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公开(公告)号：US20080138893A1
公开(公告)日：2008-06-12
申请号：US11568834
申请日：2005-06-09
申请人： Lance E. Steward , Marcella A. Gilmore , Ester G. Fernandez-Salas , Shengwen Li , Ronald G. Miller , Kei Roger Aoki
发明人： Lance E. Steward , Marcella A. Gilmore , Ester G. Fernandez-Salas , Shengwen Li , Ronald G. Miller , Kei Roger Aoki
CPC分类号： C07K14/33
摘要： Nucleic acid molecules that comprise modified open reading frames providing increased expression of the encoded active BoNT/E in a heterologous cell, expression constructs and cells comprising such nucleic acid molecules and methods useful for expressing the encoding active BoNT/E from such nucleic acid molecules, expression constructs and cells.
摘要翻译： 包含修饰的开放阅读框的核酸分子提供编码的活性BoNT / E在异源细胞中的表达增加，表达构建体和包含此类核酸分子的细胞和用于从该核酸分子表达编码活性BoNT / E的方法， 表达构建体和细胞。
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公开(公告)号：US07825233B2
公开(公告)日：2010-11-02
申请号：US11568834
申请日：2005-06-09
申请人： Lance E. Steward , Marcella A. Gilmore , Ester G. Fernandez-Salas , Shengwen Li , Ronald G. Miller , Kei Roger Aoki
发明人： Lance E. Steward , Marcella A. Gilmore , Ester G. Fernandez-Salas , Shengwen Li , Ronald G. Miller , Kei Roger Aoki
CPC分类号： C07K14/33
摘要： Nucleic acid molecules that comprise modified open reading frames providing increased expression of the encoded active BoNT/E in a heterologous cell, expression constructs and cells comprising such nucleic acid molecules and methods useful for expressing the encoding active BoNT/E from such nucleic acid molecules, expression constructs and cells.
摘要翻译： 包含修饰的开放阅读框的核酸分子提供编码的活性BoNT / E在异源细胞中的表达增加，表达构建体和包含此类核酸分子的细胞和用于从该核酸分子表达编码活性BoNT / E的方法， 表达构建体和细胞。
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公开(公告)号：US20090023198A1
公开(公告)日：2009-01-22
申请号：US12192873
申请日：2008-08-15
申请人： Marcella A. Gilmore , Shengwen Li , Ester G. Fernandez-Salas , Lance E. Steward , Ronald G. Miller , Kei Roger Aoki
发明人： Marcella A. Gilmore , Shengwen Li , Ester G. Fernandez-Salas , Lance E. Steward , Ronald G. Miller , Kei Roger Aoki
CPC分类号： C07K14/33
摘要： Nucleic acid molecules that comprise modified open reading frames providing increased expression of the encoded active BoNT/A in a heterologous cell, expression constructs and cells comprising such nucleic acid molecules and methods useful for expressing the encoding active BoNT/A from such nucleic acid molecules, expression constructs and cells.
摘要翻译： 包含修饰的开放阅读框的核酸分子提供编码的活性BoNT / A在异源细胞中的表达增加，表达构建体和包含此类核酸分子的细胞以及用于从该核酸分子表达编码活性BoNT / A的方法， 表达构建体和细胞。
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公开(公告)号：US07998489B2
公开(公告)日：2011-08-16
申请号：US12192905
申请日：2008-08-15
申请人： Lance E. Steward , Ester G. Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Shengwen Li , Kei Roger Aoki
发明人： Lance E. Steward , Ester G. Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Shengwen Li , Kei Roger Aoki
CPC分类号： C07K14/33 , C07K2319/33 , C07K2319/55
摘要： The specification discloses modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; polynucleotide molecules encoding modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; and method of producing modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain.
摘要翻译： 该说明书公开了修饰的梭菌毒素，其包含PAR配体结构域，梭菌毒素酶促结构域，梭菌毒素易位结构域和梭菌毒素结合结构域; 编码经修饰的梭菌毒素的多核苷酸分子，其包含PAR配体结构域，梭菌毒素酶促结构域，梭菌毒素易位结构域和梭菌毒素结合结构域; 以及产生包含PAR配体结构域，梭菌毒素酶促结构域，梭菌毒素易位结构域和梭菌毒素结合结构域的修饰梭菌毒素的方法。
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公开(公告)号：US20090023901A1
公开(公告)日：2009-01-22
申请号：US12192905
申请日：2008-08-15
申请人： Lance E. Steward , Ester G. Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Shengwen Li , Kei Roger Aoki
发明人： Lance E. Steward , Ester G. Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Shengwen Li , Kei Roger Aoki
CPC分类号： C07K14/33 , C07K2319/33 , C07K2319/55
摘要： The specification discloses modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; polynucleotide molecules encoding modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; and method of producing modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain.
