-
公开(公告)号：US08946260B2
公开(公告)日：2015-02-03
申请号：US13823792
申请日：2011-09-14
申请人： Mark Gary Bock , Christoph Gaul , Venkateshwar Rao Gummadi , Henrik Moebitz , Saumitra Sengupta
发明人： Mark Gary Bock , Christoph Gaul , Venkateshwar Rao Gummadi , Henrik Moebitz , Saumitra Sengupta
IPC分类号： A01N43/42 , A61K31/47 , A61K31/44 , C07D513/02 , C07D515/02 , C07D221/06 , C07D207/22 , C07D455/04 , C07D471/00 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00 , C07D401/04 , C07D471/04 , C07D471/14 , C07D495/04 , A61K31/4365 , A61K31/437 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D401/14
CPC分类号： A61K31/473 , A61K31/4365 , A61K31/437 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/14 , C07D471/04 , C07D471/14 , C07D495/04
摘要： The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，A和n如本文所定义。 还提供了式（I）化合物的氘代衍生物。
-
公开(公告)号：US20140045872A1
公开(公告)日：2014-02-13
申请号：US13823792
申请日：2011-09-14
申请人： Mark Gary Bock , Christoph Gaul , Venkateshwar Rao Gummadi , Henrik Moebitz , Saumitra Sengupta
发明人： Mark Gary Bock , Christoph Gaul , Venkateshwar Rao Gummadi , Henrik Moebitz , Saumitra Sengupta
IPC分类号： C07D495/04 , A61K31/4725 , A61K31/4365 , A61K45/06 , C07D401/14 , A61K31/506 , C07D471/04 , A61K31/437 , C07D401/04 , A61K31/473
CPC分类号： A61K31/473 , A61K31/4365 , A61K31/437 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/14 , C07D471/04 , C07D471/14 , C07D495/04
摘要： The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，A和n如本文所定义。 还提供了式（I）化合物的氘代衍生物。
-
公开(公告)号：US08614239B2
公开(公告)日：2013-12-24
申请号：US13514208
申请日：2010-12-07
申请人： Dinesh Chikkanna , Mark Gary Bock , Clive McCarthy , Henrik Moebitz , Chetan Pandit , Ramulu Poddutorri
发明人： Dinesh Chikkanna , Mark Gary Bock , Clive McCarthy , Henrik Moebitz , Chetan Pandit , Ramulu Poddutorri
IPC分类号： A61K31/423 , A61K31/343 , C07D263/56 , C07D307/79
CPC分类号： C07D263/56 , C07D307/79
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds have been demonstrated as inhibitors of MEK and therefore may be useful in the treatment of hyperproliferative diseases (e.g., cancer and inflammation).
摘要翻译： 本发明涉及式（I）的化合物及其药学上可接受的盐。 这些化合物已被证明是MEK的抑制剂，因此可用于治疗过度增生性疾病（例如癌症和炎症）。
-
公开(公告)号：US09227969B2
公开(公告)日：2016-01-05
申请号：US14451563
申请日：2014-08-05
IPC分类号： C07D471/04 , A61K31/53 , A61K31/4745 , A61K31/506 , A61K31/513 , A61K31/437 , A61K45/06
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4745 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/53 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compounds of formula I: in which n, R1, R2, R3a, R4 and R5 are defined in the Summary of the Invention; capable of inhibiting the activity of MEK. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of hyperproliferative diseases like cancer.
摘要翻译： 本发明涉及式I化合物：其中n，R1，R2，R3a，R4和R5定义在发明概述中; 能够抑制MEK的活性。 本发明还提供了制备本发明化合物的方法，包含这些化合物的药物制剂以及使用这些化合物和组合物来控制过度增殖性疾病如癌症的方法。
-
公开(公告)号：US20120245209A1
公开(公告)日：2012-09-27
申请号：US13514208
申请日：2010-12-07
申请人： Dinesh Chikkanna , Mark Gary Bock , Clive McCarthy , Henrik Moebitz , Chetan Pandit , Ramulu Poddutorri
发明人： Dinesh Chikkanna , Mark Gary Bock , Clive McCarthy , Henrik Moebitz , Chetan Pandit , Ramulu Poddutorri
IPC分类号： C07D263/56 , A61P35/00 , A61K31/343 , A61K31/423 , C07D307/79
CPC分类号： C07D263/56 , C07D307/79
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds have been demonstrated as inhibitors of MEK and therefore may be useful in the treatment of hyperproliferative diseases (e.g., cancer and inflammation).
