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1.发明申请公开(公告)号：US20110015522A1
公开(公告)日：2011-01-20
申请号：US12811089
申请日：2008-12-23
CPC分类号： A61B8/481 , A61B8/14 , A61B8/5223 , G06F19/12
摘要： An embodiment of a solution is proposed for analyzing a body part of a patient, which is perfused with a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target. An embodiment of a corresponding system includes means for providing an echo signal indicative of a response over time to an interrogation signal of the body part, means for associating the echo signal with a model function of time modeling an evolution over time of the contrast agent in the body part, the model function including a combination of a circulation function modeling the circulation of the contrast agent and a decay function modeling a decay of the echo signal from the immobilized contrast agent, and means for estimating at least one kinetics indicator of the contrast agent from the model function.
摘要翻译： 提出了一种解决方案的实施例，用于分析患者的身体部位，其被灌注了能够在患者体内循环并且基本上固定在生物靶上的造影剂。 相应系统的实施例包括用于提供指示随着时间的响应的回声信号到身体部位的询问信号的装置，用于将回波信号与造影剂随时间推移的模型函数相关联的模块的装置 身体部分，模型功能包括建模造影剂的循环的循环功能和从固定的造影剂对回波信号衰减建模的衰减函数的组合，以及用于估计对比度的至少一个动力学指标的装置 代理从模型函数。
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2.发明授权Quantification analysis of immobilized contrast agent in medical imaging applications 有权医学成像应用中固定化造影剂的定量分析公开(公告)号：US09072492B2
公开(公告)日：2015-07-07
申请号：US12811089
申请日：2008-12-23
CPC分类号： A61B8/481 , A61B8/14 , A61B8/5223 , G06F19/12
摘要： An embodiment analyzes a body part of a patient, which patient is perfused with a contrast agent that is capable of circulating within the patient and of being substantially immobilized on a biological target. An embodiment of a corresponding system provides an echo signal that is indicative of a response over time to an interrogation signal of the body part, fits the echo signal with a time model function that models an evolution over time of the contrast agent in the body part, the time model function including a combination of a circulation function that models the circulation of the contrast agent and a decay function that models a decay of the echo signal from the immobilized contrast agent, and estimates at least one kinetics indicator of the contrast agent from the time model function.
摘要翻译： 一个实施方案分析患者的身体部分，该患者被灌注了能够在患者体内循环并且基本上固定在生物靶上的造影剂。 对应系统的一个实施例提供一个回波信号，其指示随着时间的推移对身体部位的询问信号的响应，将回波信号与时间模型函数拟合，该时间模型函数对身体部位中造影剂的时间演化进行建模 时间模型功能包括对造影剂的循环进行建模的循环功能和对来自固定的造影剂的回波信号的衰减进行建模的衰减函数的组合，并估计造影剂的至少一个动力学指标 时间模型功能。
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3.发明申请公开(公告)号：US20090304593A1
公开(公告)日：2009-12-10
申请号：US12520839
申请日：2007-12-21
CPC分类号： G01S7/52041 , A61B8/481 , G01S7/52026 , G01S7/52038 , G01S7/52071 , G01S7/52074
摘要： An embodiment of a solution is proposed for imaging a body-part that is perfused with a contrast agent. A corresponding method includes the step of providing a sequence of input images (for example, acquired with an ultrasound scanner); the input images offer a digital representation over time of the body-part. Each input image includes a plurality of input values (i.e., pixel or voxel values); each input value is indicative of a response to an interrogation signal (such as an echo signal for ultrasound waves) of a corresponding location of the body-part, which possibly includes the contrast agent. The method further includes the step of generating at least one filtered image from a plurality of selected ones of the input images (such as all of them or a subset thereof). Each filtered image includes a filtered value for each of a plurality of selected ones of the locations (for example, in a region of interest, or ROI). The filtered value of each selected location is indicative of the contrast agent that leaves the selected location after being substantially stationary at the selected location for a period of time, which is comprised between a first non-zero threshold and a second threshold higher than the first threshold (such as because the contrast agent detaches from the location after having been immobilized thereon, or because it was moving very slowly). The filtered value is obtained by reducing, where present, a contribution of the contrast agent that is substantially stationary at the selected location along the selected input images for a period of time equal to or shorter than the first threshold, and by reducing a contribution of the contrast agent that is substantially stationary at the selected location along the selected input images for a period of time equal to or longer than the second threshold.
