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公开(公告)号：US08802664B2
公开(公告)日：2014-08-12
申请号：US13825989
申请日：2011-09-27
申请人： Isabelle Berrebi-Bertrand , Xavier Billot , Thierry Calmels , Marc Capet , Denis Danvy , Stephane Krief , Olivier Labeeuw , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Philippe Robert , Jean-Charles Schwartz
发明人： Isabelle Berrebi-Bertrand , Xavier Billot , Thierry Calmels , Marc Capet , Denis Danvy , Stephane Krief , Olivier Labeeuw , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Philippe Robert , Jean-Charles Schwartz
IPC分类号： C07D417/12 , C07D401/12 , C07D401/14 , A61K31/5377 , A61K31/454 , A61K31/428
CPC分类号： C07D417/14 , A61K31/428 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/04 , C07D417/12
摘要： The present patent application concerns new ligands of the H4-receptor of formula (I), their process of preparation and their therapeutic use.
摘要翻译： 本专利申请涉及式（I）的H 4受体的新配体，其制备方法及其治疗用途。
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公开(公告)号：US20130231329A1
公开(公告)日：2013-09-05
申请号：US13825989
申请日：2011-09-27
申请人： Isabelle Berrebi-Bertrand , Xavier Billot , Thierry Calmels , Marc Capet , Denis Danvy , Stéphane Krief , Olivier Labeeuw , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Philippe Robert , Jean-Charles Schwartz
发明人： Isabelle Berrebi-Bertrand , Xavier Billot , Thierry Calmels , Marc Capet , Denis Danvy , Stéphane Krief , Olivier Labeeuw , Jeanne-Marie Lecomte , Nicolas Levoin , Xavier Ligneau , Philippe Robert , Jean-Charles Schwartz
IPC分类号： C07D417/12 , C07D401/12 , C07D401/14 , A61K31/5377 , A61K31/454 , A61K31/428 , A61K31/4545 , A61K31/496 , C07D417/14 , A61K45/06
CPC分类号： C07D417/14 , A61K31/428 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/04 , C07D417/12
摘要： The present patent application concerns new ligands of the H4-receptor of formula (I), their process of preparation and their therapeutic use.
摘要翻译： 本专利申请涉及式（I）的H 4受体的新配体，其制备方法及其治疗用途。
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3.发明申请NOVEL PHARMACEUTICALLY ACCEPTABLE SALTS OF 4-(1H-IMIDAZOL-4-YLMETHYL)PYRIDINE AND THEIR THERAPEUTICAL USES 审中-公开4-（1H-咪唑-4-基）甲基吡啶的新药物接受量及其治疗用途公开(公告)号：US20120129892A1
公开(公告)日：2012-05-24
申请号：US13321479
申请日：2010-05-18
申请人： Marc Capet , Olivier Labeeuw , Isabelle Berrebi-Bertrand , Philippe Robert , Xavier Ligneau , Jeanne-Marie Lecomte , Jean-Charles Schwartz
发明人： Marc Capet , Olivier Labeeuw , Isabelle Berrebi-Bertrand , Philippe Robert , Xavier Ligneau , Jeanne-Marie Lecomte , Jean-Charles Schwartz
IPC分类号： A61K31/4439 , A61P25/06 , A61P25/00 , A61P25/18 , A61P29/00 , A61P9/00 , A61P11/00 , A61P37/08 , A61P1/00 , A61P17/00 , A61P19/02 , A61P27/02 , A61P25/08 , A61P25/24 , A61P37/00 , C07D401/06
CPC分类号： A61K31/4439
摘要： The present invention concerns novel pharmaceutical compositions of immethridine, in particular of novel pharmaceutically acceptable salts thereof, such as the dioxalate salt of immethridine, as well as its therapeutical uses and novel process of preparation.
摘要翻译： 本发明涉及新马来酰亚胺的药物组合物，特别是其新颖的药学上可接受的盐，例如异月桂胺的二恶烷酸盐，以及其治疗用途和新的制备方法。
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公开(公告)号：US08802678B2
公开(公告)日：2014-08-12
申请号：US12306044
申请日：2007-06-21
申请人： Marc Capet , Denis Danvy , Nicolas Levoin , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jeanne-Marie Lecomte , Jean-Charles Schwartz , Xavier Ligneau
发明人： Marc Capet , Denis Danvy , Nicolas Levoin , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jeanne-Marie Lecomte , Jean-Charles Schwartz , Xavier Ligneau
IPC分类号： A61K31/497 , A61K31/4965 , C07D401/06 , C07D413/06 , C07D403/06
CPC分类号： C07D213/74 , C07D211/26 , C07D211/60 , C07D211/70 , C07D215/40 , C07D217/02 , C07D239/42 , C07D295/10 , C07D295/112 , C07D295/135 , C07D295/14 , C07D295/155 , C07D307/24
摘要： The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent.
