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公开(公告)号：US5268491A
公开(公告)日：1993-12-07
申请号：US962518
申请日：1992-10-16
申请人： Marco Villa , Paolo Cavalleri
发明人： Marco Villa , Paolo Cavalleri
IPC分类号： C07D317/24 , C07C41/48 , C07C43/313 , C07C43/315 , C07D317/32 , C07D319/06 , C07D321/00 , C07D317/12 , C07C41/22 , C07C41/24
CPC分类号： C07D317/32 , C07C41/48
摘要： A process for the selective dehalogenation in position 5 of the naphthalenic nucleus of compounds of formula ##STR1## (wherein X, X.sub.1 and R have the meanings reported in the description) by treatment with a dehalogenating agent selected among hydrogen sulfide, aliphatic thiols or mixtures thereof in an inert anhydrous solvent at acid pH.
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公开(公告)号：US11933070B2
公开(公告)日：2024-03-19
申请号：US16649221
申请日：2018-09-11
申请人： Marco Villa , Danilo Ferremi
发明人： Marco Villa , Danilo Ferremi
CPC分类号： E05B3/04 , E05B1/003 , E05B9/082 , E05B15/0033 , E05B15/04 , E05B17/007 , E05B63/006 , E05Y2201/628 , E05Y2201/682 , E05Y2600/46 , E05Y2600/502 , E05Y2600/61 , E05Y2600/632 , E05Y2900/132 , E05Y2900/148
摘要： A handle assembly for a door or window comprises a handle and a second element, installable on opposite sides of the door or window, and a pin element rotatable around a pin rotation axis and insertable into the handle or in the second element at variable depths. The handle assembly further comprises a friction reducing group positioned coaxially to the pin element and positionable between the handle and the door or window in the axial direction of the pin rotation axis. Clamping devices constrain the handle and/or the second element on the pin element at adjustable distances along the axial direction according to the thickness of the door or window, so that when the handle assembly is installed on the door or window, an axial clamping pressure of the handle and of the second element is maintained on the respective side of the door or window. An installation method of the handle assembly on the door or window is also provided.
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公开(公告)号：US08891910B2
公开(公告)日：2014-11-18
申请号：US13991868
申请日：2011-12-06
CPC分类号： G02F1/225 , G02F1/2255 , G02F2001/212 , G02F2201/122
摘要： A photonic assembly is described. The assembly comprises a substrate. An optical modulator (100) in or on the substrate has an output port coupled to an output waveguide (106) mounted in or on the substrate. A spiller waveguide (107, 108) is mounted in or on the substrate. The spiller waveguide (107, 108) has an input end (109, 110) physically separated from but proximate to the output waveguide (106) so as to collect light spilt from the output port or output waveguide (106). The modulator (106) may be a MZI modulator.
摘要翻译： 描述了光子组件。 组件包括基底。 衬底中或衬底上的光学调制器（100）具有耦合到安装在衬底中或衬底上的输出波导（106）的输出端口。 垃圾波导（107,108）安装在基板中或基板上。 垃圾波导（107,108）具有与输出波导（106）物理分离但接近输出波导（106）的输入端（109,110），以便收集从输出端口或输出波导（106）溢出的光。 调制器（106）可以是MZI调制器。
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公开(公告)号：US07759517B2
公开(公告)日：2010-07-20
申请号：US11571192
申请日：2005-06-22
申请人： Marco Villa , Maurizio Paiocchi , Katiuscia Arrighi , Francesco Corcella , Vincenzo Cannata , Giorgio Soriato , Massimo Verzini
发明人： Marco Villa , Maurizio Paiocchi , Katiuscia Arrighi , Francesco Corcella , Vincenzo Cannata , Giorgio Soriato , Massimo Verzini
IPC分类号： C07C61/08
CPC分类号： C07C231/10 , C07D221/20 , C07C233/08
摘要： The present invention relates to a process for the preparation of gabapentin and, more in particular, to a method of synthesis of 1,1-cyclohexane acetic acid monoamide, an intermediate used in the preparation of gabapentin, comprising the basic hydrolysis reaction of α, -diaminocarbonyl-β,β-pentamethylene glutarimide.
摘要翻译： 本发明涉及一种制备加巴喷丁的方法，更具体地涉及合成1,1-环己烷乙酸单酰胺的方法，该方法是用于制备加巴喷丁的中间体，其包括α的碱性水解反应， - 二氨基羰基 - 和bgr-五亚甲基戊二酰亚胺。
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公开(公告)号：US20090240049A1
公开(公告)日：2009-09-24
申请号：US12383049
申请日：2009-03-18
申请人： Marco Villa , Donato Motolese
发明人： Marco Villa , Donato Motolese
IPC分类号： C07J75/00
CPC分类号： C07J7/009 , C07J43/003
摘要： The present invention provides a purification method for air sensitive steroids, by reacting an amino acid or an analogue thereof with the 21-aldehyde oxidation product of such air sensitive steroids to form an adduct that is separated from the purified air sensitive steroids.
摘要翻译： 本发明通过使氨基酸或其类似物与这种空气敏感性类固醇的21-醛氧化产物反应形成与纯化的空气敏感类固醇分离的加合物，提供了一种用于空气敏感性类固醇的纯化方法。
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6.发明申请Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid 有权制备培美曲塞二酸的冻干药学上可接受的盐的方法公开(公告)号：US20080139810A1
公开(公告)日：2008-06-12
申请号：US11893234
申请日：2007-08-14
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Provided are processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid, in particular, pemetrexed disodium salt, directly from pemetrexed diacid or salts thereof, i.e., without isolating the obtained pemetrexed salt prior to lyophilizing it.
