Glycosylation site-specific antibodies and anti-cancer compounds

    公开(公告)号:US10317409B2

    公开(公告)日:2019-06-11

    申请号:US14195209

    申请日:2014-03-03

    申请人: Hyesook Kim Sohee Kim

    发明人: Hyesook Kim Sohee Kim

    摘要: A method of characterizing the protein O-GlcNAcylation site-specificity of an antibody. A method of detecting or quantitating the expression of site-specific O-GlcNAcylated proteins expressed in cells and biological samples. A method of diagnosing cancer in a host based on the cellular expression of site-specific O-GlcNAcylated proteins. A method of screening anti-cancer compounds according to their ability to increase a level O-GlcNAcylation of oncogene or tumor suppressor proteins. Methods of treating cancer in an animal host by administering compounds that increase a level of O-GlcNAcylated c-myc or p53 in cancer cells. A method of distinguishing subclasses of pancreatic cancer according to the sensitivity of pancreatic cancer cells to an imidazole derivative, and a method of personalized pancreatic cancer treatment delivered according to the sensitivity subclasses.

    In vivo implantable coil assembly
    4.
    发明申请
    In vivo implantable coil assembly 有权
    体内可植入线圈组件

    公开(公告)号:US20080021525A1

    公开(公告)日:2008-01-24

    申请号:US11880103

    申请日:2007-07-17

    IPC分类号: A61N1/02 B05D5/00 G03C5/00

    CPC分类号: A61N2/02 A61N1/40

    摘要: An in-vivo implantable coil assembly includes a planar coil having at least one coil layer formed from conductive traces disposed in or on a polymer matrix. A ferrite platelet is bonded to a surface of the polymer matrix. Methods of making and using the in-vivo implantable coil assembly are also disclosed.

    摘要翻译: 体内可植入线圈组件包括具有至少一个线圈层的平面线圈,该线圈层由设置在聚合物基体中或其上的导电迹线形成。 铁氧体血小板结合到聚合物基质的表面。 还公开了制造和使用体内可植入线圈组件的方法。