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公开(公告)号：US20090202557A1
公开(公告)日：2009-08-13
申请号：US12322088
申请日：2009-01-29
申请人： Maria A. Argiriadi , David W. Borhani , Tao Xiang , Chengbin Wu , Tariq Ghayur
发明人： Maria A. Argiriadi , David W. Borhani , Tao Xiang , Chengbin Wu , Tariq Ghayur
IPC分类号： A61K39/395 , C07K1/00 , C07K14/54 , C07K16/24
CPC分类号： C30B29/58 , C07K1/306 , C07K16/244 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C30B7/00
摘要： The invention provides methods of crystallizing antibodies and fragments thereof as well as crystals produced thereby. More particularly, the invention provides methods of crystallizing human and non-human Fab fragments of antibodies, either alone or as co-crystals with their target ligand. For example, a crystal comprising a murine Fab fragment of the antibody 125-2H or a human Fab fragment of the antibody ABT-325, which bind to IL-18, are provided as well as a co-crystal of a murine Fab fragment bound to IL-18. ABT-325 and 125-2H differ significantly in combining site character and architecture, thus explaining their ability to bind IL-18 simultaneously at distinct epitopes.
摘要翻译： 本发明提供了结晶抗体及其片段以及由此制备的晶体的方法。 更具体地说，本发明提供了将人抗体和非人Fab片段单独结晶或与其靶配体共结晶的方法。 例如，提供了包含结合IL-18的抗体125-2H的鼠Fab片段或抗体ABT-325的人Fab片段的结晶以及结合于鼠Fab片段的共晶体 到IL-18。 ABT-325和125-2H在组合位点特征和结构上有显着差异，从而说明了它们在不同表位同时结合IL-18的能力。
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公开(公告)号：US09035027B2
公开(公告)日：2015-05-19
申请号：US12477711
申请日：2009-06-03
申请人： Tariq Ghayur , Peter C. Isakson , Lisa M. Olson , Chengbin Wu , Margaret Hugunin , Rajesh V. Kamath , Carolyn A. Cuff , Hamish J. Allen
发明人： Tariq Ghayur , Peter C. Isakson , Lisa M. Olson , Chengbin Wu , Margaret Hugunin , Rajesh V. Kamath , Carolyn A. Cuff , Hamish J. Allen
IPC分类号： A61K39/395 , C07K16/46 , C07K16/22 , C07K16/24 , A61K45/06 , A61K47/48 , G01N33/68 , A61K39/00
CPC分类号： C07K16/2887 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K2039/505 , A61K2039/70 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/248 , C07K16/2866 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/545 , Y02A50/386 , Y02A50/41 , Y02A50/412
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：US20130004416A1
公开(公告)日：2013-01-03
申请号：US13601774
申请日：2012-08-31
申请人： Chengbin WU , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
发明人： Chengbin WU , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
IPC分类号： A61K39/395 , A61K49/00 , C12P21/02 , C12N9/96 , C12N5/10 , C12N1/21 , C12N1/15 , C12N1/19 , C12N1/11 , C12N15/63 , C07K16/00 , A61P21/02 , A61P29/00 , A61P23/00 , A61P21/00 , A61P31/04 , A61P17/06 , A61P37/06 , A61P25/24 , A61P25/18 , A61P11/06 , A61P19/02 , A61P1/00 , A61P3/10 , A61P37/08 , A61P17/00 , A61P41/00 , A61P9/10 , A61P13/12 , A61P31/12 , A61P31/00 , A61P25/16 , A61P25/28 , A61P9/00 , A61P11/00 , A61P7/06 , A61P15/00 , A61P19/04 , A61P1/16 , A61P25/32 , A61P35/00 , A61P35/02 , A61P31/18 , A61P25/06 , A61P25/00 , A61P19/10 , A61K51/00
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
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公开(公告)号：US20100047239A1
公开(公告)日：2010-02-25
申请号：US12459624
申请日：2009-07-02
申请人： Chengbin Wu , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
发明人： Chengbin Wu , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/48384 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
摘要翻译： 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及其用于预防和/或治疗急性和慢性炎症和其它疾病的用途。
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公开(公告)号：US20070071675A1
公开(公告)日：2007-03-29
申请号：US11507050
申请日：2006-08-18
申请人： Chengbin Wu , Tariq Ghayur , Richard Dixon , Jochen Salfeld
发明人： Chengbin Wu , Tariq Ghayur , Richard Dixon , Jochen Salfeld
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/48384 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
摘要翻译： 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及其用于预防和/或治疗急性和慢性炎症和其它疾病的用途。
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公开(公告)号：US08853365B2
公开(公告)日：2014-10-07
申请号：US13331422
申请日：2011-12-20
CPC分类号： A61K39/395 , A61K2039/505 , A61K2039/507 , C07K16/245 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00 , Y02A50/386 , Y02A50/41 , Y02A50/412
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译： 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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公开(公告)号：US08841417B2
公开(公告)日：2014-09-23
申请号：US13107439
申请日：2011-05-13
IPC分类号： A61K38/00 , C07K14/545 , C07K16/24 , A61K39/395 , A61K47/48 , A61K45/06 , G01N33/68
CPC分类号： C07K16/245 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K9/007 , A61K9/0085 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K47/6879 , C07K14/545 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/545 , G01N2800/00 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/412 , Y02A50/463 , Y02A50/478 , Y02A50/481
摘要： Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.
摘要翻译： 结合IL-1α和IL-1和bgr的蛋白质 描述其用于治疗，预防和诊断IL-1相关疾病和用于检测IL-1α和IL-1和bgr的组合物和方法中的用途; 在细胞，组织，样品和组合物中。
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公开(公告)号：US08258268B2
公开(公告)日：2012-09-04
申请号：US12459624
申请日：2009-07-02
申请人： Chengbin Wu , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
发明人： Chengbin Wu , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/48384 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
摘要翻译： 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及其用于预防和/或治疗急性和慢性炎症和其它疾病的用途。
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公开(公告)号：US07612181B2
公开(公告)日：2009-11-03
申请号：US11507050
申请日：2006-08-18
申请人： Chengbin Wu , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
发明人： Chengbin Wu , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/48384 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
摘要翻译： 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及其用于预防和/或治疗急性和慢性炎症和其它疾病的用途。
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公开(公告)号：US20090215992A1
公开(公告)日：2009-08-27
申请号：US11890215
申请日：2007-08-03
申请人： Chengbin Wu , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
发明人： Chengbin Wu , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
CPC分类号： C07K16/244 , A61K2039/505 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/468 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
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