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公开(公告)号：US4313442A
公开(公告)日：1982-02-02
申请号：US170947
申请日：1980-07-21
申请人： Mark B. Knudson , David C. Amundson
发明人： Mark B. Knudson , David C. Amundson
CPC分类号： A61N1/368
摘要： An electrical pacer device which responds to cardiac demand so as to alter the cardiac output in a fashion to satisfy that demand. Changes in the fundamental period of the atrial electrical cycle are detected and averaged over a predetermined time interval and the resulting control signal is used to raise and lower the ventricular heart rate to increase and decrease the foresaid cardiac output. At the same time, means are provided for continuously driving the ventricular rate toward a predetermined lower rate (the at rest rate) on a time cycle which is significantly longer than the above-mentioned predetermined time interval.
摘要翻译： 一种响应于心脏需求以便以满足该需求的方式改变心输出量的电子起搏装置。 在预定时间间隔内检测和平均心房电循环的基本周期的变化，并且使用所得到的控制信号来提高和降低心室心率以增加和减少预期的心输出量。 同时，提供了用于在明显长于上述预定时间间隔的时间周期上将心室率持续地驱动到预定的较低速率（静止时）的装置。
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2.发明授权Device and method for treating cardiac disorders by modulating autonomic response 有权通过调节自主反应来治疗心脏疾病的装置和方法公开(公告)号：US09392971B2
公开(公告)日：2016-07-19
申请号：US13515630
申请日：2010-12-03
IPC分类号： A61N1/05 , A61N1/20 , A61B18/14 , A61B5/00 , A61B5/04 , A61M25/00 , A61M25/04 , A61M25/10 , A61B5/02 , A61B5/0215 , A61B5/0402 , A61B18/02 , A61B18/00 , A61N1/06
CPC分类号： A61B18/1492 , A61B5/02 , A61B5/0215 , A61B5/04001 , A61B5/0402 , A61B5/4035 , A61B18/02 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022 , A61B2018/00351 , A61B2018/00434 , A61B2018/00577 , A61B2018/00839 , A61B2018/00994 , A61B2218/002 , A61M25/007 , A61M25/04 , A61M25/10 , A61M2025/105 , A61N1/0587 , A61N1/06 , A61N1/20 , A61N1/36114
摘要： A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
摘要翻译： 用于调节毗邻心包空间以治疗心律不齐的自主神经系统的方法和装置包括：设置成供应治疗介质的治疗源，具有尺寸用于插入心包空间的端部的导管，具有远端的介质递送组件 布置成由导管定位成心包，其中输送组件的远端包括布置成远离导管的远端延伸到心包空间中的输送尖端。 连接器将介质输送组件的输送末端可操作地连接到治疗源，并且介质递送组件的输送末端包括用于在心包空间内的多个治疗区域处递送治疗介质的多个递送点。 该装置在心包内的选定治疗区域进行自主神经系统的调制或消融。
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公开(公告)号：US08768469B2
公开(公告)日：2014-07-01
申请号：US12537019
申请日：2009-08-06
IPC分类号： A61N1/00
CPC分类号： A61N1/36117 , A61N1/36053 , A61N1/36114 , A61N1/36139 , A61N1/37211 , A61N1/3787
摘要： A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.
摘要翻译： 一种用于治疗与受试者中受损的血压和/或心率相关的病症的方法和装置，包括施加电治疗信号，其中所述电治疗信号被选择为至少部分阻断神经冲动，或在一些实施例中增加 神经冲动
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公开(公告)号：US07986995B2
公开(公告)日：2011-07-26
申请号：US11656121
申请日：2007-01-22
IPC分类号： A61N1/18
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is bulimia. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.
摘要翻译： 通过包括将电极定位在迷走神经上的方法来治疗至少部分地由支配患者的多个器官中的至少一个的迷走神经活动表征的患者的多种病症中的至少一种。 将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。 在一些实施方案中，该疾病是贪食症。 该信号可以是阻塞或刺激信号。 在一些实施方案中，所述信号被选择为至少部分地下调迷走神经的神经活动。
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公开(公告)号：US07672727B2
公开(公告)日：2010-03-02
申请号：US11205415
申请日：2005-08-17
CPC分类号： A61N1/36146 , A61N1/36053 , A61N1/36085 , A61N1/36114
摘要： An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.
摘要翻译： 用于向神经施加信号以用于治疗病症的装置包括第一电极和第二电极。 每个电极适于固定到患者的神经。 信号发生器电连接到第一和第二电极中的每一个。 信号发生器适于产生在第一电极处具有第一波形的信号和在第二电极处的第二波形。 波形具有选择的参数以阻止神经动作电位的传播。 这些波形具有脉冲周期的重复模式，其中延迟周期至少在所选择的脉冲之间。 在一个实施例中，在另一个波形的延迟周期期间，波形中的一个波形的周期是第一和第二波形异相。
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公开(公告)号：US07167750B2
公开(公告)日：2007-01-23
申请号：US10752944
申请日：2004-01-06
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning a neurostimulator carrier around a body organ of the patient where the organ is innervated by at least a vagal trunk. An electrode is disposed on the carrier and positioned at the vagal trunk. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.
