公开(公告)号：US08288109B2

公开(公告)日：2012-10-16

申请号：US11658021

申请日：2005-07-20

申请人： Lone Kjaer Rasmussen ,  Torben Frandsen ,  Soren Kofoed Rasmussen ,  Peter Sejer Andersen

发明人： Lone Kjaer Rasmussen ,  Torben Frandsen ,  Soren Kofoed Rasmussen ,  Peter Sejer Andersen

IPC分类号： C40B40/10 ,  C40B50/06

CPC分类号： C12Q1/6876 ,  G01N30/96 ,  G01N33/6803

摘要： The present invention provides a structural characterization platform that can be used to assess the stability of a polyclonal cell line during production, as well as batch-to-batch consistency of the final polyclonal products. The structural characterization platform is based on genetic analyses as well as protein characterization techniques that alone or in combination provide the necessary information to characterize the polyclonal cell line and final products. The collection of different homologous proteins to be analyzed with the platform techniques if for example a recombinant polyclonal antibody or a mixture of monoclonal antibodies.

摘要翻译： 本发明提供了可用于评估生产过程中多克隆细胞系的稳定性以及最终多克隆产物的批次间一致性的结构表征平台。 结构表征平台基于遗传分析以及蛋白质表征技术，其单独或组合提供了表征多克隆细胞系和最终产物的必要信息。 使用平台技术收集不同的同源蛋白质，例如重组多克隆抗体或单克隆抗体的混合物。

公开(公告)号：US20080131882A1

公开(公告)日：2008-06-05

申请号：US11658021

申请日：2005-07-20

申请人： Lone Kjaer Rasmussen ,  Torben Frandsen ,  Soren Kofoed Rasmussen ,  Peter Sejer Andersen

发明人： Lone Kjaer Rasmussen ,  Torben Frandsen ,  Soren Kofoed Rasmussen ,  Peter Sejer Andersen

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07K16/00

CPC分类号： C12Q1/6876 ,  G01N30/96 ,  G01N33/6803

摘要： The present invention provides a structural characterization platform that can be used to assess the stability of a polyclonal cell line during production, as well as batch-to-batch consistency of the final polyclonal products. The structural characterization platform is based on genetic analyses as well as protein characterization techniques that alone or in combination provide the necessary information to characterize the polyclonal cell line and final products. The collection of different homologous proteins to be analyzed with the platform techniques if for example a recombinant polyclonal antibody or a mixture of monoclonal antibodies.

摘要翻译： 本发明提供了可用于评估生产过程中多克隆细胞系的稳定性以及最终多克隆产物的批次间一致性的结构表征平台。 结构表征平台基于遗传分析以及蛋白质表征技术，其单独或组合提供了表征多克隆细胞系和最终产物的必要信息。 使用平台技术收集不同的同源蛋白质，例如重组多克隆抗体或单克隆抗体的混合物。

公开(公告)号：US20130004500A1

公开(公告)日：2013-01-03

申请号：US13579847

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

IPC分类号： A61K39/40 ,  A61P31/04 ,  C07K16/12 ,  C12N15/13 ,  C12N5/16

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype A and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了与血清型A的铜绿假单胞菌菌株的LPS结合并且具有优异的体外和体内抗菌活性的抗体。

公开(公告)号：US20130045207A1

公开(公告)日：2013-02-21

申请号：US13579748

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

IPC分类号： C07K16/12 ,  A61P31/04 ,  A61K39/40 ,  C12N5/12 ,  C12N15/13

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype G and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型G的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。

公开(公告)号：US20130022603A1

公开(公告)日：2013-01-24

申请号：US13579764

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

IPC分类号： A61K39/40 ,  A61P31/04 ,  C12N5/16 ,  C07K16/12 ,  C12N15/13

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype I and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型I的铜绿假单胞菌菌株的LPS并在体外和体内具有优异抗菌活性的抗体。

公开(公告)号：US20130004499A1

公开(公告)日：2013-01-03

申请号：US13579757

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Jun Saito ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Yasuyo Hagiwara

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Jun Saito ,  Hiroshi Nagaso ,  Masashi Kumagai ,  Yasuyo Hagiwara

IPC分类号： C07K16/12 ,  C12N5/12 ,  A61P17/02 ,  A61P31/04 ,  A61P11/00 ,  C12N15/13 ,  A61K39/395

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype E and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型E的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。

公开(公告)号：US20130022604A1

公开(公告)日：2013-01-24

申请号：US13579826

申请日：2011-02-18

申请人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

发明人： Jiro Tanaka ,  Peter Sejer Andersen ,  Takafumi Okutomi ,  Tsuneyoshi Inaba ,  Keiko Otsuka ,  Hirotomo Akabane ,  Yukari Hoshina ,  Hiroshi Nagaso ,  Masashi Kumagai

IPC分类号： A61K39/40 ,  A61P31/04 ,  C12N5/16 ,  C07K16/12 ,  C12N15/13

CPC分类号： C07K16/1214 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/21

摘要： Provided is a novel antibody having an excellent antibacterial activity against P. aeruginosa. By using plasmablasts obtained from cystic fibrosis patients with chronic P. aeruginosa pulmonary infection as starting materials, antibodies which bind to LPS of a P. aeruginosa strain of serotype B and which have excellent antibacterial activities in vitro and in vivo were successfully obtained.

摘要翻译： 提供对铜绿假单胞菌具有优异抗菌活性的新型抗体。 通过使用从慢性铜绿假单胞菌肺感染的囊性纤维化患者获得的浆细胞作为起始材料，成功获得了结合血清型B的铜绿假单胞菌菌株的体外和体内具有优异抗菌活性的LPS的抗体。