摘要翻译： 本发明涉及通式（I）的化合物：其制备方法及其作为治疗剂的用途。
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5.发明申请公开(公告)号：US20090286801A1
公开(公告)日：2009-11-19
申请号：US12306044
申请日：2007-06-21
申请人： Marc Capet , Denis Danvy , Nicolas Levoin , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jeanne-Marie Lecomte , Jean-Charles Schwartz , Xavier Ligneau
发明人： Marc Capet , Denis Danvy , Nicolas Levoin , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jeanne-Marie Lecomte , Jean-Charles Schwartz , Xavier Ligneau
IPC分类号： A61K31/496 , C07D241/04 , C07D401/06 , C07D403/04 , C07D401/10 , A61P25/00
CPC分类号： C07D213/74 , C07D211/26 , C07D211/60 , C07D211/70 , C07D215/40 , C07D217/02 , C07D239/42 , C07D295/10 , C07D295/112 , C07D295/135 , C07D295/14 , C07D295/155 , C07D307/24
摘要： The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent.
摘要翻译： 本发明涉及通式（I）的化合物：其制备方法及其作为治疗剂的用途。
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公开(公告)号：US20080167320A1
公开(公告)日：2008-07-10
申请号：US12044243
申请日：2008-03-07
申请人： Marc Capet , Denis Danvy , Nicolas Levoin , Marcel Morvan , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte
发明人： Marc Capet , Denis Danvy , Nicolas Levoin , Marcel Morvan , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte
IPC分类号： A61K31/497 , C07D401/02 , A61P15/10 , A61P25/28 , C07D401/14
CPC分类号： C07D217/22 , C07D215/38
摘要： Compounds of the general formula (I) below: are provided along with a process for preparing them, and these compounds may be used as therapeutic agents, e.g., for prevention and/or treatment of a neuropsychiatric illness or any illness involving the dopamine D3 receptor.
摘要翻译： 以下通式（I）的化合物与其制备方法一起提供，并且这些化合物可用作治疗剂，例如用于预防和/或治疗神经精神疾病或涉及多巴胺D3受体的任何疾病 。
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公开(公告)号：US09266867B2
公开(公告)日：2016-02-23
申请号：US14111438
申请日：2012-04-10
申请人： Marc Capet , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Rajamannar Thennati , Ranjan Kumar Pal , Biswajit Samanta , Muthukumaran Natarajan Pillai , Japan Nitinkumar Desai , Dijixa Chandubhai Rana , Kaushik Dhanjubhai Prajapati , Sandeep Pankajbhai Pathak , Bhavesh M. Panchal , Jayraj D. Aradhye
发明人： Marc Capet , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Rajamannar Thennati , Ranjan Kumar Pal , Biswajit Samanta , Muthukumaran Natarajan Pillai , Japan Nitinkumar Desai , Dijixa Chandubhai Rana , Kaushik Dhanjubhai Prajapati , Sandeep Pankajbhai Pathak , Bhavesh M. Panchal , Jayraj D. Aradhye
IPC分类号： C07D413/10 , C07D271/06 , A61K31/454 , A61K45/06
CPC分类号： C07D413/10 , A61K31/454 , A61K45/06 , C07D271/06
摘要： The present invention relates to novel compounds acting as agonists at S1P (sphingosine-1-phosphate) receptors, compositions containing these compounds, use of these compounds in medicine and their process of preparation.
