公开(公告)号：US5385578A

公开(公告)日：1995-01-31

申请号：US18832

申请日：1993-02-18

申请人： M. Elizabeth Bush ,  Drew Hoffmann ,  M. Dean Matthews ,  Pedro G. Medrano

发明人： M. Elizabeth Bush ,  Drew Hoffmann ,  M. Dean Matthews ,  Pedro G. Medrano

IPC分类号： A61N1/05 ,  A61N1/00

CPC分类号： A61N1/056

摘要： An improved endocardial lead for electrocardial stimulation includes a sleeve that has a face surface. A conductor fitted into the sleeve, such that a distal end of the conductor passes completely through the sleeve, past the face surface, is electrically and mechanically connected to the face surface of the sleeve by mechanical means, e.g. crimping, and/or through the application of heat, e.g. welding or brazing. An electrode is integrated with the sleeve along an outer sleeve surface. A highly reliable, redundant joint is thereby provided between the sleeve and the conductor that secures the conductor against movement and therefore minimizes stress placed on the conductor, preventing fatigue to the conductor at the joint. A sleeve made in accordance with the present invention provides the narrowest and shortest possible conductor/electrode joint to minimize impact on the patient, while at the same time providing an endocardial lead that has excellent electrical properties, mechanical stability, and ease of manufacture, and that may be made from any desired material to thereby take advantage of new and/or improved materials.

摘要翻译： 用于心电图刺激的改进的心内膜导联包括具有面部表面的套筒。 导体装配到套筒中，使得导体的远端完全穿过套筒穿过面表面，通过机械装置电气地和机械地连接到套筒的表面。 卷曲和/或通过施加热，例如， 焊接或钎焊。 电极与套筒沿着外套筒表面一体化。 因此，在套筒和导体之间提供了高度可靠的冗余接头，其固定住导体免受运动，从而使放置在导体上的应力最小化，防止接头处的导体疲劳。 根据本发明制造的套筒提供最窄和最短的导体/电极接头，以最小化对患者的影响，同时提供具有优异电气性能，机械稳定性和易于制造的心内膜导联，以及 其可以由任何期望的材料制成，从而利用新的和/或改进的材料。

公开(公告)号：US5755762A

公开(公告)日：1998-05-26

申请号：US663850

申请日：1996-06-14

申请人： M. Elizabeth Bush

发明人： M. Elizabeth Bush

IPC分类号： A61N1/05 ,  A61N5/04

CPC分类号： A61N1/056 ,  A61N1/057

摘要： A continuous sheath of open-celled porous plastic, preferably ePTFE, is used on the outside of an implantable lead, extending along the lead body and the electrodes, in such a way that the lead is isodiametric along its length, and is very strong in tension as is required for lead removal. Because the plastic is open-celled, when the pores are filled with saline, the lead can deliver defibrillation energy through the pores in the plastic. Pore size is chosen to discourage tissue ingrowth while allowing for defibrillation energy delivery through it.

摘要翻译： 开放式多孔塑料的连续护套，优选为ePTFE，用于沿着引线主体和电极延伸的可植入引线的外侧，使得引线沿着其长度是等直径的，并且非常强 导线去除所需的张力。 因为塑料是开孔的，当细孔充满盐水时，铅可以通过塑料中的孔传递除颤能量。 选择孔径以阻止组织向内生长，同时允许组织向内生长，同时允许组织向内生长，同时允许组织向内生长，同时允许组织向内生长，同时允许组织向

公开(公告)号：US5749901A

公开(公告)日：1998-05-12

申请号：US646409

申请日：1996-05-07

申请人： M. Elizabeth Bush ,  Eric S. Fain

发明人： M. Elizabeth Bush ,  Eric S. Fain

IPC分类号： A61N1/39

CPC分类号： A61N1/3925 ,  A61N1/3987

摘要： A method for defibrillating a patient's heart with an implantable defibrillator having defibrillation synchronized to the fibrillation waveform is disclosed. The defibrillator is used to detect fibrillation in a patient's heart, monitor at least two far-field fibrillation voltages across at least three spaced-apart electrodes while the high voltage capacitors are charging, then deliver a high energy shock during a period of ventricular fibrillation when the absolute values of the peak and trough voltages exceed a threshold based on a desired percentage greater than a running average of the absolute values of the peaks and troughs of the fibrillation voltages monitored during and after capacitor charging. The shock is then delivered synchronous with the next significant cardiac complex. The defibrillator also includes a safety timer so that if the threshold is not reached within a specified safe time limit, the high energy shock will be delivered without further delay.

