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公开(公告)号：US08685089B2
公开(公告)日：2014-04-01
申请号：US13441754
申请日：2012-04-06
申请人： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
发明人： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
IPC分类号： A61F2/16
CPC分类号： B29D11/023 , A61F2/14 , A61F2/142 , A61F2/16 , A61F2002/16905 , A61F2210/0014 , A61F2210/0019 , A61F2210/0023 , A61L27/16 , A61L27/50 , A61L2400/16 , A61L2430/16 , B29C61/003 , B29C61/06 , B29C69/025 , B29L2011/0016 , C08L33/08 , C08L33/10 , C08F2220/1825 , C08F2222/108 , C08F226/02 , C08F2220/302
摘要： A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.
摘要翻译： 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过在角膜或巩膜或其他解剖结构中小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。
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公开(公告)号：US09427493B2
公开(公告)日：2016-08-30
申请号：US14026832
申请日：2013-09-13
申请人： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech , Michael D. Lowery , Daniel Urbaniak
发明人： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech , Michael D. Lowery , Daniel Urbaniak
IPC分类号： A61L27/16 , A61K6/083 , A61L27/50 , B29D11/02 , B29C61/00 , B29C61/06 , B29L11/00 , A61F2/14 , A61F2/16
CPC分类号： A61L27/16 , A61F2/14 , A61F2/142 , A61F2/16 , A61F2/1659 , A61F9/007 , A61F2002/1683 , A61F2002/169 , A61F2002/169053 , A61F2002/1696 , A61F2002/16965 , A61F2210/0014 , A61F2240/001 , A61L27/26 , A61L27/50 , A61L2400/16 , A61L2430/16 , B29C61/003 , B29C61/06 , B29C69/025 , B29D11/023 , B29K2995/0037 , B29L2011/0016 , B29L2031/7532 , C08L33/08 , C08L33/10
摘要： A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.
摘要翻译： 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过角膜或巩膜或其他解剖结构中的小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。
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公开(公告)号：US20140232025A1
公开(公告)日：2014-08-21
申请号：US13500884
申请日：2012-03-07
申请人： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
发明人： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
IPC分类号： B29D11/02
CPC分类号： B29D11/023 , A61F2/14 , A61F2/142 , A61F2/16 , A61F2002/16905 , A61F2210/0014 , A61F2210/0019 , A61F2210/0023 , A61L27/16 , A61L27/50 , A61L2400/16 , A61L2430/16 , B29C61/003 , B29C61/06 , B29C69/025 , B29L2011/0016 , C08L33/08 , C08L33/10 , C08F2220/1825 , C08F2222/108 , C08F226/02 , C08F2220/302
摘要： A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.
摘要翻译： 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过角膜或巩膜或其他解剖结构中的小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。
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公开(公告)号：US20140172094A1
公开(公告)日：2014-06-19
申请号：US14026832
申请日：2013-09-13
申请人： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech , Michael D. Lowery , Daniel Urbaniak
发明人： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech , Michael D. Lowery , Daniel Urbaniak
CPC分类号： A61L27/16 , A61F2/14 , A61F2/142 , A61F2/16 , A61F2/1659 , A61F9/007 , A61F2002/1683 , A61F2002/169 , A61F2002/169053 , A61F2002/1696 , A61F2002/16965 , A61F2210/0014 , A61F2240/001 , A61L27/26 , A61L27/50 , A61L2400/16 , A61L2430/16 , B29C61/003 , B29C61/06 , B29C69/025 , B29D11/023 , B29K2995/0037 , B29L2011/0016 , B29L2031/7532 , C08L33/08 , C08L33/10
摘要： A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45
摘要翻译： 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过角膜或巩膜或其他解剖结构中的小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值
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公开(公告)号：US20120232651A1
公开(公告)日：2012-09-13
申请号：US13441754
申请日：2012-04-06
申请人： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
发明人： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
IPC分类号： A61F2/16
CPC分类号： B29D11/023 , A61F2/14 , A61F2/142 , A61F2/16 , A61F2002/16905 , A61F2210/0014 , A61F2210/0019 , A61F2210/0023 , A61L27/16 , A61L27/50 , A61L2400/16 , A61L2430/16 , B29C61/003 , B29C61/06 , B29C69/025 , B29L2011/0016 , C08L33/08 , C08L33/10 , C08F2220/1825 , C08F2222/108 , C08F226/02 , C08F2220/302
摘要： A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.
