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公开(公告)号：US07919588B2
公开(公告)日：2011-04-05
申请号：US12151062
申请日：2008-05-01
IPC分类号： G01N33/53 , C07K14/435
CPC分类号： C07K14/71 , A61K39/00 , C07K16/2803 , C07K16/2863 , G01N33/6872
摘要： The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译： 本发明提供了与作为网蛋白的受体蛋白（一种细胞指导蛋白）起作用的脊椎动物UNC-5蛋白质相关的方法和组合物。 可以从所公开的编码脊椎动物UNC-5的核酸的转化宿主细胞重组产生蛋白质，或者从人细胞纯化。 本发明提供能够与所公开的脊椎动物unc-5基因，脊椎动物UNC-5特异性结合剂如特异性抗体特异性杂交的特异性杂交探针和引物，以及制备和使用本发明组合物在诊断，治疗和 生物制药行业。
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公开(公告)号：US20060147988A1
公开(公告)日：2006-07-06
申请号：US11370424
申请日：2006-03-07
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/71 , A61K39/00 , C07K16/2803 , C07K16/2863 , G01N33/6872
摘要： The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
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公开(公告)号：US06277585B1
公开(公告)日：2001-08-21
申请号：US09306902
申请日：1999-05-07
IPC分类号： G01N3353
CPC分类号： C07K14/71 , A61K39/00 , C07K16/2803 , C07K16/2863 , G01N33/6872
摘要： The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译： 本发明提供了与作为网蛋白的受体蛋白（一种细胞指导蛋白）起作用的脊椎动物UNC-5蛋白质相关的方法和组合物。 可以从所公开的编码脊椎动物UNC-5的核酸的转化宿主细胞重组产生蛋白质，或者从人细胞纯化。 本发明提供能够与所公开的脊椎动物unc-5基因，脊椎动物UNC-5特异性结合剂如特异性抗体特异性杂交的特异性杂交探针和引物，以及制备和使用本发明组合物在诊断，治疗和 生物制药行业。
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公开(公告)号：US07041806B2
公开(公告)日：2006-05-09
申请号：US10256702
申请日：2002-09-27
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , G01N33/53
CPC分类号： C07K14/71 , A61K39/00 , C07K16/2803 , C07K16/2863 , G01N33/6872
摘要： The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
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公开(公告)号：US20080241857A1
公开(公告)日：2008-10-02
申请号：US12151062
申请日：2008-05-01
IPC分类号： G01N33/68 , C07K14/435 , C07H21/00 , C12N5/08 , C12P21/00
CPC分类号： C07K14/71 , A61K39/00 , C07K16/2803 , C07K16/2863 , G01N33/6872
摘要： The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译： 本发明提供了与作为网蛋白的受体蛋白（一种细胞指导蛋白）起作用的脊椎动物UNC-5蛋白质相关的方法和组合物。 可以从所公开的编码脊椎动物UNC-5的核酸的转化宿主细胞重组产生蛋白质，或者从人细胞纯化。 本发明提供能够与所公开的脊椎动物unc-5基因，脊椎动物UNC-5特异性结合剂如特异性抗体特异性杂交的特异性杂交探针和引物，以及制备和使用本发明组合物在诊断，治疗和 生物制药行业。
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公开(公告)号：US5939271A
公开(公告)日：1999-08-17
申请号：US808982
申请日：1997-02-19
IPC分类号： G01N33/50 , A61K31/7088 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P25/00 , C07K1/00 , C07K14/00 , C07K14/705 , C07K14/71 , C07K16/28 , C07K17/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/68 , C12N15/12
CPC分类号： C07K14/71 , C07K16/2803 , C07K16/2863 , G01N33/6872 , A61K39/00
摘要： The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceuticai industry.
摘要翻译： 本发明提供了与作为网蛋白的受体蛋白（一种细胞指导蛋白）起作用的脊椎动物UNC-5蛋白质相关的方法和组合物。 可以从所公开的编码脊椎动物UNC-5的核酸的转化宿主细胞重组产生蛋白质，或者从人细胞纯化。 本发明提供能够与所公开的脊椎动物unc-5基因，脊椎动物UNC-5特异性结合剂如特异性抗体特异性杂交的特异性杂交探针和引物，以及制备和使用本发明组合物在诊断，治疗和 生物制药行业。
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公开(公告)号：US6087326A
公开(公告)日：2000-07-11
申请号：US007604
申请日：1998-01-15
IPC分类号： G01N33/53 , A61K38/00 , C07K14/475 , C07K14/48 , C07K14/52 , C07K14/71 , C07K14/715 , C12N15/00 , C12N15/09 , C12Q1/02 , G01N33/566 , A61K38/02 , A61K38/17 , C07K2/00 , C07K14/435
CPC分类号： C07K14/71 , C07K14/475 , A61K38/00
摘要： Compositions for identifying lead compounds for pharmacological agents useful in the diagnosis or treatment of neurological disease or injury include mixtures comprising an isolated netrin and an isolated natural netrin receptor such as "Deleted in Colorectal Carcinoma" (DCC) and neogenin. The general methods involve incubating a mixture of an isolated mammalian netrin, an isolated natural mammalian netrin receptor, and a candidate pharmacological agent, and determining if the presence of the agent modulates the binding of the netrin to the receptor.
摘要翻译： 用于鉴定可用于诊断或治疗神经疾病或损伤的药理学试剂的铅化合物的组合物包括包含分离的网状蛋白和分离的天然netrin受体的混合物，例如“在结肠直肠癌中被删除”（DCC）和新生素。 一般方法包括孵育分离的哺乳动物netrin，分离的天然哺乳动物netrin受体和候选药理学试剂的混合物，并确定试剂的存在是否调节netrin与受体的结合。
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公开(公告)号：US5747262A
公开(公告)日：1998-05-05
申请号：US551874
申请日：1995-10-16
IPC分类号： G01N33/53 , A61K38/00 , C07K14/475 , C07K14/48 , C07K14/52 , C07K14/71 , C07K14/715 , C12N15/00 , C12N15/09 , C12Q1/02 , G01N33/566
CPC分类号： C07K14/71 , C07K14/475 , A61K38/00
摘要： Compositions for identifying lead compounds for pharmacological agents useful in the diagnosis or treatment of neurological disease or injury include mixtures comprising an isolated netrin and an isolated natural netrin receptor such as "Deleted in Colorectal Carcinoma" (DCC) and neogenin. The general methods involve incubating a mixture of an isolated mammalian netrin, an isolated natural mammalian netrin receptor, and a candidate pharmacological agent, and determining if the presence of the agent modulates the binding of the netrin to the receptor.
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