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公开(公告)号：US20080188453A1
公开(公告)日：2008-08-07
申请号：US11932615
申请日：2007-10-31
IPC分类号： A61K31/40 , C07D207/34 , C07D261/02 , A61K31/4245 , A61P35/00 , A61K31/397 , A61K31/42 , C07D271/07
CPC分类号： C07D207/34 , C07D403/04 , C07D403/06 , C07D413/12
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with MEK that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
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公开(公告)号：US20080312307A1
公开(公告)日：2008-12-18
申请号：US12126772
申请日：2008-05-23
IPC分类号： A61K31/403 , C07D209/02 , A61P11/00 , A61P13/12 , A61P29/00 , A61P35/00 , C07D209/52
CPC分类号： C07D209/42 , C07D209/52
摘要： Compounds are provided for inhibition of MEK that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供化合物用于抑制MEK，其包含：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US20080255160A1
公开(公告)日：2008-10-16
申请号：US11958999
申请日：2007-12-18
申请人： Qing Dong , Xianchang Gong , Stephen W. Kaldor , Toufike Kanouni , Nicholas Scorah , Michael B. Wallace , Feng Zhou
发明人： Qing Dong , Xianchang Gong , Stephen W. Kaldor , Toufike Kanouni , Nicholas Scorah , Michael B. Wallace , Feng Zhou
IPC分类号： A61K31/519 , C07D487/02 , C12N9/99 , A61P35/00 , A61P9/10 , A61P11/06 , A61P13/12 , A61P17/00
CPC分类号： C07D471/04
摘要： Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供下式的化合物用于MEK：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US20090124595A1
公开(公告)日：2009-05-14
申请号：US12267353
申请日：2008-11-07
申请人： MarK Adams , Qing Dong , Toufike Kanouni , Stephen W. Kaldor , Nicholas Scorah , Michael B. Wallace
发明人： MarK Adams , Qing Dong , Toufike Kanouni , Stephen W. Kaldor , Nicholas Scorah , Michael B. Wallace
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , C07D513/04 , C07D498/04 , A61P35/04 , C12N9/99
CPC分类号： C07D471/04 , C07D498/04 , C07D513/04
摘要： Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供下式的化合物用于MEK：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US20100130518A1
公开(公告)日：2010-05-27
申请号：US12520247
申请日：2007-12-18
申请人： Qing Dong , Xianchang Gong , Stephen W. Kaldor , Toufike Kanouni , Nicholas Scorah , Michael B. Wallace , Feng Zhou
发明人： Qing Dong , Xianchang Gong , Stephen W. Kaldor , Toufike Kanouni , Nicholas Scorah , Michael B. Wallace , Feng Zhou
IPC分类号： A61K31/519 , C07D471/04 , A61P35/00 , A61P37/02 , A61P11/06
CPC分类号： C07D471/04
摘要： Compounds of the following formula are provided for use with MEK (I): wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供下式的化合物用于MEK（I）：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US07687625B2
公开(公告)日：2010-03-30
申请号：US10809637
申请日：2004-03-24
申请人： Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
发明人： Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
IPC分类号： C07D285/16 , A61K31/5395
CPC分类号： C07D471/04 , C07D401/04 , C07D403/04 , C07D473/18 , C07D487/04
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 protease that comprise a compound comprising the formula: wherein Q is selected from the group of CO, SO, SO2, or C═NR9; and R1, R2, R3 and R4 are as defined herein.
摘要翻译： 提供化合物，药物，试剂盒和方法用于DPP-IV和其它包含下式的化合物的S9蛋白酶：其中Q选自CO，SO，SO 2或C = NR 9; 并且R 1，R 2，R 3和R 4如本文所定义。
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公开(公告)号：US07550590B2
公开(公告)日：2009-06-23
申请号：US10809635
申请日：2004-03-24
申请人： Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
发明人： Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
IPC分类号： C07D285/16 , A61K31/5395
CPC分类号： C07D471/04 , C07D401/04 , C07D403/04 , C07D473/18 , C07D487/04
摘要： Compounds, pharmaceuticals, kits, and methods are provided for use with DPP-IV and other S9 protease that comprise a compound comprising the formula: wherein Q is selected from the group of CO, SO, SO2, or C═NR9; and R1, R2, R3 and R4 are as defined herein.
摘要翻译： 提供化合物，药物，试剂盒和方法用于DPP-IV和其它S9蛋白酶，其包含下式的化合物：其中Q选自CO，SO，SO 2或C-NR 9; 并且R 1，R 2，R 3和R 4如本文所定义。
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公开(公告)号：US07790736B2
公开(公告)日：2010-09-07
申请号：US10918317
申请日：2004-08-12
申请人： Jun Feng , Stephen L. Gwaltney, II , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
发明人： Jun Feng , Stephen L. Gwaltney, II , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
IPC分类号： C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , A61K31/506 , A61P19/02
CPC分类号： C07D239/36 , C07D239/47 , C07D239/52 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
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公开(公告)号：US07790734B2
公开(公告)日：2010-09-07
申请号：US10934326
申请日：2004-09-02
申请人： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Xiao-Yi Xiao , Zhiyuan Zhang
发明人： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Xiao-Yi Xiao , Zhiyuan Zhang
IPC分类号： C07D239/47 , C07D239/48 , C07D403/12 , A61K31/505
CPC分类号： C07D401/04
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
摘要翻译： 提供化合物，药物，试剂盒和方法用于包含式I的DPP-IV抑制剂：其中取代基如本文所述。
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公开(公告)号：US07723344B2
公开(公告)日：2010-05-25
申请号：US10918327
申请日：2004-08-12
申请人： Jun Feng , Stephen L. Gwaltney, II , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
发明人： Jun Feng , Stephen L. Gwaltney, II , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
IPC分类号： C07D239/47 , C07D239/48 , C07D403/12 , A61K31/505
CPC分类号： C07D239/36 , C07D239/47 , C07D239/52 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
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