专利检索 ap:("Los Alamos National Security, LLC" OR "Oxford University Innovation Limited") AND inv:"Bette T. M. Korber" 第 1 页

1.

发明申请
MOSAIC CONSERVED REGION HIV IMMUNOGENIC POLYPEPTIDES 审中-公开

公开(公告)号：US20190151440A1

公开(公告)日：2019-05-23

申请号：US16023871

申请日：2018-06-29

申请人： Los Alamos National Security, LLC , Oxford University Innovation Limited

发明人： Bette T. M. Korber , Tomas Hanke , Andrew McMichael

IPC分类号： A61K39/21 , A61K39/12 , C07K14/005

摘要： Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.

2.

发明授权
Nucleic acids encoding mosaic conserved region HIV immunogenic polypeptides 有权

公开(公告)号：US11235055B2

公开(公告)日：2022-02-01

申请号：US16023871

申请日：2018-06-29

申请人： Los Alamos National Security, LLC , Oxford University Innovation Limited

发明人： Bette T. M. Korber , Tomas Hanke , Andrew McMichael

IPC分类号： A61K39/21 , A61K39/12 , C07K14/16 , C07K14/005

摘要： Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.

3.

发明授权
Mosaic HIV envelope immunogenic polypeptides 有权

公开(公告)号：US09855329B2

公开(公告)日：2018-01-02

申请号：US15025806

申请日：2014-09-30

申请人： Los Alamos National Security, LLC , Duke University , Dana-Farber Cancer Institute, Inc.

发明人： Bette T. M. Korber , S. Gnanakaran , Simon Perkins , Joseph Sodroski , Barton Haynes

IPC分类号： A61K39/12 , A61K39/21 , C07K14/16 , C07K16/10 , A61K45/06 , C07K14/005 , C12N7/00 , A61K39/00

CPC分类号： A61K39/21 , A61K39/12 , A61K45/06 , A61K2039/57 , C07K14/005 , C07K14/162 , C07K16/1063 , C07K2317/34 , C07K2317/76 , C12N7/00 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171

摘要： Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.

4.

发明授权
Mosaic conserved region HIV immunogenic polypeptides 有权

公开(公告)号：US10010606B2

公开(公告)日：2018-07-03

申请号：US15025733

申请日：2014-09-30

申请人： Los Alamos National Security, LLC , Isis Innovation Limited

发明人： Bette T. M. Korber , Tomas Hanke , Andrew McMichael

IPC分类号： A61K39/21 , A61K39/12 , C07K14/005

CPC分类号： A61K39/21 , A61K39/12 , C07K14/005 , C12N2740/16034

摘要： Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.