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公开(公告)号：US07158903B2
公开(公告)日：2007-01-02
申请号：US10508068
申请日：2003-03-14
IPC分类号： G06F19/00
CPC分类号： H01J49/0009 , H01J49/004 , Y10T436/11
摘要： The present invention provides methods for high throughput analysis of analytes in complex mixtures for unresolved chromatographic peaks including specific embodiment for summing intensities for each mass transition of interest over a selected chromatographic peak (50) to generate a signal corresponding to total intensity for each transition (55, 60). The intensities are deconvoluted into intensities of individual analytes (65, 70), based on branching ratios acquired from authentic standards, and a comparison to calibration curve is performed to obtain a quantitative concentration measurement of a particular analyte in a sample.
摘要翻译： 本发明提供了用于未分辨色谱峰的复杂混合物中分析物的高通量分析的方法，包括用于在所选择的色谱峰（50）上对每个感兴趣的质量转换求和强度的特定实施方案，以产生对应于每个转变的总强度的信号 55，60）。 基于从真实标准获得的分支比例，将强度解卷积成单个分析物（65,70）的强度，并且进行与校准曲线的比较以获得样品中特定分析物的定量浓度测量。
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公开(公告)号：US09834578B2
公开(公告)日：2017-12-05
申请号：US13114885
申请日：2011-05-24
申请人： Bingfang Yue , Alan L. Rockwood , Mark M. Kushnir
发明人： Bingfang Yue , Alan L. Rockwood , Mark M. Kushnir
CPC分类号： C07J1/0022 , C07J41/0016
摘要： The present disclosure provides methods and composition involving increased sensitivity of compounds using mass spectrometry. In one embodiment, a method of increasing the sensitivity for detection of a carbonyl group-containing compound by mass spectrometry can comprise derivatizing the carbonyl group-containing compound with an O-substituted hydroxylamine thereby producing an oxime, resulting in enhanced sensitivity of detection by mass spectrometry, as compared to the underivatized carbonyl group-containing compound.Additionally, a method for assaying a carbonyl group-containing compound can comprise reacting the carbonyl group-containing compound in a sample with an O-substituted hydroxylamine to produce an oxime and performing analysis with mass spectrometric detection of the oxime by a mass spectrometry instrument.Further, an assay for a ketosteroid can comprise a derivatized ketosteroid produced by reacting the ketosteroid with an O-substituted hydroxylamine to produce an oxime and a mass spectrometry instrument for performing mass spectrometric analysis on the derivatized ketosteroid.
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3.发明申请公开(公告)号：US20120126107A1
公开(公告)日：2012-05-24
申请号：US13114885
申请日：2011-05-24
申请人： Bingfang Yue , Alan L. Rockwood , Mark M. Kushnir
发明人： Bingfang Yue , Alan L. Rockwood , Mark M. Kushnir
CPC分类号： C07J1/0022 , C07J41/0016
摘要： The present disclosure provides methods and composition involving increased sensitivity of compounds using mass spectrometry. In one embodiment, a method of increasing the sensitivity for detection of a carbonyl group-containing compound by mass spectrometry can comprise derivatizing the carbonyl group-containing compound with an O-substituted hydroxylamine thereby producing an oxime, resulting in enhanced sensitivity of detection by mass spectrometry, as compared to the underivatized carbonyl group-containing compound.Additionally, a method for assaying a carbonyl group-containing compound can comprise reacting the carbonyl group-containing compound in a sample with an O-substituted hydroxylamine to produce an oxime and performing analysis with mass spectrometric detection of the oxime by a mass spectrometry instrument.Further, an assay for a ketosteroid can comprise a derivatized ketosteroid produced by reacting the ketosteroid with an O-substituted hydroxylamine to produce an oxime and a mass spectrometry instrument for performing mass spectrometric analysis on the derivatized ketosteroid.
