Selective modulation of renal nerves

    公开(公告)号:US10342592B2

    公开(公告)日:2019-07-09

    申请号:US14379834

    申请日:2013-03-07

    摘要: Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including selectively neuromodulating afferent or efferent renal nerves. One or more measurable physiological parameters corresponding to systemic sympathetic overactivity or hyperactivity in the patient can thereby be reduced. Selectively neuromodulating afferent renal nerves can include inhibiting sympathetic neural activity in nerves proximate a renal pelvis. This can include, for example, neuromodulating via fluid within the renal pelvis. Selectively neuromodulating efferent renal nerves can include inhibiting sympathetic neural activity in nerves proximate a portion of a renal artery or a renal branch artery proximate a renal parenchyma. This can include, for example, neuromodulating via a therapeutic element within the portion of the renal artery or the renal branch artery.

    SELECTIVE MODULATION OF RENAL NERVES
    3.
    发明申请
    SELECTIVE MODULATION OF RENAL NERVES 审中-公开
    选择性调节肾脏神经

    公开(公告)号:US20150133850A1

    公开(公告)日:2015-05-14

    申请号:US14379834

    申请日:2013-03-07

    摘要: Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including selectively neuromodulating afferent or efferent renal nerves. One or more measurable physiological parameters corresponding to systemic sympathetic overactivity or hyperactivity in the patient can thereby be reduced. Selectively neuromodulating afferent renal nerves can include inhibiting sympathetic neural activity in nerves proximate a renal pelvis. This can include, for example, neuromodulating via fluid within the renal pelvis. Selectively neuromodulating efferent renal nerves can include inhibiting sympathetic neural activity in nerves proximate a portion of a renal artery or a renal branch artery proximate a renal parenchyma. This can include, for example, neuromodulating via a therapeutic element within the portion of the renal artery or the renal branch artery.

    摘要翻译: 本文公开了使用治疗性肾神经调节和相关联的装置,系统和方法治疗患者的方法。 本技术的一个方面涉及包括选择性神经调节传入或传出肾神经的方法。 因此可以减少对应于患者的全身交感神经过度活动或多动症的一个或多个可测量的生理参数。 选择性神经调节传入肾神经可以包括抑制邻近肾盂的神经中的交感神经活动。 这可以包括例如通过肾盂内的流体进行神经调节。 选择性神经调节传出肾神经可以包括抑制邻近肾动脉的一部分或靠近肾实质的肾分支动脉的神经中的交感神经活动。 这可以包括例如通过肾动脉或肾分支动脉部分内的治疗元件神经调节。