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公开(公告)号：US07375320B2
公开(公告)日：2008-05-20
申请号：US11805789
申请日：2007-05-24
IPC分类号： H01J49/00
CPC分类号： A41C5/005 , H01J49/4295
摘要： A virtual ion trap that uses electric focusing fields instead of machined metal electrodes that normally surround the trapping volume, wherein two opposing surfaces include a plurality of uniquely designed and coated electrodes, and wherein the electrodes can be disposed on the two opposing surfaces using plating techniques that enable much higher tolerances to be met than existing machining techniques.
摘要翻译： 一种虚拟离子阱，其使用电聚焦场而不是通常围绕捕获体积的加工的金属电极，其中两个相对的表面包括多个独特设计和涂覆的电极，并且其中电极可以使用电镀技术设置在两个相对的表面上 这使得可以实现比现有的加工技术更高的公差。
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公开(公告)号：US07227138B2
公开(公告)日：2007-06-05
申请号：US10878989
申请日：2004-06-28
IPC分类号： H01J49/00
CPC分类号： A41C5/005 , H01J49/4295
摘要： A virtual ion trap that uses electric focusing fields instead of machined metal electrodes that normally surround the trapping volume, wherein two opposing surfaces include a plurality of uniquely designed and coated electrodes, and wherein the electrodes can be disposed on the two opposing surfaces using plating techniques that enable much higher tolerances to be met than existing machining techniques.
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公开(公告)号：US07199362B2
公开(公告)日：2007-04-03
申请号：US10821660
申请日：2004-04-09
IPC分类号： H01J49/40
CPC分类号： G01N27/622
摘要： A cross-flow ion mobility analyzer (CIMA) that includes a component of gas flow that opposes an electric field that is established within a channel, wherein ions are carried through the channel, wherein ions of a specific mobility are trapped by the opposing electric field and flow field within the channel and are detected when the ions reach the end of the channel, wherein a detector at the end of the channel sees a continuous stream of mobility-selected ions, and wherein different ions are selected by modifying the electric field and/or the velocity of the flow field.
摘要翻译： 一种交叉流离子迁移率分析仪（CIMA），其包括与在通道内建立的电场相对的气流成分，其中离子通过通道传送，其中特定迁移率的离子被相对的电场 和通道内的流场，并且当离子到达通道的末端时被检测，其中在通道末端的检测器看到连续的迁移率选择的离子流，并且其中通过修改电场来选择不同的离子，并且 /或流场的速度。
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4.发明授权Printed circuit boards as insulated components for a time of flight mass spectrometer 失效印刷电路板作为飞行时间质谱仪的绝缘组件公开(公告)号：US06316768B1
公开(公告)日：2001-11-13
申请号：US08818376
申请日：1997-03-14
IPC分类号： H01J4940
CPC分类号： H01J49/40 , H05K1/0218 , H05K1/14 , H05K2201/047
摘要： The present invention is embodied in a method and apparatus for utilizing inherently insulative material, such as the glass and epoxy resins used in construction of printed circuit boards, for construction of components in a time of flight mass spectrometer. By using printed circuit board materials, the present invention can take advantage of fabrication techniques for providing circuit traces on surfaces, from one side to another as a via, or embedded within the printed circuit material so as to be covered except where necessary to be exposed to make contact with other electrical devices. Embedded circuit traces also enable capacitive coupling to AC energy while maintaining electrical and physical isolation. Consequently, the present invention enables both invasive and non-invasive access to pressure and vacuum chambers.
摘要翻译： 本发明在用于构建印刷电路板中的玻璃和环氧树脂等固有绝缘材料的飞行时间质谱仪中构成部件的方法和装置中体现。 通过使用印刷电路板材料，本发明可以利用制造技术，用于在表面上提供电路迹线，从一侧到另一侧作为通孔，或嵌入在印刷电路材料内，以便被覆盖，除非需要暴露 与其他电气设备接触。 嵌入式电路迹线还可以实现电容耦合到交流能量，同时保持电气和物理隔离。 因此，本发明能够使侵入式和非侵入性地进入压力和真空室。
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公开(公告)号：US4990775A
公开(公告)日：1991-02-05
申请号：US453037
申请日：1989-12-12
申请人： Alan L. Rockwood , Ying Pan , D. P. Ridge , John Wronka
发明人： Alan L. Rockwood , Ying Pan , D. P. Ridge , John Wronka
IPC分类号： H01J49/38
CPC分类号： H01J49/38
摘要： In an ion cyclotron resonance mass spectrometer, ion cyclotron resonance signals at higher harmonics of cyclotron frequency are employed to increase the resolution of ICR mass spectrometer without increasing the magnetic field. The detection electrodes consist of M (where M is an integer) identical electrodes arranged in M-fold symmetry about the axis of the coherent cyclotron motion of the observed ions. In an ion cyclotron having four points of voltage in space, the cyclotron electrodes are set up in clockwise symmetric fashion. To increase the resolution in signal detection resulting from the potential induced by ions moving in orbits in the specrometer, the first and third voltages are added and the second and fourth voltages are subtracted from the sum of the first and third voltages.
