公开(公告)号：US07779571B1

公开(公告)日：2010-08-24

申请号：US12150665

申请日：2008-04-29

Applicant: Mark Roth

Inventor： Mark Roth

IPC: F41A9/00

CPC classification number: F41A9/26

Abstract: The present invention can have an adjustable length adapter that attaches to the firearm, and in one embodiment directly to an existing load tube. A mounting assembly and an indexing assembly are further provided. The mounting assembly has a mounting plate with an alignment hole for allowing a shell to pass there through from an aligned tube and into the adapter. The indexing assembly indexes relative the mounting assembly to successively align one of a plurality of tubes with the alignment hole. As one tube fills, the invention can be rotated to index the next tube and tension a rotator that can be positioned generally parallel to the firearm barrel. This process can be repeated until all four tubes are full. Upon emptying of a tube, a pin can be automatically activated to allow the indexing assembly to rotate relative the mounting assembly to align the next successive tube.

Abstract translation: 本发明可以具有附接到枪支的可调节长度的适配器，并且在一个实施例中可以直接连接到现有的负载管。 还提供了安装组件和分度组件。 安装组件具有带有对准孔的安装板，用于允许壳体从对准的管道进入到适配器中。 分度组件相对于安装组件进行索引，以使多个管中的一个与对准孔连续对准。 当一个管填充时，本发明可以旋转以对下一个管进行索引并且张紧可以大致平行于枪械枪筒定位的转子。 这个过程可以重复，直到所有四个管都满了。 在排空管时，可以自动启动销以允许分度组件相对于安装组件旋转以对准下一个连续的管。

公开(公告)号：US07610577B1

公开(公告)日：2009-10-27

申请号：US10978517

申请日：2004-11-01

Applicant: Mark Roth

Inventor： Mark Roth

IPC: G06F9/44

CPC classification number: G06F8/71 ,  G06F8/60 ,  G06F9/44542

Abstract: A method, computer program product, and system for providing launchable application source code are presented. A determination is made regarding which target platforms a launchable application executable will be run on. Once the platforms have been determined, a cross platform executable is generated using the launchable application source code. Platform specific executables are also generated for each selected platform. The cross platform executable is then combined with the platform specific executable for the platform to provide the platform independent launchable application. The platform specific executable is launched by an Operating System as part of a system service, such as a screensaver, and calls the cross platform executable which is executed on a virtual machine running on the platform.

Abstract translation: 提出了一种提供可启动应用程序源代码的方法，计算机程序产品和系统。 确定可运行可启动应用程序可执行文件的目标平台。 一旦确定了平台，就可以使用可启动的应用程序源代码生成跨平台可执行文件。 还为每个选定的平台生成平台特定的可执行文件。 然后将跨平台可执行程序与平台特定的可执行文件组合，以提供平台独立的可启动应用程序。 平台特定的可执行文件由操作系统作为系统服务的一部分（如屏幕保护程序）启动，并调用在平台上运行的虚拟机上执行的跨平台可执行文件。

公开(公告)号：US20050147692A1

公开(公告)日：2005-07-07

申请号：US10972063

申请日：2004-10-22

Applicant: Mark Roth

Inventor： Mark Roth

IPC: A01N1/02 ,  A61K33/00 ,  A61K33/04 ,  A61K51/00 ,  B65D81/20 ,  C12M1/04 ,  C12N5/00 ,  C12N15/06

CPC classification number: C12N5/00 ,  A01N1/02 ,  A01N1/0221 ,  C12N2500/02

Abstract: The present invention concerns the use of oxygen antagonists for inducing stasis in tissue, including all or part of organs. It includes methods and apparatuses for achieving stasis in tissue, so as to preserve and/or protect them. In specific embodiments, preservation methods and apparatuses for preserving tissue for transplantation purposes is provided.

