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公开(公告)号：US09604074B2
公开(公告)日：2017-03-28
申请号：US13843099
申请日：2013-03-15
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
CPC分类号： A61N5/1028 , A61B2018/0025 , A61B2090/036 , A61N5/025 , A61N5/1029 , A61N5/1071 , A61N7/00 , A61N7/02 , A61N2005/1018
摘要： Radiation therapy devices, systems and methods are in general sheet-like form, are characterized by flexibility, and include at least one spacer that can be a balloon or bubble that assists in placement of radio therapeutic members at desired treatment locations along or around a limb, within an existing body cavity, or at a site that was formed under a patient's skin for treatment purposes. Sarcoma treatment is particularly conducive to treatment by these devices, systems and methods. One or more detectors, such as microdiodes, are accommodated when desired on the device, and a hyperthermia tube or the like is also includable that delivers hyperthermia treatment for the target treatment site or sites. Data collected by the detector allows the medical professional to monitor radiation treatment and, when desired, interaction between hyperthermia treatment and radiation delivery by the radiation treatment member.
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公开(公告)号：US09192345B2
公开(公告)日：2015-11-24
申请号：US13793184
申请日：2013-03-11
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
CPC分类号： A61B6/425 , A61B5/4836 , A61B5/4839 , A61B5/6853 , A61F7/123 , A61M25/0108 , A61N5/1014 , A61N5/1048
摘要： Radiation diagnosis devices, systems and methods are in general catheter form and include at least one diagnostic balloon that provides at least one diagnosis function and assists in placement of at least one radiation detector at a desired diagnosis location within an existing body cavity or at a percutaneous site. Data collected by the detector that is positioned as determined by the medical professional allows the medical professional to monitor radiation levels, either residual from a prior radiation treatment, during a brachytherapy treatment at the diagnostic catheter insertion site or in adjoining site, or during externally administered radiation.
摘要翻译： 辐射诊断装置，系统和方法通常是导管形式，并且包括至少一个诊断气囊，其提供至少一个诊断功能，并且有助于将至少一个放射线检测器放置在现有体腔内的所需诊断位置或经皮 现场。 由医疗专业人员确定的检测器收集的数据允许医疗专业人员在诊断导管插入部位或相邻部位的近距离放射治疗期间或在外部给药期间监测辐射水平，即来自先前放射治疗的残留物 辐射。
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公开(公告)号：US10086213B2
公开(公告)日：2018-10-02
申请号：US14693986
申请日：2015-04-23
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
IPC分类号： A61N5/10
摘要： Brachytherapy oncology treatment systems and methods are provided. One such system and method employs a catheter or tandem and a mobile balloon device having an enclosed inner volume and an internal surface with an internal perimeter size larger than the external surface perimeter size and adequate to allow sliding longitudinal movement between the catheter or tandem and the mobile balloon device. The mobile balloon device has a radiation dose delivery tube that is at or moves by inflation to a strategic radiation dose delivery location for brachytherapy. An embodiment allows for a multi-part catheter or tandem having a detachable distal section suitable for retaining within a body cavity such as the uterus, both during radiation treatment and during recovery time between radiation treatments. This distal portion can be intended for single-patient use and be disposed of after completion of a radiation treatment session having multiple radiation dose treatment times. One or both of real time in vivo detection and monitoring and hypertherapy features can be included.
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公开(公告)号：US09320915B2
公开(公告)日：2016-04-26
申请号：US14613038
申请日：2015-02-03
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
CPC分类号： A61N5/1016 , A61B18/04 , A61B2017/22051 , A61B2017/22054 , A61B2017/22055 , A61B2017/22061 , A61B2017/22062 , A61B2017/22068 , A61B2017/22069 , A61B2018/00273 , A61B2018/00285 , A61B2018/00559 , A61B2018/046 , A61B2090/033 , A61B2090/0445 , A61B2090/0481 , A61N5/1067 , A61N5/1071 , A61N2005/1003 , A61N2005/1012 , A61N2005/1094
摘要： Intracavitary brachytherapy tandem and ovoid oncology treatment systems and methods are provided. One such system and method employs a multi-part tandem having a detachable distal section suitable for retaining within a body cavity such as the uterus, both during radiation treatment and during recovery time between radiation treatments. This distal portion can be intended for single-patient use and be disposed of after completion of a radiation treatment session having multiple radiation dose treatment times. One or both of real time in vivo detection and monitoring and hypertherapy features can be included. One or more of the system tandem or ovoid colpostats feature bendability to tailor the system to the specific body and patient being treated. The method includes having a tandem distal section inserted into a body cavity such as a uterus and remaining within the body cavity in between treatment times. Other systems and methods incorporate balloon devices that assist in spacing radiation doses away from body sites at which radiation treatment is not intended. Balloon devices also can be provided for adjusting and maintaining separation spacing between two ovoid colpostats while intracavitary.
