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公开(公告)号:US20100196338A1
公开(公告)日:2010-08-05
申请号:US12522714
申请日:2008-01-10
申请人: Marc S. Penn , Matthew Kiedrowski
发明人: Marc S. Penn , Matthew Kiedrowski
CPC分类号: C07K14/4702 , A61K38/00 , A61K48/00 , C07K2319/10
摘要: A fusion protein for treating cardiovascular disease includes a transcription factor (TF) and a cell-penetrating peptide (CPP). The fusion protein can be expressed from a cell that is delivered to the tissue being treated.
摘要翻译: 用于治疗心血管疾病的融合蛋白包括转录因子(TF)和细胞穿透肽(CPP)。 融合蛋白可以从递送到被治疗组织的细胞中表达。
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公开(公告)号:US08445453B2
公开(公告)日:2013-05-21
申请号:US11157603
申请日:2005-06-21
申请人: Marc S. Penn , Matthew Kiedrowski
发明人: Marc S. Penn , Matthew Kiedrowski
CPC分类号: A61K35/28 , A61K38/195 , C12N5/0663 , C12N2501/21 , C12N2502/1323 , A61K2300/00
摘要: Chemokines ligands to at least one of CCR1, CCR2, CCR3, or CCR5 can be used to home stem cells for therapeutic applications.
摘要翻译: CCR1,CCR2,CCR3或CCR5中的至少一个的趋化因子配体可用于家庭干细胞用于治疗应用。
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公开(公告)号:US20100272679A1
公开(公告)日:2010-10-28
申请号:US12808056
申请日:2008-12-15
申请人: Marc S. Penn , Matthew Kiedrowski , Rahul Aras , Joseph Pastore
发明人: Marc S. Penn , Matthew Kiedrowski , Rahul Aras , Joseph Pastore
CPC分类号: A61K38/195 , A61K38/00 , A61K48/00 , C07K14/522
摘要: A method of treating a wound in a subject includes administering directly to the wound or an area proximate the wound an amount of SDF-I effective to promote healing of the wound of the subject.
摘要翻译: 治疗受试者的伤口的方法包括直接对伤口或接近伤口的区域施用有效促进受试者伤口愈合的SDF-1量。
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公开(公告)号:US20060182712A1
公开(公告)日:2006-08-17
申请号:US11157603
申请日:2005-06-21
申请人: Marc Penn , Matthew Kiedrowski
发明人: Marc Penn , Matthew Kiedrowski
CPC分类号: A61K35/28 , A61K38/195 , C12N5/0663 , C12N2501/21 , C12N2502/1323 , A61K2300/00
摘要: Chemokines ligands to at least one of CCR1, CCR2, CCR3, or CCR5 can be used to home stem cells for therapeutic applications.
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公开(公告)号:US20070258943A1
公开(公告)日:2007-11-08
申请号:US11824528
申请日:2007-06-29
申请人: Marc Penn , Matthew Kiedrowski
发明人: Marc Penn , Matthew Kiedrowski
CPC分类号: A61K38/1793 , A61K35/28 , A61K35/545 , A61K38/193 , A61K38/195 , A61K45/06 , A61K48/00 , C12N5/0663 , C12N2501/21 , C12N2510/02 , A61K2300/00
摘要: An isolated mesenchymal stem cell, multipotent adult progenitor cell, or other stem cells is genetically modified to express at least one of CXCR4, SDF-1, or a variant thereof.
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公开(公告)号:US20050271639A1
公开(公告)日:2005-12-08
申请号:US11028922
申请日:2005-01-04
申请人: Marc Penn , Matthew Kiedrowski
发明人: Marc Penn , Matthew Kiedrowski
IPC分类号: A61K35/12 , A61K35/28 , A61K35/545 , A61K48/00 , C12N5/0775 , C12N5/08
CPC分类号: A61K38/1793 , A61K35/28 , A61K35/545 , A61K38/193 , A61K38/195 , A61K45/06 , A61K48/00 , C12N5/0663 , C12N2501/21 , C12N2510/02 , A61K2300/00
摘要: An isolated mesenchymal stem cell, multipotent adult progenitor cell, or other stem cells is genetically modified to express at least one of CXCR4, SDF-1, or a variant thereof.
摘要翻译: 分离的间充质干细胞,多潜能成体祖细胞或其它干细胞被遗传修饰以表达CXCR4,SDF-1或其变体中的至少一种。
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公开(公告)号:US20070224171A1
公开(公告)日:2007-09-27
申请号:US11807282
申请日:2007-05-25
申请人: Marc Penn , Matthew Kiedrowski
发明人: Marc Penn , Matthew Kiedrowski
CPC分类号: A61K38/1793 , A61K35/28 , A61K35/545 , A61K38/193 , A61K38/195 , A61K45/06 , A61K48/00 , C12N5/0663 , C12N2501/21 , C12N2510/02 , A61K2300/00
摘要: An isolated mesenchymal stem cell, multipotent adult progenitor cell, or other stem cells is genetically modified to express at least one of CXCR4, SDF-1, or a variant thereof.
摘要翻译: 分离的间充质干细胞,多潜能成体祖细胞或其它干细胞被遗传修饰以表达CXCR4,SDF-1或其变体中的至少一种。
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