公开(公告)号：US20070270466A1

公开(公告)日：2007-11-22

申请号：US11810388

申请日：2007-06-04

申请人： Maria-Jesus Blanco-Pillado ,  Michael Cohen ,  Sandra Filla ,  Kevin Hudziak ,  Daniel Kohlman ,  Dana Benesh ,  Frantz Victor ,  Yao-Chang Xu ,  Bai-Ping Ying ,  DeAnna Zacherl ,  Deyi Zhang ,  Brian Mathes

发明人： Maria-Jesus Blanco-Pillado ,  Michael Cohen ,  Sandra Filla ,  Kevin Hudziak ,  Daniel Kohlman ,  Dana Benesh ,  Frantz Victor ,  Yao-Chang Xu ,  Bai-Ping Ying ,  DeAnna Zacherl ,  Deyi Zhang ,  Brian Mathes

IPC分类号： A61K31/4468 ,  A61K31/4523 ,  A61P25/06

CPC分类号： C07D211/58 ,  A61K31/4468 ,  A61K31/4523 ,  C04B35/632 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14

摘要： The present invention relates to compounds of formula I: or a pharmaceutically acceptable acid addition salt thereof, wherein X is C(R3c)═ or N═; R1 is C2-C6 alkyl, substituted C2-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2 is hydrogen, C1-C3 n-alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II provided that when R1 is C2-C6 alkyl or substituted C2-C6 alkyl, R2 is hydrogen or methyl; R3a, R3b and, when X is —C(R3c)═, R3c, are each independently hydrogen, fluoro, or methyl, provided that no more than one of R3a, R3b, and R3c may be other than hydrogen; R4 is hydrogen or C1-C3 alkyl; R5 is hydrogen, C1-C3 alkyl, or C3-C6 cycloalkylcarbonyl, provided that when R3a is other than hydrogen, R5 is hydrogen; R6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5HT1F receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal.

公开(公告)号：US20060287363A1

公开(公告)日：2006-12-21

申请号：US10569109

申请日：2004-09-03

申请人： Maria-Jesus Blanco-Pillado ,  Michael Cohen ,  Sandra Filla ,  Kevin Hudzlak ,  Daniel Kohlman ,  Dana Benesh ,  Frantz Victor ,  Yao-Chang Xu ,  Bai-Ping Ying ,  DeAnna Zacherl ,  Deyi Zhang ,  Brian Mathes

发明人： Maria-Jesus Blanco-Pillado ,  Michael Cohen ,  Sandra Filla ,  Kevin Hudzlak ,  Daniel Kohlman ,  Dana Benesh ,  Frantz Victor ,  Yao-Chang Xu ,  Bai-Ping Ying ,  DeAnna Zacherl ,  Deyi Zhang ,  Brian Mathes

IPC分类号： A61K31/4545 ,  A61K31/454 ,  C07D403/14

CPC分类号： C07D211/58 ,  A61K31/4468 ,  A61K31/4523 ,  C04B35/632 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14

摘要： The present invention relates to compounds of formula I: (I) or a pharmaceutically acceptable acid addition salt thereof, where; X is C(R3c═ or N═; R1 is C2-C6 alkyl, substituted C2-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2 is hydrogen, C1-C3 n-alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II (II) provided that when R1 is C2-C6 alkyl or substituted C2-C6 alkyl, R2 is hydrogen or methyl; R3a, R3b, and, when X is C(R3c)═, R3c, are each independently hydrogen, fluoro, or methyl, provided that no more than one of R3a, R3b, and R3c may be other than hydrogen; R4 is hydrogen or C1-C3 alkyl; R5 is hydrogen, C1-C3 alkyl, or C3-C6 cycloalkylcarbonyl, provided that when R3a is other than hydrogen, R5 is hydrogen; R6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HT1F receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal.