摘要翻译： 本发明涉及作为S1P（鞘氨醇-1-磷酸）受体的激动剂的新化合物，含有这些化合物的组合物，这些化合物在医药中的应用及其制备方法。
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8.发明申请公开(公告)号：US20140099316A1
公开(公告)日：2014-04-10
申请号：US14111438
申请日：2012-04-10
申请人： Marc Capet , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Rajamannar Thennati , Ranjan Kumar Pal , Biswajit Samanta , Muthukumaran Natarajan Pillai , Japan Nitinkumar Desai , Dijixa Chandubhai Rana , Kaushik Dhanjubhai Prajapati , Sandeep Pankajbhai Pathak , Bhavesh M. Panchal , Jayraj D. Aradhye
发明人： Marc Capet , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Rajamannar Thennati , Ranjan Kumar Pal , Biswajit Samanta , Muthukumaran Natarajan Pillai , Japan Nitinkumar Desai , Dijixa Chandubhai Rana , Kaushik Dhanjubhai Prajapati , Sandeep Pankajbhai Pathak , Bhavesh M. Panchal , Jayraj D. Aradhye
IPC分类号： C07D413/10 , A61K31/454 , A61K45/06 , C07D271/06
CPC分类号： C07D413/10 , A61K31/454 , A61K45/06 , C07D271/06
摘要： The present invention relates to novel compounds acting as agonists at S1P (sphingosine-1-phosphate) receptors, compositions containing these compounds, use of these compounds in medicine and their process of preparation.
摘要翻译： 本发明涉及作为S1P（鞘氨醇-1-磷酸）受体的激动剂的新化合物，含有这些化合物的组合物，这些化合物在医药中的应用及其制备方法。
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9.发明授权公开(公告)号：US07432269B2
公开(公告)日：2008-10-07
申请号：US11252870
申请日：2005-10-19
申请人： Marc Capet , Denis Danvy , Nicolas Levoin , Marcel Morvan , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte
发明人： Marc Capet , Denis Danvy , Nicolas Levoin , Marcel Morvan , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte
IPC分类号： A61K31/497 , C07D401/00 , C07D413/00 , C07D417/00
CPC分类号： C07D217/22 , C07D215/38
摘要： The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent having the property of being selective ligands for the dopamine D3 receptor. These selective D3 ligands are useful as medicines in neuropsychiatry, in particular in the treatment of psychotic or depressive states, or in the treatment of motor disorders, such as dyskinesia or essential tremor. They are furthermore useful in the treatment of dependency on nicotine, cocaine, alcohol, opioids and for facilitating withdrawal in drug-dependent individuals.
摘要翻译： 本发明涉及通式（I）的化合物：其制备方法及其作为具有作为多巴胺D3受体的选择性配体的性质的治疗剂的用途。 这些选择性D3配体可用作神经精神病学中的药物，特别是用于治疗精神病或抑郁状态，或用于治疗运动障碍，例如运动障碍或原发性震颤。 它们还可用于治疗对尼古丁，可卡因，酒精，阿片样物质的依赖，并有利于药物依赖个体的戒断。
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公开(公告)号：US20100249187A1
公开(公告)日：2010-09-30
申请号：US12664718
申请日：2008-06-16
申请人： Marc Capet , Nicolas Levoin , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Jayraj Dilipbhal Aradhye , Muthukumaran Natarajan Pillai , Bhavesh Mohanbhai Panchal , Jignesh Kantilal Jivani , Biswajit Samanta , Ranjan Kumar Pal , Rajamannar Thennati
发明人： Marc Capet , Nicolas Levoin , Isabelle Berrebi-Bertrand , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte , Jayraj Dilipbhal Aradhye , Muthukumaran Natarajan Pillai , Bhavesh Mohanbhai Panchal , Jignesh Kantilal Jivani , Biswajit Samanta , Ranjan Kumar Pal , Rajamannar Thennati
IPC分类号： A61K31/4545 , C07D401/14 , C07D213/02 , A61K31/454 , A61P37/06
CPC分类号： C07D413/10 , C07D271/06 , C07D413/14
摘要： The present invention relates to new compounds of formula (I) possessing agonistic activity at sphingosine-1-phosphate (S1P) receptors, their process of preparation and their use as immunosuppressive agents. The invention is also directed to pharmaceutical compositions containing these compounds and use of these compounds for treatment/prevention of immune mediated diseases and conditions or inflammatory diseases and conditions.
摘要翻译： 本发明涉及在鞘氨醇-1-磷酸（S1P）受体，其制备方法及其作为免疫抑制剂的用途中具有激动作用的式（I）化合物。 本发明还涉及含有这些化合物的药物组合物和这些化合物用于治疗/预防免疫介导的疾病和病症或炎性疾病和病症的药物组合物。
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