Abstract translation: 本发明涉及使用氧拮抗剂诱导组织中的淤滞，包括全部或部分器官。 它包括用于在组织中实现淤滞的方法和装置，以保护和/或保护它们。 在具体实施方案中，提供了用于保持用于移植的组织的保存方法和装置。

公开(公告)号：US20050053912A1

公开(公告)日：2005-03-10

申请号：US10480430

申请日：2002-06-10

Applicant: Mark Roth ,  Pamela Padilla

Inventor： Mark Roth ,  Pamela Padilla

IPC: A01N1/02 ,  C12N1/04 ,  C12N5/02 ,  G01N33/50 ,  A01N1/00 ,  C12Q1/00

CPC classification number: G01N33/5011 ,  A01N1/02 ,  A01N1/0278 ,  C12N1/04 ,  G01N33/5082 ,  G01N33/5088

Abstract: The present invention concerns compositions and methods involving incubating biological materials under hypoxic or anoxic conditions to induce stasis or suspended animation. Methods of screening for compounds that induce stasis or compounds that increase the ability to undergo stasis are included. Such methods have ramifications for preserving biological materials as well as reducing or preventing trauma to biological materials. Also contemplated are methods for screening compounds that are active or more active under hypoxic conditions than normoxic conditions. Such methods can be used to identify antitumor compounds that would operate under hypoxic conditions in which tumor cells survive.

Abstract translation: 本发明涉及在缺氧或缺氧条件下培养生物材料以诱导淤滞或悬浮动画的组合物和方法。 包括筛选引起淤滞的化合物或增加瘀血能力的化合物的方法。 这种方法具有保护生物材料以及减少或预防生物材料创伤的后果。 还考虑了用于筛选在缺氧条件下比正常氧条件下活性或更有活性的化合物的方法。 这样的方法可用于鉴定将在其中肿瘤细胞存活的缺氧条件下操作的抗肿瘤化合物。

公开(公告)号：US20070078113A1

公开(公告)日：2007-04-05

申请号：US11408734

申请日：2006-04-20

Applicant: Mark Roth ,  Mike Morrison ,  Eric Blackstone ,  Dana Miller

Inventor： Mark Roth ,  Mike Morrison ,  Eric Blackstone ,  Dana Miller

IPC: A61K31/66 ,  A61K31/555 ,  A61K31/185 ,  A61K31/165 ,  A61K31/275 ,  A61K31/26 ,  A61K31/095 ,  A61K31/21

CPC classification number: A61K33/04 ,  A01N1/02 ,  A01N1/0226 ,  A61K31/095 ,  A61K31/165 ,  A61K31/185 ,  A61K31/21 ,  A61K31/26 ,  A61K31/275 ,  A61K31/555 ,  A61K31/66 ,  A61K45/06 ,  Y10S514/921 ,  A61K2300/00

Abstract: The present invention concerns the use of oxygen antagonists and other active compounds for inducing stasis or pre-stasis in cells, tissues, and/or organs in vivo or in an organism overall, in addition to enhancing their survivability. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability and for achieving stasis or pre-stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, there are also therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the active compounds described.

Abstract translation: 本发明涉及氧还原剂和其它活性化合物在体内或生物体中的细胞，组织和/或器官中的用途，除了提高其生存性之外，还可用于其中。 它包括组合物，方法，制品和用于提高生存能力的装置，以及用于在这些生物材料中的任何一种中实现淤滞或止血，从而保存和/或保护它们。 在具体实施方案中，还使用所述活性化合物进行器官移植，热疗，伤口愈合，出血性休克，旁路手术的心脏停搏，神经变性，低温和癌症的治疗方法和装置。

公开(公告)号：US20060046313A1

公开(公告)日：2006-03-02

申请号：US11027470

申请日：2004-12-30

Applicant: Mark Roth ,  Tae-Woong Koo ,  Andrew Berlin ,  Selena Chan ,  Xing Su ,  Lei Sun

Inventor： Mark Roth ,  Tae-Woong Koo ,  Andrew Berlin ,  Selena Chan ,  Xing Su ,  Lei Sun