摘要翻译： 提供腔内近距离放射治疗系统和卵巢肿瘤治疗系统和方法。 一种这样的系统和方法采用多部分串联，其具有适于在放射治疗期间和在放射治疗之间的恢复时间期间保持在诸如子宫的体腔内的可分离远端部分。 该远端部分可以用于单次患者使用，并且在完成具有多个辐射剂量治疗时间的放射治疗会话之后进行处置。 可以包括实时体内检测和监测和超治疗特征中的一个或两个。 一个或多个系统串联或卵巢粘滞剂具有弯曲性，可以将系统定制到被治疗的特定身体和患者。 该方法包括将串联远端部分插入到诸如子宫的体腔中并在治疗时间之间保留在体腔内。 其他系统和方法包括气球装置，其有助于将辐射剂量与远离身体部位的辐射处理隔开。 还可以提供气球装置用于在腔内调节和保持两个卵状粘液瓶之间的间隔。
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公开(公告)号：US20150157878A1
公开(公告)日：2015-06-11
申请号：US14613038
申请日：2015-02-03
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
IPC分类号： A61N5/10
CPC分类号： A61N5/1016 , A61B18/04 , A61B2017/22051 , A61B2017/22054 , A61B2017/22055 , A61B2017/22061 , A61B2017/22062 , A61B2017/22068 , A61B2017/22069 , A61B2018/00273 , A61B2018/00285 , A61B2018/00559 , A61B2018/046 , A61B2090/033 , A61B2090/0445 , A61B2090/0481 , A61N5/1067 , A61N5/1071 , A61N2005/1003 , A61N2005/1012 , A61N2005/1094
摘要： Intracavitary brachytherapy tandem and ovoid oncology treatment systems and methods are provided. One such system and method employs a multi-part tandem having a detachable distal section suitable for retaining within a body cavity such as the uterus, both during radiation treatment and during recovery time between radiation treatments. This distal portion can be intended for single-patient use and be disposed of after completion of a radiation treatment session having multiple radiation dose treatment times. One or both of real time in vivo detection and monitoring and hypertherapy features can be included. One or more of the system tandem or ovoid colpostats feature bendability to tailor the system to the specific body and patient being treated. The method includes having a tandem distal section inserted into a body cavity such as a uterus and remaining within the body cavity in between treatment times. Other systems and methods incorporate balloon devices that assist in spacing radiation doses away from body sites at which radiation treatment is not intended. Balloon devices also can be provided for adjusting and maintaining separation spacing between two ovoid colpostats while intracavitary.
