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    Gas sensor
    1.
    发明授权
    Gas sensor 失效
    气体传感器

    公开(公告)号：US4694834A

    公开(公告)日：1987-09-22

    申请号：US846388

    申请日：1986-03-31

    申请人： Mark E. Meyerhoff ,  Eric J. Fogt ,  Darrel F. Untereker

    发明人： Mark E. Meyerhoff ,  Eric J. Fogt ,  Darrel F. Untereker

    IPC分类号： G01N27/414 ,  A61B5/00

    CPC分类号： G01N27/4141

    摘要： A simplified gas sensor which includes a pH sensitive transducer having a gate-insulated field effect transistor (FET) structure. The gas sensor is particularly adapted to detect carbon dioxide in fluids.

    摘要翻译： 一种简化的气体传感器，其包括具有栅极绝缘场效应晶体管（FET）结构的pH敏感传感器。 气体传感器特别适用于检测流体中的二氧化碳。

    Methods and Systems for Measurement of Tear Glucose Levels
    2.
    发明申请
    Methods and Systems for Measurement of Tear Glucose Levels 审中-公开
    用于测量泪液葡萄糖水平的方法和系统

    公开(公告)号：US20130008803A1

    公开(公告)日：2013-01-10

    申请号：US13342634

    申请日：2012-01-03

    申请人： Mark E. Meyerhoff ,  Bruce E. Cohan ,  Qinyi Yan ,  Bo Peng ,  Zvi Flanders

    发明人： Mark E. Meyerhoff ,  Bruce E. Cohan ,  Qinyi Yan ,  Bo Peng ,  Zvi Flanders

    IPC分类号： G01N27/327

    CPC分类号： G01N27/3271 ,  A61B5/1486

    摘要： A sensor system for determining glucose concentration in a tear fluid sample includes a working electrode including an immobilized glucose oxidase enzyme portion for reacting with glucose in the tear fluid sample, and a selectivity portion for enhancing the selectivity for glucose over electroactive interferent species in the tear fluid sample. Alternatively, a vessel for receiving the tear fluid sample may include the enzyme portion on an inner wall thereof. A reference electrode is disposed adjacent the working electrode, wherein the electrochemical reaction of the enzyme portion with glucose in the tear fluid sample generates a current related to the glucose concentration in the tear fluid sample.

    摘要翻译： 用于测定泪液样品中的葡萄糖浓度的传感器系统包括工作电极，其包括用于与泪液样品中的葡萄糖反应的固定的葡萄糖氧化酶部分和用于提高对泪液中的电活性干扰物种的葡萄糖选择性的选择性部分 流体样品。 或者，用于接收泪液样品的容器可以包括在其内壁上的酶部分。 参考电极设置在工作电极附近，其中酶部分与泪液样品中的葡萄糖的电化学反应产生与泪液样品中的葡萄糖浓度相关的电流。

    BIOCOMPATIBLE COATINGS, AND METHODS OF MAKING AND USING THE SAME
    3.
    发明申请
    BIOCOMPATIBLE COATINGS, AND METHODS OF MAKING AND USING THE SAME 失效
    生物涂料，以及制备和使用它们的方法

    公开(公告)号：US20110144229A1

    公开(公告)日：2011-06-16

    申请号：US13059317

    申请日：2009-08-19

    申请人： Mark E. Meyerhoff ,  Jun Yang

    发明人： Mark E. Meyerhoff ,  Jun Yang

    IPC分类号： C08G73/04 ,  A61L33/06

    CPC分类号： A61L27/34 ,  A61L17/145 ,  A61L29/085 ,  A61L31/10

    摘要： Disclosed herein are biocompatible coatings for a substrate, the biocompatible coating including at least one polyanionic/polycationic bilayer including at least one nitric oxide generating moiety, wherein the polyanionic/polycationic bilayer has a layer of a polycationic polymeric material; and a layer of polyanionic material capable of non-covalently bonding to the polycationic polymeric material. Devices incorporating such coatings, and methods of making and using such coatings are also disclosed herein.

