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    SINGLE CHAIN FC, METHODS OF MAKING AND METHODS OF TREATMENT
    1.
    发明申请
    SINGLE CHAIN FC, METHODS OF MAKING AND METHODS OF TREATMENT 审中-公开
    单链FC，制备方法和治疗方法

    公开(公告)号：US20080260738A1

    公开(公告)日：2008-10-23

    申请号：US12106081

    申请日：2008-04-18

    申请人： Margaret D. Moore ,  Marshall D. Snavely ,  Brian A. Fox ,  Gabriela H. Hoyos

    发明人： Margaret D. Moore ,  Marshall D. Snavely ,  Brian A. Fox ,  Gabriela H. Hoyos

    IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  A61P43/00 ,  C12N1/14 ,  C12N5/06 ,  C12P21/04

    CPC分类号： C07K16/32 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734

    摘要： The present invention relates generally to scFc molecules. The scFc molecules comprise at least two Fc regions and at least one linker, and can be produced in a variety of single chain configurations. The scFc molecules can further comprise at least one binding entity and/or at least one functional molecule. Binding entities can be fused to the scFc molecule in a variety of configurations. The present invention also relates generally to methods for making such molecules and methods for their use. The scFc molecules provided herein can be recombinantly produced. Also provided are monovalent forms of the scFc molecules that have an equivalent or superior ADCC and/or CDC response than do bivalent molecules targeting the same antigens. Provided herein are improved antigen binding compositions. Methods for using the scFc molecules of the present inventions are provided

    摘要翻译： 本发明一般涉及scFc分子。 scFc分子包含至少两个Fc区和至少一个接头，并且可以以多种单链构型生产。 scFc分子可进一步包含至少一个结合实体和/或至少一个功能性分子。 结合实体可以以各种配置融合到scFc分子。 本发明一般还涉及制备这种分子的方法及其使用方法。 本文提供的scFc分子可以重组生产。 还提供了与靶向相同抗原的二价分子相比，具有等同或优异的ADCC和/或CDC响应的scFc分子的单价形式。 本文提供了改进的抗原结合组合物。 提供了使用本发明的scFc分子的方法

    SINGLE CHAIN FC, METHODS OF MAKING AND METHODS OF TREATMENT
    2.
    发明申请
    SINGLE CHAIN FC, METHODS OF MAKING AND METHODS OF TREATMENT 审中-公开
    单链FC，制备方法和治疗方法

    公开(公告)号：US20110081345A1

    公开(公告)日：2011-04-07

    申请号：US12941194

    申请日：2010-11-08

    申请人： Margaret D. Moore ,  Marshall D. Snavely ,  Brian A. Fox

    发明人： Margaret D. Moore ,  Marshall D. Snavely ,  Brian A. Fox

    IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P37/04

    CPC分类号： C07K16/32 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734

    摘要： The present invention relates generally to scFc molecules. The scFc molecules comprise at least two Fc regions and at least one linker, and can be produced in a variety of single chain configurations. The scFc molecules can further comprise at least one binding entity and/or at least one functional molecule. Binding entities can be fused to the scFc molecule in a variety of configurations. The present invention also relates generally to methods for making such molecules and methods for their use. The scFc molecules provided herein can be recombinantly produced. Also provided are monovalent forms of the scFc molecules that have an equivalent or superior ADCC and/or CDC response than do bivalent molecules targeting the same antigens. Provided herein are improved antigen binding compositions. Methods for using the scFc molecules of the present inventions are provided

    摘要翻译： 本发明一般涉及scFc分子。 scFc分子包含至少两个Fc区和至少一个接头，并且可以以多种单链构型生产。 scFc分子可进一步包含至少一个结合实体和/或至少一个功能性分子。 结合实体可以以各种配置融合到scFc分子。 本发明一般还涉及制备这种分子的方法及其使用方法。 本文提供的scFc分子可以重组生产。 还提供了与靶向相同抗原的二价分子相比，具有等同或优异的ADCC和/或CDC响应的scFc分子的单价形式。 本文提供了改进的抗原结合组合物。 提供了使用本发明的scFc分子的方法

    Dimeric fusion proteins and materials and methods for producing them
    4.
    发明授权
    Dimeric fusion proteins and materials and methods for producing them 失效
    二聚融合蛋白及其制备方法

    公开(公告)号：US07381794B2

    公开(公告)日：2008-06-03

    申请号：US11075351

    申请日：2005-03-08

    申请人： Margaret D. Moore ,  Brian A. Fox

    发明人： Margaret D. Moore ,  Brian A. Fox

    IPC分类号： C07K14/705 ,  C07K16/00

    CPC分类号： C07K14/7051 ,  C07K14/49 ,  C07K14/70539 ,  C07K2319/00 ,  C07K2319/30 ,  C12N15/62 ,  C12P21/02

    摘要： Polypeptide fusions, dimeric fusion proteins, and materials and methods for making them are disclosed. One of the polypeptide fusions consists of a non-immunoglobulin polypeptide, a polypeptide linker, a dimerizing domain, and, optionally, a linking polypeptide. Another of the polypeptide fusions consists of a non-immunoglobulin polypeptide, a polypeptide linker, and a second dimerizing domain.