公开(公告)号：US20050222206A1

公开(公告)日：2005-10-06

申请号：US10509770

申请日：2003-03-27

申请人： Michael Cohen ,  Daniel Kohlman ,  Sidney Liang ,  Vincent Mancuso ,  Yao-Chang Xu ,  Bai-Ping Ying ,  DeAnna Zacherl ,  Deyi Zhang ,  Frantz Victor

发明人： Michael Cohen ,  Daniel Kohlman ,  Sidney Liang ,  Vincent Mancuso ,  Yao-Chang Xu ,  Bai-Ping Ying ,  DeAnna Zacherl ,  Deyi Zhang ,  Frantz Victor

IPC分类号： A61K31/4545 ,  A61K31/506 ,  A61P15/00 ,  A61P15/10 ,  A61P17/14 ,  A61P25/06 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/32 ,  A61P25/34 ,  A61P43/00 ,  C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D41/02

CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

摘要： The present invention relates to compounds of formula I: or pharmaceutically acceptable acid addition salts thereof, where; R1 is C1-C6 alkyl, substituted C1-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C3 alkyl, substituted C3-C7 cycloalkyl-C1-C3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2 is hydrogen, C1-C3 alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II R3 is hydrogen or C1-C3 alkyl; R4 is hydrogen, halo, or C1-C3 alkyl; R5 is hydrogen or C1-C3 alkyl; R6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HT1F receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.

摘要翻译： 本发明涉及式I化合物或其药学上可接受的酸加成盐，其中： R 1是C 1 -C 6烷基，取代的C 1 -C 6亚烷基 烷基，C 3 -C 7环烷基，取代的C 3 -C 7环烷基，C 1 -C 3烷基， 取代的C 3 -C 3烷基，取代的C 3 -C 3烷基，C 1 -C 3烷基，C 3 -C 3 - 苯基，取代的苯基，杂环或取代的杂环; R 2是氢，C 1 -C 3烷基，C 3 -C 6烷基，C 3 -C 3烷基，C 3 -C 3烷基， 或者式II的基团R 3是氢或C 1 -C 6烷基， C 1 -C 3烷基; R 4是氢，卤素或C 1 -C 3烷基; R 5是氢或C 1 -C 3烷基; R 5是氢或C 1 -C 3烷基; R 6是氢或C 1 -C 6烷基; n为1〜6的整数。 本发明的化合物可用于活化5-HT 1F受体，抑制神经元蛋白质外渗，以及治疗或预防哺乳动物偏头痛。 本发明还涉及合成式I化合物中的中间体的方法。

公开(公告)号：US08798357B2

公开(公告)日：2014-08-05

申请号：US13544817

申请日：2012-07-09

申请人： Sudipta N Sinha ,  Hyon Lim ,  Michael Cohen ,  Matt Uyttendaele

发明人： Sudipta N Sinha ,  Hyon Lim ,  Michael Cohen ,  Matt Uyttendaele

IPC分类号： G06K9/00

CPC分类号： G06K9/46 ,  G06K9/00664 ,  G06T7/73 ,  G06T2207/10016 ,  G06T2207/20016 ,  G06T2207/30244

摘要： Image-based localization technique embodiments are presented which provide a real-time approach for image-based video camera localization within large scenes that have been reconstructed offline using structure from motion or similar techniques. From monocular video, a precise 3D position and 3D orientation of the camera can be estimated on a frame by frame basis using only visual features.

摘要翻译： 提出了基于图像的定位技术实施例，其提供了使用已经使用运动或类似技术的结构离线重建的大场景内基于图像的摄像机定位的实时方法。 从单眼视频，可以使用仅视觉特征逐帧估计摄像机的精确3D位置和3D取向。

公开(公告)号：US20130302887A1

公开(公告)日：2013-11-14

申请号：US13947884

申请日：2013-07-22

申请人： Michael Shamblott ,  Michael Cohen

发明人： Michael Shamblott ,  Michael Cohen

IPC分类号： C12N5/0735

CPC分类号： C12N5/0606 ,  C12N2502/04 ,  C12N2533/54

摘要： Methods for deriving and cultivating human embryonic stem (ES) cells and maintaining their pluripotency in culture is provided by utilizing secreted products obtained from the culture medium of human embryonic gem (EG) cell derivatives, such as embryoid body-derived cells. Substrates include compounds such as collagen I, fibronectin, or superfibronectin, or extracellular matrix, typically human derived.