摘要翻译： 提供腔内近距离放射治疗系统和卵巢肿瘤治疗系统和方法。 一种这样的系统和方法采用多部分串联，其具有适于在放射治疗期间和在放射治疗之间的恢复时间期间保持在诸如子宫的体腔内的可分离远端部分。 该远端部分可以用于单次患者使用，并且在完成具有多个辐射剂量治疗时间的放射治疗会话之后进行处置。 可以包括实时体内检测和监测和超治疗特征中的一个或两个。 一个或多个系统串联或卵巢粘滞剂具有弯曲性，可以将系统定制到被治疗的特定身体和患者。 该方法包括将串联远端部分插入到诸如子宫的体腔中并在治疗时间之间保留在体腔内。 其他系统和方法包括气球装置，其有助于将辐射剂量与远离身体部位的辐射处理隔开。 还可以提供气球装置用于在腔内调节和保持两个卵状粘液瓶之间的间隔。
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公开(公告)号：US08979725B2
公开(公告)日：2015-03-17
申请号：US13478794
申请日：2012-05-23
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
CPC分类号： A61N5/1016 , A61B18/04 , A61B2017/22051 , A61B2017/22054 , A61B2017/22055 , A61B2017/22061 , A61B2017/22062 , A61B2017/22068 , A61B2017/22069 , A61B2018/00273 , A61B2018/00285 , A61B2018/00559 , A61B2018/046 , A61B2090/033 , A61B2090/0445 , A61B2090/0481 , A61N5/1067 , A61N5/1071 , A61N2005/1003 , A61N2005/1012 , A61N2005/1094
摘要： Intracavitary brachytherapy tandem and ovoid oncology treatment systems and methods are provided. One such system and method employs a multi-part tandem having a detachable distal section retained within a body cavity during and between radiation treatments. This can be for single-patient use and disposed of after completion of a multiple-dose radiation treatment session. Real time in vivo detection and monitoring and hytpertherapy features can be included. Tandem or ovoid colpostats can feature bendability to tailor the system to the specific body and patient being treated. Other systems and methods incorporate balloon devices that assist in spacing radiation doses away from chosen body sites. Balloon devices also can be provided for adjusting and maintaining separation spacing between two ovoid colpostats.
摘要翻译： 提供腔内近距离放射治疗系统和卵巢肿瘤治疗系统和方法。 一种这样的系统和方法采用多部分串联，其中在放射治疗期间和之间具有保持在体腔内的可分离远端部分。 这可以用于单次患者使用，并在多剂量放射治疗会话完成后进行处置。 可以包括实时的体内检测和监测和疗法特征。 串联或卵球蛋白凝块可以具有弯曲性，可以将系统定制到特定身体和被治疗的患者。 其他系统和方法包括有助于将辐射剂量与所选择的身体部位隔开的球囊装置。 还可以提供气球装置用于调节和保持两个卵巢凝块体之间的间隔。
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公开(公告)号：US10207127B2
公开(公告)日：2019-02-19
申请号：US15439008
申请日：2017-02-22
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
摘要： Radiation therapy devices, systems and methods are in general sheet-like form, are characterized by flexibility, and include at least one spacer that can be a balloon or bubble that assists in placement of radio therapeutic members at desired treatment locations along or around a limb, within an existing body cavity, or at a site that was formed under a patient's skin for treatment purposes. Sarcoma treatment is particularly conducive to treatment by these devices, systems and methods. One or more detectors, such as microdiodes, are accommodated when desired on the device, and a hyperthermia tube or the like is also includable that delivers hyperthermia treatment for the target treatment site or sites. Data collected by the detector allows the medical professional to monitor radiation treatment and, when desired, interaction between hyperthermia treatment and radiation delivery by the radiation treatment member.
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公开(公告)号：US20150375010A1
公开(公告)日：2015-12-31
申请号：US14837508
申请日：2015-08-27
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
摘要： Radiation therapy or brachytherapy devices, systems and methods are in general catheter form and include at least one balloon that assists in placement of radio therapeutic members at desired treatment locations within an existing body cavity or at a site that was formed under a patient's skin for treatment purposes. One or more detectors, such as microdiodes, are present on the device, and a hyperthermia tube or the like is also included that delivers hyperthermia treatment for the target treatment site or sites. Data collected by the detector allows the medical professional to monitor radiation treatment and, when desired, interaction between hyperthermia treatment and radiation delivery by the radiation treatment member.
