公开(公告)号：US20050239070A1

公开(公告)日：2005-10-27

申请号：US10511698

申请日：2003-04-17

申请人： Magnus Von Knebel-Doeberitz ,  Johannes Gebert ,  Michael Linnebacher ,  Stefan Woerner ,  Ruediger Ridder ,  Peer Bork ,  Yan Yuan

发明人： Magnus Von Knebel-Doeberitz ,  Johannes Gebert ,  Michael Linnebacher ,  Stefan Woerner ,  Ruediger Ridder ,  Peer Bork ,  Yan Yuan

IPC分类号： C07K14/47 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/82 ,  G01N33/574

CPC分类号： G01N33/57419 ,  A61K2039/53 ,  C07K14/47

摘要： The present invention relates to compounds and methods useful for the detection and treatment of disorders associated with frameshift mutations in coding microsatellite regions. The compounds and methods are applicable in cancers, especially of DNA mismatch repair deficient (MMR) sporadic tumors and HNPCC associated tumors. The compounds disclosed in the invention are useful for detection of disorders and in therapy such as e.g. immuno-therapy. The diagnostic methods relate to diagnosis and prognostic assessment of disorders associated with frameshift polypeptides originating from frameshift mutations in coding microsatellite regions of genes based on the detection of immunological entities directed against said frameshift polypeptides in body fluids. With respect to the treatment of cancer, especially of DNA mismatch repair deficient (MMR) sporadic tumors and HNPCC associated tumors, the invention pertains to methods which use immuno therapy with combinatorial mixtures of tumor specific frameshift peptides to elicit a cytotoxic T-cell response specifically directed against tumor cells for use in prevention as well as in curative treatment of cancers and precancers.

摘要翻译： 本发明涉及可用于检测和治疗与编码微卫星区域中的移码突变相关的病症的化合物和方法。 这些化合物和方法适用于癌症，特别是DNA错配修复缺陷（MMR）散发性肿瘤和HNPCC相关肿瘤。 本发明中公开的化合物可用于疾病的检测和治疗中的检测。 免疫治疗。 诊断方法涉及基于针对针对体液中所述移码多肽的免疫学实体的检测而编码基因编码微卫星区域中的移码突变的与移码多肽相关的病症的诊断和预后评估。 关于癌症的治疗，特别是DNA错配修复缺陷（MMR）散发性肿瘤和HNPCC相关肿瘤的治疗，本发明涉及使用具有肿瘤特异性移码肽的组合混合物的免疫治疗来引发细胞毒性T细胞应答的方法 针对肿瘤细胞用于预防以及治疗癌症和预防药物。

公开(公告)号：US20120207472A1

公开(公告)日：2012-08-16

申请号：US13504291

申请日：2010-04-02

申请人： Xiaopeng Song ,  Yan Yuan

发明人： Xiaopeng Song ,  Yan Yuan

IPC分类号： H04B10/20

CPC分类号： H04J3/0623 ,  H04J3/1652 ,  H04J2203/0082

摘要： A method and system for service clock transparent transmission in an optical transport network (OTN) are provided. The system includes a service accessing end and an OTN receiving end; the method includes the following steps: the OTN receiving end performs de-mapping operation to an OTN frame after receiving the OTN frame, and performs two-level buffering operation to the service data flow recovered therefrom, a first buffering unit performs a homogenization treatment to the service data flow and then outputs to a second buffering unit, which the second buffering unit outputs the service data flow according to the service clock after receiving the service data flow. After adopting the present invention, it is able to ensure that the quality of the recovered service clock is relatively higher, which meets the customer requirement on the related specification of the service clock.

