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公开(公告)号：US06077858A
公开(公告)日：2000-06-20
申请号：US401416
申请日：1999-09-21
申请人： Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人： Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号： C07D409/14 , C07D487/08 , A61K31/44
CPC分类号： C07D409/14 , C07D487/08
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US5985901A
公开(公告)日：1999-11-16
申请号：US83479
申请日：1998-05-22
申请人： Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人： Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , C07D521/00 , A61K31/44
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D413/12
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US5981550A
公开(公告)日：1999-11-09
申请号：US83574
申请日：1998-05-22
申请人： Mark Goulet , Thomas F. Walsh , Feroze Ujjainwalla , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人： Mark Goulet , Thomas F. Walsh , Feroze Ujjainwalla , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号： C07D409/14 , C07D487/08 , C07D401/12 , A61K31/44
CPC分类号： C07D409/14 , C07D487/08
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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4.发明授权公开(公告)号：US07015235B2
公开(公告)日：2006-03-21
申请号：US10468515
申请日：2002-02-25
申请人： Mark T. Goulet , Ravi P. Nargund , Iyassu K. Sebhat , Feroze Ujjainwalla , Thomas F. Walsh , Daniel Warner , Zhixiong Ye , Jonathan R. Young , Raman K. Bakshi
发明人： Mark T. Goulet , Ravi P. Nargund , Iyassu K. Sebhat , Feroze Ujjainwalla , Thomas F. Walsh , Daniel Warner , Zhixiong Ye , Jonathan R. Young , Raman K. Bakshi
IPC分类号： A61K31/445 , C07D211/06
CPC分类号： C07D491/08 , A61K31/445 , C07D211/62 , C07D211/64 , C07D401/06 , C07D401/14 , C07D413/06 , C07D413/14
摘要： Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
摘要翻译： 某些新的4-取代N-酰化哌啶衍生物是人黑皮质素受体的激动剂，特别是人黑皮质素-4受体（MC-4R）的选择性激动剂。 因此，它们可用于治疗，控制或预防对MC-4R的活化反应的疾病和病症，例如肥胖，糖尿病，性功能障碍，包括勃起功能障碍和女性性功能障碍。
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公开(公告)号：US6110931A
公开(公告)日：2000-08-29
申请号：US276028
申请日：1999-03-25
IPC分类号： A61P5/02 , C07D519/00 , A61K31/437 , A61K31/4375 , C07D471/04 , C07D487/04
CPC分类号： C07D519/00
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US6150522A
公开(公告)日：2000-11-21
申请号：US180646
申请日：1998-11-12
IPC分类号： C07D215/16 , A61K31/50 , A61K31/47 , C07D239/70
CPC分类号： C07D215/16
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related conditions in both men and women. ##STR1##
摘要翻译： PCT No.PCT / US97 / 08782 Sec。 371日期：1998年11月12日 102（e）1998年11月12日日期PCT提交1997年5月16日PCT公布。 第WO97 / 44041号公报 日期1997年11月27日公开了可用作GnRH拮抗剂的式（I）化合物及其药学上可接受的盐，因此可用于治疗男性和女性中各种性激素相关病症。
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公开(公告)号：US6025366A
公开(公告)日：2000-02-15
申请号：US275754
申请日：1999-03-25
IPC分类号： C07D471/04 , C07D519/00 , A61K31/435
CPC分类号： C07D471/04
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US6162813A
公开(公告)日：2000-12-19
申请号：US180656
申请日：1998-11-12
IPC分类号： A61K31/00 , A61K31/47 , A61K31/4709 , A61P5/00 , A61P5/06 , A61P5/24 , A61P15/00 , A61P25/20 , A61P35/00 , C07D409/14 , A61K31/4704 , C07D215/20 , C07D215/22
CPC分类号： C07D409/14
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related conditions in both men and women.
摘要翻译： PCT No.PCT / US97 / 08428 Sec。 371日期：1998年11月12日 102（e）1998年11月12日日期PCT提交1997年5月16日PCT公布。 出版物WO97 / 44037 日期1997年11月27日公开了可用作GnRH拮抗剂的式（I）化合物及其药学上可接受的盐，因此可用于治疗男性和女性中各种性激素相关病症。
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9.发明授权公开(公告)号：US07329673B2
公开(公告)日：2008-02-12
申请号：US10548350
申请日：2004-03-31
申请人： Liangqin Guo , Shuwen He , Tianying Jian , Yingjie Lai , Jian Liu , Ravi P. Nargund , Iyassu K. Sebhat , Feroze Ujjainwalla , Zhixiong Ye , Jonathan R. Young
发明人： Liangqin Guo , Shuwen He , Tianying Jian , Yingjie Lai , Jian Liu , Ravi P. Nargund , Iyassu K. Sebhat , Feroze Ujjainwalla , Zhixiong Ye , Jonathan R. Young
IPC分类号： A61K31/438 , C07D221/20 , C07D401/02
CPC分类号： A61K31/445 , C07D401/06 , C07D401/14 , C07D471/10 , C07D491/10
摘要： Certain novel N-acylated spiropiperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
摘要翻译： 某些新的N-酰化螺哌啶衍生物是人类黑皮质素受体的激动剂，特别是人黑素皮质素-4受体（MC-4R）的选择性激动剂。 因此，它们可用于治疗，控制或预防对MC-4R的激活反应的疾病和病症，例如肥胖，糖尿病，性功能障碍，包括勃起功能障碍和女性性功能障碍。
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公开(公告)号：US6159975A
公开(公告)日：2000-12-12
申请号：US247240
申请日：1999-02-10
IPC分类号： C07D519/00 , C07D401/12 , A61K31/407 , C07D215/06 , C07D471/04 , C07D487/06
CPC分类号： C07D519/00
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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