    摘要翻译： 本文公开了用于底物的生物相容性涂层，所述生物相容性涂层包括至少一种包含至少一种一氧化氮产生部分的聚阳离子/阳离子双层，其中所述聚阴离子/阳离子双层具有聚阳离子聚合物材料层; 以及能够与聚阳离子聚合物材料非共价键合的聚阴离子材料层。 包含这种涂层的装置以及制造和使用这种涂层的方法也在本文中公开。

    SENSOR FOR DETECTING NITROSOTHIOLS
    6.
    发明申请
    SENSOR FOR DETECTING NITROSOTHIOLS 失效
    用于检测硝基酪氨酸的传感器

    公开(公告)号：US20100276284A1

    公开(公告)日：2010-11-04

    申请号：US12061271

    申请日：2008-04-02

    申请人： Mark E. Meyerhoff ,  Wansik Cha

    发明人： Mark E. Meyerhoff ,  Wansik Cha

    IPC分类号： G01N27/26

    CPC分类号： A61K33/34 ,  A61L31/16 ,  A61L2300/114 ,  A61M1/3672 ,  A61M1/3673 ,  A61M2202/0275 ,  B01J23/72 ,  B01J31/003 ,  B01J31/1805 ,  C12N11/02 ,  C12N11/14 ,  C12Q1/005 ,  G01N33/84

    摘要： A device for detecting nitrosothiol content in a solution includes at least two electrodes disposed in a housing, wherein one of the at least two electrodes is a working electrode having a platinized tip and the other of the at least two electrodes is a counter electrode. A filter membrane is disposed at an end of the housing and is configured to come in contact with the solution. The filter membrane and at least a portion of the working electrode have a material coated thereon. The material includes a polymer and a source of copper dispersed within the material. The material and the platinized tip are configured to come into contact with the solution containing nitrosothiols to convert the nitrosothiols to nitric oxide in order to detect the nitrosothiol content.

    摘要翻译： 用于检测溶液中亚硝基硫醇含量的装置包括设置在壳体中的至少两个电极，其中所述至少两个电极中的一个是具有镀铂尖端的工作电极，并且所述至少两个电极中的另一个是对电极。 过滤膜设置在壳体的端部并且被配置为与溶液接触。 过滤膜和至少一部分工作电极具有涂覆在其上的材料。 该材料包括聚合物和分散在该材料内的铜源。 材料和镀铂的尖端被配置为与含有亚硝基硫醇的溶液接触以将亚硝基硫醇转化成一氧化氮以检测亚硫醇含量。

    Optical monitoring of cleaving enzyme activity
    8.
    发明授权
    Optical monitoring of cleaving enzyme activity 失效
    光学监测切割酶活性

    公开(公告)号：US07521188B2

    公开(公告)日：2009-04-21

    申请号：US11070568

    申请日：2005-03-02

    申请人： Hyoungsik Yim ,  Mark E. Meyerhoff ,  Youngmi Lee

    发明人： Hyoungsik Yim ,  Mark E. Meyerhoff ,  Youngmi Lee

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07K14/47

    CPC分类号： C12Q1/37 ,  C12Q1/34 ,  G01N2333/922

    摘要： A marker molecule for monitoring cleaving enzyme activity is disclosed. The marker molecule includes a protein, a peptide, or an oligonucleotide. A co-factor is conjugated to the protein, the peptide, or the oligonucleotide, thereby forming a co-factor labeled protein, a co-factor labeled peptide, or a co-factor labeled oligonucleotide. The co-factor is adapted to produce an enzymatic signal that is optically detectable.