摘要翻译： 辐射治疗或近距离放射治疗装置，系统和方法通常为导管形式，并且包括至少一个气囊，其有助于将放射治疗构件放置在现有体腔内或在患者皮肤下形成的位置处的所需治疗位置处理 目的 一个或多个检测器，例如微二极管，存在于该装置上，并且还包括用于对目标治疗部位或部位进行高热治疗的热疗管等。 由检测器收集的数据允许医学专业人员监测放射治疗，并且在需要时，辐射治疗部件的热疗治疗与辐射传递之间的相互作用。
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公开(公告)号：US5653683A
公开(公告)日：1997-08-05
申请号：US395865
申请日：1995-02-28
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
CPC分类号： A61N5/1014 , A61B2017/22068 , A61M2025/1047 , A61N2005/1003 , A61N2005/1012 , A61N2005/1018 , A61N5/1016
摘要： The present invention provides a significantly improved therapeutic tool for radiation therapy in or near body cavities accessible through existing orifices. At least one therapeutic balloon of a catheter and balloon assembly is inflated by fluid communication through the catheter. Several embodiments provide radiation therapy, at times in association with one or more of formation of seals, control of movement, nutrient passage and drainage. The radiation therapy is provided by means of rods or other radiotherapeutic items secured, positioned or inserted along the contour of the surface of the therapeutic balloon and which are thus deployed to treatment position by balloon inflation. Control of movement can be achieved through the use of a small balloon usually located where the body cavity changes size, such as at the body orifice; through the use of a template, which may be sutured to nearby tissue or secured with tether catheter assemblies inserted in other body cavities; through the use of a catheter lead which is inserted into narrow portions of a body cavity; or through the use of a secondary balloon located distally of the larger therapeutic balloon. Drainage, often required when performing this procedure in the bladder or rectum, is achieved by the use of a Foley-type catheter. Feeding, inhalation and exhalation are permitted through a communication channel within the catheter.
摘要翻译： 本发明提供了一种显着改进的治疗工具，用于通过现有孔可接近的体腔内或附近的放射治疗。 导管和球囊组件的至少一个治疗气球通过通过导管的流体连通而膨胀。 有几个实施例提供放射治疗，有时与形成密封件，运动控制，营养物通过和引流有关。 放射治疗通过杆或其它放射治疗物质来提供，所述杆或其它放射治疗物质沿着治疗球囊的表面的轮廓固定，定位或插入，并且因此通过球囊膨胀而部署到治疗位置。 可以通过使用通常位于体腔改变尺寸的小气球（例如在身体孔口）来实现运动的控制; 通过使用模板，其可以缝合到附近的组织或用插入其他体腔的系绳导管组件固定; 通过使用插入到体腔的狭窄部分中的导管引线; 或通过使用位于较大治疗气球远端的二次气囊。 通过使用Foley型导管，可以在膀胱或直肠中进行此过程时经常需要的排水。 通过导管内的通讯通道允许进食，吸入和呼气。
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10.发明授权
公开(公告)号：US5520646A
公开(公告)日：1996-05-28
申请号：US205896
申请日：1994-03-03
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
IPC分类号： A61F2/958 , A61M25/098 , A61M29/00 , A61M25/00
CPC分类号： A61M25/10
摘要： The present invention provides a significantly improved diagnostic tool and procedure for radiation therapy in or near body cavities accessible through existing orifices. This invention makes use of a flexible catheter and balloon. The balloon is inflated by fluid communication through the catheter. This invention makes use of several preferable embodiments which provide radiopaque references, seals, control of movement, and drainage. The radiopaque references are provided by means of radiopaque lines painted on the balloon's interior or exterior surface, by means of the use of radiopaque fluid to inflate the balloon, or by means of a slidable clip made of radiopaque material which is positioned at the patient's orifice. Sealing is provided by means of the slidable clip which also permits adjustment of the balloon size and shape. Control of movement is achieved through the use of a small balloon usually located near the patient's orifice. Drainage, often required when performing this procedure in the bladder, is achieved by the use of a Foley-type catheter.
摘要翻译： 本发明提供了一种显着改进的用于通过现有孔可接近的体腔内或附近的放射治疗的诊断工具和程序。 本发明利用柔性导管和球囊。 气囊通过导管的流体连通而膨胀。 本发明利用提供不透射线参考，密封，运动控制和排水的几个优选实施例。 通过使用不透射线的流体使球囊膨胀，或借助于由不透射线的材料制成的可滑动的夹子（其位于患者的孔口处），通过涂在气球的内部或外部表面上的不透射线的方式提供不透射线的参考 。 通过可滑动的夹子提供密封，其还允许调整气囊尺寸和形状。 通过使用通常位于患者孔口附近的小气球来实现运动的控制。 通过使用Foley型导管实现在膀胱中执行该过程时经常需要的排水。
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