公开(公告)号：US10436784B2

公开(公告)日：2019-10-08

申请号：US14854514

申请日：2015-09-15

申请人： Meso Scale Technologies, LLC ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

发明人： William F Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC分类号： G01N33/53 ,  G01N33/569 ,  G01N33/68 ,  G01N33/566

摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US20180246100A1

公开(公告)日：2018-08-30

申请号：US15902597

申请日：2018-02-22

申请人： Meso Scale Technologies, LLC. ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

发明人： William F. Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC分类号： G01N33/569 ,  G01N33/566 ,  G01N33/68

CPC分类号： G01N33/56972 ,  G01N33/566 ,  G01N33/6893 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60 ,  G01T1/00 ,  G01T1/02

摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US11967410B2

公开(公告)日：2024-04-23

申请号：US15902597

申请日：2018-02-22

申请人： Meso Scale Technologies, LLC. ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

发明人： William F Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC分类号： G01N33/53 ,  G01N27/327 ,  G01N33/68 ,  G01N35/00 ,  G01T1/00 ,  G01T1/02 ,  G16H20/40

CPC分类号： G16H20/40 ,  G01N27/3273 ,  G01N33/6893 ,  G01N35/00 ,  G01T1/00 ,  G01T1/02 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60

摘要： Methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. Also, algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US20200011866A1

公开(公告)日：2020-01-09

申请号：US16555271

申请日：2019-08-29

申请人： MESO SCALE TECHNOLOGIES, LLC ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

发明人： William F. Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC分类号： G01N33/569 ,  G01N33/68 ,  G01N33/566

摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US20160003822A1

公开(公告)日：2016-01-07

申请号：US14854514

申请日：2015-09-15

申请人： Meso Scale Technologies, LLC ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

发明人： William F. Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC分类号： G01N33/569 ,  G01N33/68

CPC分类号： G01N33/56972 ,  G01N33/566 ,  G01N33/6893 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60 ,  G01T1/00 ,  G01T1/02

摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

摘要翻译： 本发明涉及用于评估电离辐射吸收剂量和/或患者辐射组织损伤严重程度的方法和试剂盒。 本发明还涉及用于基于在辐射暴露的情况下相对于正常对照改变的多个生物标志物的生物标志物测量来计算辐射的吸收剂量的算法。

公开(公告)号：US11600373B2

公开(公告)日：2023-03-07

申请号：US16555271

申请日：2019-08-29

申请人： MESO SCALE TECHNOLOGIES, LLC ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

发明人： William F. Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC分类号： G01N33/566 ,  G01N33/569 ,  G01N33/68 ,  G16H20/40 ,  G01T1/02 ,  G01T1/00 ,  G01N27/327 ,  G01N35/00

摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US20140315742A1

公开(公告)日：2014-10-23

申请号：US14348275

申请日：2012-09-28

申请人： MESO SCALE TECHNOLOGIES, LLC ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

发明人： William F Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC分类号： G01N33/566

CPC分类号： G01N33/56972 ,  G01N33/566 ,  G01N33/6893 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60 ,  G01T1/00 ,  G01T1/02

摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

摘要翻译： 本发明涉及用于评估电离辐射吸收剂量和/或患者辐射组织损伤严重程度的方法和试剂盒。 本发明还涉及用于基于在辐射暴露的情况下相对于正常对照改变的多个生物标志物的生物标志物测量来计算辐射的吸收剂量的算法。

公开(公告)号：USRE49774E1

公开(公告)日：2024-01-02

申请号：US17173898

申请日：2021-02-11

申请人： Meso Scale Technologies, LLC.

发明人： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC分类号： C12Q1/68 ,  B01L3/00 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/543 ,  G01N33/68

CPC分类号： B01L3/50853 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/6845 ,  B01L2300/021 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/0829 ,  G01N2458/10 ,  C12Q1/6816 ,  C12Q2563/131

摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US11148145B2

公开(公告)日：2021-10-19

申请号：US16210165

申请日：2018-12-05

申请人： Meso Scale Technologies, LLC

发明人： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC分类号： C12Q1/68 ,  B01L3/00 ,  C12Q1/6876 ,  G01N33/543 ,  C12Q1/6816 ,  C12Q1/6804 ,  G01N33/68

摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US20210285966A1

公开(公告)日：2021-09-16

申请号：US17213954

申请日：2021-03-26

申请人： Meso Scale Technologies, LLC.

发明人： George Sigal

IPC分类号： G01N33/68 ,  G01N33/576

摘要： The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or regimen. The invention also relates to assay kits used in connection with the diagnostic methods described herein.