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公开(公告)号：US08660875B2
公开(公告)日：2014-02-25
申请号：US12917434
申请日：2010-11-01
申请人： Manjunath Yedatore , Deepak Bhatia , John Prescott
发明人： Manjunath Yedatore , Deepak Bhatia , John Prescott
IPC分类号： G06Q10/00
CPC分类号： G05B23/0283 , G05B2219/24019 , G06F11/0748 , G06F11/0793 , G06F11/2294 , G06Q10/06311
摘要： A method and system for automated corrective and predictive maintenance is described herein. In one embodiment, a failure notification associated with a tool is received, wherein the failure notification indicates one or more failure events for the tool. Maintenance data associated with the tool is obtained, wherein the maintenance data includes one or more maintenance events for the tool. An optimal schedule is created for the tool by merging the failure notification and the maintenance data.
摘要翻译： 本文描述了用于自动校正和预测维护的方法和系统。 在一个实施例中，接收与工具相关联的故障通知，其中故障通知指示该工具的一个或多个故障事件。 获得与该工具相关联的维护数据，其中维护数据包括用于该工具的一个或多个维护事件。 通过合并故障通知和维护数据，为工具创建最佳时间表。
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公开(公告)号：US20110137697A1
公开(公告)日：2011-06-09
申请号：US12917434
申请日：2010-11-01
申请人： MANJUNATH YEDATORE , Deepak Bhatia , John Prescott
发明人： MANJUNATH YEDATORE , Deepak Bhatia , John Prescott
CPC分类号： G05B23/0283 , G05B2219/24019 , G06F11/0748 , G06F11/0793 , G06F11/2294 , G06Q10/06311
摘要： A method and system for automated corrective and predictive maintenance is described herein. In one embodiment, a failure notification associated with a tool is received, wherein the failure notification indicates one or more failure events for the tool. Maintenance data associated with the tool is obtained, wherein the maintenance data includes one or more maintenance events for the tool. An optimal schedule is created for the tool by merging the failure notification and the maintenance data.
摘要翻译： 本文描述了用于自动校正和预测维护的方法和系统。 在一个实施例中，接收与工具相关联的故障通知，其中故障通知指示该工具的一个或多个故障事件。 获得与该工具相关联的维护数据，其中维护数据包括用于该工具的一个或多个维护事件。 通过合并故障通知和维护数据，为工具创建最佳时间表。
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公开(公告)号：US20050186630A1
公开(公告)日：2005-08-25
申请号：US11107658
申请日：2005-04-15
IPC分类号： C07B61/00 , C07D333/38 , C07D333/70 , C07D401/04 , C07D405/12 , C40B30/04 , G01N33/68 , C12Q1/68 , G01N33/53
CPC分类号： C07D333/38 , C07B2200/11 , C07D333/70 , C07D401/04 , C07D405/12 , C40B30/04 , G01N33/6845 , G01N2500/04
摘要： The invention concerns a method for rapid identification and characterization of binding partners for a target molecule, and for providing binding partners with improved binding affinity. More specifically, the invention concerns an improved tethering method for the rapid identification of at least two binding partners that bind near one another to a target molecule.
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公开(公告)号：US06919178B2
公开(公告)日：2005-07-19
申请号：US09990421
申请日：2001-11-21
IPC分类号： C07B61/00 , C07D333/38 , C07D333/70 , C07D401/04 , C07D405/12 , C40B30/04 , G01N33/68 , C12Q1/68
CPC分类号： C07D333/38 , C07B2200/11 , C07D333/70 , C07D401/04 , C07D405/12 , C40B30/04 , G01N33/6845 , G01N2500/04
摘要： The invention concerns a method for rapid identification and characterization of binding partners for a target molecule, and for providing binding partners with improved binding affinity. More specifically, the invention concerns an improved tethering method for the rapid identification of at least two binding partners that bind near one another to a target molecule.