摘要翻译： 通过使用从人胚胎宝石（EG）细胞衍生物（例如胚状体衍生细胞）的培养基获得的分泌产物，提供用于衍生和培养人胚胎干（ES）细胞并维持其培养多能性的方法。 底物包括诸如胶原I，纤连蛋白或超纤连蛋白的化合物，或通常人衍生的细胞外基质。

公开(公告)号：US08572606B1

公开(公告)日：2013-10-29

申请号：US11365012

申请日：2006-03-01

申请人： Ole Agesen ,  Michael Cohen ,  Jeffrey W. Sheldon

发明人： Ole Agesen ,  Michael Cohen ,  Jeffrey W. Sheldon

IPC分类号： G06F9/455

CPC分类号： G06F11/1402 ,  G06F9/45516 ,  G06F11/004 ,  G06F2201/815 ,  G06F2201/82

摘要： A system and method for reducing the likelihood of concurrency errors by identifying vulnerable segments of computer code and stalling other virtual machine threads of execution. According to one embodiment of the present invention, the vulnerable segment is identified at runtime, for example in a dynamic translator. According to another embodiment of the present invention, the vulnerable segment is identified ahead of time, for example in a static translator. According to yet another embodiment of the present invention, the vulnerable segment is identified in the binary translator of a virtual machine monitor.

摘要翻译： 通过识别计算机代码的易受攻击的部分并拖延执行其他虚拟机线程来减少并发错误的可能性的系统和方法。 根据本发明的一个实施例，在运行时识别易受攻击的段，例如在动态翻译器中。 根据本发明的另一个实施例，提前识别易受攻击的段，例如在静态转换器中。 根据本发明的另一个实施例，在虚拟机监视器的二进制转换器中识别易受攻击的段。

公开(公告)号：US20120034183A1

公开(公告)日：2012-02-09

申请号：US12448435

申请日：2007-12-19

申请人： Michael Cohen ,  Jacob Cohen

发明人： Michael Cohen ,  Jacob Cohen

IPC分类号： A61K38/19 ,  A61K8/66 ,  A61Q19/08 ,  A61P17/00 ,  A61Q19/00 ,  A61K38/48 ,  A61K8/67

CPC分类号： A61K8/365 ,  A61K8/64 ,  A61K8/66 ,  A61K8/981 ,  A61K9/0014 ,  A61K9/06 ,  A61K35/54 ,  A61K38/00 ,  A61K45/06 ,  A61Q19/08

摘要： Compositions including topical formulations comprising secreted products obtained from the culture medium of human embryonic germ (EG) cell derivatives and particular combinations of components therefrom are provided for treatment of various dermatological conditions, such as adverse consequences of aging, wrinkling, altered pigmentation, altered viscoelasticity, and altered thickness, among others. Methods for using the compositions and topical formulations for treating adverse or undesirable dermatological conditions are also provided, as well as preventing the appearance of undesirable dermatological conditions.

摘要翻译： 提供包括由人类胚胎（EG）细胞衍生物的培养基获得的分泌产物和其组分的特定组合的包含局部制剂的组合物用于治疗各种皮肤病学条件，例如老化，起皱，改变的色素沉着，改变的粘弹性的不良后果 ，厚度变化等。 还提供了使用组合物和局部制剂治疗不利或不期望的皮肤病学条件的方法，以及防止不期望的皮肤病学病症的出现。

公开(公告)号：US20110173851A1

公开(公告)日：2011-07-21

申请号：US12691382

申请日：2010-01-21

申请人： Michael Cohen

发明人： Michael Cohen

IPC分类号： G09F17/00 ,  G09F19/02

CPC分类号： G09F19/02

摘要： An article, such as a towel, having an opening to secure a twirling mechanism thereto. The twirling mechanism having a handle extending from a bottom portion thereof and having a mechanism to permit rotating of the handle with respect to the fabric-article, such that the fabric article is capable of twirling around the twirling mechanism. The twirling mechanism may in other embodiments include noise maker when the handle is rotated.