摘要翻译： 公开了一种使用具有与原纤维波形同步的除颤的可植入除颤器对患者心脏进行除颤的方法。 除颤器用于检测患者心脏中的纤维性颤动，在高压电容器充电的同时监测至少三个间隔开的电极的至少两个远场原纤维电压，然后在心室颤动期间传递高能量冲击， 基于大于电容器充电期间和之后监测的原始电压电压的峰值和谷值的绝对值的运行平均值的期望百分比，峰值和谷值电压的绝对值超过阈值。 然后，冲击与下一个重要的心脏复合体同步传递。 除颤器还包括安全定时器，使得如果在指定的安全时限内未达到阈值，则高能量冲击将不会再延迟。

公开(公告)号：US5709644A

公开(公告)日：1998-01-20

申请号：US663832

申请日：1996-06-14

申请人： M. Elizabeth Bush

发明人： M. Elizabeth Bush

IPC分类号： A61N1/05 ,  A61N5/00

CPC分类号： A61N1/057 ,  A61N2001/0582

摘要： An implantable suture sleeve for use with an implantable lead with a pacemaker/cardioverter/defibrillator lead. Since irradiation from a radioisotope source is capable of inhibiting the growth of hyperproliferating cells as compared with normal cells, a radioisotope material which is incorporated into the lead can be used to decrease the rate of fibrotic growth. The radioisotope may be located inside the suture sleeve, alloyed into or coated onto the metal from which a wire or coil within the suture sleeve is made, or molded into the rubber of the suture sleeve. Beta emitting radioisotopes having a half-life between 1 and 100 days would be best suited as the radioactive material due to their comparatively short range of action within human tissue, and because of their comparatively short half-life.

摘要翻译： 可植入缝合套管，用于与起搏器/心律转复/除纤颤器引线的可植入引线。 由于与正常细胞相比，放射性同位素源的照射能够抑制过度增殖细胞的生长，因此可以使用引入到铅中的放射性同位素材料来降低纤维化生长速度。 放射性同位素可以位于缝合套筒内部，合金化或涂覆在金属上，缝线套筒内的线或线圈从该金属制成，或者模制到缝合套筒的橡胶中。 半衰期为1至100天的β射线放射性同位素由于其在人体组织内的相对较短的作用范围以及半衰期相对较短而最适合作为放射性物质。

公开(公告)号：US07052802B2

公开(公告)日：2006-05-30

申请号：US10272415

申请日：2002-10-15

申请人： Hisashi Tsukamoto ,  Kaname Takeya ,  Hiroyuki Yumoto ,  M. Elizabeth Bush

发明人： Hisashi Tsukamoto ,  Kaname Takeya ,  Hiroyuki Yumoto ,  M. Elizabeth Bush

IPC分类号： H01M4/58

CPC分类号： H01M4/583 ,  H01G11/30 ,  H01G11/32 ,  H01G11/38 ,  H01M4/04 ,  H01M4/0421 ,  H01M4/0423 ,  H01M4/0426 ,  H01M4/0428 ,  H01M4/0483 ,  H01M4/06 ,  H01M4/133 ,  H01M4/1393 ,  H01M4/624 ,  H01M10/0525 ,  H01M2004/028 ,  Y02E60/13 ,  Y10T29/49115

摘要： Disclosed is an improved type of fluorinated carbon (CFx) for use in electrical storage devices such as batteries and capacitors. The CFx is coated with a conductive material such as gold or carbon using vapor deposition. The resulting material exhibits better conductivity with concomitant lower impedance, higher electrical stability, and improved potential throughout the useful life of the device, as compared to uncoated CFx. The improved conductivity reduces the amount of nonactive material (e.g., carbon black) that needs to be added, thus improving the volumetric energy density. In addition, cells made with the subject CFx exhibit more constant voltages and higher overall voltage (2.0 volts with a lithium metal anode) throughout their useful life. Chemical or physical vapor deposition techniques to deposit a variety of metals or carbon may be used to create the improved CFx. The coated CFx may be used in primary or secondary batteries, as well as capacitors and hybrid devices. Methods for making and using the coated CFx are described.