摘要翻译： 本公开提供涉及使用质谱法的化合物增加的灵敏度的方法和组合。 在一个实施方案中，通过质谱法提高检测含羰基化合物的灵敏度的方法可以包括用O-取代的羟胺衍生含羰基化合物，从而产生肟，从而提高质量检测的灵敏度 与未衍生的含羰基化合物相比较。 此外，用于测定含羰基化合物的方法可以包括将样品中的含羰基化合物与O-取代的羟胺反应以产生肟，并通过质谱仪对肟的质谱检测进行分析。 此外，酮甾类的测定可以包括通过使酮类固醇与O-取代的羟胺反应以产生肟而产生的衍生的酮类固醇，以及用于对衍生的酮类固醇进行质谱分析的质谱仪。
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公开(公告)号：US06992299B2
公开(公告)日：2006-01-31
申请号：US10739949
申请日：2003-12-18
申请人： Edgar D. Lee , Milton L. Lee , Alan L. Rockwood , Li Zhou
发明人： Edgar D. Lee , Milton L. Lee , Alan L. Rockwood , Li Zhou
IPC分类号： H01J49/24
摘要： A method and apparatus for focusing ions for delivery to an ion detection device using an aerodynamic ion focusing system that uses a high-velocity converging gas flow at an entrance aperture to focus an ion plume by reducing spreading and increasing desolvation of ions, and wherein a voltage is applied to at least a portion of the aerodynamic ion focusing system to assist in the focusing and delivery of ions to the ion detection device.
摘要翻译： 一种用于将离子聚焦到离子检测装置的方法和装置，所述方法和装置使用空气动力离子聚焦系统，所述空气动力学离子聚焦系统在入口孔处使用高速会聚气体流动，通过减少散射并增加离子的去溶剂化来聚焦离子羽流，并且其中a 电压被施加到空气动力学离子聚焦系统的至少一部分，以帮助将离子聚焦和输送到离子检测装置。
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5.发明授权Tapered or tilted electrodes to allow the superposition of independently controllable DC field gradients to RF fields 失效锥形或倾斜的电极，以允许将独立可控DC场梯度叠加到RF场
公开(公告)号：US6163032A
公开(公告)日：2000-12-19
申请号：US814898
申请日：1997-03-12
申请人： Alan L. Rockwood
发明人： Alan L. Rockwood
CPC分类号： H01J49/063
摘要： The present invention is embodied in a method and apparatus for transporting ions via a path generated by RF electrodes having a controllable DC field gradient generated thereon which does not suffer from mass discrimination. In a preferred embodiment, the number of electrodes are doubled to thereby use symmetry to cancel an undesirable DC quadrapole field. By eliminating the DC quadrapole field, the passband of the DC field gradient is increased, allowing for ions of higher mass to be transported. The electrodes are either tilted or tapered to thereby generate the desirable DC field gradient. Tilting and/or tapering the electrodes advantageously modifies the DC field gradient to increase the high ion mass cut-off.
摘要翻译： 本发明体现在用于通过由其上产生的可控DC场梯度的RF电极产生的路径输送离子的方法和装置，其中不产生质量鉴别。 在优选实施例中，电极的数量加倍，从而使用对称性来消除不需要的DC四极场。 通过消除DC四极场，直流场梯度的通带增加，允许较高质量的离子传输。 电极是倾斜的或锥形的，从而产生期望的DC场梯度。 电极的倾斜和/或渐缩有利地改变了DC场梯度以增加高离子质量截止。
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6.发明授权Electron ionization source for othogonal acceleration time-of-flight mass spectrometry 有权用于正交加速时间飞行质谱的电子电离源公开(公告)号：US07060987B2
公开(公告)日：2006-06-13
申请号：US10793689
申请日：2004-03-03
申请人： Edgar D. Lee , Alan L. Rockwood , Bingfang Yue , Milton L. Lee
发明人： Edgar D. Lee , Alan L. Rockwood , Bingfang Yue , Milton L. Lee
IPC分类号： H01J27/00
CPC分类号： H01J49/147 , H01J49/063
摘要： A radio-frequency quadrupole ion guide having a symmetrical magnetic field disposed along an axis of the ion guide, wherein the system provides prolonged interaction between electrons and uncharged compounds within an ionization volume of the ion guide, resulting in enhanced ion creation.
