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公开(公告)号：US10531957B2
公开(公告)日：2020-01-14
申请号：US15159406
申请日：2016-05-19
发明人： Michele McAllister , David Wang , Michelle Bubear , Joed Canales , Amy Chang , Roman Shikhanovich , Mark Spilker , Eric Semler
摘要： Surgical implants (or grafts) for the repair of bone defects, more particularly, surgical implants that include demineralized bone fibers, are disclosed. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration. Methods for making such implants and for increasing their wettability and ensuring uniform density are also disclosed.
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公开(公告)号：US11786637B2
公开(公告)日：2023-10-17
申请号：US17188183
申请日：2021-03-01
发明人： Eric Semler , Mark Spilker , Kevin Wu , Yen-Chen Huang , Evangelia Chnari , Jeffrey Cartmell , Morris Jacobs , Alison Ling , Moon Hae Sunwoo
CPC分类号： A61L27/3895 , A01N1/0284 , A61L27/3604 , A61L27/3683 , A61L27/38 , A61L2430/02
摘要： Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli comprising simulated hypoxia to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.
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公开(公告)号：US11596517B2
公开(公告)日：2023-03-07
申请号：US16598354
申请日：2019-10-10
发明人： Michele McAllister , David Wang , Michelle Bubear , Joed Canales , Amy Chang , Roman Shikhanovich , Mark Spilker , Eric Semler
摘要： Methods for making surgical implants (or grafts) for the repair of bone defects, and more particularly, surgical implants that include demineralized bone fibers, are disclosed. Also disclosed are methods for increasing the wettability and ensuring uniform density of such implants. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration.
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4.发明授权Tissue-derived tissuegenic implants, and methods of fabricating and using same 有权组织衍生的组织生成植入物，以及制造和使用它们的方法公开(公告)号：US09352003B1
公开(公告)日：2016-05-31
申请号：US13690542
申请日：2012-11-30
发明人： Eric Semler , Alex Callahan , Joed Canales , Katrina Carroll , Anouska Dasgupta , Roman Shikanovich
CPC分类号： A61K35/32 , A61K35/35 , A61K35/50 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/19 , A61L27/00 , A61L27/3608 , A61L27/3847 , C12N5/0605 , C12N5/0654 , C12N5/0667 , C12N5/0668 , C12N2533/90 , A61K2300/00
摘要： The disclosure provides implants containing a plurality of particles containing at least one population of viable osteogenic cells adherent to and resident in an osteoconductive matrix or at least one viable population of osteogenic cells caused to be in contact with the osteoconductive matrix; methods of fabricating the implants; and use of the implants in bone repair. The implant further contains an osteoinductive component. An example of an osteoinductive component is a demineralized bone matrix in the form of particles or fibers.
摘要翻译： 本公开提供了含有多个颗粒的植入物，所述植入物含有至少一个活着的成骨细胞群，所述至少一个存活的成骨细胞群粘附并存在于骨诱导基质中，或至少一个存活的骨源细胞群与骨诱导基质接触; 制造植入物的方法; 并使用植入物进行骨修复。 植入物还含有骨诱导成分。 骨诱导成分的实例是颗粒或纤维形式的脱矿质骨基质。
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公开(公告)号：US20220111120A1
公开(公告)日：2022-04-14
申请号：US17557525
申请日：2021-12-21
发明人： Eric Semler , Alex Callahan , Joed Canales , Katrina Carroll , Anouska Dasgupta , Roman Shikanovich
IPC分类号： A61L27/36 , A61K35/32 , A61K38/18 , A61K38/19 , C12N5/073 , C12N5/0775 , A61L27/38 , A61L27/00 , C12N5/077 , A61L27/40 , A61L27/54
摘要： The disclosure provides implants containing a plurality of particles containing at least one population of viable cells adherent to and resident in soft tissue matrix or at least one viable population of cells caused to be in contact with the soft tissue matrix; methods of fabricating the implants; and use of the implants in tissue repair.
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公开(公告)号：US20190134265A1
公开(公告)日：2019-05-09
申请号：US16229650
申请日：2018-12-21
发明人： Eric Semler , Alex Callahan , Joed Canales , Katrina Carroll , Anouska Dasgupta , Roman Shikanovich
摘要： The disclosure provides implants containing a plurality of particles containing at least one population of viable cells adherent to and resident in soft tissue matrix or at least one viable population of cells caused to be in contact with the soft tissue matrix; methods of fabricating the implants; and use of the implants in tissue repair.
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7.发明申请公开(公告)号：US20230030907A1
公开(公告)日：2023-02-02
申请号：US17966092
申请日：2022-10-14
发明人： Michele Christine McAllister , David Wang , Michelle Bubear , Joed Canales , Amy Chang , Roman Shikhanovich , Mark Spilker , Eric Semler
摘要： Methods for making surgical implants (or grafts) for the repair of bone defects, and more particularly, surgical implants that include demineralized bone fibers, are disclosed. Also disclosed are methods for increasing the wettability and ensuring uniform density of such implants. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration.
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公开(公告)号：US20210178022A1
公开(公告)日：2021-06-17
申请号：US17188183
申请日：2021-03-01
发明人： Eric Semler , Mark Spilker , Kevin Wu , Yen-Chen Huang , Evangelia Chnari , Jeffrey Cartmell , Morris Jacobs , Alison Ling , Moon Hae Sunwoo
摘要： Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli comprising simulated hypoxia to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.
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9.发明授权Tissue-derived tissugenic implants, and methods of fabricating and using same 有权组织衍生的组织生成植入物，以及制造和使用它们的方法公开(公告)号：US08834928B1
公开(公告)日：2014-09-16
申请号：US13948798
申请日：2013-07-23
发明人： Katherine Gomes Truncale , Arthur A. Gertzman , Yen-Chen Huang , Eric Semler , Evangelia Chnari , Anouska Dasgupta , Judith Yannariello-Brown , Terri Riley
CPC分类号： C12N5/0654 , A61L27/3604 , A61L27/3608 , A61L27/3804 , A61L27/3847 , A61L2300/414 , A61L2430/02 , C12N5/0605 , C12N5/0653 , C12N5/0663 , C12N2533/90
摘要： The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.
摘要翻译： 本公开提供了包含多个颗粒的植入物，所述植入物含有至少一组存活组织发生细胞群，所述活组织生成细胞粘附并驻留在生长传导性基质中或至少存活的生长群体的组织发生细胞中，所述群体与生长传导性基质接触; 制造植入物的方法; 制造植入物的方法; 并使用植入物进行组织修复。
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公开(公告)号：US11305035B2
公开(公告)日：2022-04-19
申请号：US16229650
申请日：2018-12-21
发明人： Eric Semler , Alex Callahan , Joed Canales , Katrina Carroll , Anouska Dasgupta , Roman Shikanovich
IPC分类号： A61K9/32 , A61L27/36 , A61K35/32 , A61K38/18 , A61K38/19 , C12N5/073 , C12N5/0775 , A61L27/38 , A61L27/00 , C12N5/077 , A61L27/40 , A61L27/54 , A61K35/50 , A61K35/35
摘要： The disclosure provides implants containing a plurality of particles containing at least one population of viable cells adherent to and resident in soft tissue matrix or at least one viable population of cells caused to be in contact with the soft tissue matrix; methods of fabricating the implants; and use of the implants in tissue repair.
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