摘要:
Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365-370, inclusive. The linker polypeptide consists of from 11-40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.
摘要翻译:公开了由氨基至羧基末端组成第一PDGF-D生长因子结构域多肽,接头多肽和第二PDGF-D生长因子结构域多肽的蛋白质,以及用于制备蛋白质的材料和方法。 第一和第二PDGF-D生长因子结构域多肽中的每一个由从氨基酸x至氨基酸y的SEQ ID NO:2或SEQ ID NO:4所示的氨基酸残基序列组成,其中x是 246至258(含),y为365-370的整数,包括端值。 接头多肽由11-40个氨基酸残基组成。 蛋白质可用于刺激人和非人动物中骨和/或结缔组织的产生。
摘要:
Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO: 2 or SEQ ID NO: 4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365-370, inclusive. The linker polypeptide consists of from 11-40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.
摘要翻译:公开了由氨基至羧基末端组成第一PDGF-D生长因子结构域多肽,接头多肽和第二PDGF-D生长因子结构域多肽的蛋白质,以及用于制备蛋白质的材料和方法。 第一和第二PDGF-D生长因子结构域多肽中的每一个由从氨基酸x至氨基酸y的SEQ ID NO:2或SEQ ID NO:4所示的氨基酸残基序列组成,其中x是 246至258(含),y为365-370的整数,包括端值。 接头多肽由11-40个氨基酸残基组成。 蛋白质可用于刺激人和非人动物中骨和/或结缔组织的产生。
摘要:
Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365–370, inclusive. The linker polypeptide consists of from 11–40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.
摘要翻译:公开了由氨基至羧基末端组成第一PDGF-D生长因子结构域多肽,接头多肽和第二PDGF-D生长因子结构域多肽的蛋白质,以及用于制备蛋白质的材料和方法。 第一和第二PDGF-D生长因子结构域多肽中的每一个由从氨基酸x至氨基酸y的SEQ ID NO:2或SEQ ID NO:4所示的氨基酸残基序列组成,其中x是 246至258(含),y为365-370的整数,包括端值。 接头多肽由11-40个氨基酸残基组成。 蛋白质可用于刺激人和非人动物中骨和/或结缔组织的产生。
摘要:
Disclosed are soluble hybrid Fcγ receptor (FcγR) polypeptide compositions and related methods of using such polypeptides to treat IgG-mediated and immune complex-mediated inflammation. Also disclosed are related compositions and methods for producing the soluble hybrid FcγR polypeptides.
摘要:
Disclosed are soluble hybrid Fcγ receptor (FcγR) polypeptide compositions and related methods of using such polypeptides to treat IgG-mediated and immune complex-mediated inflammation. Also disclosed are related compositions and methods for producing the soluble hybrid FcγR polypeptides.
摘要:
Disclosed are bispecific binding proteins comprising a antibody/soluble receptor bispecific binding protein that reduces the biological activity of both VEGF-A and FGF. The FGF binding moieties are generally soluble FGFR3 or FGFR2. An Fc polypeptide is fused to the C-terminus of the FGF binding moiety and VEGF-A binding moiety are polypeptides fused using peptide or polypeptide linker sequences, and can be expressed as single bispecific binding protein. The bispecific antibody/soluble receptor binding proteins can be used to treat cancers characterized by solid tumor growth as well as other diseases.