摘要翻译： 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过在角膜或巩膜或其他解剖结构中小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。
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公开(公告)号：US20120232648A1
公开(公告)日：2012-09-13
申请号：US13441764
申请日：2012-04-06
申请人： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
发明人： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
CPC分类号： B29D11/023 , A61F2/14 , A61F2/142 , A61F2/16 , A61F2002/16905 , A61F2210/0014 , A61F2210/0019 , A61F2210/0023 , A61L27/16 , A61L27/50 , A61L2400/16 , A61L2430/16 , B29C61/003 , B29C61/06 , B29C69/025 , B29L2011/0016 , C08L33/08 , C08L33/10 , C08F2220/1825 , C08F2222/108 , C08F226/02 , C08F2220/302
摘要： A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.
摘要翻译： 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过在角膜或巩膜或其他解剖结构中小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。
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公开(公告)号：US20120203160A1
公开(公告)日：2012-08-09
申请号：US13501599
申请日：2010-10-12
申请人： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
发明人： Malik Y. Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61K9/0051 , A61L2400/16 , A61L2430/16 , C08L2201/12
摘要： The present invention provides ocular implants adapted to reside in Schlemm's canal for reducing intraocular pressure of an eye and methods for using the same. In some embodiments the ocular implants comprise a thin rod adapted and configured to extend in a curved volume in Schlemm's canal. The thin rod comprises a plurality of wave-shaped segments such that a sufficient number and amount of wave-shaped segments extend to the inner wall of the trabecular meshwork and to the outer wall of Schlemm's canal thereby keeping Schlemm's canal open.
摘要翻译： 本发明提供适于驻留在施莱姆氏管中以减少眼睛眼内压的眼部植入物及其使用方法。 在一些实施例中，眼部植入物包括适于和构造成在Schlemm管中以弯曲体积延伸的细杆。 细杆包括多个波形段，使得足够数量的波形段延伸到小梁网的内壁和Schlemm管的外壁，从而保持施莱姆管的开放。
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公开(公告)号：US20130267887A1
公开(公告)日：2013-10-10
申请号：US13825495
申请日：2011-09-21
申请人： Malik Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
发明人： Malik Kahook , Naresh Mandava , Robin Shandas , Bryan Rech
CPC分类号： A61F9/00781 , B29C53/02
摘要： A small shunt can be placed within the eye to aid in drainage of aqueous humor from the anterior chamber of the eye to a pocket between the conjunctiva and the sclera to be absorbed, or to secrete through the cornea or the sclera external to the eye for glaucoma or ocular hypertension treatment. This drainage can decrease the pressure of the eye and potentially modify the course of advancing glaucomatous optic neuropathy as it relates to eye pressure. The shunt is formed of a shape memory polymer material and deformed into a smaller form factor to reduce trauma to the eye resulting from the insertion of the shunt through the sclera to the anterior chamber. Once in situ, the shunt deploys in response to body heat or other external stimulus and expands to its original, larger form factor to provide a secure friction fit of the shunt within the scleral tissue and to enlarge the lumen of the shunt to allow for aqueous flow.
摘要翻译： 可以将小分流器放置在眼睛内以帮助房水从眼前房排出到结膜和巩膜之间的口袋中以被吸收，或通过眼睛外部的角膜或巩膜分泌 青光眼或高眼压症治疗。 这种引流可以降低眼睛的压力，并可能改变与眼压有关的青光眼性视神经病变进展。 分流器由形状记忆聚合物材料形成并变形成更小的形状因子，以减少由于将分流器穿过巩膜插入前房而引起的对眼睛的创伤。 一旦就地，分流器响应于身体热量或其他外部刺激部署，并扩展到其原始的更大的形状因子，以提供分流器在巩膜组织内的可靠的摩擦配合并且扩大分流器的内腔以允许水分 流。
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公开(公告)号：US20130310931A1
公开(公告)日：2013-11-21
申请号：US13937761
申请日：2013-07-09
IPC分类号： A61F2/16
CPC分类号： A61F2/1648 , A61F2/16 , A61F2/1613 , A61F2/1662 , A61F9/0017 , A61F9/007 , A61F9/00736 , A61F2002/1681 , A61F2002/1683 , A61F2002/1689 , A61F2002/169 , A61F2002/16902 , A61F2220/0025 , A61F2250/006
摘要： A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary lens for stability. Such attachment may reside radially inside the perimeter of the capsulorhexis and radially outside the field of view to avoid interference with light transmission.
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公开(公告)号：US20130190868A1
公开(公告)日：2013-07-25
申请号：US13748207
申请日：2013-01-23
IPC分类号： A61F2/16
CPC分类号： A61F2/1648 , A61F2/16 , A61F2/1613 , A61F2/1662 , A61F9/0017 , A61F9/007 , A61F9/00736 , A61F2002/1681 , A61F2002/1683 , A61F2002/1689 , A61F2002/169 , A61F2002/16902 , A61F2220/0025 , A61F2250/006
摘要： A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary lens for stability. Such attachment may reside radially inside the perimeter of the capsulorhexis and radially outside the field of view to avoid interference with light transmission.
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