公开(公告)号：US20130115199A1

公开(公告)日：2013-05-09

申请号：US13734625

申请日：2013-01-04

申请人： Takara Bio Inc. ,  Mie University

发明人： Hiroshi SHIKU ,  Atsunori Hiasa ,  Satoshi Okumura ,  Hiroaki Naota ,  Yoshihiro Miyahara

IPC分类号： C07K14/705

CPC分类号： C07K14/705 ,  A61K35/12 ,  A61K38/00 ,  C07K14/7051 ,  C12N5/0636 ,  C12N2501/515 ,  C12N2510/00

摘要： A polypeptide comprising a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 5 of Sequence Listing or a polypeptide consisting of an amino acid sequence having deletion, addition, insertion or substitution of one to several amino acid residues in the sequence, the polypeptide being capable of constituting an HLA-A24-restricted, MAGE-A4143-151-specific T cell receptor together with a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 2 of Sequence Listing.

摘要翻译： 一种多肽，其包含由序列表的SEQ ID NO：5所示的氨基酸序列组成的多肽或由序列中一至数个氨基酸残基的缺失，添加，插入或取代的氨基酸序列组成的多肽， 能够构成HLA-A24限制性MAGE-A4143-151特异性T细胞受体的多肽以及由序列表的SEQ ID NO：2所示的氨基酸序列组成的多肽。

公开(公告)号：US08951510B2

公开(公告)日：2015-02-10

申请号：US13734625

申请日：2013-01-04

申请人： Mie University ,  Takara Bio Inc.

发明人： Hiroshi Shiku ,  Atsunori Hiasa ,  Satoshi Okumura ,  Hiroaki Naota ,  Yoshihiro Miyahara

IPC分类号： A01N63/00 ,  A01N65/00 ,  C07H21/02 ,  C12N15/00 ,  C12N5/00 ,  C12N5/02 ,  C12N5/071 ,  C07K14/705 ,  C07K14/725 ,  C12N5/0783 ,  A61K35/12 ,  A61K38/00

CPC分类号： C07K14/705 ,  A61K35/12 ,  A61K38/00 ,  C07K14/7051 ,  C12N5/0636 ,  C12N2501/515 ,  C12N2510/00

摘要： A polypeptide comprising a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 5 of Sequence Listing or a polypeptide consisting of an amino acid sequence having deletion, addition, insertion or substitution of one to several amino acid residues in the sequence, the polypeptide being capable of constituting an HLA-A24-restricted, MAGE-A4143-151-specific T cell receptor together with a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 2 of Sequence Listing.

摘要翻译： 一种多肽，其包含由序列表的SEQ ID NO：5所示的氨基酸序列组成的多肽或由序列中一至数个氨基酸残基的缺失，添加，插入或取代的氨基酸序列组成的多肽， 能够构成HLA-A24限制性MAGE-A4143-151特异性T细胞受体的多肽以及由序列表的SEQ ID NO：2所示的氨基酸序列组成的多肽。

公开(公告)号：US11497768B2

公开(公告)日：2022-11-15

申请号：US16619212

申请日：2018-06-05

申请人： MIE UNIVERSITY

发明人： Hiroshi Shiku ,  Yasushi Akahori ,  Yuya Kato ,  Yoshihiro Miyahara

IPC分类号： A61K35/17 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  C12N15/63 ,  A61K39/00

摘要： CAR-T cells for cancer therapy are provided with an antibody that recognizes the MAGE-A4-derived-peptide/HLA-A2 complex. The antibody includes the VH amino acid sequence of SEQ ID NO: 36 and the VL amino acid sequence of SEQ ID NO: 38. The antibody preferably is provided with the amino acid sequence of SEQ ID NO: 32. Such CAR-T cells can be used in CAR infusion therapy in which a cancer-specific intracellular antigen is used.

公开(公告)号：US20210161963A1

公开(公告)日：2021-06-03

申请号：US17262900

申请日：2019-07-31

申请人： Mie University

发明人： Hiroshi Shiku ,  Yoshihiro Miyahara ,  Satoshi Okumura ,  Takuma Kato ,  Tae Hayashi ,  Yoshimasa Tanaka

IPC分类号： A61K35/17 ,  C07K14/725 ,  C12N5/0783 ,  C12N15/85

摘要： The present invention provides a method for efficiently producing highly pure γδT cells introduced with foreign genes by culturing in the presence of IL-7 and IL-15 after stimulating the γδT cells with a bisphosphonic acid ester derivative. When a T cell receptor (TCR) or a chimeric antigen receptor (CAR) is introduced as a foreign gene, γδT cells in which TCR and CAR are functionally expressed can be obtained.