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![NOVEL PROCESS FOR THE PREPARATION OF 1,3-THIAZOL-5-YLMETHYL [(2R,5R)-5- CARBAMOYL) AMINO] -4-(MORPHOLIN-4-YL)BUTANOYL]AMINO}-1,6-DIPHENYLHEXAN-2-YL]CARBAMATE](/abs-image/US/2018/02/01/US20180030043A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180030043A1
公开(公告)日：2018-02-01
申请号：US15551856
申请日：2016-02-17
申请人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARAIAH , Gutta MADHUSUDHAN , Komati SATYANARAYANA , Jakku MALLESWARA REDDY , MSN LABORATORIES PRIVATE LIMITED
发明人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARAIAH , Gutta MADHUSUDHAN , Komati SATYANA RAYAMA , Jakku MALLESWARA REDDY
IPC分类号： C07D417/12 , A61K9/16 , A61K31/5377 , C07C271/20 , C07C269/04
CPC分类号： C07D417/12 , A61K9/1611 , A61K9/1652 , A61K9/1682 , A61K31/5377 , C07C269/04 , C07C271/20 , C07D277/28
摘要： The present invention relates to novel processes for the preparation 1,3-Thiazol-5-ylmethyl[(2R,5R)-5-{[(2S)-2-[(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl} carbamoyl)amino]-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl] carbamate having the following structural formula-1 and it's intermediates thereof.
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![SOLID STATE FORMS OF N-[2-[(i S)-1 -(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYL SULFONYL)ETHYL]-2,3-DIHYDRO-1,3-DIOXO-L H-ISOINDOL-4-YL]ACETAMIDE AND PROCESS FOR PREPARATION THEREOF](/abs-image/US/2019/01/24/US20190023655A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190023655A1
公开(公告)日：2019-01-24
申请号：US15755993
申请日：2016-08-26
IPC分类号： C07D209/48
CPC分类号： C07D209/48 , C07B2200/13 , C07C315/04 , C07C317/28
摘要： The present invention, relates to solid state forms of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide represented by the following structural formula-1 and process for their preparation. The present invention also relates to an improved process for the preparation of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide compound of formula-1 and intermediates thereof.
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公开(公告)号：US20180298056A1
公开(公告)日：2018-10-18
申请号：US15568392
申请日：2016-04-22
申请人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARAIAH , Ghojala VENKAT REDDY , Katta LAXMI REDDY , MSN LABORATORIES PRIVATE LIMITED
CPC分类号： C07K5/1008 , C07K5/06078 , C07K5/0812 , C07K5/10 , C07K5/1016
摘要： The present invention relates to process for the preparation of (2S)—N—((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phenyethyl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)-4- methylpentanamide represented by the following structural formula-1.
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![Process for the preparation of (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl) methyl]phenyl]-D-glucitol and its solvate thereof](/abs-image/US/2019/05/16/US20190144411A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190144411A1
公开(公告)日：2019-05-16
申请号：US16202840
申请日：2018-11-28
IPC分类号： C07D309/10
摘要： The present invention provides a process for the preparation of (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol which is represented by the following structural formula-1 and its glycerol solvate.
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![PROCESS FOR THE PREPARATION OF 4-[-(AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE AND ITS POLYMORPHS THEREOF](/abs-image/US/2017/08/31/US20170247331A1/abs.jpg.150x150.jpg)
5.发明申请公开(公告)号：US20170247331A1
公开(公告)日：2017-08-31
申请号：US15515109
申请日：2015-09-29
申请人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARAIAH , Gutta MADHUSUDHAN , MSN LABORATORIES PRIVATE LIMITED
IPC分类号： C07D213/81
CPC分类号： C07D213/81
摘要： The present invention relates to a process for the preparation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluophenoxy]-N-methylpyridine-2-carboxamide compound of formula-I, its amorphous form and its crystalline polymorph-I which is represented by the following structural formula: (I)
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![IMPROVED PROCESS FOR THE PREPARATION OF [[2(S)-[[4(R)-(3-HYDROXYPHENYL)-3(R),4-DIMETHYL-1-PIPERIDINYL]METHYL]-1-OXO-3-PHENYLPROPYL]AMINO]ACETIC ACID DIHYDRATE](/abs-image/US/2017/08/31/US20170247328A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170247328A1
公开(公告)日：2017-08-31
申请号：US15509786
申请日：2015-09-08
IPC分类号： C07D211/22 , C07C51/367 , C07D263/24 , C07C51/06
CPC分类号： C07D211/22 , C07B2200/07 , C07C51/02 , C07C51/06 , C07C51/09 , C07C51/367 , C07C51/412 , C07D263/24 , C07C59/48
摘要： The present invention relates to an improved process for the preparation of [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic acid dihydrate, represented by the following structural formula (I).
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![CRYSTALLINE FORMS OF N-(2-CHLORO-6-METHY]PHENVN-2-[F6-[4-(2-HVDROXVETHVL)-L-PIPERAZIN-VIL-2-METHVIL-4-PVRIMIDINVLLAMINOL-5-THIAZOLECARBOXAMIDE AND THEIR PROCESS THEREOF](/abs-image/US/2018/07/05/US20180186784A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180186784A1
公开(公告)日：2018-07-05
申请号：US15741086
申请日：2016-06-27
申请人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARIAH , Gutta MADHUSUDHAN , Peri SEETHA RAMA SARMA , Mogal KHALIL AHAMED , MSN LABORATORIES PRIVATE LIMITED
发明人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARAIAH , Gutta MADHUSUDHAN , Peri SEETHA RAMA SARMA , Mogal KHALIL AHAMED
IPC分类号： C07D417/14 , C07C31/20 , B01D9/00
CPC分类号： C07D417/14 , B01D9/005 , C07B2200/13 , C07C31/205 , C07D417/12
摘要： The present invention relates to crystalline 1,2-Propanediol solvate of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide compound of formula-1b, its process for the preparation and its use in the preparation of anhydrous crystalline form (N-6) and monohydrate of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxy ethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide. [formula] 1,2-Propanediol solvate Formula-1b
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