公开(公告)号：US06325796B1

公开(公告)日：2001-12-04

申请号：US09305143

申请日：1999-05-04

申请人： Dany Berube ,  M. Elizabeth Bush

发明人： Dany Berube ,  M. Elizabeth Bush

IPC分类号： A61B1818

CPC分类号： A61B18/18 ,  A61B18/1815

摘要： A microwave ablation assembly and method including a relatively thin, elongated probe (21) having a proximal access end (22) and an opposite distal penetration end (23) adapted to penetrate into bio-tissue (25). The probe (21) defines an insert passage (26) extending therethrough from the access end (22) to the penetration end (23) thereof. An ablation catheter includes a coaxial transmission line (28) with an antenna device (30) coupled to a distal end of the transmission line (28) for generating an electric field sufficiently strong to cause tissue ablation. The coaxial transmission line (28) includes an inner conductor (31) and an outer conductor (32) separated by a dielectric material medium (33). A proximal end of the transmission line (28) is coupled to a microwave energy source. The antenna device (30) and the transmission line (28) each have a transverse cross-sectional dimension adapted for sliding receipt through the insert passage (26) while the elongated probe (21) is positioned in the bio-tissue (25). Such sliding advancement continues until the antenna device (30) is moved to a position beyond the penetration end (23) and further into direct contact with the bio-tissue (25).

摘要翻译： 一种微波消融组件和方法，包括具有近端进入端（22）和适于穿透入生物组织（25）的相对的远端穿透端（23）的相对薄的细长探针（21）。 探针（21）限定了从入口端（22）穿过其延伸到其穿透端（23）的插入通道（26）。 消融导管包括具有耦合到传输线（28）的远端的天线装置（30）的同轴传输线（28），用于产生足够强的电场以引起组织消融。 同轴传输线（28）包括由介电材料介质（33）分开的内部导体（31）和外部导体（32）。 传输线（28）的近端耦合到微波能量源。 天线装置（30）和传输线（28）各自具有适于在细长探针（21）定位在生物组织（25）中时通过插入通道（26）滑动接收的横截面尺寸。 这种滑动推进继续进行，直到天线装置（30）移动到超过穿透端（23）的位置并进一步直接与生物组织（25）接触。

公开(公告)号：US06306132B1

公开(公告)日：2001-10-23

申请号：US09336371

申请日：1999-06-17

申请人： Jack W. Moorman ,  M. Elizabeth Bush

发明人： Jack W. Moorman ,  M. Elizabeth Bush

IPC分类号： A61B1818

CPC分类号： A61B10/0233 ,  A61B10/0275 ,  A61B17/3403 ,  A61B18/1477 ,  A61B18/18 ,  A61B18/1815 ,  A61B90/11 ,  A61B2018/00577 ,  A61B2018/183 ,  A61B2018/1846 ,  A61B2090/3937

摘要： A modular biopsy, ablation and track coagulation needle apparatus is disclosed that allows the biopsy needle to be inserted into the delivery needle and removed when not needed, and that allows an inner ablation needle to be introduced and coaxially engaged with the delivery needle to more effectively biopsy a tumor, ablate it and coagulate the track through ablation while reducing blood loss and track seeding. The ablation needle and biopsy needle are adapted to in situ assembly with the delivery needle. In a preferred embodiment, the ablation needle, when engaged with the delivery needle forms a coaxial connector adapted to electrically couple to an ablating source. Methods for biopsying and ablating tumors using the device and coagulating the track upon device removal are also provided.

摘要翻译： 公开了一种模块化活检，消融和跟踪凝固针装置，其允许活检针插入输送针并且在不需要时被移除，并且允许内消融针被引导并与输送针同轴地接合以更有效地 活检肿瘤，消融并通过消融凝固轨道，同时减少失血和追踪播种。 消融针和活检针适于与输送针原位组装。 在优选实施例中，消融针当与输送针接合时形成适于电耦合到消融源的同轴连接器。 还提供了使用装置活组织切割和消融肿瘤并在装置移除时凝固轨道的方法。

公开(公告)号：US5534022A

公开(公告)日：1996-07-09

申请号：US343293

申请日：1994-11-22

申请人： Drew A. Hoffmann ,  M. Elizabeth Bush

发明人： Drew A. Hoffmann ,  M. Elizabeth Bush

IPC分类号： A61N1/04 ,  A61N1/05

CPC分类号： A61N1/0563

摘要： An implantable defibrillator lead having an improved integrated bipolar defibrillation electrode is disclosed. The defibrillation electrode is electrically connected to the lead conductor at the distal end, and has an increased surface area portion at the distal end, for bipolar sensing with a right ventricular pacing electrode.

