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    Diagnostic kits comprising genetically engineered human immunodeficiency virus-like particles containing heterologous antigenic markers
    10.
    发明授权
    Diagnostic kits comprising genetically engineered human immunodeficiency virus-like particles containing heterologous antigenic markers 失效
    包含遗传工程改造的含有异源抗原标记的人类免疫缺陷病毒样颗粒的诊断试剂盒

    公开(公告)号：US06342228B1

    公开(公告)日：2002-01-29

    申请号：US09636805

    申请日：2000-08-10

    申请人： Benjamin Rovinski ,  Shi-Xian Cao ,  Fei-Long Yao ,  Roy Persson ,  Michel H. Klein

    发明人： Benjamin Rovinski ,  Shi-Xian Cao ,  Fei-Long Yao ,  Roy Persson ,  Michel H. Klein

    IPC分类号： A61K3912

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C07K2319/00 ,  C12N7/00 ,  C12N2740/16023 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2760/16022 ,  C12N2770/00022 ,  C12Q1/703 ,  G01N33/56988

    摘要： Non-infectious, retrovirus-like particles comprise an assembly of an env gene product, a pol gene product and a gag gene product contain an antigenic marker which is non-retroviral or non-HIV retroviral. In one embodiment, the marker comprises an amino acid sequence containing an epitope inserted into the gag gene product at an antigenically-active insertion site. In another embodiment, the marker comprises an antigenic anchor sequence operatively connected to the env gene product replacing endogenous anchoring function. The corresponding nucleic acid molecules are described. The non-infectious, retrovirus-like particles have utility in in vivo administration including to humans and in diagnosis. The presence of the antigenic marker enables recognition that antiserum containing anti-retroviral antibodies has been generated by exposure to the non-infectious retrovirus-like particles by testing for antibodies specific to the antigenic marker.

    摘要翻译： 非感染性逆转录病毒样颗粒包含env基因产物，pol基因产物和含有非逆转录病毒或非HIV逆转录病毒的抗原标记的gag基因产物的组合。 在一个实施方案中，标记物包含含有在抗原活性插入位点插入到gag基因产物中的表位的氨基酸序列。 在另一个实施方案中，标记物包含可操作地连接到代替内源锚定功能的env基因产物的抗原锚定序列。 描述了相应的核酸分子。 非感染性逆转录病毒样颗粒在体内给药中具有用途，包括对人类和诊断。 抗原标记的存在使得能够通过测试抗原标记物特异性的抗体来识别含有抗逆转录病毒抗体的抗血清是通过暴露于非感染性逆转录病毒样颗粒而产生的。