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    Carbamoyl-2-pyrrolidinone compounds
    2.
    发明授权
    Carbamoyl-2-pyrrolidinone compounds 失效
    卡巴酸-2-吡咯烷酮化合物

    公开(公告)号：US5229402A

    公开(公告)日：1993-07-20

    申请号：US449923

    申请日：1989-12-13

    申请人： Makoto Kajitani ,  Etsuo Hasegawa ,  Akihiro Kawaguchi ,  Junji Yamamoto ,  Katsuo Toide ,  Takaji Honna ,  Mitsugi Yasumoto ,  Nobuo Kasahara

    发明人： Makoto Kajitani ,  Etsuo Hasegawa ,  Akihiro Kawaguchi ,  Junji Yamamoto ,  Katsuo Toide ,  Takaji Honna ,  Mitsugi Yasumoto ,  Nobuo Kasahara

    IPC分类号： C07D207/26 ,  C07D207/263 ,  C07D207/273 ,  C07D401/12 ,  C07D417/12

    CPC分类号： C07D207/27 ,  C07D207/26 ,  C07D207/273 ,  C07D401/12 ,  C07D417/12

    摘要： The present invention provides a carbamoyl-2-pyrrolidinone compound which has the following formula (2) and is useful as medicaments for treating senile dementia, i.e., as cerebral function improving agents and cerebral metabolism activators or anoxic brain damage protectives ##STR1## wherein R.sup.1 is a hydrogen atom, hydroxyl or lower alkyl substituted or unsubstituted with hydroxyl, and R.sup.3 is phenyl, tetrahydronaphthyl, pyridyl or thiazolyl having or not having lower alkoxyl, lower alkylamino, a halogen atom or halogenomethyl as a substituent.Further, the present invention provides novel carbamoyl-2-pyrrolidinone compounds represented by the formula ##STR2## wherein R.sup.1 is a hydrogen atom, hydroxyl or lower alkyl substituted or unsubstituted with hydroxyl, and R.sup.2 is phenyl, tetrahydronaphthyl, pyridyl or thiazolyl having or not having methoxy or lower alkylamino as a substituent, provided that when R.sup.1 is a hydrogen atom or unsubstituted lower alkyl, R.sup.2 is not unsubstituted phenyl.

    摘要翻译： PCT No.PCT / JP89 / 00401 Sec。 371日期1989年12月13日第 102（e）日期1989年12月13日PCT提交1989年4月12日PCT公布。 公开号WO89 / 09767 本发明提供具有下式（2）的氨基甲酰基-2-吡咯烷酮化合物，可用作治疗老年痴呆的药物，即作为脑功能改善剂和脑代谢激活剂或缺氧性脑 （2）其中R1是氢原子，羟基或被羟基取代或未取代的低级烷基，R3是具有或没有低级烷氧基，低级烷基氨基，卤原子或卤代甲基的苯基，四氢萘基，吡啶基或噻唑基 作为取代基。 此外，本发明提供由式（1）表示的新型氨基甲酰基-2-吡咯烷酮化合物，其中R 1是氢原子，羟基或被羟基取代或未取代的低级烷基，R 2是苯基，四氢萘基，吡啶基或噻唑基 具有或不具有甲氧基或低级烷基氨基作为取代基，条件是当R 1为氢原子或未取代的低级烷基时，R 2为未取代的苯基。

    Oxindole derivative
    4.
    发明授权
    Oxindole derivative 失效
    OXINDOLE DERIVATIVE

    公开(公告)号：US5206261A

    公开(公告)日：1993-04-27

    申请号：US663960

    申请日：1991-03-20

    申请人： Akihiro Kawaguchi ,  Atsushi Sato ,  Makoto Kajitani ,  Mitsugi Yasumoto ,  Junji Yamamoto

    发明人： Akihiro Kawaguchi ,  Atsushi Sato ,  Makoto Kajitani ,  Mitsugi Yasumoto ,  Junji Yamamoto

    IPC分类号： A61K31/40 ,  A61K31/44 ,  C07D209/34 ,  C07D401/06 ,  C07D405/06

    CPC分类号： C07D401/06 ,  C07D209/34 ,  C07D405/06

    摘要： The present invention provides an oxindole derivative which has the following formula and is useful as medicaments for treating senile dementia, i.e., as cerebral function improving agents and cerebral metabolism activators or anoxic brain damage protectives ##STR1## wherein R.sup.1 is hydrogen atom, halogen atom, lower alkyl group or lower alkoxyl group, R.sup.2 is hydrogen atom or lower alkyl group, R.sup.3 is --CH.sub.2 --R.sup.5 group (R.sup.5 being alkyl group which may form a ring; benzodioxanyl group; or phenyl group which may have plural substituents selected from among halogen atom, lower alkyl group, lower alkoxyl group, hydroxyl group, diethylamino group, trifluoromethyl group, nitrile group, nitro group and benzyloxy group), R.sup.2 and R.sup.3 may form together .dbd.CH--R.sup.5 (R.sup.5 being same as above), R.sup.4 is 1-propylbutyl group; pyridyl group; or phenyl group which may be substituted by lower alkoxyl group, halogen atom, diethylamino group, benzyloxy group, trifluoromethyl group, nitrile group, nitro group or lower alkyl group.