摘要翻译： 公开了具有改进的集成双极除颤电极的可植入除颤器引线。 除颤电极在远端电连接到引线导体，并且在远端具有增加的表面积部分，用于与右心室起搏电极进行双极感测。

公开(公告)号：US5456706A

公开(公告)日：1995-10-10

申请号：US177293

申请日：1994-01-04

申请人： Benjamin D. Pless ,  Drew A. Hoffmann ,  Michael B. Sweeney ,  M. Elizabeth Bush ,  Steven M. Mitchell

发明人： Benjamin D. Pless ,  Drew A. Hoffmann ,  Michael B. Sweeney ,  M. Elizabeth Bush ,  Steven M. Mitchell

IPC分类号： A61N1/05 ,  A61N1/39

CPC分类号： A61N1/0563 ,  A61N1/3956

摘要： A lead for use with an implantable cardioverter/defibrillator system is disclosed. In the preferred embodiment, the lead combines a right ventricular endocardial electrode, a superior vena cava electrode and one or more atrial sensing electrodes on a single catheter lead. The distal end of the lead is transvenously implanted, typically through an incision in the cephalic or subclavian vein. The proximal end of the lead is then tunneled below the fascia to the location of the pulse generator. Ventricular sensing and/or pacing electrode(s) may also be included at the distal end of the combined lead to provide ventricular intracardiac electrogram sensing and bradycardia pacing.

摘要翻译： 公开了一种用于植入式心律转复/除颤器系统的引导件。 在优选实施例中，引线将单个导管引线上的右心室心内膜电极，上腔静脉电极和一个或多个心房感测电极组合。 导管的远端经常植入，通常通过头部或锁骨下静脉中的切口。 引线的近端然后在筋膜下方隧道穿过脉冲发生器的位置。 心室感应和/或起搏电极也可以包括在组合导联的远端，以提供心室心电图检测和心动过缓起搏。

公开(公告)号：US08690868B2

公开(公告)日：2014-04-08

申请号：US11640624

申请日：2006-12-18

申请人： Jack W. Moorman ,  M. Elizabeth Bush

发明人： Jack W. Moorman ,  M. Elizabeth Bush

IPC分类号： A61B18/18

CPC分类号： A61B10/0233 ,  A61B10/0275 ,  A61B17/3403 ,  A61B18/1477 ,  A61B18/18 ,  A61B18/1815 ,  A61B90/11 ,  A61B2018/00577 ,  A61B2018/183 ,  A61B2018/1846 ,  A61B2090/3937

摘要： A modular biopsy, ablation and track coagulation needle apparatus is disclosed that allows the biopsy needle to be inserted into the delivery needle and removed when not needed, and that allows an inner ablation needle to be introduced and coaxially engaged with the delivery needle to more effectively biopsy a tumor, ablate it and coagulate the track through ablation while reducing blood loss and track seeding. The ablation needle and biopsy needle are adapted to in situ assembly with the delivery needle. In a preferred embodiment, the ablation needle, when engaged with the delivery needle forms a coaxial connector adapted to electrically couple to an ablating source. Methods for biopsying and ablating tumors using the device and coagulating the track upon device removal are also provided.

摘要翻译： 公开了一种模块化活检，消融和跟踪凝固针装置，其允许活检针插入输送针并且在不需要时被移除，并且允许内消融针被引导并与输送针同轴地接合以更有效地 活检肿瘤，消融并通过消融凝固轨道，同时减少失血和追踪播种。 消融针和活检针适于与输送针原位组装。 在优选实施例中，消融针当与输送针接合时形成适于电耦合到消融源的同轴连接器。 还提供了使用装置活组织切割和消融肿瘤并在装置移除时凝固轨道的方法。