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公开(公告)号:US08932992B2
公开(公告)日:2015-01-13
申请号:US12330709
申请日:2008-12-09
申请人: Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
发明人: Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
CPC分类号: C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要: The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译: 本发明涉及一种合成模板分子的方法。 在本发明的一个方面,模板分子连接到模板,其模板化其合成。 该内容允许生成可以被筛选的文库。 治疗活动。
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公开(公告)号:US07727713B2
公开(公告)日:2010-06-01
申请号:US10175539
申请日:2002-06-20
申请人: Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
发明人: Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
CPC分类号: C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要: The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译: 本发明涉及一种合成模板分子的方法。 在本发明的一个方面,模板分子连接到模板,其模板化其合成。 该内容允许生成可以被筛选的文库。 治疗活动。
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公开(公告)号:US20100016177A1
公开(公告)日:2010-01-21
申请号:US12330709
申请日:2008-12-09
申请人: Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Slok , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Thomas Thisted , Per-Ola Freskgard , Anette Holtmann
发明人: Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Slok , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Thomas Thisted , Per-Ola Freskgard , Anette Holtmann
CPC分类号: C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要: The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译: 本发明涉及一种合成模板分子的方法。 在本发明的一个方面,模板分子连接到模板,其模板化其合成。 该内容允许生成可以被筛选的文库。 治疗活动。
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公开(公告)号:US20060122278A1
公开(公告)日:2006-06-08
申请号:US11269913
申请日:2005-11-08
申请人: Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson
发明人: Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson
IPC分类号: A61K31/192 , A61K31/13 , A61K31/045 , C07C39/12 , C07C50/04
CPC分类号: C07C37/055 , C07C17/263 , C07C17/2632 , C07C37/14 , C07C37/62 , C07C39/17 , C07C39/42 , C07C43/21 , C07C43/225 , C07C43/23 , C07C43/30 , C07C43/303 , C07C45/71 , C07C49/517 , C07C49/753 , C07C49/84 , C07C59/72 , C07C65/17 , C07C65/26 , C07C69/017 , C07C69/24 , C07C69/76 , C07C307/02 , C07C2601/14 , C07C2601/18 , C07C2602/20 , C07C2602/24 , C07D213/30 , C07D263/32 , C07D265/06 , C07D265/10 , C07D295/096 , C07D309/06 , C07D313/04 , C07D319/06 , C07D333/06 , C07D333/16 , C07F9/12 , C07C25/24 , C07C22/08 , C07C25/18
摘要: Disclosed herein are novel di-aromatic compounds and methods for using various di-aromatic compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
摘要翻译: 本文公开了新的二芳族化合物和用于使用各种二芳族化合物治疗和预防与雌激素受体相关的疾病和病症的方法。
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公开(公告)号:US08101651B2
公开(公告)日:2012-01-24
申请号:US12258313
申请日:2008-10-24
IPC分类号: A61K31/381 , C07D333/80
CPC分类号: C07D307/93 , C07D307/91 , C07D333/80
摘要: Disclosed herein are compounds of Formula I as disclosed herein, methods of modulating the activity of an estrogen receptor and methods of treating a disorder associated with estrogen receptors.
摘要翻译: 本文公开的是本文公开的式I的化合物,调节雌激素受体的活性的方法和治疗与雌激素受体相关的病症的方法。
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公开(公告)号:US08822548B2
公开(公告)日:2014-09-02
申请号:US12915354
申请日:2010-10-29
申请人: Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson , Vladimir Sherbukhin , Birgitte Winther Lund
发明人: Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson , Vladimir Sherbukhin , Birgitte Winther Lund
IPC分类号: A61K31/055 , A61K31/05 , C07C37/055 , C07C37/62 , C07D263/32 , C07C39/42
CPC分类号: C07C37/055 , C07C17/263 , C07C17/2632 , C07C37/14 , C07C37/62 , C07C39/17 , C07C39/42 , C07C43/21 , C07C43/225 , C07C43/23 , C07C43/30 , C07C43/303 , C07C45/71 , C07C49/517 , C07C49/753 , C07C49/84 , C07C59/72 , C07C65/17 , C07C65/26 , C07C69/017 , C07C69/24 , C07C69/76 , C07C307/02 , C07C2601/14 , C07C2601/18 , C07C2602/20 , C07C2602/24 , C07D213/30 , C07D263/32 , C07D265/06 , C07D265/10 , C07D295/096 , C07D309/06 , C07D313/04 , C07D319/06 , C07D333/06 , C07D333/16 , C07F9/12 , C07C25/24 , C07C22/08 , C07C25/18
摘要: Disclosed herein are methods of treatment and prevention of diseases and disorders related to estrogen receptors comprising administering novel di-aromatic compounds to patients in need thereof.
