公开(公告)号：US20050059031A1

公开(公告)日：2005-03-17

申请号：US10735608

申请日：2003-12-12

申请人： Marcel Bruchez ,  R. Daniels ,  Jennifer Dias ,  Larry Mattheakis ,  Hongjian Liu ,  Aquanette Burt ,  Berndt Christoffer ,  Danith Ly

发明人： Marcel Bruchez ,  R. Daniels ,  Jennifer Dias ,  Larry Mattheakis ,  Hongjian Liu ,  Aquanette Burt ,  Berndt Christoffer ,  Danith Ly

IPC分类号： C12N5/00 ,  C12N5/06 ,  G01N33/50 ,  G01N33/566 ,  G01N33/58 ,  C12Q1/68 ,  A61K33/24

CPC分类号： G01N33/588 ,  B82Y15/00 ,  C07K7/06 ,  G01N33/5008 ,  G01N33/5014 ,  G01N33/5076 ,  G01N33/566 ,  G01N2333/726 ,  G01N2500/10

摘要： Semiconductor nanoparticle complexes comprising semiconductor nanoparticles in association with cationic polymers are described. Also described are methods for enhancing the transport of semiconductor nanoparticles across biological membranes to provide encoded cells. The methods are particularly useful in multiplex settings where a plurality of encoded cells are to be assayed. Kits comprising reagents for performing such methods are also provided.

摘要翻译： 描述了包含与阳离子聚合物结合的半导体纳米颗粒的半导体纳米颗粒络合物。 还描述了用于增强跨越生物膜的半导体纳米颗粒的输送以提供编码细胞的方法。 该方法在多重设置中特别有用，其中要测定多个编码的细胞。 还提供了包含用于执行这些方法的试剂的试剂盒。

公开(公告)号：US20070148634A1

公开(公告)日：2007-06-28

申请号：US11682063

申请日：2007-03-05

申请人： Marcel Bruchez ,  R. Daniels ,  Jennifer Dias ,  Larry Mattheakis ,  Jianquan Liu

发明人： Marcel Bruchez ,  R. Daniels ,  Jennifer Dias ,  Larry Mattheakis ,  Jianquan Liu

IPC分类号： G01N33/53 ,  C12Q1/00

CPC分类号： G01N33/588 ,  B82Y15/00 ,  G01N33/5008 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5041 ,  G01N33/5076 ,  G01N33/5097 ,  G01N33/566 ,  G01N2333/726 ,  G01N2500/10

摘要： Methods, compositions and articles of manufacture for encoding a cell with semiconductor nanocrystals and/or other fluorophors are provided. The encoded cells can be subjected to functional assays in mixed populations, and an assay result can be determined and associated with individual cells by virtue of their code. The methods are particularly useful in multiplex settings where a plurality of encoded cells are to be assayed.

摘要翻译： 提供了用于编码具有半导体纳米晶体和/或其它荧光体的电池的方法，组合物和制品。 编码的细胞可以在混合群体中进行功能测定，并且可以通过其代码确定测定结果并与单个细胞相关联。 该方法在多重设置中特别有用，其中要测定多个编码的细胞。

公开(公告)号：US20080044911A1

公开(公告)日：2008-02-21

申请号：US11874412

申请日：2007-10-18

申请人： Larry Bock ,  R. Daniels ,  Stephen Empedocles ,  John Owicki

发明人： Larry Bock ,  R. Daniels ,  Stephen Empedocles ,  John Owicki

IPC分类号： G01N33/66 ,  G01N33/48

CPC分类号： G01N27/4146 ,  B82Y5/00 ,  C12Q1/001 ,  C12Q1/6825 ,  G01N33/54366 ,  Y10T436/144444

摘要： Methods of detecting a component of interest, a change in charge, a pH, a cellular response using nanosensors are provided. Nanosensors, including nanowires and nanowire arrays comprising functionalized and/or non-functionalized nanowires are provided. Nanosensors are used for detection in cellular fragmentation, multiple concentration analysis, glucose detection, and intracellular analysis.

