公开(公告)号：US20060099687A1

公开(公告)日：2006-05-11

申请号：US11305477

申请日：2005-12-16

申请人： Maria Glucksmann ,  Immaculada Silos-Santiago

发明人： Maria Glucksmann ,  Immaculada Silos-Santiago

IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/705

CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00

摘要： The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.

摘要翻译： 本发明涉及属于G蛋白偶联受体的超家族的新鉴定的受体。 本发明还涉及编码受体的多核苷酸。 本发明还涉及使用受体多肽和多核苷酸作为在受体介导的病症中进行诊断和治疗的靶标的方法。 本发明还涉及使用受体多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于受体多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及产生受体多肽和多核苷酸的方法。

公开(公告)号：US06444802B1

公开(公告)日：2002-09-03

申请号：US09409180

申请日：1999-09-30

申请人： Rosana Kapeller-Libermann ,  David White ,  Immaculada Silos-Santiago

发明人： Rosana Kapeller-Libermann ,  David White ,  Immaculada Silos-Santiago

IPC分类号： C07H2104

CPC分类号： C12N9/48 ,  A01K2217/05 ,  A61K38/00 ,  Y02A50/411 ,  Y10S435/81 ,  Y10S435/975

摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.

摘要翻译： 本发明涉及新鉴定的人类氨基肽酶。 本发明还涉及编码氨基肽酶的多核苷酸。 本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。 本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。

公开(公告)号：US06897056B2

公开(公告)日：2005-05-24

申请号：US09927112

申请日：2001-08-10

申请人： Rachel Meyers ,  Immaculada Silos-Santiago

发明人： Rachel Meyers ,  Immaculada Silos-Santiago

IPC分类号： A61K48/00 ,  C12N9/16 ,  C12N15/54 ,  C12Q1/68 ,  C12N9/20 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00 ,  C12P21/04

CPC分类号： C12Y301/04003 ,  A01K2217/05 ,  A01K2217/075 ,  A61K48/00 ,  A61K2039/505 ,  C07K2319/00 ,  C12N9/16 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

摘要： The invention provides isolated nucleic acids molecules, designated 32544 nucleic acid molecules, which encode novel phospholipase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32544 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 32544 gene has been introduced or disrupted. The invention still further provides isolated 32544 proteins, fusion proteins, antigenic peptides and anti-32544 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供编码新的磷脂酶家族成员的分离的核酸分子，命名为32544核酸分子。 本发明还提供反义核酸分子，含有32544个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及32544基因导入或破坏的非人类转基因动物。 本发明还进一步提供分离的32544蛋白，融合蛋白，抗原肽和抗32544抗体。 还提供了利用本发明组合物的诊断方法。