摘要翻译： 本发明涉及用于快速鉴定和表征靶分子的结合配偶体的方法，并且提供具有改善的结合亲和力的结合配偶体。 更具体地，本发明涉及用于快速鉴定与靶分子彼此接近结合的至少两个结合配偶体的改进的束缚方法。
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公开(公告)号：US20100255022A1
公开(公告)日：2010-10-07
申请号：US12666264
申请日：2008-05-30
CPC分类号： A61K39/08 , A23K20/153 , A23K50/70 , A23K50/75 , A61K2039/523 , A61K2039/53 , A61K2039/542 , A61K2039/552
摘要： There is provided a vaccine for controlling Clostridium perfringens in animals, and particularly necrotic enteritis in poultry. The vaccine may comprise a C. perfringens antigenic polypeptide or variant thereof, a nucleic acid encoding the C. perfringens antigenic polypeptide or variant thereof, or a recombinant cell producing the C. perfringens antigenic polypeptide or variant thereof.
摘要翻译： 提供了用于控制动物产气荚膜梭菌的疫苗，特别是家禽中的坏死性肠炎。 疫苗可以包含产气荚膜梭菌抗原多肽或其变体，编码产气荚膜梭菌抗原多肽或其变体的核酸，或产生产气荚膜梭菌抗原多肽或其变体的重组细胞。
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公开(公告)号：US20050084905A1
公开(公告)日：2005-04-21
申请号：US10666927
申请日：2003-09-17
申请人： John Prescott , Andrew Braisted , Joelle Morrow
发明人： John Prescott , Andrew Braisted , Joelle Morrow
CPC分类号： C40B30/04 , C12Q1/485 , G01N2500/00
摘要： The invention concerns the identification of protein kinase inhibitors that preferentially bind to the inactive conformation of a target protein kinase. The inhibitors are identified by locking the target protein kinase in an inactive conformation, and using Tethering to identify inhibitors preferentially targeting the inactive conformation.
摘要翻译： 本发明涉及优先结合靶蛋白激酶的无活性构象的蛋白激酶抑制剂的鉴定。 通过将靶蛋白激酶锁定在无活性构象中，并使用Tethering鉴定优先靶向非活性构象的抑制物来鉴定抑制剂。
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公开(公告)号：US08501190B2
公开(公告)日：2013-08-06
申请号：US12666264
申请日：2008-05-30
CPC分类号： A61K39/08 , A23K20/153 , A23K50/70 , A23K50/75 , A61K2039/523 , A61K2039/53 , A61K2039/542 , A61K2039/552
摘要： There is provided a vaccine for controlling Clostridium perfringens in animals, and particularly necrotic enteritis in poultry. The vaccine may comprise a C. perfringens antigenic polypeptide or variant thereof, a nucleic acid encoding the C. perfringens antigenic polypeptide or variant thereof, or a recombinant cell producing the C. perfringens antigenic polypeptide or variant thereof.
摘要翻译： 提供了用于控制动物产气荚膜梭菌的疫苗，特别是家禽中的坏死性肠炎。 疫苗可以包含产气荚膜梭菌抗原多肽或其变体，编码产气荚膜梭菌抗原多肽或其变体的核酸，或产生产气荚膜梭菌抗原多肽或其变体的重组细胞。
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公开(公告)号：US20110086837A1
公开(公告)日：2011-04-14
申请号：US12902062
申请日：2010-10-11
申请人： Marcia Belvin , Iris T. Chan , Lori Friedman , Klaus P. Hoeflich , John Prescott , Jeffrey Wallin
发明人： Marcia Belvin , Iris T. Chan , Lori Friedman , Klaus P. Hoeflich , John Prescott , Jeffrey Wallin
IPC分类号： A61K31/5377 , A61P35/02
CPC分类号： A61K31/5377 , A61K31/4523
摘要： The invention relates methods of treating a patient with locally advanced or metastatic solid tumors with a combination of an inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase or PI3K) and an inhibitor of mitogen activated protein kinase (MEK) described herein.
摘要翻译： 本发明涉及用本文所述的磷脂酰肌醇3-激酶（PI3-激酶或PI3K）抑制剂和丝裂原活化蛋白激酶（MEK）抑制剂的组合治疗患有局部晚期或转移性实体瘤的患者的方法。
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