摘要翻译： 提供了检测感兴趣的组分，电荷变化，pH，使用纳米传感器的细胞反应的方法。 提供纳米传感器，包括纳米线和包含官能化和/或非官能化纳米线的纳米线阵列。 纳米传感器用于细胞分裂，多重浓度分析，葡萄糖检测和细胞内分析中的检测。

公开(公告)号：US20070282247A1

公开(公告)日：2007-12-06

申请号：US11677680

申请日：2007-02-22

申请人： Tejal Desai ,  R. Daniels ,  Vijendra Sahi

发明人： Tejal Desai ,  R. Daniels ,  Vijendra Sahi

IPC分类号： A61M37/00

CPC分类号： A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/622 ,  A61L2400/12 ,  Y10S514/926 ,  Y10S514/927 ,  Y10S977/722 ,  Y10S977/742 ,  Y10S977/762 ,  Y10S977/902 ,  Y10S977/906

摘要： This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, a method of administering a composition to a patient is disclosed which comprises providing a composition-eluting device, said composition-eluting device comprising at least a first surface and a plurality of nanostructures attached to the first surface, and introducing the composition-eluting device into the body of the patient.

摘要翻译： 本发明提供了新颖的纳米纤维增强表面积基材和包括用于各种医疗装置的这种基底的结构，以及用于这种基底和医疗装置的方法和用途。 在一个具体实施方案中，公开了向患者施用组合物的方法，其包括提供组合物洗脱装置，所述组合物洗脱装置至少包括连接到第一表面的第一表面和多个纳米结构， 组合物洗脱装置进入患者体内。

公开(公告)号：US20070264634A1

公开(公告)日：2007-11-15

申请号：US10683583

申请日：2003-10-09

申请人： Larry Bock ,  R. Daniels ,  Stephen Empedocles ,  Chumming Niu ,  John Owicki ,  Vijendra Sahi ,  Calvin Chow ,  George Pontis

发明人： Larry Bock ,  R. Daniels ,  Stephen Empedocles ,  Chumming Niu ,  John Owicki ,  Vijendra Sahi ,  Calvin Chow ,  George Pontis

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12Q1/54 ,  C12M3/00

CPC分类号： G01N27/4146 ,  B82Y5/00 ,  C12Q1/001 ,  C12Q1/6825 ,  G01N33/54366 ,  Y10T436/144444

摘要： Methods of detecting a component of interest, a change in charge, a pH, a cellular response using nanosensors are provided. Nanosensors, including nanowires and nanowire arrays comprising functionalized and/or non-functionalized nanowires are provided. Nanosensors are, used for detection in cellular fragmentation, multiple concentration analysis, glucose detection, and intracellular analysis.

摘要翻译： 提供了检测感兴趣的组分，电荷变化，pH，使用纳米传感器的细胞反应的方法。 提供纳米传感器，包括纳米线和包含官能化和/或非官能化纳米线的纳米线阵列。 纳米传感器用于细胞分裂检测，多重浓度分析，葡萄糖检测和细胞内分析。

公开(公告)号：US20060204738A1

公开(公告)日：2006-09-14

申请号：US11330722

申请日：2006-01-12

申请人： Robert Dubrow ,  Lawrence Bock ,  R. Daniels ,  Veeral Hardev ,  Chunming Niu ,  Vijendra Sahi

发明人： Robert Dubrow ,  Lawrence Bock ,  R. Daniels ,  Veeral Hardev ,  Chunming Niu ,  Vijendra Sahi

IPC分类号： D04H13/00

CPC分类号： A61L31/10 ,  A61F13/02 ,  A61L27/34 ,  A61L2400/12 ,  A61L2420/04 ,  A61N1/05 ,  B82Y30/00 ,  Y10S977/762 ,  Y10S977/764 ,  Y10S977/773 ,  Y10S977/811 ,  Y10S977/813 ,  Y10S977/90 ,  Y10S977/904 ,  Y10S977/906 ,  Y10T428/12111 ,  Y10T428/249924 ,  Y10T428/29

摘要： This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.