    摘要翻译： 公开了一种用于监测切割酶活性的标记分子。 标记分子包括蛋白质，肽或寡核苷酸。 辅因子与蛋白质，肽或寡核苷酸结合，从而形成辅因子标记的蛋白质，辅因子标记肽或辅因子标记的寡核苷酸。 辅因子适于产生可光学检测的酶信号。

    Rotating potentiometric electrode
    9.
    发明授权
    Rotating potentiometric electrode 失效
    旋转电位电极

    公开(公告)号：US06908542B2

    公开(公告)日：2005-06-21

    申请号：US10013301

    申请日：2001-12-07

    申请人： Mark E. Meyerhoff ,  Qingshan Ye

    发明人： Mark E. Meyerhoff ,  Qingshan Ye

    IPC分类号： G01N33/483 ,  G01N27/28 ,  G01N27/333 ,  G01N27/403 ,  G01N33/68

    CPC分类号： G01N27/3335

    摘要： A rotating electrode configuration lowers the detection limits of polyion-sensitive membrane electrodes. Planar potentiometric polycation and polyanion-sensitive membrane electrodes were prepared by incorporating tridodecylmethylammonium chloride and calcium dinonylnaphthalene sulfonate, respectively, into plasticized PVC or polyurethane membranes, and mounting discs of such films on an electrode body housed in a rotating disk electrode apparatus of the type used in voltammetry. Due to the unique non-equilibrium response mechanism of such sensors, rotation of the polyion-sensitive membrane electrodes at 5000 rpm resulted in an enhancement in the detection limits toward heparin (polyanion) and protamine (polycation) of at least 1 order of magnitude (to 0.01 U/ml for heparin; 0.02 μg/ml for protamine) over that observed when the EMF responses of the same electrodes were assessed using a stir-bar to achieve convective mass transport.

    摘要翻译： 旋转电极结构降低了聚偏敏膜电极的检测限。 通过将十三烷基甲基氯化铵和二壬基萘磺酸钙分别加入到塑化的PVC或聚氨酯膜中并将这种膜的安装盘安装在所用类型的旋转圆盘电极装置中的电极体上，制备平面电位聚阳离子和聚阴离子敏感膜电极 用伏安法 由于这种传感器的独特的非平衡响应机制，聚偏转膜电极以5000rpm的旋转导致了对肝素（聚阴离子）和鱼精蛋白（聚阳离子）的检测限度的提高至少1个数量级 对于肝素为0.01U / ml;对于鱼精蛋白为0.02mug / ml）超过使用搅拌棒评估相同电极的EMF响应以实现对流质量传输时观察到的。

    Device for detecting nitrosothiol content in solution
    10.
    发明授权
    Device for detecting nitrosothiol content in solution 失效
    用于检测溶液中亚硝基硫醇含量的装置

    公开(公告)号：US08168423B2

    公开(公告)日：2012-05-01

    申请号：US12061271

    申请日：2008-04-02

    申请人： Mark E. Meyerhoff ,  Wansik Cha

    发明人： Mark E. Meyerhoff ,  Wansik Cha

    IPC分类号： C12M1/34 ,  C12Q1/00

    CPC分类号： A61K33/34 ,  A61L31/16 ,  A61L2300/114 ,  A61M1/3672 ,  A61M1/3673 ,  A61M2202/0275 ,  B01J23/72 ,  B01J31/003 ,  B01J31/1805 ,  C12N11/02 ,  C12N11/14 ,  C12Q1/005 ,  G01N33/84

    摘要： A device for detecting nitrosothiol content in a solution includes at least two electrodes disposed in a housing, wherein one of the at least two electrodes is a working electrode having a platinized tip and the other of the at least two electrodes is a counter electrode. A filter membrane is disposed at an end of the housing and is configured to come in contact with the solution. The filter membrane and at least a portion of the working electrode have a material coated thereon. The material includes a polymer and a source of copper dispersed within the material. The material and the platinized tip are configured to come into contact with the solution containing nitrosothiols to convert the nitrosothiols to nitric oxide in order to detect the nitrosothiol content.

    摘要翻译： 用于检测溶液中亚硝基硫醇含量的装置包括设置在壳体中的至少两个电极，其中所述至少两个电极中的一个是具有镀铂尖端的工作电极，并且所述至少两个电极中的另一个是对电极。 过滤膜设置在壳体的端部并且被配置为与溶液接触。 过滤膜和至少一部分工作电极具有涂覆在其上的材料。 该材料包括聚合物和分散在该材料内的铜源。 材料和镀铂的尖端被配置为与含有亚硝基硫醇的溶液接触以将亚硝基硫醇转化成一氧化氮以检测亚硫醇含量。