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公开(公告)号：US10010606B2
公开(公告)日：2018-07-03
申请号：US15025733
申请日：2014-09-30
IPC分类号： A61K39/21 , A61K39/12 , C07K14/005
CPC分类号： A61K39/21 , A61K39/12 , C07K14/005 , C12N2740/16034
摘要： Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.
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公开(公告)号：US09855329B2
公开(公告)日：2018-01-02
申请号：US15025806
申请日：2014-09-30
IPC分类号： A61K39/12 , A61K39/21 , C07K14/16 , C07K16/10 , A61K45/06 , C07K14/005 , C12N7/00 , A61K39/00
CPC分类号： A61K39/21 , A61K39/12 , A61K45/06 , A61K2039/57 , C07K14/005 , C07K14/162 , C07K16/1063 , C07K2317/34 , C07K2317/76 , C12N7/00 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171
摘要： Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.
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公开(公告)号：US20190151440A1
公开(公告)日：2019-05-23
申请号：US16023871
申请日：2018-06-29
IPC分类号： A61K39/21 , A61K39/12 , C07K14/005
摘要： Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.
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公开(公告)号：US11235055B2
公开(公告)日：2022-02-01
申请号：US16023871
申请日：2018-06-29
IPC分类号： A61K39/21 , A61K39/12 , C07K14/16 , C07K14/005
摘要： Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.
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