摘要翻译： 在离子回旋共振质谱仪中，采用回旋加速器高次谐波处的离子回旋共振信号来提高ICR质谱仪的分辨率，而不增加磁场。 检测电极由M（其中M是整数）组成的相同的电极以观察到的离子的相干回旋加速器的运动的轴线对M排列。 在空间中具有四个电压点的离子回旋加速器中，回旋加速器电极以顺时针对的方式设置。 为了增加由在测微计中的轨道中移动的离子引起的电位引起的信号检测中的分辨率，加上第一和第三电压，并从第一和第三电压的和中减去第二和第四电压。
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公开(公告)号：US09834578B2
公开(公告)日：2017-12-05
申请号：US13114885
申请日：2011-05-24
申请人： Bingfang Yue , Alan L. Rockwood , Mark M. Kushnir
发明人： Bingfang Yue , Alan L. Rockwood , Mark M. Kushnir
CPC分类号： C07J1/0022 , C07J41/0016
摘要： The present disclosure provides methods and composition involving increased sensitivity of compounds using mass spectrometry. In one embodiment, a method of increasing the sensitivity for detection of a carbonyl group-containing compound by mass spectrometry can comprise derivatizing the carbonyl group-containing compound with an O-substituted hydroxylamine thereby producing an oxime, resulting in enhanced sensitivity of detection by mass spectrometry, as compared to the underivatized carbonyl group-containing compound.Additionally, a method for assaying a carbonyl group-containing compound can comprise reacting the carbonyl group-containing compound in a sample with an O-substituted hydroxylamine to produce an oxime and performing analysis with mass spectrometric detection of the oxime by a mass spectrometry instrument.Further, an assay for a ketosteroid can comprise a derivatized ketosteroid produced by reacting the ketosteroid with an O-substituted hydroxylamine to produce an oxime and a mass spectrometry instrument for performing mass spectrometric analysis on the derivatized ketosteroid.
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7.发明申请公开(公告)号：US20120126107A1
公开(公告)日：2012-05-24
申请号：US13114885
申请日：2011-05-24
申请人： Bingfang Yue , Alan L. Rockwood , Mark M. Kushnir
发明人： Bingfang Yue , Alan L. Rockwood , Mark M. Kushnir
CPC分类号： C07J1/0022 , C07J41/0016
摘要： The present disclosure provides methods and composition involving increased sensitivity of compounds using mass spectrometry. In one embodiment, a method of increasing the sensitivity for detection of a carbonyl group-containing compound by mass spectrometry can comprise derivatizing the carbonyl group-containing compound with an O-substituted hydroxylamine thereby producing an oxime, resulting in enhanced sensitivity of detection by mass spectrometry, as compared to the underivatized carbonyl group-containing compound.Additionally, a method for assaying a carbonyl group-containing compound can comprise reacting the carbonyl group-containing compound in a sample with an O-substituted hydroxylamine to produce an oxime and performing analysis with mass spectrometric detection of the oxime by a mass spectrometry instrument.Further, an assay for a ketosteroid can comprise a derivatized ketosteroid produced by reacting the ketosteroid with an O-substituted hydroxylamine to produce an oxime and a mass spectrometry instrument for performing mass spectrometric analysis on the derivatized ketosteroid.
