质谱仪入口以减少化学背景之前，界面使用分析物离子束的非同轴取样路径，并且可以以允许多个喷雾器，增加LC / MS的样品通量和灵敏度的方式进行 液相色谱/质谱）。 该界面包括离子源，其具有从其分离的离子束射出的出口，帘板和帘板构件中的孔，其中具有孔口的孔板。 孔板与限定其间的流动通道的帘板构件间隔开，并且孔板中的孔与进入维持在基本上低于大气压的质谱仪的第一真空级的样品入口对准。 帘板构件中的孔与孔板中的孔不同轴地对准，并且界面包括用于将逆流气体引导到流动通道中的气流机构。
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