摘要翻译： 本发明提供了培美曲塞二酸的冻干药学上可接受的盐，特别是培美曲塞二钠盐的制备方法，其直接来自培美曲塞二酸或其盐，即在将其冻干之前不分离得到的培美曲塞盐。
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公开(公告)号：US20060035872A1
公开(公告)日：2006-02-16
申请号：US11202191
申请日：2005-08-12
申请人： Marco Villa , Roberta Fretta , Nicola Diulgheroff
发明人： Marco Villa , Roberta Fretta , Nicola Diulgheroff
CPC分类号： C07J41/00 , C07J41/0016
摘要： The present invention provides a method of preparing norelgestromin or norgestimate by reacting the corresponding 3-oxosteroid precursor with hydroxylamine HCl and a base to obtain a reaction mixture forming norelgestromin or norgestimate; monitoring the anti/syn ratio of the norelgestromin or norgestimate produced in the reaction mixture; adding a base to the reaction mixture to neutralize acidity in the reaction mixture when a desired anti/syn ratio is detected; and isolating the norelgestromin or norgestimate. The present invention also provides a process allowing a control of the formation of the anti isomer and syn isomer of norelgestromin or norgestimate by reacting the corresponding 3-oxosteroid precursor with hydroxylamine HCl and a base to obtain a reaction mixture forming norelgestromin or norgestimate; regulating the acidity of the reaction mixture to adjust the anti/syn ratio of the norelgestromin or norgestimate produced in the reaction mixture; adding a base to the reaction mixture to neutralize acidity in the reaction mixture when a desired anti/syn ratio is detected; and isolating the norelgestromin or norgestimate.
摘要翻译： 本发明提供了通过使相应的3-氧代甾体前体与羟胺HCl和碱反应来制备诺美孕酮或诺孕酯的方法，以获得形成诺美孕酮或诺孕酯的反应混合物; 监测反应混合物中产生的去甲孕酮或诺孕酯的抗/顺应比; 当检测到所需的抗/顺式比时，向反应混合物中加入碱以中和反应混合物中的酸度; 并分离去甲孕酮或诺孕酯。 本发明还提供一种方法，其通过使相应的3-氧代甾体前体与羟胺HCl和碱反应以获得形成去甲孕激素或诺孕酯的反应混合物，从而控制去甲孕酮或诺孕酯的抗异构体和顺式异构体的形成; 调节反应混合物的酸度以调节反应混合物中产生的诺美辛溴或诺孕酯的抗/顺比; 当检测到所需的抗/顺式比时，向反应混合物中加入碱以中和反应混合物中的酸度; 并分离去甲孕酮或诺孕酯。
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公开(公告)号：US20050101788A1
公开(公告)日：2005-05-12
申请号：US10509668
申请日：2003-03-26
申请人： Jacopo Zanon , Marco Villa , Francesco Ciardell
发明人： Jacopo Zanon , Marco Villa , Francesco Ciardell
IPC分类号： A61P25/18 , B01J31/22 , C07B61/00 , C07D20060101 , C07D209/04 , C07D209/08 , C07D401/14 , C07F1/08
CPC分类号： C07D401/14 , C07D209/08
摘要： The present invention relates to a novel method for manufacture of sertindole comprising manufacturing 5-chloro-1-(4-fluorophenyl)-indole and converting it to sertindole wherein the method for manufacture of 5-chloro-1-(4-fluorophenyl)-indole comprises reacting 5-chloro-indole with a 4-fluorophenylhalide in the presence of a base, a chelating ligand and catalytic amounts of a copper salt comprising copper(I) or copper(II) and an anion which does not interfere in an unfavourable way with the reaction.
摘要翻译： 本发明涉及一种制造塞丁醇的新方法，其包括制备5-氯-1-（4-氟苯基） - 吲哚并将其转化为三氢吲哚，其中制备5-氯-1-（4-氟苯基） - 吲哚的方法， 吲哚包括在碱，螯合配体和催化量的包含铜（I）或铜（II）的铜盐和不妨碍不利的阴离子的存在下，使5-氯 - 吲哚与4-氟苯基卤反应 方式与反应。
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公开(公告)号：US06211387B1
公开(公告)日：2001-04-03
申请号：US09555509
申请日：2000-06-05
IPC分类号： C07D31500
CPC分类号： C07C33/483 , Y02P20/55
摘要： A compound of formula (II), wherein R1 is chloro, fluoro or trifluoromethyl; R2 is hydrogen, chloro, fluoro or trifluoromethyl; and R is hydrogen or a protective group for the hydroxy moiety useful as an intermediate for the synthesis of antimycotic azole compounnds.
摘要翻译： 式（II）的化合物，其中R 1是氯，氟或三氟甲基; R2是氢，氯，氟或三氟甲基; 并且R是氢或用作羟基部分的保护基团，其用作合成抗真菌唑化合物的中间体。
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公开(公告)号：US6114523A
公开(公告)日：2000-09-05
申请号：US176189
申请日：1998-10-21
IPC分类号： C07B55/00 , C07B61/00 , C07C319/20 , C07C323/56 , C07C323/62 , C07D281/10
CPC分类号： C07D281/10 , C07C319/20
摘要： A process which allows the re-use of compounds of formula ##STR1## in diltiazem synthesis through a process of conversion to a mixture of enantiomers III-(2R,3R) and III-(2S,3S) is described.
摘要翻译： 描述了允许通过转化成对映体III-（2R，3R）和III-（2S，3S）的混合物的方法在地尔硫卓合成中重复使用式的化合物的方法。
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