    摘要翻译： 公开了多肽融合物，二聚融合蛋白质及其制备方法。 多肽融合物之一由非免疫球蛋白多肽，多肽接头，二聚化结构域和任选的连接多肽组成。 多肽融合体中的另一种由非免疫球蛋白多肽，多肽接头和第二二聚体结构域组成。

    Trimerizing polypeptides
    6.
    发明授权
    Trimerizing polypeptides 有权
    三聚多肽

    公开(公告)号：US08084230B2

    公开(公告)日：2011-12-27

    申请号：US12686896

    申请日：2010-01-13

    申请人： Margaret Dow Moore ,  Brian A. Fox

    发明人： Margaret Dow Moore ,  Brian A. Fox

    IPC分类号： C12P21/06

    CPC分类号： C12N15/62 ,  A61K38/00 ,  C07K14/005 ,  C07K14/705 ,  C07K2319/03 ,  C07K2319/81 ,  C12N2740/10022 ,  C12N2740/13022

    摘要： The present invention relates to a method of preparing a trimeric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a ZymoZipper (ZZ) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion of the heterologous protein that included in the fusion protein is the extracellular domain of that protein, and the resulting fusion protein is soluble. In another embodiment of the present invention, the ZZ domain is derived from the transmembrane (TM) subunit of a virus envelope protein or another heptad repeat containing gene of a virus genome. The method can be used to produced homo- and hetero-trimeric proteins. The present invention also encompasses DNA molecules, expression vectors, and host cells used in the present method and fusion proteins produced by the present method.

    摘要翻译： 本发明涉及一种三聚蛋白的制备方法，其包括用编码包含ZymoZipper（ZZ）结构域和异源蛋白质的融合蛋白的表达载体转化或转染的宿主细胞。 在一个实施方案中，异源蛋白质是膜蛋白，融合蛋白中包含的异源蛋白质的部分是该蛋白质的细胞外结构域，并且所得的融合蛋白质是可溶的。 在本发明的另一个实施方案中，ZZ结构域衍生自病毒包膜蛋白的跨膜（TM）亚基或其它含有病毒基因组的七重复重复基因。 该方法可用于产生同型和异三聚体蛋白质。 本发明还包括本方法中使用的DNA分子，表达载体和宿主细胞以及通过本发明方法产生的融合蛋白。

    TRIMERIZING POLYPEPTIDES
    7.
    发明申请
    TRIMERIZING POLYPEPTIDES 有权
    调整多糖

    公开(公告)号：US20100297701A1

    公开(公告)日：2010-11-25

    申请号：US12686896

    申请日：2010-01-13

    申请人： Margaret Dow Moore ,  Brian A. Fox

    发明人： Margaret Dow Moore ,  Brian A. Fox

    IPC分类号： C12P21/06

    CPC分类号： C12N15/62 ,  A61K38/00 ,  C07K14/005 ,  C07K14/705 ,  C07K2319/03 ,  C07K2319/81 ,  C12N2740/10022 ,  C12N2740/13022

    摘要： The present invention relates to a method of preparing a trimeric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a ZymoZipper (ZZ) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion of the heterologous protein that included in the fusion protein is the extracellular domain of that protein, and the resulting fusion protein is soluble. In another embodiment of the present invention, the ZZ domain is derived from the transmembrane (TM) subunit of a virus envelope protein or another heptad repeat containing gene of a virus genome. The method can be used to produced homo- and hetero-trimeric proteins. The present invention also encompasses DNA molecules, expression vectors, and host cells used in the present method and fusion proteins produced by the present method.

    摘要翻译： 本发明涉及一种三聚蛋白的制备方法，其包括用编码包含ZymoZipper（ZZ）结构域和异源蛋白质的融合蛋白的表达载体转化或转染的宿主细胞。 在一个实施方案中，异源蛋白质是膜蛋白，融合蛋白中包含的异源蛋白质的部分是该蛋白质的细胞外结构域，并且所得的融合蛋白质是可溶的。 在本发明的另一个实施方案中，ZZ结构域衍生自病毒包膜蛋白的跨膜（TM）亚基或其它含有病毒基因组的七重复重复基因。 该方法可用于产生同型和异三聚体蛋白质。 本发明还包括本方法中使用的DNA分子，表达载体和宿主细胞以及通过本发明方法产生的融合蛋白。

    MATERIALS AND METHODS FOR PREPARING DIMERIC GROWTH FACTORS
    10.
    发明申请
    MATERIALS AND METHODS FOR PREPARING DIMERIC GROWTH FACTORS 审中-公开
    制备二元生长因子的材料与方法

    公开(公告)号：US20090280562A1

    公开(公告)日：2009-11-12

    申请号：US12494050

    申请日：2009-06-29

    申请人： Brian A. Fox ,  Margaret Dow Moore ,  Kristine M. Swiderek ,  Carl W. Birks

    发明人： Brian A. Fox ,  Margaret Dow Moore ,  Kristine M. Swiderek ,  Carl W. Birks

    IPC分类号： C12N15/63 ,  C12N5/10

    CPC分类号： C07K14/49 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/50 ,  C07K2319/735 ,  C12N2710/14043

    摘要： Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365-370, inclusive. The linker polypeptide consists of from 11-40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.

    摘要翻译： 公开了由氨基至羧基末端组成第一PDGF-D生长因子结构域多肽，接头多肽和第二PDGF-D生长因子结构域多肽的蛋白质，以及用于制备蛋白质的材料和方法。 第一和第二PDGF-D生长因子结构域多肽中的每一个由从氨基酸x至氨基酸y的SEQ ID NO：2或SEQ ID NO：4所示的氨基酸残基序列组成，其中x是 246至258（含），y为365-370的整数，包括端值。 接头多肽由11-40个氨基酸残基组成。 蛋白质可用于刺激人和非人动物中骨和/或结缔组织的产生。