摘要翻译： 提出了一种解决方案的实施例，用于对用造影剂灌注的身体部位进行成像。 相应的方法包括提供输入图像序列（例如，用超声波扫描器获取）的步骤; 输入图像随着身体部位的时间而提供数字表示。 每个输入图像包括多个输入值（即像素或体素值）; 每个输入值表示对可能包括造影剂的身体部位的对应位置的询问信号（例如超声波的回波信号）的响应。 该方法还包括从输入图像中的多个所选择的图像生成至少一个滤波图像（例如它们全部或其子集）的步骤。 每个滤波图像包括针对多个选择的位置（例如，在感兴趣区域或ROI中）中的每一个的滤波值。 每个所选择的位置的经滤波的值指示造影剂，其在被选择的位置基本上静止一段时间之后离开所选择的位置，该时间段包括在高于第一个的第一非零阈值和第二阈值之间 阈值（例如因为造影剂在被固定在其上之后从该位置分离，或者由于其移动非常缓慢）。 通过在现有的情况下，通过在等于或小于第一阈值的时间段内减少在所选择的位置处基本上静止在所选择的位置处的造影剂的贡献，并且通过减少 所述造影剂在所选择的输入图像的选定位置基本上静止等于或长于所述第二阈值的时间段。
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4.发明授权公开(公告)号：US08512249B2
公开(公告)日：2013-08-20
申请号：US12520839
申请日：2007-12-21
CPC分类号： G01S7/52041 , A61B8/481 , G01S7/52026 , G01S7/52038 , G01S7/52071 , G01S7/52074
摘要： An input image includes a plurality of input values (i.e., pixel or voxel values), each input value indicative of a response to an interrogation signal of a corresponding location of a body-part, which possibly includes a contrast agent. At least one filtered image is generated from a plurality of selected input images and includes a filtered value for each of a plurality of selected ones of the locations. Each filtered value is indicative of the contrast agent leaving the selected location and is obtained by reducing a contribution of the contrast agent that is substantially stationary at the selected location along the selected input images for a period of time equal to or shorter than a first threshold and by reducing a contribution of the contrast agent that is substantially stationary for a period of time equal to or longer than a second higher threshold.
摘要翻译： 输入图像包括多个输入值（即，像素或体元值），每个输入值指示对身体部位的相应位置的询问信号的响应，其可能包括造影剂。 从多个选择的输入图像生成至少一个滤波图像，并且包括针对多个选定位置中的每一个的滤波值。 每个滤波值表示离开所选择的位置的造影剂，并且是通过在所选择的输入图像的等于或小于第一阈值的时间段内减少基本上静止在选定位置的造影剂的贡献而获得的 并且通过减少在等于或长于第二较高阈值的时间段内基本静止的造影剂的贡献。
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公开(公告)号：US20080049994A1
公开(公告)日：2008-02-28
申请号：US11659887
申请日：2005-08-05
IPC分类号： G06K9/00
CPC分类号： G06T7/35 , G06T2207/30048
摘要： An image registration method for use in medical imaging is proposed. The method includes the steps of: providing a sequence of images each one including a digital representation of a body-part under analysis, selecting a reference image within the sequence, the remaining images of the sequence defining moving images, and re-aligning at least one portion of a moving image with respect to the reference image. The step of re-aligning includes: defining a delimitation mask identifying a region on the reference image with which the at least one portion of the moving image has to be re-aligned, and a feature mask identifying a further region on the reference image within which the re-alignment is calculated, determining an optimized transformation for compensating a displacement of the moving image with respect to the reference image by optimizing a similarity measure, and transforming the at least one portion of the moving image according to the optimized transformation. The similarity measure is calculated alternatively between: a) a first computation region identified on the reference image by a computation mask and a second computation region identified by the computation mask on the moving image transformed according to a proposed transformation, the computation mask being determined by the intersection between the feature mask and the delimitation mask transformed according to the proposed transformation, or b) a first computation region identified by a computation mask on the reference image transformed according to a proposed transformation and a second computation region identified by the computation mask on the moving image, the computation mask being determined by the intersection between the feature mask transformed according to the proposed transformation and the delimitation mask, or c) a first computation region identified on the reference image by a computation mask transformed according to the reverse of a proposed transformation and a second computation region identified by the computation mask on the moving image, the computation mask being determined by the intersection between the feature mask transformed according to the proposed transformation and the delimitation mask.
