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公开(公告)号:US5468771A
公开(公告)日:1995-11-21
申请号:US190110
申请日:1994-02-02
申请人: Magda M. Gagliardi , Shieh-Shung T. Chen , Byron H. Arison , George M. Garrity , Leeyuan Huang , John G. MacConnell , Raymond F. White
发明人: Magda M. Gagliardi , Shieh-Shung T. Chen , Byron H. Arison , George M. Garrity , Leeyuan Huang , John G. MacConnell , Raymond F. White
IPC分类号: C07D493/08 , C07H19/01 , C12P17/18 , C12P19/02 , A61K31/35 , C07D319/04
CPC分类号: C07D493/08 , C07H19/01 , C12P17/181 , C12P19/02
摘要: A compound of structural formula ##STR1## having antihypercholesterolemic utility is produced by culturing a Streptomyces sp. in a nutrient medium in the presence of a substrate of structural formula: ##STR2##
摘要翻译: PCT No.PCT / US92 / 06520 Sec。 371日期:1994年2月2日 102(e)日期1994年2月2日PCT提交1992年8月5日PCT公布。 公开号WO93 / 03038 日期:1993年2月18日。具有抗高胆固醇血症效用的结构式
化合物通过培养链霉菌属(Streptomyces sp。 在营养培养基中存在下述结构式的底物: -
公开(公告)号:US5359096A
公开(公告)日:1994-10-25
申请号:US979559
申请日:1992-11-20
申请人: Laszlo R. Treiber , Byron H. Arison , Shieh-Shung T. Chen , George A. Doss , Leeyuan Huang , John G. MacConnell
发明人: Laszlo R. Treiber , Byron H. Arison , Shieh-Shung T. Chen , George A. Doss , Leeyuan Huang , John G. MacConnell
IPC分类号: A61K31/335 , A61K31/355 , A61K31/365 , A61K31/455 , C07D493/04 , C07D493/08 , C07H19/01 , C12P1/06 , C12P17/18 , C07D319/08
CPC分类号: C07D493/04 , A61K31/335 , A61K31/355 , A61K31/365 , A61K31/455 , C07D493/08 , C07H19/01 , C12P1/06 , C12P17/181 , C12R1/465
摘要: New cholesterol lowering compounds are formed from the photochemical treatment of the zaragozic acids.
摘要翻译: 新的胆固醇降低化合物由萨拉哥酸的光化学处理形成。
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公开(公告)号:US5270332A
公开(公告)日:1993-12-14
申请号:US934134
申请日:1992-08-21
IPC分类号: C07D493/08 , A61K31/335 , C07D319/08
CPC分类号: C07D493/08
摘要: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents. The compounds also exhibit antifungal activity and are inhibitors of farnesyl-protein transferase.
摘要翻译: 本发明涉及结构式(I)的化合物:作为角鲨烯合成酶抑制剂,因此可用作胆固醇降低剂。 化合物还具有抗真菌活性,并且是法呢基蛋白转移酶的抑制剂。
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公开(公告)号:US5362752A
公开(公告)日:1994-11-08
申请号:US61518
申请日:1993-05-17
IPC分类号: C07C59/90 , C07C69/738 , A61K31/215 , C07C57/03
CPC分类号: C07C69/738 , C07C59/90
摘要: New cholesterol lowering compounds are formed from the photochemical treatment of zaragozic acid A.