摘要翻译： 该说明书公开了修饰的梭菌毒素，其包含PAR配体结构域，梭菌毒素酶促结构域，梭菌毒素易位结构域和梭菌毒素结合结构域; 编码经修饰的梭菌毒素的多核苷酸分子，其包含PAR配体结构域，梭菌毒素酶促结构域，梭菌毒素易位结构域和梭菌毒素结合结构域; 以及产生包含PAR配体结构域，梭菌毒素酶促结构域，梭菌毒素易位结构域和梭菌毒素结合结构域的修饰梭菌毒素的方法。
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6.发明申请MODIFIED CLOSTRIDIAL TOXINS WITH ENHANCED TRANSLOCATION CAPABILITIES AND ALTERED TARGETING ACTIVITY FOR CLOSTRIDIAL TOXIN TARGET CELLS 有权具有增强的转录能力的修饰的关节炎毒素和用于闭合毒素靶向细胞的改变的靶向活性公开(公告)号：US20080241881A1
公开(公告)日：2008-10-02
申请号：US11776052
申请日：2007-07-11
申请人： Lance E. Steward , Joseph Francis , Ester G. Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester G. Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , Kei Roger Aoki
CPC分类号： C12N9/52 , C07K14/33 , C07K2319/00 , C07K2319/50 , C12N2760/16011 , C12N2760/18111 , C12N2760/18211 , C12N2760/18311 , C12N2760/18411 , C12N2760/18611 , C12N2760/20211 , C12N2770/36111
摘要： The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain, a translocation facilitating domain and an altered target domain; polynucleotide molecules encoding such modified Clostridial toxins; and methods of producing such modified Clostridial toxins.
摘要翻译： 该说明书公开了包含梭菌毒素酶促结构域，梭菌毒素易位结构域，易位结构域和改变的靶结构域的经修饰的梭菌毒素; 编码这种经修饰的梭菌毒素的多核苷酸分子; 以及生产这种经修饰的梭菌毒素的方法。
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7.发明授权Modified clostridial toxins with enhanced translocation capability and enhanced targeting activity 有权改良梭菌毒素具有增强的易位能力和增强的靶向活性公开(公告)号：US08518417B1
公开(公告)日：2013-08-27
申请号：US11776043
申请日：2007-07-11
申请人： Lance E. Steward , Joseph Francis , Ester G. Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester G. Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , Kei Roger Aoki
CPC分类号： C12N9/52 , A61K38/00 , C07K14/33 , C07K2319/01 , C12N9/96
摘要： The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain, a translocation facilitating domain and an enhanced targeting domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.
摘要翻译： 该说明书公开了修饰的梭菌毒素，其包含梭菌毒素酶促结构域，梭菌毒素易位结构域，易位域和增强的靶向结构域; 编码这种经修饰的梭菌毒素的多核苷酸分子; 以及生产这种经修饰的梭菌毒素的方法。
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8.发明申请MODIFIED CLOSTRIDIAL TOXINS WITH ENHANCED TRANSLOCATION CAPABILITY AND ENHANCED TARGETING ACTIVITY 有权具有增强转录能力和增强目标活动的改性离子毒素公开(公告)号：US20130203148A1
公开(公告)日：2013-08-08
申请号：US11776043
申请日：2007-07-11
申请人： Lance E. Steward , Joseph Francis , Ester G. Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester G. Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , Kei Roger Aoki
IPC分类号： C12N9/96
CPC分类号： C12N9/52 , A61K38/00 , C07K14/33 , C07K2319/01 , C12N9/96
摘要： The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain, a translocation facilitating domain and an enhanced targeting domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.
摘要翻译： 该说明书公开了修饰的梭菌毒素，其包含梭菌毒素酶促结构域，梭菌毒素易位结构域，易位域和增强的靶向结构域; 编码这种经修饰的梭菌毒素的多核苷酸分子; 以及生产这种经修饰的梭菌毒素的方法。
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9.发明授权Modified clostridial toxins with enhanced translocation capabilities and altered targeting activity for clostridial toxin target cells 有权改良梭菌毒素具有增强的易位能力和改变梭菌毒素靶细胞的靶向活性公开(公告)号：US07993656B2
公开(公告)日：2011-08-09
申请号：US11776052
申请日：2007-07-11
申请人： Lance E. Steward , Joseph Francis , Ester G. Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester G. Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , Kei Roger Aoki
CPC分类号： C12N9/52 , C07K14/33 , C07K2319/00 , C07K2319/50 , C12N2760/16011 , C12N2760/18111 , C12N2760/18211 , C12N2760/18311 , C12N2760/18411 , C12N2760/18611 , C12N2760/20211 , C12N2770/36111
摘要： The invention provides modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain, a translocation facilitating domain and an altered target domain; polynucleotide molecules encoding such modified Clostridial toxins; and methods of producing such modified Clostridial toxins.
摘要翻译： 本发明提供了修饰的梭菌毒素，其包含梭菌毒素酶促结构域，梭菌毒素易位结构域，易位结构域和改变的靶结构域; 编码这种经修饰的梭菌毒素的多核苷酸分子; 以及生产这种经修饰的梭菌毒素的方法。
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公开(公告)号：US07892565B2
公开(公告)日：2011-02-22
申请号：US11572512
申请日：2005-09-01
申请人： Lance E. Steward , Ester G. Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Shengwen Li , Kei Roger Aoki
发明人： Lance E. Steward , Ester G. Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Shengwen Li , Kei Roger Aoki
CPC分类号： C07K14/33 , C07K2319/33 , C07K2319/55
摘要： The specification discloses modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; polynucleotide molecules encoding modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; and method of producing modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain.
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