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公开(公告)号：US06077858A
公开(公告)日：2000-06-20
申请号：US401416
申请日：1999-09-21
申请人： Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人： Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号： C07D409/14 , C07D487/08 , A61K31/44
CPC分类号： C07D409/14 , C07D487/08
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US5985901A
公开(公告)日：1999-11-16
申请号：US83479
申请日：1998-05-22
申请人： Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人： Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , C07D521/00 , A61K31/44
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D413/12
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US5981550A
公开(公告)日：1999-11-09
申请号：US83574
申请日：1998-05-22
申请人： Mark Goulet , Thomas F. Walsh , Feroze Ujjainwalla , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人： Mark Goulet , Thomas F. Walsh , Feroze Ujjainwalla , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号： C07D409/14 , C07D487/08 , C07D401/12 , A61K31/44
CPC分类号： C07D409/14 , C07D487/08
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US6156767A
公开(公告)日：2000-12-05
申请号：US83477
申请日：1998-05-22
IPC分类号： C07D401/12 , C07D401/14 , C07D487/08 , C07D217/00 , A61K31/56 , C07D215/12 , C07D401/00
CPC分类号： C07D401/14 , C07D401/12 , C07D487/08
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译： 公开了式（I）化合物及其药学上可接受的盐，其可用作GnRH的拮抗剂，因此可用于治疗男性和女性中各种性激素相关和其他病症。
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5.发明申请公开(公告)号：US20060211677A1
公开(公告)日：2006-09-21
申请号：US10565604
申请日：2004-07-20
申请人： Lin Chu , Mark Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John Hutchinson
发明人： Lin Chu , Mark Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John Hutchinson
IPC分类号： C07D471/02 , C07D215/12 , C07D237/28 , A61K31/50 , A61K31/4965 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/4164 , A61K31/4745 , A61K31/433 , A61K31/4245
CPC分类号： C07D215/14 , C07D215/12 , C07D237/28 , C07D277/64 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/02
摘要： The instant invention provides compounds of formula: (I) which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cyto-protective agents.
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公开(公告)号：US06211224B1
公开(公告)日：2001-04-03
申请号：US09178688
申请日：1998-10-26
IPC分类号： A61K31404
CPC分类号： C07D209/14
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译： 公开了式（I）化合物及其药学上可接受的盐，其可用作GnRH的拮抗剂，因此可用于治疗男性和女性中各种性激素相关和其他病症。
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公开(公告)号：US6159989A
公开(公告)日：2000-12-12
申请号：US465199
申请日：1999-12-15
IPC分类号： A61P15/08 , C07D453/06 , C07D487/08 , A61K31/405 , A61K31/454 , C07D211/26 , C07D401/14
CPC分类号： C07D487/08 , C07D453/06
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US5849764A
公开(公告)日：1998-12-15
申请号：US760817
申请日：1996-12-05
申请人： Mark Goulet , Lin Chu , Thomas F. Walsh , Michael H. Fisher , Narindar N. Girotra , Matthew J. Wyvratt , Peter Lin , Wallace T. Ashton
发明人： Mark Goulet , Lin Chu , Thomas F. Walsh , Michael H. Fisher , Narindar N. Girotra , Matthew J. Wyvratt , Peter Lin , Wallace T. Ashton
IPC分类号： C07D20060101 , C07D209/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D471/04 , A61K31/44 , A61K31/40 , C07D209/02 , C07D215/12
CPC分类号： C07D209/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D471/04
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US6017944A
公开(公告)日：2000-01-25
申请号：US178689
申请日：1998-10-26
IPC分类号： A61P15/08 , C07D453/06 , C07D487/08 , A61K31/40 , A61K31/405 , C07D209/02 , C07D209/12 , C07D403/10
CPC分类号： C07D487/08 , C07D453/06
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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10.发明授权Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use 失效二苯基取代的环烷烃，含这些化合物的组合物和使用方法公开(公告)号：US07629467B2
公开(公告)日：2009-12-08
申请号：US10565604
申请日：2004-07-20
申请人： Lin Chu , Mark T. Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John H. Hutchinson
发明人： Lin Chu , Mark T. Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John H. Hutchinson
IPC分类号： C07D215/06 , C07D215/12 , C07D215/16 , A61K31/4375
CPC分类号： C07D215/14 , C07D215/12 , C07D237/28 , C07D277/64 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/02
摘要： The instant invention provides compounds of formula: (I) which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cyto-protective agents.
摘要翻译： 本发明提供了式（I）化合物，其为5-脂氧合酶活化蛋白抑制剂：式（I）。 式（I）化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。
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