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公开(公告)号：US20060147988A1
公开(公告)日：2006-07-06
申请号：US11370424
申请日：2006-03-07
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/71 , A61K39/00 , C07K16/2803 , C07K16/2863 , G01N33/6872
摘要： The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
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公开(公告)号：US07919588B2
公开(公告)日：2011-04-05
申请号：US12151062
申请日：2008-05-01
IPC分类号： G01N33/53 , C07K14/435
CPC分类号： C07K14/71 , A61K39/00 , C07K16/2803 , C07K16/2863 , G01N33/6872
摘要： The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译： 本发明提供了与作为网蛋白的受体蛋白（一种细胞指导蛋白）起作用的脊椎动物UNC-5蛋白质相关的方法和组合物。 可以从所公开的编码脊椎动物UNC-5的核酸的转化宿主细胞重组产生蛋白质，或者从人细胞纯化。 本发明提供能够与所公开的脊椎动物unc-5基因，脊椎动物UNC-5特异性结合剂如特异性抗体特异性杂交的特异性杂交探针和引物，以及制备和使用本发明组合物在诊断，治疗和 生物制药行业。
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公开(公告)号：US06277585B1
公开(公告)日：2001-08-21
申请号：US09306902
申请日：1999-05-07
IPC分类号： G01N3353
CPC分类号： C07K14/71 , A61K39/00 , C07K16/2803 , C07K16/2863 , G01N33/6872
摘要： The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译： 本发明提供了与作为网蛋白的受体蛋白（一种细胞指导蛋白）起作用的脊椎动物UNC-5蛋白质相关的方法和组合物。 可以从所公开的编码脊椎动物UNC-5的核酸的转化宿主细胞重组产生蛋白质，或者从人细胞纯化。 本发明提供能够与所公开的脊椎动物unc-5基因，脊椎动物UNC-5特异性结合剂如特异性抗体特异性杂交的特异性杂交探针和引物，以及制备和使用本发明组合物在诊断，治疗和 生物制药行业。
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公开(公告)号：US07041806B2
公开(公告)日：2006-05-09
申请号：US10256702
申请日：2002-09-27
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , G01N33/53
CPC分类号： C07K14/71 , A61K39/00 , C07K16/2803 , C07K16/2863 , G01N33/6872
摘要： The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
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公开(公告)号：US20080241857A1
公开(公告)日：2008-10-02
申请号：US12151062
申请日：2008-05-01
IPC分类号： G01N33/68 , C07K14/435 , C07H21/00 , C12N5/08 , C12P21/00
CPC分类号： C07K14/71 , A61K39/00 , C07K16/2803 , C07K16/2863 , G01N33/6872
摘要： The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译： 本发明提供了与作为网蛋白的受体蛋白（一种细胞指导蛋白）起作用的脊椎动物UNC-5蛋白质相关的方法和组合物。 可以从所公开的编码脊椎动物UNC-5的核酸的转化宿主细胞重组产生蛋白质，或者从人细胞纯化。 本发明提供能够与所公开的脊椎动物unc-5基因，脊椎动物UNC-5特异性结合剂如特异性抗体特异性杂交的特异性杂交探针和引物，以及制备和使用本发明组合物在诊断，治疗和 生物制药行业。
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公开(公告)号：US5939271A
公开(公告)日：1999-08-17
申请号：US808982
申请日：1997-02-19
IPC分类号： G01N33/50 , A61K31/7088 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P25/00 , C07K1/00 , C07K14/00 , C07K14/705 , C07K14/71 , C07K16/28 , C07K17/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/68 , C12N15/12
CPC分类号： C07K14/71 , C07K16/2803 , C07K16/2863 , G01N33/6872 , A61K39/00
摘要： The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceuticai industry.
摘要翻译： 本发明提供了与作为网蛋白的受体蛋白（一种细胞指导蛋白）起作用的脊椎动物UNC-5蛋白质相关的方法和组合物。 可以从所公开的编码脊椎动物UNC-5的核酸的转化宿主细胞重组产生蛋白质，或者从人细胞纯化。 本发明提供能够与所公开的脊椎动物unc-5基因，脊椎动物UNC-5特异性结合剂如特异性抗体特异性杂交的特异性杂交探针和引物，以及制备和使用本发明组合物在诊断，治疗和 生物制药行业。
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