-
公开(公告)号：US20060252939A1
公开(公告)日：2006-11-09
申请号：US11485714
申请日：2006-07-12
申请人： Marina Etinger , Boris Fedotev , Ben-Zion Dolitzky
发明人： Marina Etinger , Boris Fedotev , Ben-Zion Dolitzky
IPC分类号： C07D403/02
CPC分类号： C07D403/10
摘要： The invention encompasses processes for the synthesis of cilexetil trityl candesartan from the reaction of trityl candesartan with cilexetil halide in the presence of a base and a low boiling organic solvent. Optionally, the reaction may be conducted in the presence of a phase transfer catalyst.
-
公开(公告)号：US20050250827A1
公开(公告)日：2005-11-10
申请号：US10966418
申请日：2004-10-15
IPC分类号： A61K31/4178 , A61K31/4184 , A61P9/12 , A61P43/00 , C07D403/10 , C07D43/02
CPC分类号： C07D403/10 , Y02P20/55
摘要： The present invention is directed to the preparation of substantially pure candesartan cilexetil by the deprotection of trityl candesartan cilexetil and crystallization and/or recrystallization of candesartan cilexetil.
摘要翻译： 本发明涉及通过三苯甲基坎地沙坦碳酸酯的脱保护和坎地沙坦碳酸酯的结晶和/或重结晶来制备基本上纯的坎地沙坦酯。
-
公开(公告)号：US20050131037A1
公开(公告)日：2005-06-16
申请号：US10968710
申请日：2004-10-18
申请人： Marina Etinger , Boris Fedotev , Ben-Zion Dolitzky
发明人： Marina Etinger , Boris Fedotev , Ben-Zion Dolitzky
IPC分类号： C07D403/10 , A61K31/4178 , C07D43/02
CPC分类号： C07D403/10
摘要： The invention encompasses processes for the synthesis of cilexetil trityl candesartan from the reaction of trityl candesartan with cilexetil halide in the presence of a base and a low boiling organic solvent. Optionally, the reaction may be conducted in the presence of a phase transfer catalyst.
摘要翻译： 本发明包括在碱和低沸点有机溶剂的存在下，从三苯甲基坎地沙坦与碳酸吡哩啶卤化物的反应合成曲塞沙星三苯甲基坎地沙坦的方法。 任选地，反应可以在相转移催化剂的存在下进行。
-
公开(公告)号：US20050043329A1
公开(公告)日：2005-02-24
申请号：US10791451
申请日：2004-03-01
申请人： Shlomit Wizel , Judith Aronhime , Valerie Niddam-Hildesheim , Ben-Zion Dolitzky , Marina Etinger , Michael Yuzefovich , Gennady Nisnevich , Boris Pertsikov , Boris Tishin , Dina Blasberger
发明人： Shlomit Wizel , Judith Aronhime , Valerie Niddam-Hildesheim , Ben-Zion Dolitzky , Marina Etinger , Michael Yuzefovich , Gennady Nisnevich , Boris Pertsikov , Boris Tishin , Dina Blasberger
IPC分类号： A61K31/522 , C07D473/00 , C07D473/18
CPC分类号： A61K31/522 , C07D473/00 , C07D473/18
摘要： Provided are novel crystalline forms of valacyclovir hydrochloride, in particular a novel hydrated form of valacyclovir hydrochloride having about 6% to about 10% by weight water. Also provided are methods for making the novel crystalline forms.
摘要翻译： 提供盐酸伐昔洛韦的新型结晶形式，特别是具有约6％至约10％重量水的新型水合形式的盐酸伐昔洛韦。 还提供了制备新型结晶形式的方法。
-
公开(公告)号：US20050187229A1
公开(公告)日：2005-08-25
申请号：US11042526
申请日：2005-01-25
申请人： Shlomit Wizel , Judith Aronhime , Valerie Niddam-Hildesheim , Ben-Zion Dolitzky , Marina Etinger , Michael Yuzefovich , Gennady Nisnevich , Boris Pertsikov , Boris Tishin , Dina Blasberger
发明人： Shlomit Wizel , Judith Aronhime , Valerie Niddam-Hildesheim , Ben-Zion Dolitzky , Marina Etinger , Michael Yuzefovich , Gennady Nisnevich , Boris Pertsikov , Boris Tishin , Dina Blasberger
IPC分类号： C07D473/18 , A61K31/522 , A61P31/12 , A61P43/00 , C07D473/00 , C07D473/10
CPC分类号： C07D473/00 , A61K31/522 , C07D473/18
摘要： Provided are novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these. Also provided are methods for making the novel polymorphs and pseudopolymorphs, which include valacyclovir hydrochloride monohydrate and valacyclovir hydrochloride dihydrate.