IPC: G01N33/543

CPC classification number: G01N33/54366 ,  G01N33/54373 ,  G01N33/58 ,  Y10T436/10

Abstract: Methods and apparatus are provided for assaying cell samples, which may be living cells, using probes labeled with composite organic-inorganic nanoparticles (COINs) and microspheres with COINs embedded within a polymer matrix to which the probe moiety is attached. COINs intrinsically produce SERS signals upon laser irradiation, making COIN-labeled probes particularly suitable in a variety of methods for assaying cells, including biological molecules that may be contained on or within cells, most of which are not inherently Raman-active. The invention provides variations of the sandwich immunoassay employing both specific and degenerate binding, methods for reverse phase assay of tissue samples and cell microstructures, in solution displacement and competition assays, and the like. Systems and chips useful for practicing the invention assays are also provided.

Abstract translation: 提供了用于使用用复合有机 - 无机纳米颗粒（COIN）标记的探针和嵌入探针部分所连接的聚合物基质内的COIN的微球来测定可能为活细胞的细胞样品的方法和装置。 COIN在激光照射下固有地产生SERS信号，使得COIN标记的探针特别适用于多种测定细胞的方法，包括可能包含在细胞内或细胞内的生物分子，其中大部分不是固有的拉曼活性的。 本发明提供使用特异性和简并结合的夹心免疫测定的变体，组织样品和细胞微结构的反相测定方法，溶液置换和竞争测定等。 还提供了用于实施本发明测定的系统和芯片。

公开(公告)号：US06596501B2

公开(公告)日：2003-07-22

申请号：US09256497

申请日：1999-02-23

Applicant: Mark Roth

Inventor： Mark Roth

IPC: G01N33543

CPC classification number: G01N33/564 ,  G01N2800/24 ,  Y10S977/959

Abstract: The present invention relates to diagnostic applications. For autoimmune diseases more particularly, it is demonstrated herein that individuals with SLE, APLA, MCDS and PSS have antibodies that are specific for SR proteins. Thus, in particular aspects the present invention provides methods and compositions for diagnosing autoimmune disease using SR proteins and antibodies to detect the presence of SR protein-specific antibodies in an individual suspected of having autoimmune disease, wherein the presence of such antibodies is indicative of said individual suffering from autoimmune disease.

Abstract translation: 本发明涉及诊断应用。 对于自身免疫性疾病更具体地，本文证明具有SLE，APLA，MCDS和PSS的个体具有对SR蛋白特异的抗体。 因此，在特定方面，本发明提供了使用SR蛋白和抗体诊断自身免疫疾病的方法和组合物，以检测在怀疑患有自身免疫性疾病的个体中SR蛋白特异性抗体的存在，其中所述抗体的存在表示所述 个体患有自身免疫性疾病。

公开(公告)号：US06419055B1

公开(公告)日：2002-07-16

申请号：US09450411

申请日：1999-11-29

Applicant: John Walsh ,  Mark Roth ,  Joseph B. Wells ,  Jason A. Reichard

Inventor： John Walsh ,  Mark Roth ,  Joseph B. Wells ,  Jason A. Reichard

IPC: F16D6514

CPC classification number: B60K37/04

Abstract: A positioner member having a spherically curved wall with an opening through it, a receiver having a surface complementary to the curved wall to nestably interfit with it, a releasable locking member disposed behind the curved wall, and an elongated connector member extending from the receiver through the opening in the curved wall and into engagement with the locking member to permit tightening and loosening of the positioner and receiver, whereby they may be moved relative to one another in a three-dimensionally orbital manner when the connector and locking element are loosened but immovably clamped when these two elements are tightened. The positioner member is attachable to a desired external support such as an automobile dashboard, and the receiver is attachable to a brake controller or other such device. The receiver may be integral with the brake controller, formed in or attached to a side thereof.

