公开(公告)号：US20070043380A1

公开(公告)日：2007-02-22

申请号：US11197783

申请日：2005-08-05

申请人： Mark Ortiz ,  William Kraimer ,  David Griffith ,  Lynetta Freeman

发明人： Mark Ortiz ,  William Kraimer ,  David Griffith ,  Lynetta Freeman

IPC分类号： A61F11/00

CPC分类号： A61B1/2736 ,  A61B17/3417 ,  A61B17/3421 ,  A61B17/3474 ,  A61B17/3478 ,  A61B17/3498 ,  A61B2017/00243 ,  A61B2017/00278 ,  A61B2017/00867 ,  A61B2017/3425 ,  A61B2017/3445 ,  A61B2017/3484 ,  A61B2017/3486 ,  A61B2017/3488

摘要： A transgastric instrument provides a sterile and repeatable pathway to and through a gastric wall for the purpose of facilitating endoscopic transgastric procedures. The instrument includes at least one guide tube having a proximal end and a distal end, the distal end being shaped and dimensioned for positioning adjacent a desired location along the gastric wall. The instrument also includes a fixation mechanism at the distal end of the guide tube for selectively securing the distal end of the guide tube at a desired location along the gastric wall. An otomy creation device circumferentially smaller than the guide tube extends through the guide tube, the otomy creation device including a distal end shaped and dimensioned for cutting and dilating the gastric wall.

摘要翻译： 经胃仪器为胃壁提供无菌且可重复的途径，以便于内镜经胃手术。 所述器械包括至少一个具有近端和远端的导管，所述远端的形状和尺寸用于沿着胃壁邻近所需位置定位。 仪器还包括在引导管的远端处的固定机构，用于将引导管的远端选择性地固定在沿着胃壁的期望位置。 造型装置周向地小于引导管延伸穿过引导管，所述造口装置包括形状和尺寸用于切割和扩张胃壁的远端。

公开(公告)号：US20070038238A1

公开(公告)日：2007-02-15

申请号：US11161265

申请日：2005-07-28

申请人： Lynetta Freeman ,  Mark Ortiz

发明人： Lynetta Freeman ,  Mark Ortiz

IPC分类号： A61M29/00

CPC分类号： A61J15/0015 ,  A61B2017/00398 ,  A61B2017/00871 ,  A61J15/0038 ,  A61J15/0061 ,  A61M2025/0058

摘要： Embodiments of the present invention generally provide methods and devices for providing percutaneous access to a tissue. In one exemplary embodiment, a PEG tube is provided having an elongate member with a proximal end adapted to be positioned adjacent to a tissue surface, a distal end adapted to be inserted through tissue, and an inner lumen extending between the proximal and distal ends and adapted to allow fluid flow there through. The PEG tube can also include an electrically actuatable element coupled to the distal end of the elongate member and configured to change dimensionally upon delivery of electrical energy thereto. In use, the electrically actuatable element can be adapted to expand to engage tissue and secure the distal end of the PEG tube to the tissue.

摘要翻译： 本发明的实施方案通常提供用于提供对组织的经皮进入的方法和装置。 在一个示例性实施例中，提供了PEG管，其具有细长构件，其具有适于邻近组织表面定位的近端，适于插入穿过组织的远端和在近端和远端之间延伸的内腔，以及 适于允许流体在那里流过。 PEG管还可以包括耦合到细长构件的远端的可电致动元件，并且被配置为在将电能传递到其上时改变尺寸。 在使用中，可电致动元件可适于膨胀以接合组织并将PEG管的远端固定到组织。

公开(公告)号：US20070027466A1

公开(公告)日：2007-02-01

申请号：US11161264

申请日：2005-07-28

申请人： Mark Ortiz ,  Lynetta Freeman

发明人： Mark Ortiz ,  Lynetta Freeman

IPC分类号： A61M29/00

CPC分类号： A61B17/12045 ,  A61B17/11 ,  A61B17/1114 ,  A61B2017/00871 ,  A61B2017/081 ,  A61B2017/1139 ,  A61B2017/12127 ,  A61M2025/0058

摘要： Methods and devices for positioning tissues in apposition to each other are provided. In one exemplary embodiment, a tissue apposition device is provided having a flexible shaft with at least one expandable element coupled thereto, and a positioning element adapted to axially move the expandable element relative to the elongate shaft to move tissue engaged by the expandable element. In an exemplary embodiment, at least one of the positioning element and the expandable element(s) is formed from an electroactive polymer.

