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1.发明授权
公开(公告)号：US5914346A
公开(公告)日：1999-06-22
申请号：US963740
申请日：1997-11-04
申请人： Mark E. Cook , Sohee Kim , Michael W. Pariza , Danielle DeVoney
发明人： Mark E. Cook , Sohee Kim , Michael W. Pariza , Danielle DeVoney
IPC分类号： A23K1/16 , A61K31/201 , A61K31/231 , A61P43/00 , A61K38/00 , A61K31/20 , A61K31/70
CPC分类号： A61K31/231
摘要： A method of enhancing the activity of natural killer lymphocytes and a method for increasing the basal level of natural killer activity in an animal include the step of administering orally or parenterally to said animal a safe amount of CLA, said amount being effective to enhance the activity of killer lymphocytes or to enhance the basal activity of killer lymphocytes in the animal.
摘要翻译： 提高自然杀伤细胞淋巴细胞活性的方法和增加动物中天然杀伤活性基础水平的方法包括向所述动物口服或胃肠外施用安全量的CLA的步骤，所述量有效地增强活性 的杀伤性淋巴细胞或增强动物中杀伤性淋巴细胞的基础活性。
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2.发明授权Methods of treating animals to maintain or increase CD-4 and CD-8 cell populations 失效治疗动物维持或增加CD-4和CD-8细胞群体的方法
公开(公告)号：US5674901A
公开(公告)日：1997-10-07
申请号：US458956
申请日：1995-06-02
IPC分类号： A23C9/123 , A23C9/13 , A23K1/16 , A23K1/18 , A23L1/30 , A61K31/201 , A61K31/202 , C12P7/64 , A61K31/20
CPC分类号： A23K50/75 , A23C9/1234 , A23C9/1315 , A23K20/158 , A23L33/12 , A61K31/201 , A61K31/202 , C12P7/6427 , C12P7/6436 , C12P7/6472 , C12R1/225 , A23Y2220/71
摘要： Methods of treating animals to maintain or elevate CD-4 and CD-8 cell levels and to prevent or alleviate the adverse effects on the animal caused by the production or exogenous administration of tumor necrosis factor (TNF) or by a virus consist of administering to the animal a safe and effective amount of a conjugated linoleic acid (CLA) or a substance which is converted in the animal into CLA. A method of preparing CLA employing a bacteria isolated from a rat colon also is disclosed.
摘要翻译： 治疗动物维持或提高CD-4和CD-8细胞水平以及预防或减轻由生产或外源施用肿瘤坏死因子（TNF）或病毒引起的对动物的不利影响的方法包括给予 动物安全有效量的共轭亚油酸（CLA）或在动物中转化成CLA的物质。 还公开了使用从大鼠结肠分离的细菌制备CLA的方法。
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公开(公告)号：US5827885A
公开(公告)日：1998-10-27
申请号：US912614
申请日：1997-08-18
IPC分类号： A23C9/123 , A23C9/13 , A23K1/16 , A23K1/18 , A23L1/30 , A61K31/201 , A61K31/202 , C12P7/64 , A61K31/20
CPC分类号： A23K50/75 , A23C9/1234 , A23C9/1315 , A23K20/158 , A23L33/12 , A61K31/201 , A61K31/202 , C12P7/6427 , C12P7/6436 , C12P7/6472 , C12R1/225 , A23Y2220/71
摘要： Methods of treating animals to maintain or elevate CD-4 and CD-8 cell levels and to prevent or alleviate the adverse effects on the animal caused by the production or exogenous administration of tumor necrosis factor (TNF) or by a virus consist of administering to the animal a safe and effective amount of a conjugated linoleic acid (CLA) or a substance which is converted in the animal into CLA. A method of preparing CLA employing a bacteria isolated from a rat colon also is disclosed.
