Netrin receptors
    1.
    发明授权
    Netrin receptors 有权
    Netrin受体

    公开(公告)号:US06277585B1

    公开(公告)日:2001-08-21

    申请号:US09306902

    申请日:1999-05-07

    IPC分类号: G01N3353

    摘要: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

    摘要翻译: 本发明提供了与作为网蛋白的受体蛋白(一种细胞指导蛋白)起作用的脊椎动物UNC-5蛋白质相关的方法和组合物。 可以从所公开的编码脊椎动物UNC-5的核酸的转化宿主细胞重组产生蛋白质,或者从人细胞纯化。 本发明提供能够与所公开的脊椎动物unc-5基因,脊椎动物UNC-5特异性结合剂如特异性抗体特异性杂交的特异性杂交探针和引物,以及制备和使用本发明组合物在诊断,治疗和 生物制药行业。

    Netrin receptors
    3.
    发明申请
    Netrin receptors 有权
    Netrin受体

    公开(公告)号:US20080241857A1

    公开(公告)日:2008-10-02

    申请号:US12151062

    申请日:2008-05-01

    摘要: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

    摘要翻译: 本发明提供了与作为网蛋白的受体蛋白(一种细胞指导蛋白)起作用的脊椎动物UNC-5蛋白质相关的方法和组合物。 可以从所公开的编码脊椎动物UNC-5的核酸的转化宿主细胞重组产生蛋白质,或者从人细胞纯化。 本发明提供能够与所公开的脊椎动物unc-5基因,脊椎动物UNC-5特异性结合剂如特异性抗体特异性杂交的特异性杂交探针和引物,以及制备和使用本发明组合物在诊断,治疗和 生物制药行业。

    Netrin receptors
    5.
    发明授权
    Netrin receptors 有权
    Netrin受体

    公开(公告)号:US07919588B2

    公开(公告)日:2011-04-05

    申请号:US12151062

    申请日:2008-05-01

    IPC分类号: G01N33/53 C07K14/435

    摘要: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

    摘要翻译: 本发明提供了与作为网蛋白的受体蛋白(一种细胞指导蛋白)起作用的脊椎动物UNC-5蛋白质相关的方法和组合物。 可以从所公开的编码脊椎动物UNC-5的核酸的转化宿主细胞重组产生蛋白质,或者从人细胞纯化。 本发明提供能够与所公开的脊椎动物unc-5基因,脊椎动物UNC-5特异性结合剂如特异性抗体特异性杂交的特异性杂交探针和引物,以及制备和使用本发明组合物在诊断,治疗和 生物制药行业。