摘要翻译： 本发明涉及式（I）的化合物及其药学上可接受的盐。 这些化合物已被证明是MEK的抑制剂，因此可用于治疗过度增生性疾病（例如癌症和炎症）。
-
公开(公告)号：US09840498B2
公开(公告)日：2017-12-12
申请号：US14907225
申请日：2014-07-24
申请人： NOVARTIS AG , Zhenxing Du , Samuel Hintermann , Konstanze Hurth , Sebastien Jacquier , Hansjoerg Lehmann , Henrik Moebitz , Nicolas Soldermann , Aleksandar Stojanovic
发明人： Zhenxing Du , Samuel Hintermann , Konstanze Hurth , Sébastien Jacquier , Hansjoerg Lehmann , Henrik Moebitz , Nicolas Soldermann , Aleksandar Stojanovic
IPC分类号： C07D403/14 , C07D401/14 , C07D417/14 , C07D473/16 , A61K31/517 , A61K31/52
CPC分类号： C07D403/14 , A61K31/517 , A61K31/52 , C07D401/14 , C07D417/14 , C07D473/16
摘要： Provided are substituted quinazolin-4-one compounds of the formula (I) and/or pharmaceutically acceptable salts and/or solvates thereof, wherein R1, R2, R3, R5, R6 and L are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the class I PI3K kinases.
-
7.发明授权公开(公告)号：US08093406B2
公开(公告)日：2012-01-10
申请号：US12500093
申请日：2009-07-09
申请人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
发明人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
IPC分类号： C07D335/02
CPC分类号： C07D335/02 , C07D409/10 , C07D409/12 , C07D413/12 , C07F7/0812
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备方式，其用作药物和包含它们的药物。
-
8.发明申请公开(公告)号：US20090054427A1
公开(公告)日：2009-02-26
申请号：US12196461
申请日：2008-08-22
申请人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
发明人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
IPC分类号： A61K31/5377 , C07D335/02 , A61K31/382 , A61P25/00 , C07D413/08
CPC分类号： C07D335/02 , C07D409/12
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备方式，其用作药物和包含它们的药物。
-
公开(公告)号：US20110190334A1
公开(公告)日：2011-08-04
申请号：US12938583
申请日：2010-11-03
IPC分类号： A61K31/437 , C07D471/04 , A61P35/00
CPC分类号： C07D471/04 , C07D498/04 , C07D513/04
摘要： The present invention relates to compounds of Formula I where R1a, R1b, X, R2a, R2b, W, R3, R4, and R5 are as defined herein as well as pharmaceutically acceptable salts thereof. The compounds have been shown to act as MEK inhibitors which may be useful in the treatment of hyperproliferative diseases, like cancer and inflammation.
摘要翻译： 本发明涉及其中R1a，R1b，X，R2a，R2b，W，R3，R4和R5如本文所定义的式I化合物及其药学上可接受的盐。 已经显示这些化合物作为MEK抑制剂，其可用于治疗过度增殖性疾病如癌症和炎症。
-
10.发明申请公开(公告)号：US20100056490A1
公开(公告)日：2010-03-04
申请号：US12500093
申请日：2009-07-09
申请人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
发明人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
IPC分类号： A61K31/397 , C07D401/12 , C07D205/02 , C07D335/02 , A61K31/4535 , A61K31/382 , A61P25/00 , A61P9/10
CPC分类号： C07D335/02 , C07D409/10 , C07D409/12 , C07D413/12 , C07F7/0812
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备方式，其用作药物和包含它们的药物。
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.038 秒)