摘要翻译： 至少部分由至少部分由迷走神经活动支配至少一个患者的多个器官的患者的障碍中的至少一种通过包括将神经刺激器载体定位在患者的身体器官周围的方法来治疗， 器官由至少一个迷走神经树干支配。 电极设置在载体上并位于迷走神经干线处。 将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。 该信号可以是阻塞或刺激信号。
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公开(公告)号：US07077143B2
公开(公告)日：2006-07-18
申请号：US10825029
申请日：2004-04-14
CPC分类号： A61F5/56 , A61F2/0059
摘要： A patient's upper airway condition such as snoring and sleep apnea is treated by selecting a particulate material selected for limited migration within tissue and for encouraging a fibrotic response of tissue to the material. A bolus of the particulate material is injected into the tissue area to structurally stiffen the tissue.
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公开(公告)号：US07063089B2
公开(公告)日：2006-06-20
申请号：US10629490
申请日：2003-07-29
IPC分类号： A61B19/00
CPC分类号： A61F5/566
摘要： A method and apparatus for treating snoring of a patient includes providing an implant for altering a dynamic response of a soft palate of the patient to airflow past the soft palate. The implant is embedded in the soft palate to alter the dynamic response. For example, the implant has a mass, stiffness or dampening sufficient to alter the dynamic response following the implantation without substantially impairing a function of the soft palate to close a nasal passage of the patient during swallowing.
摘要翻译： 用于治疗患者打鼾的方法和装置包括提供植入物，用于改变患者的软腭的动态响应以使气流通过软腭。 植入物嵌入软腭以改变动态反应。 例如，植入物具有足以改变植入后的动态响应的质量，刚度或阻尼，而基本上不会损伤软腭在吞咽期间关闭患者鼻通道的功能。
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公开(公告)号：US07017582B2
公开(公告)日：2006-03-28
申请号：US10237149
申请日：2002-09-06
IPC分类号： A61F13/00
CPC分类号： A61F5/56 , A61F2/04 , A61F2/20 , A61F2002/046 , A61M31/002 , A61M37/00
摘要： A pharyngeal airway having a pharyngeal wall of a patient at least partially surrounding and defining the airway is treated by selecting an implant dimensioned so as to be implanted at or beneath a mucosal layer of the pharyngeal wall and extending transverse to said wall. The implant has mechanical characteristics for the implant, at least in combination with a fibrotic tissue response induced by the implant, to stiffen said pharyngeal wall to resist radial collapse. The implant is implanted into the pharyngeal wall transverse to a longitudinal axis of the airway.
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公开(公告)号：US06929011B2
公开(公告)日：2005-08-16
申请号：US10684198
申请日：2003-10-10
申请人： Mark B. Knudson , William L. Giese
发明人： Mark B. Knudson , William L. Giese
IPC分类号： A61B17/00 , A61B17/11 , A61B17/12 , A61B17/34 , A61B18/24 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/82 , A61F2/90
CPC分类号： A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12131 , A61B17/3415 , A61B18/24 , A61B2017/00243 , A61B2017/00247 , A61B2017/1107 , A61B2017/1135 , A61B2017/12127 , A61B2018/00392 , A61F2/06 , A61F2/064 , A61F2/07 , A61F2/2493 , A61F2/856 , A61F2/90 , A61F2/954 , A61F2/958 , A61F2002/061 , A61F2002/065 , A61F2002/068 , A61F2002/821 , A61F2240/008 , Y10S623/903
摘要： A method for revascularizing a coronary vessel with a conduit through the heart wall having a diameter transition in the myocardial leg, wherein blood flow is in the direction of transition from larger to smaller diameter. A method for revascularizing a coronary vessel using an implant with a myocardial leg having a maximum cross-sectional area proximate a first end, and inserting the first end through the myocardium into a heart chamber so that the implant directs blood flow into the coronary vessel. A transmyocardial implant with a myocardial leg including point of minimum diameter and a first end with a larger diameter, and a vessel leg in fluid communication with the myocardial leg.
摘要翻译： 一种通过心壁血管重建冠状血管的方法，该心脏壁在心肌腿部具有直径转变，其中血流在从较大直径向较小直径的过渡方向上。 一种使用具有最接近第一端的最大横截面积的心肌腿的植入物血运重建冠状动脉血管的方法，以及将第一端穿过心肌插入心室，使得植入物将血液流入冠状血管。 具有包括最小直径点和具有较大直径的第一端的心肌腿的经心肌植入物和与心肌腿流体连通的血管腿。
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