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公开(公告)号：US5504114A
公开(公告)日：1996-04-02
申请号：US297471
申请日：1994-08-29
CPC分类号： A23K50/75 , A23C9/1234 , A23C9/1315 , A23K20/158 , A23L33/12 , A61K31/20 , A61K31/201 , A23Y2220/71
摘要： A method of controlling a bird population in an area comprises administering to the female birds in the area an amount of a conjugated linoleic acid (CLA) which is effective to prevent their eggs from hatching. Baits containing the conjugated linoleic acid also are disclosed.
摘要翻译： 一种控制一个地区鸟类种群的方法包括向该地区的雌鸟施用一定量的共轭亚油酸（CLA），其有效地防止其卵孵化。 含有共轭亚油酸的饵料也被公开。
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公开(公告)号：US6113973A
公开(公告)日：2000-09-05
申请号：US60588
申请日：1998-04-15
申请人： Mark E. Cook , Rahim Aydin , Michael W. Pariza
发明人： Mark E. Cook , Rahim Aydin , Michael W. Pariza
CPC分类号： A23K50/75 , A23K20/158 , A23L15/30 , Y10S426/807
摘要： An egg enriched for conjugated linoleic acid and having a normal appearance is produced by feeding poultry a diet enriched in conjugated linoleic acid (CLA) and a selected monounsaturated fatty acid. A poultry feed supplemented having conjugated linoleic acid and a selected monounsaturated fatty acid.
摘要翻译： 通过向家禽喂养富含共轭亚油酸（CLA）的饮食和选择的单不饱和脂肪酸，产生富含共轭亚油酸并具有正常外观的蛋。 补充有共轭亚油酸和选择的单不饱和脂肪酸的家禽饲料。
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6.发明授权Method for controlling body fat and/or body weight in animals and pharmaceutical compositions for use therein comprising 20-carbon conjugated unsaturated fatty acids 失效用于控制动物体内脂肪和/或体重的方法和用于其中的药物组合物，其包含20-碳共轭不饱和脂肪酸
公开(公告)号：US5855917A
公开(公告)日：1999-01-05
申请号：US759496
申请日：1996-12-04
申请人： Mark E. Cook , Yeonhwa Park , Michael W. Pariza
发明人： Mark E. Cook , Yeonhwa Park , Michael W. Pariza
IPC分类号： C12P7/64 , A61K31/201 , A61K31/202 , A61P3/04 , A61P3/06 , C07C51/353 , C07C57/02 , C07C57/03 , A61K9/50 , C07C5/22 , C07C5/23 , C07C5/25
CPC分类号： A61K31/201 , C07C57/02
摘要： Methods of inhibiting lipoprotein lipase and controlling the body fat and the body weight of an animal employ an effective amount of at least one 20 carbon, conjugated, unsaturated, fatty acid. Pharmaceutical compositions for use in the method are also disclosed. The 20-carbon conjugated fatty acids are selected from an eicosadienoic acid, an eicosatrienoic acid, and an eicosatetraenoic acid. Preferably, the fatty acids are 11,13-eicosadienoic acid; 12,14-eicosadienoic acid; 8,11,13-eicosatrienoic acid; 5,8,11,13-eicosatetraenoic acid; 5,8,12,14-eicosatetraenoic acid, or an ester, salt, or mixture thereof.
摘要翻译： 抑制脂蛋白脂肪酶并控制动物的身体脂肪和体重的方法使用有效量的至少一种20碳，共轭，不饱和脂肪酸。 还公开了用于该方法的药物组合物。 20-碳共轭脂肪酸选自二十碳烯酸，二十碳三烯酸和二十碳四烯酸。 优选地，脂肪酸是11,13-二十碳二烯酸; 12,14-二十碳二烯酸; 8,11,13-二十碳三烯酸; 5,8,11,13-二十碳四烯酸; 5,8,12,14-二十碳四烯酸，或其酯，盐或其混合物。
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公开(公告)号：US5814663A
公开(公告)日：1998-09-29
申请号：US736562
申请日：1996-08-28
申请人： Mark E. Cook , Michael W. Pariza
发明人： Mark E. Cook , Michael W. Pariza
IPC分类号： A61P3/04 , A23C9/152 , A23D7/00 , A23D7/005 , A23K1/16 , A23L1/29 , A23L1/30 , A61K31/20 , A61K31/201
CPC分类号： A61K31/201 , A23C9/1528 , A23D7/001 , A23D7/0056 , A23K20/158 , A23L33/12 , A23L33/40 , A23V2002/00
摘要： A method of maintaining an existing level of body fat or body weight in a human which comprises administering to a human desiring to maintain that existing level a safe and effective amount of conjugated linoleic acid (CLA) to maintain that level.