Abstract translation: 具有球形弯曲壁的定位器构件，具有穿过其的开口的球形接收器，具有与弯曲壁互补的表面以与其可嵌套地相互配合的接收器，设置在弯曲壁后面的可释放锁定构件以及从接收器延伸的细长连接器构件 弯曲壁中的开口并与锁定构件接合以允许定位器和接收器的紧固和松动，由此当连接器和锁定元件松动但不可移动时，它们可以相对于彼此以三维轨道的方式移动 当这两个元件被拧紧时被夹紧。 定位器构件可附接到诸如汽车仪表板的期望的外部支撑件，并且接收器可附接到制动控制器或其他这样的装置。 接收器可以与制动控制器成一体，形成在其一侧或附着于其一侧。

公开(公告)号：US4921158A

公开(公告)日：1990-05-01

申请号：US314808

申请日：1989-02-24

Applicant: Kuen-Shyang Hwang ,  Mohammad Sedigh ,  Mark Roth

Inventor： Kuen-Shyang Hwang ,  Mohammad Sedigh ,  Mark Roth

IPC: B23K35/28 ,  B23K35/00 ,  B23K35/20 ,  B23K101/40 ,  H01L21/52 ,  H01L21/60 ,  H01L23/492

CPC classification number: H01L24/83 ,  B23K35/005 ,  H01L23/4924 ,  H01L24/29 ,  H01L24/33 ,  B23K2035/008 ,  H01L2224/29101 ,  H01L2224/83101 ,  H01L2224/8319 ,  H01L2224/83801 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01019 ,  H01L2924/01027 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01042 ,  H01L2924/01047 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/0132 ,  H01L2924/01322 ,  H01L2924/014 ,  Y10T428/12528

Abstract: A mechanical and electrical bond between a silicon semiconductor wafer and a molybdenum contact is created by a multi-layer brazing material. The material includes adjacent layers of titanium and silver along with a layer which is either composed of aluminum or an aluminum-silicon composite. The material is heated to a temperature above its melting point. The aluminum reacts first with the silver, thereby dissolving less of the silicon. This reduces spiking and lowers the contact resistance.

公开(公告)号：US07776547B2

公开(公告)日：2010-08-17

申请号：US11027470

申请日：2004-12-30

Applicant: Mark Roth ,  Andrew Berlin ,  Selena Chan ,  Tae-Woong Koo ,  Xing Su ,  Lei Sun

Inventor： Mark Roth ,  Andrew Berlin ,  Selena Chan ,  Tae-Woong Koo ,  Xing Su ,  Lei Sun

IPC: G01N33/53

CPC classification number: G01N33/54366 ,  G01N33/54373 ,  G01N33/58 ,  Y10T436/10

Abstract: Methods and apparatus are provided for assaying cell samples, which may be living cells, using probes labeled with composite organic-inorganic nanoparticles (COINs) and microspheres with COINs embedded within a polymer matrix to which the probe moiety is attached. COINs intrinsically produce SERS signals upon laser irradiation, making COIN-labeled probes particularly suitable in a variety of methods for assaying cells, including biological molecules that may be contained on or within cells, most of which are not inherently Raman-active. The invention provides variations of the sandwich immunoassay employing both specific and degenerate binding, methods for reverse phase assay of tissue samples and cell microstructures, in solution displacement and competition assays, and the like. Systems and chips useful for practicing the invention assays are also provided.

Abstract translation: 提供了用于使用用复合有机 - 无机纳米颗粒（COIN）标记的探针和嵌入探针部分所连接的聚合物基质内的COIN的微球来测定可能为活细胞的细胞样品的方法和装置。 COIN在激光照射下固有地产生SERS信号，使得COIN标记的探针特别适用于多种测定细胞的方法，包括可能包含在细胞内或细胞内的生物分子，其中大部分不是固有的拉曼活性的。 本发明提供使用特异性和简并结合的夹心免疫测定的变体，组织样品和细胞微结构的反相测定方法，溶液置换和竞争测定等。 还提供了用于实施本发明测定的系统和芯片。