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    METHODS FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY EXTRACELLULAR MICROORGANISMS, INCLUDING ANTIMICROBIAL-RESISTANT STRAINS THEREOF, USING GALLIUM COMPOUNDS
    1.
    发明申请
    METHODS FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY EXTRACELLULAR MICROORGANISMS, INCLUDING ANTIMICROBIAL-RESISTANT STRAINS THEREOF, USING GALLIUM COMPOUNDS 审中-公开
    用于预防或治疗由细胞外微生物引起的感染性疾病的方法，包括抗菌抗性菌株，使用GALLIUM化合物

    公开(公告)号：US20150352148A1

    公开(公告)日：2015-12-10

    申请号：US14829675

    申请日：2015-08-19

    申请人： MOUNT SINAI SCHOOL OF MEDICINE

    发明人： Daniel P. Perl ,  Sharon Moalem

    IPC分类号： A61K33/24 ,  A61K31/5377 ,  A61K38/08

    CPC分类号： A61K33/24 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/28 ,  A61K31/5377 ,  A61K38/08 ,  Y02A50/402 ,  Y02A50/47 ,  Y02A50/473 ,  Y02A50/478 ,  Y02A50/483 ,  Y10S424/06

    摘要： The present invention relates to methods for preventing or treating infectious diseases caused by extracellular microorganisms, such as bacteria and fungi, by systemically administering to a patient a compound containing gallium. The extracellular microorganisms targeted by the present methods include methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE), E. coli O157:H7, fluoroquinolone-resistant Salmonella typhi, and the like. Furthermore, in the present methods, gallium compounds can be co-administered with one or more conventional antimicrobial agents to treat infectious diseases with reduced risks of creating multi-drug resistant pathogens. The methods of the present invention is also applicable to those microorganisms, such as ulcer-causing Helicobacter pylori, complete eradication of which so far has been difficult to achieve.

    摘要翻译： 本发明涉及通过向患者全身施用含有镓的化合物来预防或治疗由细胞外微生物如细菌和真菌引起的感染性疾病的方法。 通过本发明方法靶向的细胞外微生物包括耐甲氧西林金黄色葡萄球菌（MRSA），万古霉素耐药性粪肠球菌（VRE），大肠杆菌O157：H7，耐氟喹诺酮类伤寒沙门氏菌等。 此外，在本方法中，镓化合物可以与一种或多种常规抗微生物剂共同给药，以降低产生多药耐药性病原体的风险来治疗感染性疾病。 本发明的方法也适用于那些微生物，如溃疡性幽门螺杆菌，迄今难以实现的完全根除。

    GROWTH CONTROL OF ORAL AND SUPERFICIAL ORGANISMS USING GALLIUM COMPOUNDS
    2.
    发明申请
    GROWTH CONTROL OF ORAL AND SUPERFICIAL ORGANISMS USING GALLIUM COMPOUNDS 审中-公开
    使用GALLIUM化合物的口服和超级有机体的生长控制

    公开(公告)号：US20160113962A1

    公开(公告)日：2016-04-28

    申请号：US14985474

    申请日：2015-12-31

    申请人： MOUNT SINAI SCHOOL OF MEDICINE

    发明人： Daniel P. Perl ,  Sharon Moalem

    IPC分类号： A61K33/24 ,  A61K8/19 ,  A61Q11/00 ,  A61K31/28

    CPC分类号： A61K33/24 ,  A01N55/02 ,  A01N59/16 ,  A23K20/20 ,  A23L3/358 ,  A23L33/16 ,  A23V2002/00 ,  A61K8/19 ,  A61K8/24 ,  A61K8/365 ,  A61K31/28 ,  A61K2800/58 ,  A61L2/16 ,  A61L2/18 ,  A61L12/088 ,  A61L15/46 ,  A61L2300/102 ,  A61L2300/404 ,  A61Q11/00 ,  A61Q11/02 ,  Y02A50/473 ,  Y02A50/483 ,  A23V2200/312 ,  A23V2200/3204 ,  A23V2250/1596 ,  A23V2200/10

    摘要： The present invention provides methods for treating or preventing diseases and disorders caused by iron-dependent pathogenic microorganisms, such as bacteria, fungi, and parasites, by applying a gallium compound to an affected area. In particular, the present invention provides methods for treating or preventing dental caries, vaginal infections, skin infections, and so forth. Gallium compounds can be formulated as toothpaste, mouthwash, cream, ointment, gel, solution, eye drops, suppository, and the like. Furthermore, the invention provides methods for controlling microbial growth on environmental surfaces, including those of toothbrush, denture, dental retainer, contact lens, catheter, food stuff, and so forth. In addition, the present invention provides animal feeds which contain gallium compounds that promote the animal growth and prevent the animals from infections as well as protect consumers from post processing infections.

    摘要翻译： 本发明提供了通过向受影响的区域施加镓化合物来治疗或预防由铁依赖性致病微生物如细菌，真菌和寄生虫引起的疾病和病症的方法。 特别地，本发明提供了治疗或预防龋齿，阴道感染，皮肤感染等的方法。 镓化合物可以配制成牙膏，漱口水，奶油，软膏，凝胶，溶液，滴眼剂，栓剂等。 此外，本发明提供了用于控制环境表面上的微生物生长的方法，包括牙刷，义齿，牙科保持器，隐形眼镜，导管，食物等的微生物生长。 此外，本发明提供含有镓化合物的动物饲料，其促进动物生长并防止动物感染，并保护消费者免受后处理感染。