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公开(公告)号：US09944904B2
公开(公告)日：2018-04-17
申请号：US15154028
申请日：2016-05-13
申请人： MERIAL INC.
发明人： Paulraj Lawrence , Frederic Dumas
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/552 , C12N2750/10034 , C12N2750/10051
摘要： This invention relates to a method for rapid production of PCV2 such that an optimum yield of the virus can be obtained. This invention also relates to the vaccine useful against PCV2 which includes the PCV2 propagated using such a method.
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公开(公告)号：US10098941B2
公开(公告)日：2018-10-16
申请号：US15419568
申请日：2017-01-30
申请人： MERIAL, INC.
IPC分类号： A61K39/102 , A61K39/00 , A61K45/06 , C12N1/38 , C12N1/36
摘要： This disclosure provides attenuated Histophilus somni strains, compositions comprising same, and methods of production and use thereof. The attenuated strains may express lower or no levels of various virulence-associated genes, relative to the corresponding pathogenic bacteria Advantageously, the attenuated Histophilus somni strains may be administered orally, intranasally, intra-tracheally, or subcutaneously.
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公开(公告)号：US20190241625A1
公开(公告)日：2019-08-08
申请号：US16118857
申请日：2018-08-31
申请人： MERIAL INC.
发明人： Paulraj Lawrence
IPC分类号： C07K14/315 , A61K39/09 , A61K39/39
CPC分类号： C07K14/315 , A61K39/092 , A61K39/39 , A61K2039/552 , C12Q1/6869 , C40B40/08 , G16B30/00 , G16B50/00
摘要： The present invention provides S. suis strains that elicit an immune response in animal S. suis, compositions comprising said strains, methods of vaccination against S. suis, and kits for use with such methods and compositions. The invention further provides a comprehensive, unambiguous method of capsular typing based on whole genome sequencing and bioinformatics. This capsular typing approach can accurately identify serotypes even when strains possess novel capsular loci and can be used to determine which strains to include when formulating vaccines, including herd specific vaccines.
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公开(公告)号：US20160333322A1
公开(公告)日：2016-11-17
申请号：US15154028
申请日：2016-05-13
申请人： Merial Inc.
发明人： Paulraj Lawrence , Frederic Dumas
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/552 , C12N2750/10034 , C12N2750/10051
摘要： This invention relates to a method for rapid production of PCV2 such that an optimum yield of the virus can be obtained. This invention also relates to the vaccine useful against PCV2 which includes the PCV2 propagated using such a method.
摘要翻译： 本发明涉及一种快速生产PCV2的方法，从而可以获得病毒的最佳产量。 本发明还涉及可用于PCV2的疫苗，其包括使用这种方法繁殖的PCV2。
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5.发明申请Recombinant Spike Protein Subunit Based Vaccine for Porcine Epidemic Diarrhea Virus (PEDV) 有权针对猪流行性腹泻病毒（PEDV）的重组穗蛋白亚基疫苗公开(公告)号：US20150328307A1
公开(公告)日：2015-11-19
申请号：US14716481
申请日：2015-05-19
申请人： MERIAL, INC.
发明人： Paulraj Lawrence , Russell Bey
IPC分类号： A61K39/225 , C12N7/00
CPC分类号： A61K39/215 , A61K39/225 , A61K2039/5256 , A61K2039/552 , A61K2039/70 , C12N7/00 , C12N2710/14041 , C12N2770/20034
摘要： The present invention encompasses porcine epidemic diarrhea virus (PEDV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing PEDV antigens. The invention also encompasses recombinant vectors encoding and expressing PEDV antigens, epitopes or immunogens which can be used to protect porcine animals against PEDV.
摘要翻译： 本发明包括猪流行性腹泻病毒（PEDV）疫苗或组合物。 疫苗或组合物可以是含有PEDV抗原的疫苗或组合物。 本发明还包括编码和表达可用于保护猪动物抵抗PEDV的PEDV抗原，表位或免疫原的重组载体。
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6.发明授权公开(公告)号：US09713639B2
公开(公告)日：2017-07-25
申请号：US14716481
申请日：2015-05-19
申请人： MERIAL, INC.