摘要翻译： 提供了一种在光传送网（OTN）中进行业务时钟透传的方法和系统。 该系统包括业务接入端和OTN接收端; 该方法包括以下步骤：OTN接收端在接收到OTN帧后对OTN帧进行去映射操作，并对从其回收的业务数据流进行两级缓存操作，第一缓存单元进行均衡处理 服务数据流，然后输出到第二缓冲单元，第二缓冲单元在接收到服务数据流之后根据服务时钟输出服务数据流。 在采用本发明之后，能够确保恢复的服务时钟的质量相对较高，这符合客户对服务时钟相关规范的要求。

公开(公告)号：US20120128363A1

公开(公告)日：2012-05-24

申请号：US13388332

申请日：2009-11-24

申请人： Wenkai Ma ,  Yan Yuan

发明人： Wenkai Ma ,  Yan Yuan

IPC分类号： H04J14/08

CPC分类号： H04L12/40013 ,  H04J3/14 ,  H04J3/1652 ,  H04J2203/006 ,  H04L12/413 ,  H04L12/4633 ,  H04L49/552

摘要： The present invention discloses an device for cross protection, including: a service unit source end, configured to map optical data unit (ODUk) signals into the same time slots of n line similar optical transport network (OTN) frame format (OTUxG) data buses, and obtain m+n line OTUxG data through protective coding and then send to a combination cross unit; the combination cross unit, configured to split and recombine the m+n line OTUxG data in the time slot, and then send to a service unit destination end; the service unit destination end, configured to protectively decode the m+n line OTUxG data, recover n line OTUxG data, and extract corresponding ODUk signals from the same time slots of n line OTUxG data.

摘要翻译： 本发明公开了一种交叉保护装置，包括：服务单元源端，用于将光数据单元（ODUk）信号映射到n行相似光传送网（OTN）帧格式（OTUxG）数据总线的相同时隙 并通过保护编码获得m + n线OTUxG数据，然后发送到组合交叉单元; 组合交叉单元，配置为在时隙中拆分并重组m + n线OTUxG数据，然后发送到服务单元的目的端; 服务单元目的地端，被配置为保护地解码m + n线OTUxG数据，恢复n线OTUxG数据，并从n线OTUxG数据的相同时隙中提取相应的ODUk信号。

公开(公告)号：US5728521A

公开(公告)日：1998-03-17

申请号：US215082

申请日：1994-03-18

申请人： Yan Yuan ,  Cecilia Guerrier-Takada ,  Sidney Altman ,  Fenyong Liu

发明人： Yan Yuan ,  Cecilia Guerrier-Takada ,  Sidney Altman ,  Fenyong Liu

IPC分类号： C12N15/09 ,  A61K9/127 ,  A61K31/70 ,  A61K35/76 ,  A61K38/00 ,  A61K47/48 ,  A61K48/00 ,  A61P31/12 ,  A61P35/02 ,  C07H21/02 ,  C07H21/04 ,  C12N9/22 ,  C12N15/113 ,  C12Q1/68 ,  C12P19/34

CPC分类号： C12N15/113 ,  A61K47/48776 ,  C12Q1/6813 ,  C12Q1/6827 ,  C12Q1/6848 ,  A61K38/00 ,  C12N2310/111 ,  C12N2310/126 ,  C12N2799/027

摘要： It has been discovered that any RNA can be targeted for cleavage by RNAase P from eukaryotic cells, for example, human RNAase P, using a suitably designed oligoribonucleotide ("external guide sequence", or EGS) to form a hybrid with the target RNA, thereby creating a substrate for cleavage by RNAase P in vitro. The EGS hydrogen bonds to the targeted RNA to form a partial tRNA like structure including the aminoacyl acceptor stem, the T stem and loop, and part of the D stem. The most efficient EGS with human RNAase P is the EGS in which the anticodon stem and loop was deleted. Modifications can also be made within the T-loop. Methods are also disclosed to randomly select and to express a suitable EGS in vivo to make a selected RNA a target for cleavage by the host cell RNAase P, thus preventing expression of the function of the target RNA. The methods and compositions should be useful to prevent the expression of disease-causing genes in vivo.