摘要翻译： 提供了将组织定位在一起的方法和装置。 在一个示例性实施例中，提供了具有柔性轴的组织安置装置，所述柔性轴具有与其相连的至少一个可扩张元件，以及定位元件，其适于相对于所述细长轴轴向移动所述可扩张元件以移动由所述可扩张元件接合的组织。 在示例性实施例中，定位元件和可膨胀元件中的至少一个由电活性聚合物形成。

公开(公告)号：US20060253134A1

公开(公告)日：2006-11-09

申请号：US11120826

申请日：2005-05-03

申请人： Mark Ortiz ,  Lynetta Freeman

发明人： Mark Ortiz ,  Lynetta Freeman

IPC分类号： A61B17/08

CPC分类号： A61B17/11 ,  A61B17/1114 ,  A61B2017/0408

摘要： A surgical instrument comprises a handle and an elongate shaft, and is operable to remove an anastomotic ring device from a patient. The elongate shaft houses a plurality of ring engaging fingers. Each of the fingers comprises sheath housing a wire having a hook at its distal end. Each hook may be advanced beyond the distal end of a respective sheath to engage petals on an anastomotic ring device. Subsequent proximal retraction of the hooks secures the anastomotic ring device to the ring engaging fingers. With the anastomotic ring device secured to the ring engaging fingers, the fingers may be drawn together to collapse the anastomotic ring device from an actuated, hollow rivet-shaped configuration to an unactuated, cylindrically-shaped configuration. The surgical instrument may then contain the collapsed anastomotic ring device, thereby facilitating removal of the anastomotic ring device from the patient.

摘要翻译： 手术器械包括手柄和细长轴，并且可操作以从患者移除吻合口环装置。 细长轴容纳多个环接合指状物。 每个指状物包括护套，其在其远端具有钩。 每个钩可以超过相应护套的远端，以接合吻合口环装置上的瓣。 钩的随后的近端缩回将吻合环装置固定到环接合的手指。 使用固定在环上的吻合环装置接合指状物，手指可以被牵拉在一起，以将吻合环装置从致动的中空铆钉形构型压缩成未致动的圆柱形构型。 然后，手术器械可以包含塌陷的吻合环装置，从而便于从患者移除吻合环装置。

公开(公告)号：US07758589B2

公开(公告)日：2010-07-20

申请号：US11120826

申请日：2005-05-03

申请人： Mark S. Ortiz ,  Lynetta Freeman

发明人： Mark S. Ortiz ,  Lynetta Freeman

IPC分类号： A61B17/10

CPC分类号： A61B17/11 ,  A61B17/1114 ,  A61B2017/0408

摘要： A surgical instrument comprises a handle and an elongate shaft, and is operable to remove an anastomotic ring device from a patient. The elongate shaft houses a plurality of ring engaging fingers. Each of the fingers comprises sheath housing a wire having a hook at its distal end. Each hook may be advanced beyond the distal end of a respective sheath to engage petals on an anastomotic ring device. Subsequent proximal retraction of the hooks secures the anastomotic ring device to the ring engaging fingers. With the anastomotic ring device secured to the ring engaging fingers, the fingers may be drawn together to collapse the anastomotic ring device from an actuated, hollow rivet-shaped configuration to an unactuated, cylindrically-shaped configuration. The surgical instrument may then contain the collapsed anastomotic ring device, thereby facilitating removal of the anastomotic ring device from the patient.

摘要翻译： 手术器械包括手柄和细长轴，并且可操作以从患者移除吻合口环装置。 细长轴容纳多个环接合指状物。 每个指状物包括护套，其在其远端具有钩。 每个钩可以超过相应护套的远端，以接合吻合口环装置上的瓣。 钩的随后的近端缩回将吻合环装置固定到环接合的手指。 使用固定在环上的吻合环装置接合指状物，手指可以被牵拉在一起，以将吻合环装置从致动的中空铆钉形构型压缩成未致动的圆柱形构型。 然后，外科器械可以包含塌陷的吻合环装置，从而便于从患者移除吻合环装置。

公开(公告)号：US07749197B2

公开(公告)日：2010-07-06

申请号：US11161265

申请日：2005-07-28

申请人： Lynetta Freeman ,  Mark S. Ortiz

发明人： Lynetta Freeman ,  Mark S. Ortiz

IPC分类号： A61M5/178

CPC分类号： A61J15/0015 ,  A61B2017/00398 ,  A61B2017/00871 ,  A61J15/0038 ,  A61J15/0061 ,  A61M2025/0058

摘要： Embodiments of the present invention generally provide methods and devices for providing percutaneous access to a tissue. In one exemplary embodiment, a PEG tube is provided having an elongate member with a proximal end adapted to be positioned adjacent to a tissue surface, a distal end adapted to be inserted through tissue, and an inner lumen extending between the proximal and distal ends and adapted to allow fluid flow there through. The PEG tube can also include an electrically actuatable element coupled to the distal end of the elongate member and configured to change dimensionally upon delivery of electrical energy thereto. In use, the electrically actuatable element can be adapted to expand to engage tissue and secure the distal end of the PEG tube to the tissue.