摘要翻译: 新的胆固醇降低化合物由萨拉哥酸A的光化学处理形成。
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公开(公告)号:US5194378A
公开(公告)日:1993-03-16
申请号:US772520
申请日:1991-10-07
申请人: Gino M. Salituro , Francis Dumont , George M. Garrity , Leeyuan Huang , E. Tracy T. Jones , Mary N. Omstead , Isabel M. Fernandez , Teresa D. Matas
发明人: Gino M. Salituro , Francis Dumont , George M. Garrity , Leeyuan Huang , E. Tracy T. Jones , Mary N. Omstead , Isabel M. Fernandez , Teresa D. Matas
IPC分类号: A61K31/435 , A61P37/06 , C07D498/18 , C12N1/20 , C12P17/18 , C12P19/44 , C12R1/325 , C12R1/465
CPC分类号: C12R1/465 , C12P17/188 , C12P19/445 , Y10S435/886
摘要: Described is a new process for producing the macrolide immunosuppressant, FK-506 under fermentation conditions utilizing the microorganism, Streptomyces sp., (Merck Culture Collection No. MA 6858) ATCC No. 55098. The immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
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公开(公告)号:US5132320A
公开(公告)日:1992-07-21
申请号:US496734
申请日:1990-03-21
申请人: James D. Bergstrom , Otto D. Hensens , Claude Dufresne , Leeyuan Huang , Janet C. Onishi , Deborah L. Zink
发明人: James D. Bergstrom , Otto D. Hensens , Claude Dufresne , Leeyuan Huang , Janet C. Onishi , Deborah L. Zink
IPC分类号: A01N43/90 , C07D491/08 , C12P17/18
CPC分类号: C07D491/08 , A01N43/90 , C12P17/181 , C12R1/645
摘要: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
摘要翻译: 本发明涉及结构式(I)的化合物:(I)(CH2)4CHCH(CH2)4CHCHCH3,它们是角鲨烯合成酶抑制剂,因此可用作胆固醇降低剂。
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公开(公告)号:US4981980A
公开(公告)日:1991-01-01
申请号:US407162
申请日:1989-09-14
申请人: Robert A. Giocobbe , Leeyuan Huang , Yu L. Kong , Yiu-Kuen T. Lam , Sagrario M. Del Val , Carol F. Wichmann , Deborah L. Zink
发明人: Robert A. Giocobbe , Leeyuan Huang , Yu L. Kong , Yiu-Kuen T. Lam , Sagrario M. Del Val , Carol F. Wichmann , Deborah L. Zink
IPC分类号: C07D307/94 , C12P17/04
CPC分类号: C07D307/94 , C12P17/04
摘要: Fermentation of a nutrient medium by a Hypomycetes fungus of the genus Memnoniella or Stachybotrys yields a product with a major component of structural formula I: ##STR1## which is an inositol monophosphate phosphatase inhibitor and thereby useful in the treatment of manic depression.
摘要翻译: 通过Memnoniella或Stachybotrys属的假单胞菌真菌发酵营养培养基产生具有结构式I的主要成分的产物:作为肌醇单磷酸酯磷酸酶抑制剂的作用(I),从而可用于治疗躁狂抑郁症。
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公开(公告)号:US4874745A
公开(公告)日:1989-10-17
申请号:US103324
申请日:1987-10-01
申请人: Leeyuan Huang , Lawrence Koupal , Joseph Dunn, Jr. , Jerrold M. Liesch , Otto Hensens , H. Boyd Woodruff
发明人: Leeyuan Huang , Lawrence Koupal , Joseph Dunn, Jr. , Jerrold M. Liesch , Otto Hensens , H. Boyd Woodruff
IPC分类号: C07K5/02
CPC分类号: C07K5/0205 , Y10S530/86
摘要: A phenyl derivative of pepstatin A, which is much more potent than pepstatin in inhibiting renin enzyme activity and has significantly greater selectivity for renin over pepsin inhibition than does pepstatin, which is useful in treating hypertension and congestive heart failure.
摘要翻译: 胃蛋白酶抑制剂A的苯基衍生物,其在抑制肾素酶活性方面比胃酶抑素更有效,并且与胃蛋白酶抑制相比,胃蛋白酶抑制的选择性比胃蛋白酶明显更高,其可用于治疗高血压和充血性心力衰竭。
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公开(公告)号:US5283256A
公开(公告)日:1994-02-01
申请号:US918727
申请日:1992-07-22
申请人: Claude Dufresne , Josep Guarro , Leeyuan Huang , Yu L. Kong , Russell B. Lingham , Maria S. Meinz , Keith C. Silverman , Sheo B. Singh
发明人: Claude Dufresne , Josep Guarro , Leeyuan Huang , Yu L. Kong , Russell B. Lingham , Maria S. Meinz , Keith C. Silverman , Sheo B. Singh
IPC分类号: A01N43/90 , C07D493/08 , A61K31/335 , C07D319/08
CPC分类号: C07D493/08 , A01N43/90
摘要: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).
摘要翻译: 本发明涉及结构式(I)的化合物:作为角鲨烯合酶抑制剂,因此可用作胆固醇降低剂和抗真菌剂。 这些化合物也是法呢基蛋白转移酶的抑制剂和致癌基因蛋白Ras的法呢基化,因此可用于治疗癌症。 本发明还涉及获得结构式(I)化合物的方法。
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公开(公告)号:US5102907A
公开(公告)日:1992-04-07
申请号:US582452
申请日:1990-09-13
IPC分类号: C07D493/08
CPC分类号: C07D493/08
摘要: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
摘要翻译: 本发明涉及结构式(I)的化合物:作为角鲨烯合成酶抑制剂,因此可用作胆固醇降低剂。
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