发明人： Paulraj Lawrence , Russell Bey
IPC分类号： A61K39/215 , A61K39/295 , A61K39/12 , A61K39/225 , C12N7/00 , A61K39/00
CPC分类号： A61K39/215 , A61K39/225 , A61K2039/5256 , A61K2039/552 , A61K2039/70 , C12N7/00 , C12N2710/14041 , C12N2770/20034
摘要： The present invention encompasses porcine epidemic diarrhea virus (PEDV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing PEDV antigens. The invention also encompasses recombinant vectors encoding and expressing PEDV antigens, epitopes or immunogens which can be used to protect porcine animals against PEDV.
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公开(公告)号：US20170182141A1
公开(公告)日：2017-06-29
申请号：US15378165
申请日：2016-12-14
申请人： MERIAL, INC.
发明人： Keith Wilson , Paulraj Lawrence
CPC分类号： A61K39/0241 , A61K39/12 , A61K2039/5252 , A61K2039/545 , A61K2039/552 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2750/10011 , C12N2750/10034 , C12N2770/10034
摘要： The present invention relates to compositions or vaccines for combating Mycoplasma hyopneumoniae (M hyo), Porcine Circovirus type 2 (PCV2), and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infections in animals and for increasing the ability of pigs to gain weight and/or improve death loss, methods of vaccination against the infections, and kits for use with such methods and compositions.
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8.发明授权公开(公告)号：US09592283B2
公开(公告)日：2017-03-14
申请号：US14668656
申请日：2015-03-25
申请人： MERIAL, INC.
发明人： Tammy Kolander , Paulraj Lawrence , Russell Bey
IPC分类号： A61K39/102 , A61K45/06 , C12N1/36 , C12N1/38 , A61K39/00
CPC分类号： A61K39/102 , A61K45/06 , A61K2039/522 , A61K2039/543 , A61K2039/552 , A61K2039/70 , C12N1/36 , C12N1/38
摘要： This disclosure provides attenuated Histophilus somni strains, compositions comprising same, and methods of production and use thereof. The attenuated strains may express lower or no levels of various virulence-associated genes, relative to the corresponding pathogenic bacteria Advantageously, the attenuated Histophilus somni strains may be administered orally, intranasally, intra-tracheally, or subcutaneously.
摘要翻译： 本公开提供减毒的嗜热索氏杆菌菌株，包含其的组合物，及其生产和使用方法。 相对于相应的致病菌，减毒菌株可以表达较低或没有各种毒力相关基因的水平。有利的是，减毒的Histophilus somni菌株可以口服，鼻内，气管内或皮下给药。
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公开(公告)号：US20180201906A1
公开(公告)日：2018-07-19
申请号：US15914420
申请日：2018-03-07
申请人： MERIAL INC.
发明人： Paulraj Lawrence , Frederic Dumas
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/552 , C12N2750/10034 , C12N2750/10051
摘要： This invention relates to a method for rapid production of PCV2 such that an optimum yield of the virus can be obtained. This invention also relates to the vaccine useful against PCV2 which includes the PCV2 propagated using such a method.
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10.发明申请公开(公告)号：US20170363622A1
公开(公告)日：2017-12-21
申请号：US15533345
申请日：2015-12-07
申请人： MERIAL INC.
发明人： Paulraj Lawrence , Russell F. Bey , Mike Stoll , Eric Bumgardner , Douglas Stine
IPC分类号： G01N33/569 , C07K14/30
CPC分类号： G01N33/56933 , C07K14/30
摘要： This disclosure presents an Enzyme-Linked Immunosorbent Assay (ELISA) for the selective detection of anti-Mycoplasma hyorhinis IgG in porcine serum, which may contain antibodies specific to multiple other Mycoplasma spp.
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