摘要翻译： 已经发现，使用适当设计的寡核糖核苷酸（“外部引导序列”或EGS），可以使用RNA酶P从真核细胞例如人RNA酶P切割任何RNA，以形成与靶RNA的杂交体， 从而在体外产生用RNA酶P切割的底物。 EGS氢键与靶RNA形成部分tRNA样结构，包括氨酰受体茎，T干和环以及部分D茎。 具有人RNA酶P的最有效的EGS是其​​中反密码子茎和环被删除的EGS。 修改也可以在T环内进行。 还公开了在体内随机选择和表达合适的EGS以使所选择的RNA成为宿主细胞RNA酶P切割的靶标，从而阻止靶RNA功能的表达的方法。 该方法和组合物应该有用于预防体内致病基因的表达。

公开(公告)号：US5624824A

公开(公告)日：1997-04-29

申请号：US207547

申请日：1994-03-07

申请人： Yan Yuan ,  Cecilia Guerrier-Takada ,  Sidney Altman ,  Fenyong Liu

发明人： Yan Yuan ,  Cecilia Guerrier-Takada ,  Sidney Altman ,  Fenyong Liu

IPC分类号： A61K47/48 ,  C12N15/113 ,  C12Q1/68 ,  C12P19/34 ,  A61K48/00 ,  C07H21/04

CPC分类号： C12N15/113 ,  A61K47/48776 ,  C12Q1/6813 ,  C12Q1/6827 ,  C12Q1/6848 ,  C12N2310/111 ,  C12N2310/126 ,  C12N2799/027

摘要： It has been discovered that any RNA can be targeted for cleavage by RNAase P from eukaryotic cells, for example, human RNAase P, using a suitably designed oligoribonucleotide ("external guide sequence", or EGS) to form a hybrid with the target RNA, thereby creating a substrate for cleavage by RNAase P in vitro. The EGS hydrogen bonds to the targeted RNA to form a partial tRNA like structure including the aminoacyl acceptor stem, the T stem and loop, and part of the D stem. The most efficient EGS with human RNAase P is the EGS in which the anticodon stem and loop was deleted. Modifications can also be made within the T-loop. Methods are also disclosed to randomly select and to express a suitable EGS in vivo to make a selected RNA a target for cleavage by the host cell RNAase P, thus preventing expression of the function of the target RNA. The methods and compositions should be useful to prevent the expression of disease-causing genes in vivo.

摘要翻译： 已经发现，使用适当设计的寡核糖核苷酸（“外部引导序列”或EGS），可以使用RNA酶P从真核细胞例如人RNA酶P切割任何RNA，以形成与靶RNA的杂交体， 从而在体外产生用RNA酶P切割的底物。 EGS氢键与靶RNA形成部分tRNA样结构，包括氨酰受体茎，T干和环以及部分D茎。 具有人RNA酶P的最有效的EGS是其​​中反密码子茎和环被删除的EGS。 修改也可以在T环内进行。 还公开了在体内随机选择和表达合适的EGS以使所选择的RNA成为宿主细胞RNA酶P切割的靶标，从而阻止靶RNA功能的表达的方法。 该方法和组合物应该有用于预防体内致病基因的表达。

公开(公告)号：US08644333B2

公开(公告)日：2014-02-04

申请号：US13259880

申请日：2009-09-28

申请人： Yuxian Wei ,  Yan Yuan

发明人： Yuxian Wei ,  Yan Yuan

IPC分类号： H04J3/00 ,  H04J14/00

CPC分类号： H04J3/1652

摘要： The present invention discloses a method for realizing cross-connect of optical channel data units (ODUk), which comprises: mapping the accessed services to the ODUk, and mapping the services mapped to the ODUk to the ODUk time slot frames according to the requirements of the time slot frames; mapping the ODUk time slot frames to the intermediate frame structures; performing the cross-connect for ODUk services in the intermediate frame structures. The present invention also discloses an apparatus for realizing cross-connect of ODUk. The present invention directly supports cross-connect of ODUk, so as to realize simple scheduling for the Optical Transport Network (OTN) services, and improve the resource utilization factor and the integration level.

