公开(公告)号：US09427493B2

公开(公告)日：2016-08-30

申请号：US14026832

申请日：2013-09-13

申请人： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech ,  Michael D. Lowery ,  Daniel Urbaniak

发明人： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech ,  Michael D. Lowery ,  Daniel Urbaniak

IPC分类号： A61L27/16 ,  A61K6/083 ,  A61L27/50 ,  B29D11/02 ,  B29C61/00 ,  B29C61/06 ,  B29L11/00 ,  A61F2/14 ,  A61F2/16

CPC分类号： A61L27/16 ,  A61F2/14 ,  A61F2/142 ,  A61F2/16 ,  A61F2/1659 ,  A61F9/007 ,  A61F2002/1683 ,  A61F2002/169 ,  A61F2002/169053 ,  A61F2002/1696 ,  A61F2002/16965 ,  A61F2210/0014 ,  A61F2240/001 ,  A61L27/26 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  B29C61/003 ,  B29C61/06 ,  B29C69/025 ,  B29D11/023 ,  B29K2995/0037 ,  B29L2011/0016 ,  B29L2031/7532 ,  C08L33/08 ,  C08L33/10

摘要： A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

摘要翻译： 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过角膜或巩膜或其他解剖结构中的小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。

公开(公告)号：US20140172094A1

公开(公告)日：2014-06-19

申请号：US14026832

申请日：2013-09-13

申请人： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech ,  Michael D. Lowery ,  Daniel Urbaniak

发明人： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech ,  Michael D. Lowery ,  Daniel Urbaniak

IPC分类号： A61L27/16 ,  A61L27/50

CPC分类号： A61L27/16 ,  A61F2/14 ,  A61F2/142 ,  A61F2/16 ,  A61F2/1659 ,  A61F9/007 ,  A61F2002/1683 ,  A61F2002/169 ,  A61F2002/169053 ,  A61F2002/1696 ,  A61F2002/16965 ,  A61F2210/0014 ,  A61F2240/001 ,  A61L27/26 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  B29C61/003 ,  B29C61/06 ,  B29C69/025 ,  B29D11/023 ,  B29K2995/0037 ,  B29L2011/0016 ,  B29L2031/7532 ,  C08L33/08 ,  C08L33/10

摘要： A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45

摘要翻译： 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过角膜或巩膜或其他解剖结构中的小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值

公开(公告)号：US20140232025A1

公开(公告)日：2014-08-21

申请号：US13500884

申请日：2012-03-07

申请人： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

发明人： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

IPC分类号： B29D11/02

CPC分类号： B29D11/023 ,  A61F2/14 ,  A61F2/142 ,  A61F2/16 ,  A61F2002/16905 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2210/0023 ,  A61L27/16 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  B29C61/003 ,  B29C61/06 ,  B29C69/025 ,  B29L2011/0016 ,  C08L33/08 ,  C08L33/10 ,  C08F2220/1825 ,  C08F2222/108 ,  C08F226/02 ,  C08F2220/302

摘要： A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

摘要翻译： 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过角膜或巩膜或其他解剖结构中的小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。

公开(公告)号：US08685089B2

公开(公告)日：2014-04-01

申请号：US13441754

申请日：2012-04-06

申请人： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

发明人： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

IPC分类号： A61F2/16

CPC分类号： B29D11/023 ,  A61F2/14 ,  A61F2/142 ,  A61F2/16 ,  A61F2002/16905 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2210/0023 ,  A61L27/16 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  B29C61/003 ,  B29C61/06 ,  B29C69/025 ,  B29L2011/0016 ,  C08L33/08 ,  C08L33/10 ,  C08F2220/1825 ,  C08F2222/108 ,  C08F226/02 ,  C08F2220/302

摘要： A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

摘要翻译： 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过在角膜或巩膜或其他解剖结构中小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。

公开(公告)号：US20120232651A1

公开(公告)日：2012-09-13

申请号：US13441754

申请日：2012-04-06

申请人： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

发明人： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

IPC分类号： A61F2/16

CPC分类号： B29D11/023 ,  A61F2/14 ,  A61F2/142 ,  A61F2/16 ,  A61F2002/16905 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2210/0023 ,  A61L27/16 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  B29C61/003 ,  B29C61/06 ,  B29C69/025 ,  B29L2011/0016 ,  C08L33/08 ,  C08L33/10 ,  C08F2220/1825 ,  C08F2222/108 ,  C08F226/02 ,  C08F2220/302

摘要： A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

摘要翻译： 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过在角膜或巩膜或其他解剖结构中小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。

公开(公告)号：US20120232648A1

公开(公告)日：2012-09-13

申请号：US13441764

申请日：2012-04-06

申请人： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

发明人： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

IPC分类号： A61F2/16 ,  A61F2/14

CPC分类号： B29D11/023 ,  A61F2/14 ,  A61F2/142 ,  A61F2/16 ,  A61F2002/16905 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2210/0023 ,  A61L27/16 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  B29C61/003 ,  B29C61/06 ,  B29C69/025 ,  B29L2011/0016 ,  C08L33/08 ,  C08L33/10 ,  C08F2220/1825 ,  C08F2222/108 ,  C08F226/02 ,  C08F2220/302