摘要翻译: 本文公开了治疗和预防与雌激素受体相关的疾病和病症的方法,包括向有需要的患者施用新的二芳族化合物。
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公开(公告)号:US07825265B2
公开(公告)日:2010-11-02
申请号:US11269913
申请日:2005-11-08
申请人: Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson , Vladimir Sherbukhin , Birgitte Winther Lund
发明人: Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson , Vladimir Sherbukhin , Birgitte Winther Lund
IPC分类号: C07D309/00 , C07D321/00 , C07D405/00
CPC分类号: C07C37/055 , C07C17/263 , C07C17/2632 , C07C37/14 , C07C37/62 , C07C39/17 , C07C39/42 , C07C43/21 , C07C43/225 , C07C43/23 , C07C43/30 , C07C43/303 , C07C45/71 , C07C49/517 , C07C49/753 , C07C49/84 , C07C59/72 , C07C65/17 , C07C65/26 , C07C69/017 , C07C69/24 , C07C69/76 , C07C307/02 , C07C2601/14 , C07C2601/18 , C07C2602/20 , C07C2602/24 , C07D213/30 , C07D263/32 , C07D265/06 , C07D265/10 , C07D295/096 , C07D309/06 , C07D313/04 , C07D319/06 , C07D333/06 , C07D333/16 , C07F9/12 , C07C25/24 , C07C22/08 , C07C25/18
摘要: Disclosed herein are novel di-aromatic compounds and methods for using various di-aromatic compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
摘要翻译: 本文公开了新型二芳族化合物和使用各种二芳族化合物治疗和预防与雌激素受体相关的疾病和病症的方法。
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公开(公告)号:US08470872B2
公开(公告)日:2013-06-25
申请号:US13325160
申请日:2011-12-14
IPC分类号: A61K31/381
CPC分类号: C07D307/93 , C07D307/91 , C07D333/80
摘要: Disclosed herein are compounds of Formula I as disclosed herein, methods of modulating the activity of an estrogen receptor and methods of treating a disorder associated with estrogen receptors.
摘要翻译: 本文公开的是本文公开的式I的化合物,调节雌激素受体的活性的方法和治疗与雌激素受体相关的病症的方法。
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公开(公告)号:US20090131510A1
公开(公告)日:2009-05-21
申请号:US12258313
申请日:2008-10-24
IPC分类号: A61K31/381 , C07D307/91 , C07D333/76 , A61P25/02 , A61K31/343
CPC分类号: C07D307/93 , C07D307/91 , C07D333/80
摘要: Disclosed herein are compounds of Formula I as disclosed herein, methods of modulating the activity of an estrogen receptor and methods of treating a disorder associated with estrogen receptors.
摘要翻译: 本文公开的是本文公开的式I的化合物,调节雌激素受体的活性的方法和治疗与雌激素受体相关的病症的方法。
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公开(公告)号:US20050256210A1
公开(公告)日:2005-11-17
申请号:US11120397
申请日:2005-05-03
申请人: Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson
发明人: Roger Olsson , Lene Hyldtoft , Fabrice Piu , Magnus Gustafsson
IPC分类号: A61K31/05 , A61K31/055 , A61P5/30 , C07C17/26 , C07C37/14 , C07C39/00 , C07C39/12 , C07C39/17 , C07C39/42 , C07C43/21 , C07C43/225 , C07C43/23 , C07C43/30 , C07C49/753 , C07C59/72 , C07C65/26 , C07D309/12
CPC分类号: C07C43/23 , A61K31/05 , A61K31/055 , C07C17/263 , C07C17/2632 , C07C37/055 , C07C37/14 , C07C37/62 , C07C39/17 , C07C39/42 , C07C43/21 , C07C43/225 , C07C43/30 , C07C49/753 , C07C59/72 , C07C65/26 , C07C2601/14 , C07C2601/18 , C07D309/12 , C07C25/18
摘要: Disclosed herein are novel di-phenyl compounds and methods for using various di-phenyl compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
摘要翻译: 本文公开了新的二苯基化合物和使用各种二苯基化合物治疗和预防与雌激素受体相关的疾病和病症的方法。
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