摘要翻译： 本发明公开了一种实现光信道数据单元（ODUk）交叉连接的方法，包括：将访问业务映射到ODUk，并将映射到ODUk的业务映射到ODUk时隙帧，根据要求 时隙帧; 将ODUk时隙帧映射到中间帧结构; 在中间帧结构中执行ODUk服务的交叉连接。 本发明还公开了一种用于实现ODUk的交叉连接的装置。 本发明直接支持ODUk的交叉连接，实现了光传输网络（OTN）业务的简单调度，提高了资源利用率和集成度。

公开(公告)号：US20120163796A1

公开(公告)日：2012-06-28

申请号：US13393964

申请日：2010-04-06

申请人： Dong Wang ,  Yan Yuan

发明人： Dong Wang ,  Yan Yuan

IPC分类号： H04B10/08 ,  H02B1/015 ,  H04J14/00

CPC分类号： H04J3/1652 ,  H04J14/0212 ,  H04J14/0293 ,  H04J14/0297 ,  H04J2203/0012 ,  H04J2203/0025 ,  H04J2203/0026 ,  H04J2203/0073

摘要： The present invention discloses a distributed electrical cross apparatus, and a system and method for the distributed electrical cross apparatus implementing an SNC cascade protection. The apparatus includes a backboard and at least four single-boards integrated with electrical cross units, wherein the single-boards are inserted in the limited number of slots in the backboard, and these single-boards also set line-side service access units, client-side service access units and backboard access units. The present invention has both accessing of line-side services and accessing of client-side services in the same single-board, access and flexible scheduling of various services such as line-side services and client-side services and so on are implemented on the backboard with limited number of slots, and the function of the distributed electrical cross system processing various services is increased in the case of low cost.

摘要翻译： 本发明公开了一种分布式电交叉装置，以及实现SNC级联保护的分布式交叉装置的系统和方法。 该装置包括背板和至少四个与电叉交叉单元集成的单板，其中单板插入在背板中的有限数量的槽中，并且这些单板还设置线路侧服务访问单元，客户端 服务接入单元和背板接入单元。 本发明在线路侧业务的访问以及客户端业务的访问方面，在同一单板，接入和灵活调度诸如线路侧业务和客户端业务等各种业务的同时， 在具有有限数量的插槽的背板上，并且在低成本的情况下，分布式电交叉系统处理各种服务的功能增加。

公开(公告)号：US20120093506A1

公开(公告)日：2012-04-19

申请号：US13259880

申请日：2009-09-28

申请人： Yuxian Wei ,  Yan Yuan

发明人： Yuxian Wei ,  Yan Yuan

IPC分类号： H04J14/00

CPC分类号： H04J3/1652

摘要： The present invention discloses a method for realizing cross-connect of optical channel data units (ODUk), which comprises: mapping the accessed services to the ODUk, and mapping the services mapped to the ODUk to the ODUk time slot frames according to the requirements of the time slot frames; mapping the ODUk time slot frames to the intermediate frame structures; performing the cross-connect for ODUk services in the intermediate frame structures. The present invention also discloses an apparatus for realizing cross-connect of ODUk. The present invention directly supports cross-connect of ODUk, so as to realize simple scheduling for the Optical Transport Network (OTN) services, and improve the resource utilization factor and the integration level.

摘要翻译： 本发明公开了一种实现光信道数据单元（ODUk）交叉连接的方法，包括：将访问业务映射到ODUk，并将映射到ODUk的业务映射到ODUk时隙帧，根据要求 时隙帧; 将ODUk时隙帧映射到中间帧结构; 在中间帧结构中执行ODUk服务的交叉连接。 本发明还公开了一种用于实现ODUk的交叉连接的装置。 本发明直接支持ODUk的交叉连接，实现了光传输网络（OTN）业务的简单调度，提高了资源利用率和集成度。

公开(公告)号：US5869248A

公开(公告)日：1999-02-09

申请号：US702652

申请日：1996-11-06

申请人： Yan Yuan ,  Cecilia Guerrier-Takada ,  Sidney Altman ,  Fenyong Liu

发明人： Yan Yuan ,  Cecilia Guerrier-Takada ,  Sidney Altman ,  Fenyong Liu

IPC分类号： C12N15/09 ,  A61K9/127 ,  A61K31/70 ,  A61K35/76 ,  A61K38/00 ,  A61K47/48 ,  A61K48/00 ,  A61P31/12 ,  A61P35/02 ,  C07H21/02 ,  C07H21/04 ,  C12N9/22 ,  C12N15/113 ,  C12Q1/68