摘要翻译： 本发明的实施方案通常提供用于提供对组织的经皮进入的方法和装置。 在一个示例性实施例中，提供了PEG管，其具有细长构件，其具有适于邻近组织表面定位的近端，适于插入穿过组织的远端和在近端和远端之间延伸的内腔，以及 适于允许流体在那里流过。 PEG管还可以包括耦合到细长构件的远端的可电致动元件，并且被配置为在将电能传递到其上时改变尺寸。 在使用中，可电致动元件可适于膨胀以接合组织并将PEG管的远端固定到组织。

公开(公告)号：US20050142161A1

公开(公告)日：2005-06-30

申请号：US10748894

申请日：2003-12-30

申请人： Lynetta Freeman ,  Susan Roweton ,  Ben Walthall ,  Kien Nguyen

发明人： Lynetta Freeman ,  Susan Roweton ,  Ben Walthall ,  Kien Nguyen

IPC分类号： A61L27/00 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61K45/00 ,  A61K31/737

CPC分类号： A61L27/58 ,  A61L27/48 ,  A61L27/56 ,  C08L5/00 ,  C08L89/06

摘要： The present invention includes methods and materials for soft tissue implant formed from biologically-compatible polymeric matrixes. The matrixes may have pores sized for in-growth of soft tissue. The material may be utilized with collagen or other matrix materials. This material may be used in a method of reforming soft tissues by implanting the material within soft body tissues to modify soft tissue defects such as wrinkles or biopsy tissue defects and to reshape soft tissue.

摘要翻译： 本发明包括由生物相容的聚合物基质形成的软组织植入物的方法和材料。 基质可以具有用于软组织生长的孔。 该材料可以与胶原蛋白或其他基质材料一起使用。 该材料可用于通过将材料植入软体组织中来改变软组织以改善软组织缺陷如皱纹或活检组织缺陷并重塑软组织的方法。

公开(公告)号：US20050131386A1

公开(公告)日：2005-06-16

申请号：US10736421

申请日：2003-12-15

申请人： Lynetta Freeman ,  Mark DiFrancesco

发明人： Lynetta Freeman ,  Mark DiFrancesco

IPC分类号： A61M5/32 ,  A61K9/00 ,  A61K9/70 ,  A61K35/12 ,  A61L31/14 ,  A61L31/16 ,  A61L31/18 ,  A61M36/04 ,  A61M31/00

CPC分类号： A61L31/148 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/00

摘要： A minimally invasive method of placing a delivery device substantially adjacent to vascular tissue and a device for use with such a method are disclosed. The delivery device may be a flexible biological construct with a flexible tethering means. The delivery device may be percutaneously inserted near vascular tissue such as, for example, peritoneal tissue. When the delivery device has been inserted, the tether may be used to pull the delivery device toward the vascular tissue and secure the device thereto. Contact between the front surface of the delivery device and the vascular tissue may be maintained by making and keeping the tether substantially taut. The delivery device may serve accomplish sustained delivery of active agents.

摘要翻译： 公开了一种将输送装置放置在基本上邻近于血管组织的微创方法和用于这种方法的装置。 递送装置可以是具有柔性束缚装置的柔性生物构建体。 递送装置可以经皮插入血管组织附近，例如腹膜组织。 当输送装置被插入时，系绳可以用于将输送装置拉向血管组织并将装置固定到其上。 输送装置的前表面和血管组织之间的接触可以通过使系统基本拉紧并保持。 递送装置可以实现活性剂的持续递送。

公开(公告)号：US20050038415A1

公开(公告)日：2005-02-17

申请号：US10890304

申请日：2004-07-12

申请人： William Rohr ,  Lynetta Freeman ,  Jean Beaupre ,  Robert McKenna ,  Alison Warren ,  Thomas Sox

发明人： William Rohr ,  Lynetta Freeman ,  Jean Beaupre ,  Robert McKenna ,  Alison Warren ,  Thomas Sox

IPC分类号： A61M31/00 ,  A23L1/29 ,  A23L1/305 ,  A61F5/00 ,  A61K9/22 ,  A61K45/06 ,  A61L31/16 ,  A61M5/142 ,  A61M37/00 ,  A61P3/04

CPC分类号： A61M5/14276 ,  A23L33/175 ,  A23L33/30 ,  A61F5/0003 ,  A61L31/16 ,  A61L2300/40 ,  A61M5/14244 ,  A61M2210/1042

摘要： The present invention includes methods and materials for manipulating the sense of satiety developed from the gastrointestinal transit of a substance in a mammal, whether the substance be a food or drug compound. The method involves administering a therapeutically effective amount, by a direct delivery route, of a pharmaceutically acceptable formulation comprising nutrients and pharmacological agents to the mammal's gastrointestinal tract. The present system is designed to maximize satiety feedback from normal intestinal sensors by small amounts of nutrients or nutrient derivatives, in essence, to “fool” body sensors that are not usually in contact with nutrients unless very large amounts are ingested.

摘要翻译： 本发明包括用于操纵从哺乳动物中的物质的胃肠道运输产生的饱腹感，不管该物质是食物还是药物化合物的方法和材料。 该方法包括通过直接递送途径向哺乳动物的胃肠道施用包含营养物和药理学试剂的药学上可接受的制剂的治疗有效量。 本系统旨在通过少量营养素或营养素衍生物来最大化来自正常肠道传感器的饱腹感反馈，实质上是通常与营养物质不接触的“愚人”身体传感器，除非摄入非常大的量。