摘要翻译： 诸如毛巾的物品，具有用于固定旋转机构的开口。 旋转机构具有从其底部延伸的手柄，并且具有允许手柄相对于织物制品旋转的机构，使得织物制品能够绕旋转机构旋转。 在其他实施例中，旋转机构可以包括手柄旋转时的噪音制造器。

公开(公告)号：US07961983B2

公开(公告)日：2011-06-14

申请号：US11779871

申请日：2007-07-18

申请人： Matthew Uyttendaele ,  Michael Cohen

发明人： Matthew Uyttendaele ,  Michael Cohen

IPC分类号： G06K9/00 ,  G06K9/36 ,  G06K9/32

CPC分类号： G06T3/4038

摘要： A gigapixel image is generated from a set of images in raw format depicting different portions of a panoramic scene that has up to a full spherical field of view. Radiometric alignment of the images creates a set of images in radiance format. Geometric alignment of the radiance format images creates a set of true poses for the images in radiance format. A gigapixel image depicting the entire scene is assembled from the set of radiance format images and radiance format true poses for the images. The set of images in raw format is captured using a conventional digital camera, equipped with a telephoto lens, attached to a motorized head. The head is programmed to pan and tilt the camera in prescribed increments to individually capture the images at a plurality of exposures and with a prescribed overlap between images depicting adjacent portions of the scene.

摘要翻译： 从原始格式的一组图像生成一个千兆像素图，描绘具有全球面视野的全景场景的不同部分。 图像的放射线对准会以辐射格式创建一组图像。 辐射格式图像的几何对齐为辐射格式的图像创建一组真实姿势。 描绘整个场景的百万像素图像是由一组辐射格式图像和辐射格式组合而成的图像的真实姿势。 原始格式的图像集是使用配有远摄镜头的常规数码相机来捕捉的，该长焦镜头连接到电动头部。 头被编程为以规定的增量平移和倾斜相机，以单独地以多次曝光并且以描绘场景的相邻部分的图像之间的规定的重叠来捕获图像。

公开(公告)号：US07729256B2

公开(公告)日：2010-06-01

申请号：US11180879

申请日：2005-07-13

申请人： Patrick J. Malloy ,  Michael Cohen ,  Alain J. Cohen

发明人： Patrick J. Malloy ,  Michael Cohen ,  Alain J. Cohen

IPC分类号： G01R31/08 ,  G06F15/173

CPC分类号： H04L63/0236 ,  H04L1/18 ,  H04L63/1416 ,  H04L2012/565

摘要： A system/method searches a traffic stream for a sequence of “matching” packets that exhibit a high degree of correlation or similarity to a sequence of “reference” packets. The correlation between matching and reference packets is based on a degree of correspondence between individual packets, as well as the sequence-order of the corresponding packets. A variation of the Needleman-Wunsch algorithm is preferably used to select corresponding packets in the traffic stream that provide a sequence-order that best matches the sequence-order of the reference packets, based on a measure of the correspondence for each match, and a penalty associated with each non-match. The algorithm is further modified to reduce the required search-space for finding corresponding packets in the traffic stream.

摘要翻译： 系统/方法在业务流中搜索与“参考”分组的序列呈现高度相关性或相似性的“匹配”分组序列。 匹配和参考分组之间的相关性基于各个分组之间的对应程度以及相应分组的顺序。 Needleman-Wunsch算法的变体优选地用于基于每个匹配的对应度的度量来选择提供与参考分组的序列顺序最佳匹配的序列顺序的业务流中的相应分组，以及 与每个不匹配相关的罚款。 该算法被进一步修改以减少用于在流量流中找到相应分组的所需搜索空间。