摘要翻译： 具有沿着离子导向器的轴线设置的对称磁场的射频四极离子导向器，其中系统在离子导向器的离子化体积内的电子和不带电荷的化合物之间提供延长的相互作用，导致增强的离子产生。
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公开(公告)号：US5073713A
公开(公告)日：1991-12-17
申请号：US530667
申请日：1990-05-29
CPC分类号： H01J49/40 , H01J49/004 , H01J49/32
摘要： Dissociations of multiple-charged ions are detected and analyzed by charge-separation tandem mass spectrometry. Analyte molecules are ionized to form multiple-charged parent ions. A particular charge parent ion state is selected in a first-stage mass spectrometer and its mass-to-charge ratio (M/Z) is detected to determine its mass and charge. The selected parent ions are then dissociated, each into a plurality of fragments including a set of daughter ions each having a mass of at least one molecular weight and a charge of at least one. Sets of daughter ions resulting from the dissociation of one parent ion (sibling ions) vary in number but typically include two to four ions, one or more multiply-charged. A second stage mass spectrometer detects mass-to-charge ratio (m/z) of the daughter ions and a temporal or temporo-spatial relationship among them. This relationship is used to correlate the daughter ions to determine which (m/z) ratios belong to a set of sibling ions. Values of mass and charge of each of the sibling ions are determined simultaneously from their respective (m/z) ratios such that the sibling ion charges are integers and sum to the parent ion charge.
摘要翻译： 通过电荷分离串联质谱法检测和分析多电荷离子的离解。 分析物分子被电离以形成多电荷的母体离子。 在第一级质谱仪中选择特定的电荷亲本离子状态，并检测其质荷比（M / Z）以确定其质量和电荷。 然后将所选择的母体离子解离，每个分离成多个片段，包括一组子离子，每个子离子具有至少一个分子量的质量和至少一个的电荷。 由一个亲本离子（同胞离子）的解离产生的子离子集在数量上变化，但通常包括两个至四个离子，一个或多个多次充电。 第二级质谱仪检测子离子的质荷比（m / z）和它们之间的时间或空间 - 空间关系。 这种关系用于关联子离子以确定哪个（m / z）比属于一组同胞离子。 每个同胞离子的质量和电荷的值由它们各自的（m / z）比同时测定，使得同胞离子电荷是整数，并且与母离子电荷相加。
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公开(公告)号：US07375320B2
公开(公告)日：2008-05-20
申请号：US11805789
申请日：2007-05-24
IPC分类号： H01J49/00
CPC分类号： A41C5/005 , H01J49/4295
摘要： A virtual ion trap that uses electric focusing fields instead of machined metal electrodes that normally surround the trapping volume, wherein two opposing surfaces include a plurality of uniquely designed and coated electrodes, and wherein the electrodes can be disposed on the two opposing surfaces using plating techniques that enable much higher tolerances to be met than existing machining techniques.
摘要翻译： 一种虚拟离子阱，其使用电聚焦场而不是通常围绕捕获体积的加工的金属电极，其中两个相对的表面包括多个独特设计和涂覆的电极，并且其中电极可以使用电镀技术设置在两个相对的表面上 这使得可以实现比现有的加工技术更高的公差。
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公开(公告)号：US07227138B2
公开(公告)日：2007-06-05
申请号：US10878989
申请日：2004-06-28
IPC分类号： H01J49/00
CPC分类号： A41C5/005 , H01J49/4295
摘要： A virtual ion trap that uses electric focusing fields instead of machined metal electrodes that normally surround the trapping volume, wherein two opposing surfaces include a plurality of uniquely designed and coated electrodes, and wherein the electrodes can be disposed on the two opposing surfaces using plating techniques that enable much higher tolerances to be met than existing machining techniques.
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公开(公告)号：US07199362B2
公开(公告)日：2007-04-03
申请号：US10821660
申请日：2004-04-09
IPC分类号： H01J49/40
CPC分类号： G01N27/622
摘要： A cross-flow ion mobility analyzer (CIMA) that includes a component of gas flow that opposes an electric field that is established within a channel, wherein ions are carried through the channel, wherein ions of a specific mobility are trapped by the opposing electric field and flow field within the channel and are detected when the ions reach the end of the channel, wherein a detector at the end of the channel sees a continuous stream of mobility-selected ions, and wherein different ions are selected by modifying the electric field and/or the velocity of the flow field.
摘要翻译： 一种交叉流离子迁移率分析仪（CIMA），其包括与在通道内建立的电场相对的气流成分，其中离子通过通道传送，其中特定迁移率的离子被相对的电场 和通道内的流场，并且当离子到达通道的末端时被检测，其中在通道末端的检测器看到连续的迁移率选择的离子流，并且其中通过修改电场来选择不同的离子，并且 /或流场的速度。
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