利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

66 条记录 (耗时 0.043 秒)

    Pooled adapter strategy for reducing bias in small RNA characterization
    1.
    发明授权
    Pooled adapter strategy for reducing bias in small RNA characterization 有权

    公开(公告)号：US10557169B2

    公开(公告)日：2020-02-11

    申请号：US15343119

    申请日：2016-11-03

    申请人： Mount Sinai School of Medicine

    发明人： Ravi Sachidanandam ,  Anitha Jayaprakash ,  Brian Brown

    IPC分类号： C12Q1/68 ,  C12Q1/6876 ,  C12Q1/6855

    摘要： Modified nucleic acid adapters are provided that collectively provide a mixture of nucleotides at the 3′ end of 5′ adapters and at the 5′ end of 3′ adapters such that at least one adapter in each set has any given nucleotide at position 1, i.e., the nucleotide position available for ligation to a small RNA, and has any given nucleotide at position 2 adjacent to position 1 for use in overcoming bias during nucleic acid manipulation, such as small RNA characterization and/or profiling by, e.g., deep sequencing, along with methods for use of the modified adapters in small RNA characterization. The modified adapters have at least two mixed nucleotides at the adapter terminus to be ligated to a nucleic acid such as a small RNA.

    MO-1, A Gene Associated With Morbid Obesity
    7.
    发明申请
    MO-1, A Gene Associated With Morbid Obesity 审中-公开
    MO-1，与病态肥胖相关的基因

    公开(公告)号：US20130254908A1

    公开(公告)日：2013-09-26

    申请号：US13650968

    申请日：2012-10-12

    申请人： MOUNT SINAI SCHOOL OF MEDICINE

    发明人： Adel Shalata ,  John Martignetti ,  Robert Desnick

    IPC分类号： C07K14/47

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0362 ,  C07K16/18 ,  C12N15/8509 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： MO-1 is a newly identified gene and gene product associated with morbid obesity. Isolated MO-1 nucleic acids, MO-1 polypeptides, oligonucleotides that hybridize to MO-1 nucleic acids, and vectors, including expression vectors, comprising MO-1 nucleic acids are disclosed, as are isolated host cells, antibodies, transgenic non-human animals, compositions, and kits relating to MO-1. Methods of detecting the presence of MO-1 nucleic acid, methods of screening for agents which affect MO-1 activity, and methods of screening for MO-1 variants are also disclosed.

    摘要翻译： MO-1是与病态肥胖相关的新鉴定的基因和基因产物。 公开了分离的MO-1核酸，MO-1多肽，与MO-1核酸杂交的寡核苷酸和包含MO-1核酸的载体，包括表达载体，分离的宿主细胞，抗体，转基因非人 与MO-1有关的动物，组合物和试剂盒。 还公开了检测MO-1核酸存在的方法，筛选影响MO-1活性的试剂的方法，以及筛选MO-1变体的方法。

    Combination therapy for treating protein deficiency disorders
    10.
    发明申请
    Combination therapy for treating protein deficiency disorders 审中-公开
    用于治疗蛋白质缺乏症的组合疗法

    公开(公告)号：US20040180419A1

    公开(公告)日：2004-09-16

    申请号：US10771236

    申请日：2004-02-02

    申请人： Mount Sinai School of Medicine of New York University

    发明人： Jian-Qiang Fan

    IPC分类号： C12N009/99 ,  C12N009/24

    CPC分类号： A61K38/47 ,  A61K9/0019 ,  A61K31/445 ,  A61K31/46

    摘要： This application provides methods of improving protein replacement therapy by combining protein replacement therapy with active site-specific chaperones (ASSC) to increase the stability and efficiency of the protein being administered. The application further provides compositions comprising the purified protein and an ASSC, and methods of treatment by administering the compositions.

    摘要翻译： 该应用提供了通过将蛋白质替代疗法与活性位点特异性伴侣（ASSC）组合来改进蛋白质替代疗法以增加所施用蛋白质的稳定性和效率的方法。 本申请还提供了包含纯化蛋白质和ASSC的组合物，以及通过施用组合物进行治疗的方法。