摘要翻译： 维持人体内脂肪或体重现有水平的方法，其包括对希望维持该现有水平的人施用安全有效量的共轭亚油酸（CLA）以维持该水平。
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8.发明授权Method of increasing fat firmness and improving meat quality in animals with conjugated linolenic acid 失效用共轭亚麻酸提高动物脂肪硬度和改善肉质的方法
公开(公告)号：US5851572A
公开(公告)日：1998-12-22
申请号：US845535
申请日：1997-04-25
CPC分类号： A23K50/00 , A23K20/158 , Y10S426/807
摘要： A method of treating meat animals to increase fat firmness and meat quality indices which increases meat processability consists of administering to the meat animals a safe and effective amount of conjugated linoleic acid or CLA.
摘要翻译： 一种治疗肉类动物以提高脂肪坚实度和增加肉加工性的肉质量指数的方法包括向肉类动物施用安全有效量的共轭亚油酸或CLA。
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9.发明授权Methods of treating animals to maintain or enhance bone mineral content and compositions for use therein 失效治疗动物维持或增强骨矿物质含量的方法和用于其中的组合物
公开(公告)号：US5804210A
公开(公告)日：1998-09-08
申请号：US693577
申请日：1996-08-07
申请人： Mark E. Cook , Michael W. Pariza
发明人： Mark E. Cook , Michael W. Pariza
IPC分类号： A61K31/201 , A61K31/231 , A61K33/06 , A61K33/10 , A61K33/42 , A61P19/08 , A61K9/68
CPC分类号： A61K33/06 , A61K31/201 , A61K33/10
摘要： A method of treating an animal to maintain or enhance the mineral content of the bones of the animal consists of administering to the animal a safe and effective amount of CLA. Compositions for use in the method are also disclosed.
摘要翻译： 治疗动物维持或增强动物骨骼的矿物质含量的方法包括向动物施用安全有效量的CLA。 还公开了用于该方法的组合物。
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公开(公告)号：US5554646A
公开(公告)日：1996-09-10
申请号：US297472
申请日：1994-08-29
申请人： Mark E. Cook , Michael W. Pariza , Yeonhwa Park
发明人： Mark E. Cook , Michael W. Pariza , Yeonhwa Park
IPC分类号： A23C9/123 , A23C9/13 , A23C9/152 , A23D7/00 , A23D7/005 , A23K1/16 , A23K1/18 , A23L1/29 , A23L1/30 , A61K9/107 , A61K31/00 , A61K31/20 , A61K31/201 , A61P3/00 , A61P3/04 , A61P43/00 , A61K31/23
CPC分类号： A23C9/1234 , A23C9/1315 , A23C9/1528 , A23D7/001 , A23D7/0056 , A23K20/158 , A23K50/75 , A23L33/12 , A23L33/40 , A61K31/20 , A61K31/201 , A23V2002/00 , A23Y2220/71
摘要： A method of reducing body fat comprises administering to the animal a safe and effective amount of a conjugated linoleic acid. Methods of preserving or increasing the animal's body protein by administering the conjugated linoleic acid also are disclosed.
摘要翻译： 降低体脂的方法包括向动物施用安全有效量的共轭亚油酸。 还公开了通过施用共轭亚油酸维持或增加动物体内蛋白质的方法。
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