摘要翻译： 本公开提供涉及使用质谱法的化合物增加的灵敏度的方法和组合。 在一个实施方案中，通过质谱法提高检测含羰基化合物的灵敏度的方法可以包括用O-取代的羟胺衍生含羰基化合物，从而产生肟，从而提高质量检测的灵敏度 与未衍生的含羰基化合物相比较。 此外，用于测定含羰基化合物的方法可以包括将样品中的含羰基化合物与O-取代的羟胺反应以产生肟，并通过质谱仪对肟的质谱检测进行分析。 此外，酮甾类的测定可以包括通过使酮类固醇与O-取代的羟胺反应以产生肟而产生的衍生的酮类固醇，以及用于对衍生的酮类固醇进行质谱分析的质谱仪。
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公开(公告)号：US06992299B2
公开(公告)日：2006-01-31
申请号：US10739949
申请日：2003-12-18
申请人： Edgar D. Lee , Milton L. Lee , Alan L. Rockwood , Li Zhou
发明人： Edgar D. Lee , Milton L. Lee , Alan L. Rockwood , Li Zhou
IPC分类号： H01J49/24
摘要： A method and apparatus for focusing ions for delivery to an ion detection device using an aerodynamic ion focusing system that uses a high-velocity converging gas flow at an entrance aperture to focus an ion plume by reducing spreading and increasing desolvation of ions, and wherein a voltage is applied to at least a portion of the aerodynamic ion focusing system to assist in the focusing and delivery of ions to the ion detection device.
摘要翻译： 一种用于将离子聚焦到离子检测装置的方法和装置，所述方法和装置使用空气动力离子聚焦系统，所述空气动力学离子聚焦系统在入口孔处使用高速会聚气体流动，通过减少散射并增加离子的去溶剂化来聚焦离子羽流，并且其中a 电压被施加到空气动力学离子聚焦系统的至少一部分，以帮助将离子聚焦和输送到离子检测装置。
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9.发明授权Tapered or tilted electrodes to allow the superposition of independently controllable DC field gradients to RF fields 失效锥形或倾斜的电极，以允许将独立可控DC场梯度叠加到RF场
公开(公告)号：US6163032A
公开(公告)日：2000-12-19
申请号：US814898
申请日：1997-03-12
申请人： Alan L. Rockwood
发明人： Alan L. Rockwood
CPC分类号： H01J49/063
摘要： The present invention is embodied in a method and apparatus for transporting ions via a path generated by RF electrodes having a controllable DC field gradient generated thereon which does not suffer from mass discrimination. In a preferred embodiment, the number of electrodes are doubled to thereby use symmetry to cancel an undesirable DC quadrapole field. By eliminating the DC quadrapole field, the passband of the DC field gradient is increased, allowing for ions of higher mass to be transported. The electrodes are either tilted or tapered to thereby generate the desirable DC field gradient. Tilting and/or tapering the electrodes advantageously modifies the DC field gradient to increase the high ion mass cut-off.
摘要翻译： 本发明体现在用于通过由其上产生的可控DC场梯度的RF电极产生的路径输送离子的方法和装置，其中不产生质量鉴别。 在优选实施例中，电极的数量加倍，从而使用对称性来消除不需要的DC四极场。 通过消除DC四极场，直流场梯度的通带增加，允许较高质量的离子传输。 电极是倾斜的或锥形的，从而产生期望的DC场梯度。 电极的倾斜和/或渐缩有利地改变了DC场梯度以增加高离子质量截止。
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公开(公告)号：US07158903B2
公开(公告)日：2007-01-02
申请号：US10508068
申请日：2003-03-14
IPC分类号： G06F19/00
CPC分类号： H01J49/0009 , H01J49/004 , Y10T436/11
摘要： The present invention provides methods for high throughput analysis of analytes in complex mixtures for unresolved chromatographic peaks including specific embodiment for summing intensities for each mass transition of interest over a selected chromatographic peak (50) to generate a signal corresponding to total intensity for each transition (55, 60). The intensities are deconvoluted into intensities of individual analytes (65, 70), based on branching ratios acquired from authentic standards, and a comparison to calibration curve is performed to obtain a quantitative concentration measurement of a particular analyte in a sample.
摘要翻译： 本发明提供了用于未分辨色谱峰的复杂混合物中分析物的高通量分析的方法，包括用于在所选择的色谱峰（50）上对每个感兴趣的质量转换求和强度的特定实施方案，以产生对应于每个转变的总强度的信号 55，60）。 基于从真实标准获得的分支比例，将强度解卷积成单个分析物（65,70）的强度，并且进行与校准曲线的比较以获得样品中特定分析物的定量浓度测量。
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