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    Pyrimidinone Derivatives and Their Use as a Drug
    2.
    发明申请
    Pyrimidinone Derivatives and Their Use as a Drug 审中-公开
    嘧啶酮衍生物及其作为药物的用途

    公开(公告)号：US20090325933A1

    公开(公告)日：2009-12-31

    申请号：US12375212

    申请日：2007-07-13

    申请人： Lydie Poitout ,  Carole Sackur ,  Eric Ferrandis

    发明人： Lydie Poitout ,  Carole Sackur ,  Eric Ferrandis

    IPC分类号： A61K31/519 ,  C07D495/04 ,  A61K31/5377 ,  A61K31/55 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00 ,  A61P19/00 ,  A61P25/00

    CPC分类号： C07D495/04

    摘要： The present application relates to new pyrimidinone derivatives. These products have a good affinity for certain sub-types of cannabinoid receptors, especially the CB2 receptors. They are particularly attractive for treating pathological conditions and diseases in which one or more cannabinoid receptors are involved. The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a drug.

    摘要翻译： 本申请涉及新的嘧啶酮衍生物。 这些产品对某些亚型大麻素受体，特别是CB2受体具有良好的亲和力。 它们对于治疗涉及一种或多种大麻素受体的病理状况和疾病特别有吸引力。 本发明还涉及含有所述产品的药物组合物及其制备药物的用途。

    Process for preparing recombinant heterocarpine
    7.
    发明申请
    Process for preparing recombinant heterocarpine 审中-公开
    制备重组异香草的方法

    公开(公告)号：US20100279949A1

    公开(公告)日：2010-11-04

    申请号：US12315581

    申请日：2008-12-04

    申请人： Eric Ferrandis

    发明人： Eric Ferrandis

    IPC分类号： A61K38/16 ,  C07K14/00 ,  A61P35/00

    CPC分类号： C07K14/415 ,  A61K38/00

    摘要： A process for preparing recombinant heterocarpine with the complete sequence of heterocarpine (SEQ. ID. NO. 10), expression vectors comprising a polynucleotide encoding for heterocarpine, host cells transformed or transfected by said expression vectors as well as a process for obtaining heterocarpine by means of said transformed or transfected host cells are described wherein the recombinant heterocarpine obtained is used to treat cancer.

    摘要翻译： 用于制备具有完整序列的异香草碱（SEQ ID NO：10）的重组异香草碱的方法，包含编码异香草碱的多核苷酸的表达载体，由所述表达载体转化或转染的宿主细胞以及通过手段获得异草甘膦的方法 描述了所述转化或转染的宿主细胞，其中所获得的重组异香草碱用于治疗癌症。

    Heterocarpine, a plant-derived protein with anti-cancer properties
    9.
    发明申请
    Heterocarpine, a plant-derived protein with anti-cancer properties 失效
    异草甘膦，具有抗癌特性的植物衍生蛋白质

    公开(公告)号：US20080167221A9

    公开(公告)日：2008-07-10

    申请号：US10522457

    申请日：2003-08-25

    申请人： Eric Ferrandis ,  Beng Poon ,  Christine Sohier ,  Christophe Thurieau

    发明人： Eric Ferrandis ,  Beng Poon ,  Christine Sohier ,  Christophe Thurieau

    IPC分类号： A61K38/16 ,  C07K14/415

    CPC分类号： A61K36/75

    摘要： The invention relates to a plant-derived protein with anti-cancer properties which binds the human growth hormone-releasing hormone (hGHRH). Said protein, which is obtained from the Pilocarpus Heterophyllus plant, is particularly adapted for preparing a medicament that is intended for the treatment of cancers for which growth is dependant on the GHRH growth factor and, in particular, for preparing a medicament that is intended for the treatment of cancers including small cell lung cancer and breast cancer.

    摘要翻译： 本发明涉及结合人生长激素释放激素（hGHRH）的具有抗癌特性的植物来源的蛋白质。 所述蛋白质，其从所述皮毛菌属植物获得，特别适用于制备用于治疗生长依赖于GHRH生长因子的癌症的药物，特别是用于制备用于 治疗癌症包括小细胞肺癌和乳腺癌。