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6.发明授权Image registration method and apparatus for medical imaging based on multiple masks 有权基于多个掩模的医学成像的图像配准方法和装置公开(公告)号：US07912259B2
公开(公告)日：2011-03-22
申请号：US11659887
申请日：2005-08-05
IPC分类号： G06K9/00
CPC分类号： G06T7/35 , G06T2207/30048
摘要： An image registration method for use in medical imaging includes the steps of: providing a sequence of images each one including a digital representation of a body-part under analysis, selecting a reference image within the sequence, the remaining images of the sequence defining moving images, and re-aligning at least one portion of a moving image with respect to the reference image. The step of re-aligning may include: defining a delimitation mask identifying a region on the reference image with which the at least one portion of the moving image has to be re-aligned, and a feature mask identifying a further region on the reference image within which the re-alignment is calculated, determining an optimized transformation for compensating a displacement of the moving image with respect to the reference image by optimizing a similarity measure, and transforming the at least one portion of the moving image according to the optimized transformation.
摘要翻译： 用于医学成像的图像配准方法包括以下步骤：提供每个图像序列，每个图像序列包括正在分析的身体部位的数字表示，选择序列内的参考图像，定义运动图像的序列的剩余图像 并且相对于参考图像重新对准运动图像的至少一部分。 重新对准的步骤可以包括：定义标识在参考图像上必须重新对齐运动图像的至少一部分的参考图像上的区域的定界掩模，以及标识参考图像上的另外区域的特征掩模 在其中计算重新对准，通过优化相似性度量来确定用于补偿运动图像相对于参考图像的位移的优化变换，以及根据优化的变换来变换运动图像的至少一部分。
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公开(公告)号：US08496591B2
公开(公告)日：2013-07-30
申请号：US11794182
申请日：2005-12-21
申请人： Marcel Arditi , Peter Frinking , Nicolas Rognin
发明人： Marcel Arditi , Peter Frinking , Nicolas Rognin
摘要： A perfusion assessment system is proposed. The system includes means for providing an echo-power signal indicative of a perfusion of a contrast agent in a body-part under analysis, the contrast agent being administered as a bolus and undergoing a significant destruction during a passage of the contrast agent in the body-part, means for associating the echo-power signal to a model function including the product between a bolus function indicative of the passage of the contrast agent without said destruction and a reperfusion function indicative of a reperfusion of the contrast agent in the body part following the destruction corresponding to a substantially constant inflow of the contrast agent, and means for estimating at least one perfusion indicator from the bolus function and/or the reperfusion function.
摘要翻译： 提出了灌注评估系统。 该系统包括用于提供指示在分析的身体部位中的造影剂的灌注的回波功率信号的装置，所述造影剂作为推注施用并在造影剂在体内通过期间经历显着的破坏 - 将所述回波功率信号与模型功能相关联的模块功能，所述模型功能包括所述产品在指示所述造影剂通过之前没有所述破坏的推注功能和指示所述造影剂在体内部分再灌注的再灌注功能 对应于造影剂的基本上恒定的流入的破坏，以及用于从推注功能和/或再灌注功能估计至少一个灌注指示符的装置。
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公开(公告)号：US20120237098A1
公开(公告)日：2012-09-20
申请号：US13393633
申请日：2010-09-01
申请人： Nicolas Rognin , Marcel Arditi , Laurent Mercier , Peter Frinking
发明人： Nicolas Rognin , Marcel Arditi , Laurent Mercier , Peter Frinking
IPC分类号： G06K9/00
CPC分类号： G06T7/0016 , G06T2207/10132 , G06T2207/30104
摘要： An embodiment for analyzing a body-part of a patient is proposed. A corresponding data-processing method includes the steps of providing a sequence of input images representing the body-part over an analysis period, each input image including a set of input values each one being indicative of a response to an interrogation signal of a corresponding location of the body-part at a corresponding acquisition instant included in the analysis period, associating an analysis function of time with each one of a set of selected locations, the analysis function modeling a trend of the input values of the selected location in the sequence of input images, and providing a reference function of time for the analysis functions; in an embodiment, the data-processing method further includes comparing the analysis function of each selected location with the reference function to determine a polarity trend representing a trend over the analysis period of a polarity of a divergence between the analysis function of the selected location and the reference function, and creating a parametric image including a parametric value for each selected location, the parametric value being indicative of the polarity trend of the selected location.