-
公开(公告)号：US20050107636A1
公开(公告)日：2005-05-19
申请号：US10936190
申请日：2004-09-07
IPC分类号： C07C45/80 , C07C45/81 , C07C51/41 , C07C51/43 , C07C51/48 , C07C209/68 , C07C209/88 , C07C211/42 , C07C29/28
CPC分类号： C07C211/42 , C07C45/80 , C07C45/81 , C07C51/412 , C07C51/43 , C07C51/48 , C07C209/68 , C07C209/88 , C07C2602/10 , C07C49/697 , C07C59/50
摘要： Provided is a recycling process for preparing sertraline, which may be carried out on an industrial scale.
摘要翻译： 提供了一种用于制备舍曲林的回收方法，其可以在工业规模上进行。
-
公开(公告)号：US20050250828A1
公开(公告)日：2005-11-10
申请号：US11056895
申请日：2005-02-11
申请人： Marina Etinger , Boris Fedotev , Tamas Koltai , Ziv Kurgan , Omer Malachi
发明人： Marina Etinger , Boris Fedotev , Tamas Koltai , Ziv Kurgan , Omer Malachi
IPC分类号： A61K31/4184 , C07D403/10 , C07D43/02
CPC分类号： C07D403/10
摘要： Provided are candesartan cilexetil forms and methods of their preparation. Also provided are pharmaceutical compositions prepared by combining at least one pharmaceutically-acceptable excipient with at least one candesartan cilexetil form of the invention.
摘要翻译： 提供坎地沙坦cilexetil形式及其制备方法。 还提供了通过将至少一种药学上可接受的赋形剂与本发明的至少一种坎地沙坦碳酸酯形式组合制备的药物组合物。
-
公开(公告)号：US20050239837A1
公开(公告)日：2005-10-27
申请号：US11112002
申请日：2005-04-22
申请人： Arie Gutman , Marina Etinger , Boris Tishin , Boris Pertsikov , Boris Fedotev , Alexander Vilensky , Pavel Potyabin , Gennady Nisnevich
发明人： Arie Gutman , Marina Etinger , Boris Tishin , Boris Pertsikov , Boris Fedotev , Alexander Vilensky , Pavel Potyabin , Gennady Nisnevich
IPC分类号： C07D211/32 , A61K31/445 , C07D211/06
CPC分类号： C07D211/32
摘要： Disclosed is a process for production of highly pure donepezil hydrochloride in the form of polymorph I that does not involve the isolation of donepezil base. The disclosed process involves intramolecular cyclization of N-benzyl-2-(3,4-dimethoxybenzyl)-3-(4-piperidine)propionic acid followed by treatment with HCl.
摘要翻译： 公开了以不含多奈哌齐碱分离的多晶型I形式的高纯度多奈哌齐盐酸盐的制造方法。 所公开的方法包括N-苄基-2-（3,4-二甲氧基苄基）-3-（4-哌啶）丙酸的分子内环化，然后用HCl处理。
-
公开(公告)号：US06927300B2
公开(公告)日：2005-08-09
申请号：US10181523
申请日：2001-01-26
申请人： Arie Gutman , Gennadiy Nisnevich , Marina Etinger , Igor Zaltzman , Lev Judovich , Boris Pertsikov
发明人： Arie Gutman , Gennadiy Nisnevich , Marina Etinger , Igor Zaltzman , Lev Judovich , Boris Pertsikov
IPC分类号： C07D307/935 , A61K31/5575 , A61P43/00 , C07B61/00 , C07C405/00 , C07D309/12 , C07D407/12 , C07C57/00
CPC分类号： C07C405/00
摘要： Disclosed is a process for the preparation of the anti-glaucoma drug Latanoprost, in good yield, in large amounts and with desired purity. Also disclosed are novel intermediates for the above process.
摘要翻译： 公开了以高产率和高纯度制备抗青光眼药物拉坦前列素的方法。 还公开了用于上述方法的新型中间体。
-
公开(公告)号：US20050209337A1
公开(公告)日：2005-09-22
申请号：US11125164
申请日：2005-05-10
申请人： Arie Gutman , Gennady Nisnevich , Marina Etinger , Igor Zaltzman , Lev Yudovich , Boris Pertsikov , Boris Tishin
发明人： Arie Gutman , Gennady Nisnevich , Marina Etinger , Igor Zaltzman , Lev Yudovich , Boris Pertsikov , Boris Tishin
IPC分类号： A61K31/557 , C07D307/93
CPC分类号： C07D307/935 , C07C405/00 , C07C2601/08
摘要： The invention provides a novel process for the preparation of prostaglandins and analogues thereof, and new crystalline intermediates in the process.
摘要翻译： 本发明提供了一种制备前列腺素及其类似物的新方法，以及该方法中的新型结晶中间体。
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.022 秒)