摘要： A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

摘要翻译： 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过在角膜或巩膜或其他解剖结构中小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。

公开(公告)号：US20120203160A1

公开(公告)日：2012-08-09

申请号：US13501599

申请日：2010-10-12

申请人： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

发明人： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

IPC分类号： A61F9/007

CPC分类号： A61F9/00781 ,  A61K9/0051 ,  A61L2400/16 ,  A61L2430/16 ,  C08L2201/12

摘要： The present invention provides ocular implants adapted to reside in Schlemm's canal for reducing intraocular pressure of an eye and methods for using the same. In some embodiments the ocular implants comprise a thin rod adapted and configured to extend in a curved volume in Schlemm's canal. The thin rod comprises a plurality of wave-shaped segments such that a sufficient number and amount of wave-shaped segments extend to the inner wall of the trabecular meshwork and to the outer wall of Schlemm's canal thereby keeping Schlemm's canal open.

摘要翻译： 本发明提供适于驻留在施莱姆氏管中以减少眼睛眼内压的眼部植入物及其使用方法。 在一些实施例中，眼部植入物包括适于和构造成在Schlemm管中以弯曲体积延伸的细杆。 细杆包括多个波形段，使得足够数量的波形段延伸到小梁网的内壁和Schlemm管的外壁，从而保持施莱姆管的开放。

公开(公告)号：US20130310931A1

公开(公告)日：2013-11-21

申请号：US13937761

申请日：2013-07-09

申请人： Malik Y. Kahook ,  Naresh Mandava ,  Paul McLean ,  Robert E. Atkinson

发明人： Malik Y. Kahook ,  Naresh Mandava ,  Paul McLean ,  Robert E. Atkinson

IPC分类号： A61F2/16

CPC分类号： A61F2/1648 ,  A61F2/16 ,  A61F2/1613 ,  A61F2/1662 ,  A61F9/0017 ,  A61F9/007 ,  A61F9/00736 ,  A61F2002/1681 ,  A61F2002/1683 ,  A61F2002/1689 ,  A61F2002/169 ,  A61F2002/16902 ,  A61F2220/0025 ,  A61F2250/006

摘要： A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary lens for stability. Such attachment may reside radially inside the perimeter of the capsulorhexis and radially outside the field of view to avoid interference with light transmission.

公开(公告)号：US20130190868A1

公开(公告)日：2013-07-25

申请号：US13748207

申请日：2013-01-23

申请人： Malik Y. Kahook ,  Naresh Mandava ,  Paul McLean ,  Robert E. Atkinson

发明人： Malik Y. Kahook ,  Naresh Mandava ,  Paul McLean ,  Robert E. Atkinson

IPC分类号： A61F2/16

CPC分类号： A61F2/1648 ,  A61F2/16 ,  A61F2/1613 ,  A61F2/1662 ,  A61F9/0017 ,  A61F9/007 ,  A61F9/00736 ,  A61F2002/1681 ,  A61F2002/1683 ,  A61F2002/1689 ,  A61F2002/169 ,  A61F2002/16902 ,  A61F2220/0025 ,  A61F2250/006

摘要： A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary lens for stability. Such attachment may reside radially inside the perimeter of the capsulorhexis and radially outside the field of view to avoid interference with light transmission.

公开(公告)号：US20110087138A1

公开(公告)日：2011-04-14

申请号：US12995175

申请日：2009-05-29

申请人： Malik Y. Kahook

发明人： Malik Y. Kahook

IPC分类号： A61F9/00

CPC分类号： A61F9/00781 ,  A61H23/006 ,  A61H23/02

摘要： The present invention provides devices and methods for non-invasively lowering intraocular pressure. In particular, some non-invasive intraocular pressure lowering devices of the invention comprise an oscillating element having a proximal end and a terminal probe. Typically, the terminal probe of said oscillating element comprises a substantially non-abrasive material that is adapted to be in contact with an ocular surface without causing any significant damage to the tissue and is shaped to conform to ocular surface at the limbal region. Devices also include an oscillating mechanism that is operatively connected to the proximal end of said oscillating tip such that when oscillating mechanism is in operation said oscillating tip moves axially without damaging ocular cells. Intraocular pressure lowering devices of the present invention are capable of non-invasively transmitting mechanical force to the tissue proximate to the limbal tissue.

摘要翻译： 本发明提供了非侵入性降低眼内压的装置和方法。 特别地，本发明的一些非侵入式眼压降低装置包括具有近端和末端探针的振荡元件。 通常，所述振荡元件的端子探针包括基本上非研磨材料，其适于与眼表面接触而不会对组织造成任何显着损伤，并且被成形为在角膜缘区域符合眼表面。 设备还包括可操作地连接到所述摆动尖端的近端的摆动机构，使得当摆动机构运行时，所述摆动尖端轴向运动而不损坏眼细胞。 本发明的眼内压降装置能够将机械力非侵入性地传递到靠近边缘组织的组织。