摘要翻译： 提出了一种用于分析患者身体部位的实施例。 相应的数据处理方法包括以下步骤：在分析周期内提供表示身体部分的输入图像序列，每个输入图像包括一组输入值，每个输入值指示对相应位置的询问信号的响应 在分析周期中包括的相应采集时刻的身体部分相关联，将时间分析功能与一组选定位置中的每一个相关联，分析功能模拟所选位置的输入值的趋势， 输入图像，并提供分析功能的时间参考功能; 在一个实施例中，数据处理方法还包括将每个所选择的位置的分析功能与参考功能进行比较，以确定代表所选位置的分析功能的极性的分析周期的趋势的极性趋势和 参考功能，以及创建包括每个选定位置的参数值的参数图像，参数值表示所选位置的极性趋势。
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公开(公告)号：US20120082359A1
公开(公告)日：2012-04-05
申请号：US13377143
申请日：2010-06-08
IPC分类号： G06K9/00
CPC分类号： A61B8/5215 , A61B5/72 , A61B6/5211 , A61B8/06 , A61B8/481 , G06T5/009 , G06T5/40 , G06T2207/10132
摘要： An embodiment is proposed for analyzing a body-part. A corresponding embodiment of a data-processing method includes the steps of providing a parametric map including a plurality of parameter values each one characterizing a corresponding location of the body-part, and determining at least one statistical indicator of at least one distribution of a plurality of analysis parameter values corresponding to selected analysis locations, each statistical indicator being indicative of a condition of an analysis region of the body-part defined by the analysis locations. In an embodiment, the step of determining at least one statistical indicator includes, for each distribution of the analysis parameter values, determining a saturation value partitioning an ordered sequence of processing parameter values, corresponding to selected processing locations at least including the analysis locations, into a first subset and a second subset consisting of a number of the processing parameter values being determined according to a predefined auto-scaling percentage, generating an auto-scaled map including, for each processing location, an auto-scaled value being equal to the corresponding processing parameter value if included in the second subset, or the saturation value if the corresponding processing parameter value is included in the first subset, and determining the at least one statistical indicator from the auto-scaled values corresponding to the analysis locations.
摘要翻译： 提出了用于分析身体部位的实施例。 数据处理方法的相应实施例包括以下步骤：提供包括表征身体部位的对应位置的多个参数值的参数图，以及确定至少一个多个分布的分布的统计指标 对应于所选分析位置的分析参数值，每个统计指标指示由分析位置定义的身体部分的分析区域的状况。 在一个实施例中，确定至少一个统计指示符的步骤包括对于分析参数值的每个分布，确定将对应于至少包括分析位置的所选处理位置的处理参数值的有序序列划分为饱和值， 由根据预定义的自动缩放百分比确定的多个处理参数值组成的第一子集和第二子集，生成自动缩放图，包括对于每个处理位置，自动缩放值等于相应的 如果包括在第二子集中则处理参数值，或者如果相应的处理参数值包括在第一子集中则为饱和值，以及根据与分析位置对应的自动缩放值确定至少一个统计指标。
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公开(公告)号：US20090028406A1
公开(公告)日：2009-01-29
申请号：US11918589
申请日：2006-04-13
申请人： Marcel Arditi , Nicolas Rognin , Peter Frinking
发明人： Marcel Arditi , Nicolas Rognin , Peter Frinking
IPC分类号： A61B8/00
CPC分类号： G06T7/20 , A61B8/06 , A61B8/13 , A61B8/463 , A61B8/481 , A61B8/5238 , G01S15/8977 , G06T2207/30004
摘要： An embodiment of a medical imaging system is proposed. The system includes means for providing a sequence of recorded input images each one offering a digital representation at a corresponding instant of a body part being perfused with a contrast agent, each input image including a plurality of visualizing values each one representing a corresponding portion of the body part, and means for associating each sequence of corresponding sets in the input images of at least one visualizing value with a model function of time; the system further includes means for generating a sequence of computed images at further instants, each computed image including a plurality of further visualizing values each one being determined by an instantaneous function-value which is calculated from the associated model function at the corresponding further instant, and means for displaying the sequence of computed images.
摘要翻译： 提出了一种医学成像系统的实施例。 该系统包括用于提供一系列记录的输入图像的装置，每个记录的输入图像在与造影剂灌注的身体部位的对应时刻提供数字表示，每个输入图像包括多个可视化值，每个可视化值表示对应部分 身体部分，以及用于将至少一个可视化值的输入图像中的对应集合的每个序列与时间的模型函数相关联的装置; 该系统还包括用于在其他时刻产生计算图像序列的装置，每个计算图像包括多个另外的可视化值，每个另外的可视化值由在相应的另外时刻从相关联的模型函数计算的瞬时功能值确定， 以及用于显示计算图像序列的装置。
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