CPC分类号： C12N15/113 ,  A61K47/48776 ,  C12Q1/6813 ,  C12Q1/6827 ,  C12Q1/6848 ,  A61K38/00 ,  C12N2310/111 ,  C12N2310/126 ,  C12N2799/027

摘要： It has been discovered that any RNA can be targeted for cleavage by RNase P from prokaryotic or eukaryotic cells using a suitably designed oligonucleotide ("external guide sequence", or EGS) to form a hybrid with the target RNA, thereby creating a substrate for cleavage by RNase P in vitro. The EGS hydrogen bonds to the targeted RNA to form a partial tRNA like structure including the aminoacyl acceptor stem, the T stem and loop, and part of the D stem. An EGS can be modified both by changes in sequence and by chemical modifications to the nucleotides. The EGS can be a separate molecule or can be combined with an RNase P catalytic RNA sequence to form a single oligonucleotide molecule ("RNase P internal guide sequence" or RIGS). Methods are also disclosed to randomly select and to express a suitable EGS or RIGS in vivo to make a selected RNA a target for cleavage by a host cell RNase P or introduced RIGS, thus preventing expression of the function of the target RNA. The methods and compositions should be useful to prevent the expression of disease- or disorder-causing genes in vivo.

摘要翻译： PCT No.PCT / US95 / 02816 Sec。 371日期：1996年11月6日 102（e）日期1996年11月6日PCT 1994年3月7日PCT公布。 公开号WO95 / 24489 日期1995年9月14日已经发现任何RNA可以使用合适设计的寡核苷酸（“外部引导序列”或EGS）从原核或真核细胞中靶向用RNA酶P切割以与靶RNA形成杂交体，由此 在体外产生RNase P切割的底物。 EGS氢键与靶RNA形成部分tRNA样结构，包括氨酰受体茎，T干和环以及部分D茎。 EGS可以通过序列变化和对核苷酸的化学修饰来修饰。 EGS可以是单独的分子，也可以与RNase P催化RNA序列组合形成单个寡核苷酸分子（“RNase P内部导向序列”或RIGS）。 还公开了在体内随机选择和表达合适的EGS或RIGS的方法，以使选定的RNA成为宿主细胞RNA酶P或引入的RIGS切割的靶标，从而阻止靶RNA功能的表达。 该方法和组合物应该有用于在体内预防疾病或障碍引起的基因的表达。

公开(公告)号：US09276690B2

公开(公告)日：2016-03-01

申请号：US13393964

申请日：2010-04-06

申请人： Dong Wang ,  Yan Yuan

发明人： Dong Wang ,  Yan Yuan

IPC分类号： H04B10/00 ,  H04J14/00 ,  H04J3/16 ,  H04J14/02

CPC分类号： H04J3/1652 ,  H04J14/0212 ,  H04J14/0293 ,  H04J14/0297 ,  H04J2203/0012 ,  H04J2203/0025 ,  H04J2203/0026 ,  H04J2203/0073

摘要： The present invention discloses a distributed electrical cross apparatus, and a system and method for the distributed electrical cross apparatus implementing an SNC cascade protection. The apparatus includes a backboard and at least four single-boards integrated with electrical cross units, wherein the single-boards are inserted in the limited number of slots in the backboard, and these single-boards also set line-side service access units, client-side service access units and backboard access units. The present invention has both accessing of line-side services and accessing of client-side services in the same single-board, access and flexible scheduling of various services such as line-side services and client-side services and so on are implemented on the backboard with limited number of slots, and the function of the distributed electrical cross system processing various services is increased in the case of low cost.

摘要翻译： 本发明公开了一种分布式电交叉装置，以及实现SNC级联保护的分布式交叉装置的系统和方法。 该装置包括背板和至少四个与电叉交叉单元集成的单板，其中单板插入在背板中的有限数量的槽中，并且这些单板还设置线路侧服务访问单元，客户端 服务接入单元和背板接入单元。 本发明在线路侧业务的访问以及客户端业务的访问方面，在同一单板，接入和灵活调度诸如线路侧业务和客户端业务等各种业务的同时， 在具有有限数量的插槽的背板上，并且在低成本的情况下，分布式电交叉系统处理各种服务的功能增加。